Biseptol syrup expiration date after opening. Antimicrobial agents Medana Biseptol for children Suspension - “Biseptol suspension. Antibiotic or not? Experience in taking a child with pharyngitis, and in an adult with an intestinal disorder. How Biseptol works - farm

The drug Biseptol is known to many parents, but not everyone is familiar with the principle of its action and composition. Sometimes it is classified as an antibiotic, but it is not. Biseptol is an antimicrobial and bactericidal drug, its spectrum of action is somewhat wider.

What does the drug help? At what age is Biseptol allowed for children, and how is its amount calculated? It is necessary to understand the effect of the drug on the child's body, possible side effects, and what drugs can replace it.

Composition and form of release of the drug

Biseptol refers to a broad-spectrum agent from the group of sulfonamides (synthetic antimicrobial agents based on artificial analogues of sulfonic acid). It performs an antimicrobial and bactericidal function, blocks the further reproduction of pathogenic microflora in the body.

This is a combined medication, which includes two active ingredients - sulfamethoxazole and trimethoprim. Regardless of the dosage, their content in the preparation is 5:1. The peculiarity of the drug lies in the special combination of active substances. In the right ratio, they enhance each other's action and increase the effectiveness of the drug. That is why Biseptol acts on microorganisms resistant to other sulfonamides.

It was previously noted that the remedy is not an antibiotic. The death of microbes occurs due to the cessation of the production of folic acid, which is necessary for their reproduction and vital activity. The drug is active against many gram-positive and gram-negative microorganisms:

• various cocci;
• coli;
• causative agents of dysentery;
• typhoid bacillus;
• salmonella;
• pneumocystis;
• causative agent of diphtheria;
• some types of fungal microorganisms, etc.

Forms of drug release:

1. tablets 120 (100 mg sulfamethoxazole and 20 mg trimethoprim);
2. tablets 480 (400 mg/80 mg);
3. syrup (suspension) 240 mg (each milliliter contains 40 mg of sulfamethaxazole and 8 mg of trimethoprim);
4. concentrated agent for solution for injection 480 mg.

Western doctors use Biseptol to treat children in adolescence, not earlier than 14 years. Pediatricians of the CIS countries widely practice the use of the drug even for infants (strictly according to the doctor's prescription). In many cases, it turns out to be the only effective remedy.

Indications for the appointment of Biseptol for children

The drug can be used for various diseases caused by pathogenic microflora, in relation to which it is active.

Usually, Biseptol is prescribed for children for infections and inflammations of the respiratory tract, ENT organs, urinary system, gastrointestinal tract, and skin.

Main indications for use:

• bronchitis (acute or chronic form);
• pneumonia;
• inflammation of the lungs, in which pus is released;
• otitis;
• sinusitis;
• pharyngitis;
• angina;
• infections of the gastrointestinal tract;
• pyelonephritis;
• infection of wounds or burns;
• after surgery as a prevention of infection;
• boils on the skin;
• scarlet fever;
• meningitis, etc.

Regarding the treatment of angina, opinions differ. On the one hand, different groups of microorganisms are sensitive to the drug, which increases the chances of a quick recovery. On the other hand, in recent years, with angina, it is prescribed less and less. Experts believe that over the years, the microbes in the throat have become resistant to the drug and have developed a defense mechanism against it.

The range of application of the drug is very wide, for which disease and in what doses the attending physician decides to use Biseptol

The doctor prescribes the medicine exclusively. Biseptol is a potent drug, so taking it for prevention is completely excluded.

Instructions for use of the drug

The instructions for use do not indicate doses and administration rules for infants and infants. In practice, the drug is used from 3 months under the supervision of doctors.

There is no fundamental difference between tablets and suspension, the composition and dosage are identical. The syrup is used for young children, so it is easy to fill it with a measuring spoon or dosing syringe. After 2-3 years, tablets can be taken.

Regardless of the form of release, the medicine is taken after meals. It is important to observe the time frame, the interval between doses should be almost the same. It is best to drink the medicine at the same time. Since most of it is excreted by the kidneys with urine, it is necessary to maintain the water balance in the body. You should provide the child with plenty of fluids (a little more than usual).

The individual dosage is determined by the doctor, based on the diagnosis, the state of health of the child, the type of infection, etc.

You need to drink tablets after meals, drinking them with a large volume of liquid (1 glass).

• At the age of 5 years, Biseptol 120 mg is indicated. You need to drink 2 tablets twice a day (a single concentration of substances is 240 mg).
• From 6 to 12 years, the drug is also taken 2 times a day, 4 tablets (120 mg) or 1 tablet 480 mg. It is inconvenient to drink four pieces at a time, so it is advisable to switch to a larger dosage.
• In case of severe or long-term course of the disease, it is allowed to increase the single amount of the drug by 50% until the state of health improves. It should be taken at regular intervals, that is, every 12 hours.

Features of the use of the suspension and the selection of the dose for the child

For infants and infants, the drug is prescribed with caution. The dosage is usually selected individually.

A handy measuring spoon is included in the syrup box. It has a pleasant berry aroma and taste. The composition of the suspension does not include sugar. The instructions for use indicate the maximum allowable and safe doses for each age group of children:

• from 2-3 to 6 months it is allowed to give 2.5 ml (120 mg) twice a day;
• from six months to 5 years, a single dose is 240 mg, and a daily dose of 480 mg (that is, 5 ml of suspension every 12 hours).

The maximum allowable concentration of active substances for tablets and suspensions is the same. The difference is only in the form of release and ease of use.

The syrup should be drunk after meals every 12 hours. It is important not to exceed its maximum allowed amount to avoid side effects. The drug in any form is taken 2 times a day. For clarity, a single dose selection is shown in the table.

Duration of treatment with Biseptol

The duration of treatment for a child with Biseptol depends on the nature of the infection, its severity and the body's response to the drug. On average, the minimum course of admission is 1 week (at least 5 days). The drug is advised to take during illness and a couple of days after to consolidate the result.

With angina, the medicine should be drunk for 10 days. The course of treatment for pneumonia is 2-3 weeks, it is regulated by the doctor depending on the condition of the child.

Contraindications for use

Biseptol is classified as a potent and even aggressive drug, so it has a number of clear contraindications:

• individual hypersensitivity or intolerance to one of the components (allergic reaction);
• newborns or premature babies;
• violations of the kidneys;
• pathologies of the cardiovascular system;
• insufficient functioning of the liver;
• elevated bilirubin;
• chronic deficiency of glucose-6-phosphate dehydrogenase.

With special care (if absolutely necessary), the drug is prescribed for:

• bronchial asthma;
• folic acid deficiency;
• allergies to other medicines;
• thyroid pathologies, etc.

Side effects and symptoms of overdose

When treating children with Biseptol, negative reactions are often encountered - allergies and disruption of the digestive tract (GIT). Basically, an allergic reaction manifests itself in the form of redness and a rash on the skin, accompanied by itching.

Quincke's edema appears rarely, mainly in children prone to allergies. Other possible adverse reactions:

• dizziness, headaches;
• state of depression, apathy;
• shortness of breath and cough;
• deterioration of kidney function;
• violation of the process of hematopoiesis (manifested in laboratory analysis).

In order to reduce the chance of adverse reactions and increase the effectiveness of the drug, it is recommended to follow some rules:

1. with long-term use, additionally drink folic acid;
2. drink plenty of fluids (within reason);
3. do not drink tablets or syrup with milk;
4. for the duration of therapy, exclude from the diet foods containing a lot of protein and fat (beans, peas, high-fat cheeses, fatty meat), which inhibit the effect of the drug;
5. exclude simple or fast carbohydrates (pastries, sweets, dried fruits and beets).

When does the drug not work?

In the instructions for the drug, cases are defined when the drug has no effect. The drug does not work when the disease is caused by microorganisms that do not respond to Biseptol. This is the main and main reason for the ineffectiveness of the drug.

The medicine is not active to the following microorganisms:

• viruses (absolutely everything, in this case, antiviral drugs are indicated);
• Pseudomonas aeruginosa;
• with tuberculosis and leptospirosis;
• all types of spirochetes;
• some microbes resistant to sulfonic acid.

Biseptol will be completely useless for influenza, SARS and acute respiratory infections, as well as for the prevention of these diseases. The bactericidal function will not help with the herpes virus. That is why the drug is prescribed by the doctor after examination and laboratory tests.

In addition, some representatives of pathogenic and pathogenic microflora have adapted not to respond to the active components of the drug. Gradually, they developed a special immunity. In particular, this applies to causative agents of angina. There is a category of specialists who have partially or completely abandoned the drug, as they consider it outdated.

What can replace Biseptol?

Analogues of the drug are divided into two main groups. The first includes drugs with an identical active ingredient, which differ in country and manufacturer. The second group includes agents that have a different composition and principle of action, but the same functions (antimicrobial and bactericidal).

Direct analogues (identical composition):

Indirect analogues are any antibiotics that are active against pathogens, as well as drugs from the group of sulfonamides:

Remember that it is strictly forbidden to replace the drug yourself. The doctor changes the medicine in the presence of one or more factors:

• allergy;
• inefficiency;
• the occurrence of adverse reactions and deterioration of the general condition.

• Compound
• Release form
• pharmachologic effect
• Contraindications
• Side effects
• Overdose
• Interaction
• Terms of sale
• Storage conditions
• Best before date
• special instructions
• children
• With alcohol
• Analogues
• Reviews
• Price where to buy

Compound

The composition of the drug includes a combined active substance Co-Trimoxazole , which in turn consists of substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and trimethoprim (40 mg for suspension and 20 mg (80 mg) for tablets).

Additional funds

For suspension: purified water, macrogol, sodium carmellose, propylene glycol, propyl parahydroxybenzoate, magnesium aluminum silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate.

For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

Release form

Available in tablet form, 120 (often also called "Children's Biseptol") and 480 mg of active substances, in the form of a suspension (syrup).

pharmachologic effect

Bactericidal, antibacterial.

Biseptol is an antibiotic or not? This remedy is not an antibiotic.

Pharmacodynamics and pharmacokinetics

Combined antimicrobial drug. The main active ingredient is Co-Trimoxazole (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on the metabolism of bacteria. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid, and converts dihydrofolate to tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In the complex, the components of the drug Biseptol block the biosynthesis of purines and nucleic acids, without which the reproduction and growth of bacteria is impossible.

The active substances are actively absorbed from the gastrointestinal tract. Excreted mainly through the kidneys.

Indications for Biseptol's use

What are these tablets and suspension from?

In general, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, urethritis , prostatitis , pyelonephritis , gonorrhea , epididymitis, venereal lymphogranuloma, soft chancre, inguinal granuloma. Consider Biseptol from which it helps in parts of the body.

Indications for Biseptol's use for gastrointestinal infections:paratyphoid , cholera, typhoid fever , cholangitis, dysentery , gastroenteritis (E. coli), cholangitis, salmonellosis.

Respiratory infections: lobar pneumonia, bronchiectasis, bronchitis (acute and chronic course), pneumocystis pneumonia, bronchopneumonia .

ENT infections: angina , sinusitis , otitis media ,scarlet fever , laryngitis .

Infections of soft tissues, skin integuments: furunculosis, acne , wound infections, pyoderma . In complex therapy, it is used to treat toxoplasmosis, malaria, South American blastomycosis, and acute brucellosis.

Contraindications

Aplastic anemia, leukopenia, pregnancy, agranulocytosis, B12 deficiency anemia, severe impairment of the renal/hepatic systems, hyperbilirubinemia in children. With caution, Biseptol is prescribed for bronchial asthma, folic acid deficiency, and thyroid diseases.

Side effects

Nervous system: dizziness, headaches, rarely depression, aseptic meningitis , tremor, apathy , peripheral neuritis.

Respiratory system: pulmonary infiltrates, bronchospasm.

Digestive system: dyspeptic disorders, cholestasis, diarrhea, vomiting, loss of appetite, glossitis, epigastric pain, gastritis, elevated liver transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis, hepatitis.

Hematopoietic organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.

Side effects from the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with anuria , oliguria, increased urea levels, hematuria, impaired renal function.

Musculoskeletal system: myalgia, arthralgia. thrombophlebitis , hypoglycemia, allergy .

Application instruction of Biseptol (Way and dosage)

The dose of the drug in each case is prescribed by the doctor.

Tablets Biseptol, instructions for use

Adults: 960 mg once, or 480 mg for 2 doses. Severe infections: three times 480 mg. Course 1-2 weeks.

With acute brucellosis the course of treatment is 3-4 weeks, paratyphoid and typhoid fever - up to 3 months.

Chronic infections: twice 480 mg tablets.

Instructions for use for children

For children, Biseptol is prescribed twice a day, the dose is from 120 to 480 mg.

At the age of 3-5 years: 2 times 120 mg in 24 hours.

Suspension Biseptol, instructions for use

The syrup is used in the same way as the dosage of tablets.

Overdose

Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , fainting, visual disturbances, leukopenia, fever, crystalluria . With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, leukopenia are noted. It is necessary to introduce trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg / day. If necessary, hemodialysis is prescribed. There is no specific antidote.

Interaction

Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia increases when taken with pyrimethamine (more than 25 mg per week). Thiazides can lead to thrombocytopenia. The effectiveness of Biseptol is reduced procainamide ,procaine , benzocaine . The drug leads to the development of cross-allergy when taken simultaneously with oral hypoglycemic drugs. Folic acid deficiency is aggravated by barbiturates, phenytoin, PASK . Crystalluria develops when taking hexamethylenetetramine , ascorbic acid.

Storage conditions

In a place inaccessible to children at a temperature not exceeding 25 degrees Celsius.

special instructions

Regular monitoring of the concentration of sulfamethoxazole in the blood is necessary. If the indicator is more than 150 μg / ml, then the treatment is stopped until the value reaches 120 μg / ml and below. If the course of treatment is designed for a month or more, then regular monitoring of the blood condition is required. When appointed folic acid hematological changes are reversible. In AIDS patients, side effects are more common and pronounced. Biseptol is not recommended for prescribing pharyngitis and tonsillitis caused by beta-hemolytic streptococcus gr. BUT.

Biseptol - an antibiotic or not? According to the annotation, the drug is not an antibiotic.

A recipe in Latin might look something like this: Rp: "Biseptoli-420" D.t.d. No. 20 in tab.

There is no description of the drug on Wikipedia.

Biseptol for children

It is noted that the drug can be used from 3 months of age, and the doses will naturally vary. However, this should be done with caution and only as directed by a doctor. In some countries of the world, Biseptol for children is allowed to be used only from the age of 12.

Usually they can prescribe a suspension from 3 months, tablets - from 2 years.

Instructions for Biseptol for children

At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years, take up to 5 ml of Biseptol suspension for children twice a day.

From 3 to 6 years, the dosage is made equal to 5-10 ml twice a day, 6-12 years - 10 ml 2 times a day. From the age of 12, take 20 ml every 12 hours.

How to take tablets for children?

At the age of 2-5 years: 2 times 120 mg in 24 hours. From 6 to 12 years of age use 480 mg every 12 hours.

The course of treatment is 5-7 days. When using drugs for children, you should drink plenty of water.

Alcohol compatibility

The reaction of combination with alcohol is impossible to predict. The use of these substances together is undesirable.

Biseptol's analogs

Analogues are drugs: Baktiseptol , Bactrim , Biseptazole , Biseptrim , Groseptol , Co-Trimoxazole , Oriprim , Raseptol , Soluseptol , Sumetrolim , Triseptol .

Reviews about Biseptol

The tool is very effective, especially in diseases of the respiratory system. It has an excellent antibacterial effect. Of the minuses, it should be noted sometimes occurring side effects. Should not be used without the direction of the attending physician.

Biseptol for children, reviews

It is considered to be a very effective tool for fighting microbes. Negative reviews in the treatment of Biseptol syrup for children are generally not found.

Reviews about Biseptol with cystitis

The drug is effective for cystitis, but do not forget about the side effects.

With angina

It is prescribed when it is impossible to take antibiotics. According to studies, the microorganisms that cause angina began to lose sensitivity to this drug.

Biseptol price

The price of Biseptol in tablets of 120 mg is 35 rubles for 20 pieces. You can buy 480 mg tablets for 100 rubles per pack of 28 pieces.

The price of Biseptol syrup is approximately equal to 130 rubles.

medicalmed.ru

Forms of release and dosage of Bromhexine

Biseptol for children is available in three dosage forms:

• tablets (with the content of active substances according to children's age);
• suspensions;
• syrup.

There is an opinion that indications for use in pediatrics are generally justified only for adolescents. But, as practice shows, the drug is simply indispensable for the rapid and effective removal of the symptoms of some infectious diseases even at a younger age.

After all, the forms of this remedy for children that exist today in the form of a suspension or syrup make the treatment process much easier, significantly reducing its time. The main thing that the dosage of Biseptol was strictly observed!

According to the instructions for use, the suspension can be administered to children, from 3 months of age. A syrup based on this drug is taken by babies from a year old, a tablet form - from two years old.

The drug is used only under the supervision of a physician, and strictly observing the method of application of Biseptol. As a rule, for successful therapy, children need to take the medicine for up to 5 days, and even after the symptoms of the disease disappear, it is recommended to continue taking the drug for another 2 days.

Required Information

Contraindications are few, but they are, like every drug. Perhaps the main ones are:

• hypersensitivity to the components of the drug (allergy);
• kidney and liver diseases;
• hyperbilirubinemia (a large amount of bilirubin in the blood serum).

Caution should be exercised when using the drug with certain drugs. Side effects of Biseptol cause:

• chloramphenicol;
• novocaine;
• furatsilin;
• folic acid;
• many diuretics, etc.

Therefore, in order to avoid undesirable consequences, they should be excluded.

During treatment, be sure adjust your child's diet. So, during the period of therapy, it is worth limiting the use of green leafy vegetables, any varieties of cabbage, legumes, tomatoes, carrots as much as possible. Confectionery and sweets should be banned, but it is better to increase the daily amount of fluid intake.

These measures are associated with the ability of Biseptol to affect the intestines and kidneys, in addition, it indirectly affects the composition of the blood, which makes it necessary to take regular tests. While taking the drug for prevention, it is necessary drink recommended vitamin complexes.

doctor-detkin.ru

Composition and form of release

Biseptol is a popular drug intended for the treatment of the respiratory system. The syrup format is ideal for children because it has a sweet taste and is easy to use.

Despite this, the drug actively copes with a number of infections. It is effective in the fight against pathogens such as:

We suggest that you read the instructions for using Biseptol syrup for children before using the medicine.

Indications

The syrup is prescribed in case of a pathological condition due to an increase in the number of pathogens. Other formulations of the drug can be used to treat diseases of the skin or genitourinary system. The syrup, in turn, is more often used to eliminate ENT diseases.

These include the following:

The main symptom of these diseases is a prolonged cough. There may be pain in the lungs.

Contraindications

Biseptol is considered a fairly strong drug. Before using it, you should read the instructions.

In some cases, taking the drug is not possible. One of the contraindications is the individual intolerance of the components.

Neglect of this information may lead to the occurrence of allergies. It manifests itself in local skin rashes, redness, itching, etc.

The active ingredients of the drug are able to settle in the kidneys and liver. For this reason, Biseptol is not recommended for people suffering from a disease of these organs.

Also, you should not take syrup for pathologies of the circulatory system and thyroid gland.

The degree of effectiveness of the drug

The active components of the drug are similar in structure to a substance called PABA. It is needed by pathogenic microbes for development. Due to its similarity to PABA, sulfamethoxazole penetrates the cells of harmful bacteria. Thus, their growth and reproduction is affected.

Biseptol is effective in eliminating microorganisms sensitive to it. A decrease in the symptoms of the disease is noted within 4-5 days after the start of the course of treatment. But there are bacteria that have developed immunity to the active substances of the drug. In this case, the syrup will not have the desired effect. The selection of the drug in this case should be carried out by a doctor.

You can find out how many drops of Aflubin to give a child in one of our articles.

Instructions for the use of Tobrex eye drops for children are discussed in detail in this publication.

Reviews on the use of Laferobion candles for children can be found in this article.

Dosage

The use of syrup should be dosed. The dosage of syrup for children directly depends on the age category of the child taking Biseptol.

1 to 2 years 120 mg of the drug should be taken. The maximum dose for children aged 2 to 6 years is 240 mg.

Between 6 and 12 years old the dosage can be doubled. It should be in the range from 240 to 480 mg.

How to use

The course of treatment with the drug is 5 days. It should continue to be taken even if the symptoms have disappeared. Their absence does not mean complete recovery.

For the duration of treatment, the following foods should be excluded from the child's diet:

During treatment, exposure to ultraviolet radiation should be limited. It is recommended to increase the daily amount of drinking pure water. With regular use of Biseptol, studies should be carried out that reveal pathologies of the circulatory system. The active substances of the syrup can affect the composition of the blood.

Familiarize yourself with various infectious diseases in children on our website, you may not know about some of them. You should know how to timely recognize signs of tuberculosis in the early stages in children and what should be the tactics of treating the disease.

Read about the ways of infecting a child with giardiasis, about the detection and treatment of the disease in this publication.

What Roseola is confused with in children and what are the symptoms of this disease, is described here.

Compatibility with other drugs

Biseptol is far from compatible with all medications. The question of the possibility of combining drugs in each individual case should be discussed with the pediatrician. Particular care must be taken with drugs such as:

Side effects and overdose

In most cases, the syrup is well tolerated. But there is a possibility of side effects.

They are expressed as follows:

Price in Russia

The cost of a suspension within the Russian Federation varies from 110 to 140 rubles. The price of syrup for children is influenced by the region, the volume of the bottle and the pricing policy of the pharmacy selling Biseptol. No prescription from a pediatrician is required to purchase.

Subject to the rules of storage, the shelf life of the syrup in the closed state is 5 years. After opening, the drug is suitable for use within 8 months. It should be kept out of the reach of children, in a dark place. The temperature should not exceed 25 degrees.

Reviews

For those who are not satisfied with just the instructions for use, we recommend that you read the reviews of loving mothers about Biseptol baby syrup.

Biseptol does not cease to be one of the most popular remedies for the treatment of childhood diseases. But its use contains a lot of nuances, so it is not suitable for self-treatment. Without the appointment of a pediatrician, it is not recommended to resort to the help of a suspension. This can harm the health of the child.

malutka.pro

Compound

5 ml of suspension contains sulfamethoxazole 200 mg, trimethoprim 40 mg;
Excipients: Cremophor RH 40, magnesium aluminum silicate, sodium carboxymethylcellulose, citric acid, sodium hydrogen phosphate, methylhydroxybenzoate, propylhydroxybenzoate, sodium saccharinate, maltitol, strawberry flavor, propylene glycol, purified water.

pharmachologic effect

Biseptol is a combined antibacterial drug with a wide spectrum of bactericidal action, the mechanism of which is due to the blocking of folate biosynthesis in microbial cells.
Sulfamethoxazole disrupts the synthesis of dihydrofolic acid, and trimethoprim prevents the conversion of dihydrofolic acid to tetrahydrofolic acid.
Active in relation to almost all groups of microorganisms - Gram-negative bacteria: Salmonella spp., Shigella spp., Neisseria spp., Proteus vulgaris, Vibrio cholerae, Yersinia spp., Escherichia coli, Corynebacterium spp.; Gram-positive bacteria: Staphylococcus spp. and others.
Also for the drug sensitive Chlamydia spp., Actinomyces spp., Klebsiella spp.
To the drug resistant mycobacteria, viruses, most anaerobic bacteria.

Indications for use

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleural empyema);
• otitis, sinusitis;
• meningitis, brain abscess;
• infections of the genitourinary system (including pyelonephritis, urethritis, salpingitis, prostatitis);
• gonorrhea;
• gastrointestinal infections (including typhoid fever, paratyphoid fever, bacillary dysentery, cholera, diarrhea).

Contraindications

• severe liver dysfunction;
• severe renal dysfunction (CC less than 15 ml / min);
• violations of the hematopoietic system;
• severe diseases of the cardiovascular system;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• children's age up to 3 months;
• hypersensitivity to the components of the drug.

Dosage and administration

The drug is prescribed at a dose of 6 mg of trimethoprim and 30 mg of sulfamethoxazole per 1 kg of body weight / day.
Children from 3 to 6 months- 2.5 ml every 12 hours
children from 7 months to 3 years- 2.5-5 ml every 12 hours
children from 4 to 6 years old- 5-10 ml every 12 hours
children from 7 to 12 years old- 10 ml every 12 hours
adults and children over 12 years old- 20 ml every 12 hours.

The duration of therapy is 10-14 days ( with shigellosis- 5 days).
In infections caused by Pneumocystis carinii, the dose is 120 mg/kg of body weight per day; the drug is taken every 6 hours for 14-21 days.
When prescribing the drug to patients with impaired renal function (CC 15-30 ml / min), the dose should be halved.

Side effect

From the digestive system: rarely - nausea, vomiting, diarrhea; in isolated cases - pseudomembranous colitis, cholestatic hepatitis.
Allergic reactions: in isolated cases - Stevens-Johnson syndrome, Lyell's syndrome.
From the hematopoietic system: in isolated cases - reversible thrombocytopenia, leukopenia, neutropenia, agranulocytosis, megaloblastic anemia.
From the urinary system: rarely - hematuria, nephritis.
From the side of the central nervous system: in isolated cases - headache, depression, dizziness.
Side effects are usually mild and reversible after discontinuation of the drug.

Overdose

Symptoms: nausea, vomiting, clouding of consciousness.
Treatment: withdrawal of the drug, gastric lavage (no later than 2 hours after taking the drug), drinking plenty of water, forced diuresis, taking calcium folinate (5-10 mg / day).

Interaction with other drugs

With the simultaneous use of trimethoprim enhances the effect of hypoglycemic agents - sulfonylurea derivatives.
With the combined use of Biseptol with thiazide diuretics, the risk of developing thrombocytopenia and increased bleeding increases.
Co-trimoxazole enhances the anticoagulant effect of warfarin and the anticonvulsant activity of phenytoin.
When used together, rifampicin reduces the half-life of trimethoprim.
The combined use of Biseptol and cyclosporine after kidney transplantation worsens the patient's condition.

Application features

Care must be taken when prescribing Biseptol to patients with impaired liver and / or kidney function, with a history of allergic reactions, with folic acid deficiency, and elderly patients.
The appearance of a skin rash or severe diarrhea is an indication for discontinuation of the drug.
The appointment of Biseptol for the treatment of angina caused by streptococcus is not indicated.
During treatment with Biseptol, adequate fluid intake should be ensured due to the risk of developing crystalluria and urolithiasis.
When determining the level of creatinine using Jaffe alkaline picrinate while taking Biseptol, it should be borne in mind that the result may be 10% higher than the true one.
Control of laboratory indicators
With prolonged use of the drug, it is necessary to control the picture of peripheral blood.

Release form

80 ml of the drug in glass vials. The vial, supplied with a label with a leaflet and a measure with a scale, is placed in individual cardboard boxes.

Storage conditions

Store at a temperature of 5°C to 25°C, out of the reach of children.

apteka.103.by

What is this drug?

Syrup Biseptol is a combined drug from the group of bactericidal drugs. The drug has a wide range of bactericidal effects on the body. The drug is active against most of the existing pathogenic microorganisms. Biseptol is used to treat many diseases accompanied by infectious and inflammatory processes.

The mechanism of action of the drug is as follows:

• blocking the biosynthesis of folates in microbial cells;
• relief of the general condition of the body;
• inhibition of the vital activity of Escherichia coli;
• destruction of pathogenic microorganisms;
• blocking the metabolism of bacteria;
• reducing the risk of developing complications of an existing disease;
• strengthening the protective functions of the body;
• prevention of recurrence of an infectious disease;
• normalization of metabolic processes in the body;
• bactericidal effect.

Compound

The active active ingredients in Biseptol syrup are trimethoprim and sulfamethoxazole. These substances have a detrimental effect on pathogens and block their negative impact on the child's body. The action of active components is complemented by auxiliary elements.

Excipients:

Indications for use

Biseptol syrup is used to treat pathological conditions of the child's body caused by pathogens. Such diseases can affect the respiratory system, the genitourinary system, infectious processes of the skin and digestive organs. Syrup is prescribed for children older than one year.

Indications for the use of the drug are the following conditions:

• meningitis;
• bronchitis (read about how to treat acute bronchitis in a child);
• pneumonia;
• tracheitis;
• malaria;
• brain abscess;
• intestinal infections;
• paratyphoid;
• lung abscess;
• urethritis;
• cystitis (read the article about the signs of cystitis in children and its treatment);
• tonsillitis (for example, herpes);
• pyelonephritis;
• typhoid fever;
• furunculosis;
• acne;
• sinusitis;
• otitis.

Contraindications and side effects

Side effects after taking Biseptol syrup occur in rare cases and are mild. Signs of incompatibility of the child's body with the components of the drug are digestive system disorders, headaches, bouts of dizziness and nausea. In severe cases, nephritis, neuropenia, leukopenia, or hematuria may occur.

Contraindications for the use of the drug are the following conditions:

• serious liver pathology;
• individual intolerance to the drug;
• children's age up to one year;
• pathology of the hematopoietic system;
• deviations in the work of the kidneys;
• severe pathologies of the cardiovascular system.

An overdose of the drug can provoke uncontrollable vomiting or dizziness. Symptoms are eliminated by gastric lavage and activated charcoal. If signs of an overdose persist for several days, then the child must be examined in a medical facility.

Method of application and dosage for a child

The dosage of Biseptol syrup and the duration of the course of treatment can be adjusted by the attending physician. It is not worth breaking the recommendations of an expert. Otherwise, not only a decrease in the effectiveness of therapy may occur, but there will also be a risk of complications. The duration of the course of treatment directly depends on the degree of development of the disease and the overall clinical picture of the child's health.

Scheme of taking Biseptol syrup for children:

• children from one to two years of age are recommended to take the drug 120 mg twice a day;
• children from two to six years old syrup is prescribed 180-240 mg twice a day;
• children over six years of age should take the drug at 240-480 mg twice a day;
• the time interval between doses of the drug should be at least twelve hours;
• the minimum course of treatment is five days.

special instructions

If the child has a tendency to allergic reactions or pathologies of the internal organs, treatment with Biseptol syrup should be carried out under the supervision of a specialist due to the high risk of side effects.

Special instructions for the use of the drug:

Analogues

Analogues of Biseptol syrup include drugs that have similar pharmacological properties and compositions. Such medicines are used to treat similar diseases and in most cases have identical contraindications. Method of application and dosage may vary.

Biseptol syrup analogues are the following medicines:

• Ingalipt(the composition includes identical active ingredients, the drug is available in the form of an aerosol, which facilitates its use for young children);
• Bactrim(antimicrobial drug with a wide spectrum of action);
• Asakol(antimicrobial agent with anti-inflammatory effect);
• Mekol(antibacterial ointment, used to treat infectious diseases of the skin);
• Ginalgin(antibacterial drug with antifungal action);
• Septocide(antimicrobial agent with antiseptic effect);
• Ingaflu(available as a spray, anti-inflammatory and antimicrobial agent for the treatment of infectious and inflammatory processes);
• Oriprim(belongs to the number of structural analogues of Biseptol syrup, has similar pharmacological properties and active ingredients);
• Procelan(antibacterial agent for external use).

Catad_pgroup Sulfonamides

Biseptol 480 mg - official instructions for use

MINISTRY OF HEALTH AND SOCIAL DEVELOPMENT OF THE RUSSIAN FEDERATION

INSTRUCTIONS
on the use of the medicinal product
for medical use

Registration number:

Tradename
Biseptol 480

International non-proprietary name of active substances
Co-trimoxazole [Sulfamethoxazole + Trimethoprim]

Dosage form
Concentrate for solution for infusion

Composition 1 ml concentrate
Active substances: sulfamethoxazole 80.00 mg + trimethoprim 16.00 mg
Excipients: propylene glycol 400.00 mg, ethyl alcohol 96% 100.00 mg. benzyl alcohol 15.00 mg, sodium disulfite (E223) 1.00 mg. sodium hydroxide 12.63 mg, sodium hydroxide 10% solution to pH 9.5 - 11.0, water for injection up to 1 ml. 1 ampoule (5 ml) contains 400 mg of sulfamethoxazole and 80 mg of trimethoprim.

Description
Clear colorless or slightly yellowish liquid.

Pharmacotherapeutic group
Combined antimicrobial agent.

Code ATX: J01EE01

Pharmacological properties
Pharmacodynamics
Biseptol is a combined antibacterial agent containing co-trimoxazole, a 5:1 mixture of sulfamethoxazole and trimethoprim. Sulfamethoxazole inhibits the synthesis of folic acid by competitive antagonism with para-aminobenzoic acid, i.e. has a bacteriostatic effect.
Trimethoprim is an inhibitor of bacterial dihydrofolate reductase. Depending on the conditions, it can have a bactericidal or bacteriostatic effect. Thus, trimethoprim and sulfamethoxazole block two successive steps in the biosynthesis of purines, and then nucleic acids necessary for numerous bacteria.
Biseptol is a broad-spectrum bactericidal drug active against the following microorganisms: Streptococcus spp. (Streptococcus pneumoniae), Staphylococcus spp., Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli (including enterotoxogenic strains), Salmonella spp. (including Salmonella typhi and Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Haemophilus influenzae (including ampicillin-resistant strains), Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis , Brucella spp., Mycobacterium spp. (including Mycobacterium leprae), Citrobacter, Enterobacter spp., Legionella pneumophila, Providencia, some species of Pseudomonas (except Pseudomonas aeruginosa), Serratia marcescens, Shigella spp., Yersinia spp., Morganella spp., Pneumocystis carinii; Chlamydia spp. (including Chlamydia trachomatis, Chlamydia psittaci); protozoa: Plasmodium spp., Toxoplasma gondii, pathogenic fungi: Actinomyces israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp.
Resistant to the drug: Corynebacterium spp., Pseudomonas aeruginosa, Mycobacterium tuberculosis, Treponema spp., Leptospira spp., viruses.
Pharmacokinetics
The maximum concentration of sulfamethoxazole and trimethoprim, determined after one hour, is higher and is reached more quickly when administered intravenously, compared with the concentration obtained when the drug is taken orally. Significant differences regarding plasma concentration, half-life and elimination after administration of co-trimoxazole in oral and intravenous form have not been established. Trimethoprim is a weak base (pKa = 7.3) with lipophilic properties. The concentration of trimethoprim in tissues is higher than the concentration determined in plasma, it is especially high in the lungs and kidneys. Higher concentrations of trimethoprim compared with plasma are observed in bile, fluid and tissues of the prostate gland, sputum, and vaginal discharge. The concentrations of trimethoprim in breast milk, cerebrospinal fluid, middle ear secretion, synovial fluid, intracellular fluid (interstitial) correspond to the concentrations necessary for antibacterial action. Trimethoprim penetrates into the amniotic fluid and fetal tissues, reaching a concentration there close to the concentration observed in the mother's blood serum.
Approximately 50% of trimethoprim binds to plasma proteins. The elimination half-life in individuals with normal renal function ranges from 8.6 to 17 hours. There were no significant differences in the elderly compared with younger patients. Trimethoprim is excreted mainly by the kidneys - approximately 50% unchanged within 24 hours in the urine. Several metabolites of trimethoprim have been identified in urine.
Sulfamethoxazole is a weak acid with pKa = 6.0. The concentration of the active form of sulfamethoxazole in amniotic fluid, bile, cerebrospinal fluid, middle ear secretion, sputum, synovial fluid, intracellular fluid is from 20 to 50% of sulfamethoxazole in plasma. Approximately 66% of sulfamethoxazole binds to plasma proteins. The elimination half-life in individuals with normal renal function is 9 to 11 hours. In persons with impaired renal function, no changes in the half-life of the active form of sulfamethoxazole have been established, but an increase in the half-life of the main acetylated metabolite is observed if the creatinine clearance is less than 25 ml / min.
Sulfamethoxazole is excreted primarily by the kidneys, from 15 to 30% of the administered dose is found in the urine in the active form. In elderly patients, there is a decrease in the renal clearance of sulfamethoxazole.

Indications for use
Infectious and inflammatory diseases caused by microorganisms sensitive to co-trimoxazole:

• urinary tract infections: urinary tract infections, soft chancre;
• respiratory tract infections: chronic bronchitis, treatment and prevention of pneumonia caused by Pneumocystis jiroveci (formerly P. carinii) (PCP);
• infections of ENT organs: otitis media (in children);
• gastrointestinal infections: typhoid fever and paratyphoid fever, cholera, dysentery, gastroenteritis caused by enterotoxic strains of Escherichia coli;
• other bacterial infections: nocardiosis, brucellosis, actinomycosis, South American blastomycosis, toxoplasmosis.

Contraindications

• Hypersensitivity to sulfonamides, trimethoprim, co-trimoxazole or any auxiliary component of the drug;
• serious damage to the liver parenchyma;
• severe renal failure (CC less than 15 ml / min);
• liver failure;
• severe hematological disorders: aplastic anemia, B12 deficiency anemia, agranulocytosis, leukopenia, deficiency of glucose-6-phosphate dehydrogenase;
• administering the drug to diagnosed porphyria or to patients who are at risk of developing acute porphyria should be avoided. the drug may increase the symptoms of this disease;
• children under 3 years of age (with the exception of the treatment or prevention of pneumonia caused by Pneumocystis jiroveci);
• pregnancy and lactation.

Carefully
Care must be taken when prescribing Biseptol 480 to patients with a deficiency of folic acid (for example, people with alcohol dependence, treatment with anticonvulsants, malabsorption syndrome and the elderly); patients with bronchial asthma and severe allergies; patients with diseases of the circulatory and respiratory systems, tk. after the introduction of high doses, excessive hydration may occur; patients with thyroid disease. Special care is advised in elderly patients, as this group is more susceptible to side effects and feels more pronounced side effects, especially with concomitant diseases, such as renal failure and / or liver dysfunction and taking other drugs.

Dosage and administration
Biseptol 480, a concentrate for solution for infusion, is intended for intravenous administration only and should be diluted immediately before use.
After the introduction of the drug Biseptol 480 into the solution for infusion, the resulting mixture must be vigorously shaken in order to completely mix. If sediment or crystals appear before mixing or during infusions, the mixture should be discarded and a new one prepared.
The following dilution scheme for Biseptol 480 is recommended:
1 ampoule (5 ml) of Biseptol 480 in 125 ml of solution for infusion;
2 ampoules (10 ml) of Biseptol 480 in 250 ml of solution for infusion;
3 ampoules (15 ml) of Biseptol 480 in 500 ml of solution for infusion.
It is allowed to use the following solutions for infusions to dilute the drug Biseptol 480:

• 5% and 10% dextrose solution;
• 0.9% NaCl solution;
• Ringer's solution;
• 0.45% NaCl solution with 2.5% dextrose solution.

• children aged 3 to 5 years: 2.5 ml every 12 hours.
• children aged 6 to 12 years: 5 ml every 12 hours.

Overdose
Symptoms: nausea, vomiting, dizziness, headache, confusion. In severe overdose of trimethoprim, bone marrow depression was noted.
Treatment: if side effects occur, the drug should be discontinued immediately. Fluid administration, correction of electrolyte disturbances. If necessary - hemodialysis.

Interaction with other drugs
Co-trimoxazole is compatible with the following drugs: 5% dextrose for IV infusion, 0.9% sodium chloride for IV infusion, a mixture of 0.18% sodium chloride and 4% dextrose for IV infusion, 6% dextran 70 for IV infusion in 5% dextrose or saline, 10% dextran 40 for IV infusion in 5% dextrose or saline, Ringer's solution for injection.
In elderly patients, biseptol in combination with diuretics, in particular with thiazide diuretics, increases the risk of thrombocytopenia. Simultaneous use with cyclosporine reduces its concentration in the blood.
Do not administer the drug intravenously in combination with drugs and solutions containing bicarbonates.
Increases the anticoagulant activity of indirect anticoagulants, enhances the effect of hypoglycemic agents and methotrexate. Reduces the intensity of hepatic metabolism of phenytoin (extends its T1 / 2 by 39%) and warfarin, enhancing their effect. With the simultaneous use of co-trimoxazole and rifampicin for a week, the half-life of trimethoprim is reduced.
In patients taking prophylactic pyrimethamine (an antimalarial drug) in doses exceeding 25 mg / week, cases of megaloblastic anemia have been noted during treatment with co-trimoxazole. This type of combination therapy is not recommended.
With the simultaneous use of co-trimoxazole and zidovudine, the risk of developing hematological disorders increases, and therefore blood tests should be performed.
Increases serum concentrations of digoxin, especially in elderly patients (control is necessary) of serum digoxin concentrations.
Reduce the therapeutic effect of co-trimoxazole benzocaine, procaine, procainamide and other drugs, as a result of the hydrolysis of which PABA is formed.
Between diuretics (thiazides, furosemide, etc.) and oral hypoglycemic drugs (sulfonylurea derivatives) on the one hand and antimicrobial sulfonamides on the other, a cross-allergic reaction may develop.
Phenytoin, barbiturates, PAS increase the manifestations of folic acid deficiency.
In patients taking cyclosporins (for example, after kidney transplantation), a transient deterioration in renal function was observed during treatment with co-trimoxazole.
With the simultaneous use of co-trimoxazole and procainamide or amantadine, an increase in the serum concentration of the listed drugs may occur.
Derivatives of salicylic acid enhance the effect of co-trimoxazole.
Ascorbic acid, hexamethylenetetramine, and other drugs that acidify urine increase the risk of crystalluria.
Co-trimoxazole reduces the reliability of oral contraception (inhibits the intestinal microflora and reduces the enterohepatic circulation of hormonal compounds).

special instructions
During the use of the drug, proper diuresis should be maintained. In malnourished patients, the risk of sulfonamide crystals is increased. In the case of prolonged administration of the drug, regular laboratory blood tests are recommended, since there is a possibility of hematological changes associated with folic acid deficiency.
After using the drug, diarrhea may occur, which may be a symptom of pseudomembranous colitis. It is necessary to stop the use of the drug and cancel antidiarrheal agents.
Biseptol 480 should not be used in the treatment of pharyngitis caused by group A beta-hemolytic streptococci.
Caution should be exercised in patients using other drugs that can cause hyperkalemia, including potassium-sparing diuretics.
It is recommended to monitor the concentration of potassium in the serum, given the risk of an increase in its concentration (hyperkalemia).
If the first symptoms of a skin rash appear, the drug should be discontinued.
Given the content of benzyl alcohol in Biseptol 480 (15 mg of benzyl alcohol in 1 ml of solution), the drug should not be used in premature and infants. Benzyl alcohol can cause intoxication and anaphylactoid reactions in infants and children under 3 years of age.

Use during pregnancy and during breastfeeding
Do not prescribe the drug during pregnancy and during breastfeeding.

Influence on the ability to drive a car and other mechanisms
During the period of treatment, care must be taken when driving vehicles and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Release form and packaging
Concentrate for solution for infusion (80.00 mg + 16.00 mg)/ml. 5 ml in colorless hydrolytic glass ampoules (class 1, Evr. Pharm.). Above the notch of the ampoule there is a dot of white or red color, as well as a strip in the form of a yellow ring. 5 ampoules are placed in a PVC ampoule tray. Two pallets in a cardboard box with instructions for use.

Storage conditions
Store in a place protected from light at a temperature not exceeding 25°C. Do not freeze!

Best before date
5 years.
Do not use after the expiry date stated on the packaging.

Holiday conditions
On prescription.

Manufacturer and holder of the registration certificate
JSC Warsaw Pharmaceutical Plant Polfa
st. Karolkova 22/24, 01-207 Warsaw, Poland.

Representation in the Russian Federation:
121248 Moscow, Kutuzovsky prospect, 13, office 85

Biseptol for children is a popular antibacterial drug that has earned numerous positive reviews from doctors and parents of children. It is often prescribed for the treatment of respiratory organs, ENT organs, but it can equally be effective in the treatment of gastrointestinal infections.

Since Biseptol is still an antibiotic with a number of side effects (like all drugs in this group), it cannot be used for babies without a doctor's prescription.

Composition, release form

Biseptol, most often used for sore throat and cough, belongs to the group of sulfonamides. It contains two active ingredients: sulfamethoxazole and trimethoprim, along with some excipients.

The antibiotic has 3 forms of release: tablets (120 and 480 mg), syrup and suspension. Tablets are round, flat, yellowish. The syrup is intended for babies and has a sweet taste. The suspension does not look like a syrup and is a different form of release that can be taken by adults.

For the treatment of babies and adolescents, syrup and tablets with a dosage of 120 mg of the active substance are most often used. In some cases, a suspension may be prescribed, the dose of which must be calculated by the doctor.

When can it be applied?

"Biseptol", like any of its analogues from the group of sulfonamides, is effective against many bacteria. According to the instructions for use, it is used to treat such diseases:

• respiratory infections;
• with angina, coughing is prescribed for children;
• infectious infection of the gastrointestinal tract;
• inflammatory processes in the genitourinary system;
• infectious diseases of the skin and soft tissues;
• severe conditions associated with the penetration of infection into the body (sepsis, brain abscess, and others).

The dosage will depend on the severity of the disease.

Contraindications for the drug exist, and they must be observed when using:

• heart disease and problems with blood formation;
• the age of babies up to 3 months;
• allergy with individual intolerance;
• severe liver and kidney disease;
• elevated bilirubin.

Also, the instructions for use indicate some conditions in which the medication should be taken with caution:

• lack of folic acid;
• thyroid disease;
• weakness in old age, premature babies.

Overdose and side effects

Syrup and suspension, like Biseptol tablets, should be taken with caution. An overdose threatens the following conditions:

• problems with digestion and functioning of the gastrointestinal tract;
• fever;
• jaundice;
• dizziness;
• depression, disorder of consciousness;
• oppression of bone marrow functions, etc.

In case of an overdose, be sure to rinse the stomach and call an ambulance. The patient should be given plenty of fluids and induce vomiting.

According to the instructions for use, in some cases, taking "Biseptol" can cause side effects:

• nervous system disorder, dizziness;
• spasms of the respiratory system, suffocation;
• disorders in the hematopoietic system;
• kidney dysfunction;
• allergic reactions in the form of itching, dermatitis;
• metabolic disease.

However, according to reviews and instructions for use, side effects are extremely rare.

How to apply?

According to the instructions for use, for children, a suspension or syrup "Biseptol" is most often prescribed for sore throat and cough. For older children, these can be tablets, the dosage of which should not exceed 120 mg. The drug is taken every 12 hours. At this time, it is desirable to reduce the amount of protein in the diet, as it impairs the absorption of the antibiotic. The duration of the medication should not exceed 14 days. Only in case of especially severe diseases is it allowed to take it for three weeks, but this decision should be made by the doctor.

With angina and other infectious diseases, the suspension is prescribed based on the age of the child:

• from three months to six months, 2.5 ml is recommended;
• from seven months to three years, take 2.5-5 ml;
• from four to six years, 5-10 ml is prescribed;
• from seven to twelve years old, children drink 10 ml;
• from twelve years, 20 ml of suspension is recommended at a time.

Syrup for sore throat and cough, as a rule, is prescribed for babies from a year old:

• from 1 year to 2 years - 120 mg;
• from 2 to 6 years - from 180 to 240 mg;
• from 6 to 12 years old - from 240 to 480 mg.

"Biseptol" in tablets of 120 mg is prescribed for tonsillitis and other dangerous diseases in the following doses:

• from 2 to 5 years - 2 tablets at a time;
• from 6 to 12 years - 4 tablets of 120 mg or 1 tablet of 480 mg.

With pneumonia, the dosage regimen may change, and the dosage is determined by the doctor, based on the weight of the child.

• confectionery, fresh pastries;
• tomatoes;
• carrot;
• legumes;
• cabbage.

Analogues, cost

Any analogue of "Biseptol" with the same success can be used for tonsillitis and other infectious diseases that threaten the health of babies. If the pharmacy did not manage to purchase "Biseptol", take any of its analogues, which the doctor will advise.

What analogue of an antibiotic can be offered?

• "Bactrim";
• "Septocide";
• "Orybact";
• "Trimosul" and others.

Any analogue for angina and other diseases should be taken only with the permission of a doctor, otherwise you can get an overdose or an incorrect effect of the medicine.

The price of "Biseptol" (tablets of 120 mg) is about 30-90 rubles. The suspension will cost more: from 100 to 150 rubles.

If you decide to choose an analogue of Biseptol, you should focus not on the cost of the medicine, but on its effect, a convenient form of release. You must be sure of the quality of the medicine that you offer your child. The analogue must contain the same active substance as the prescribed drug.

Many people consider Biseptol. In fact, it does not belong to this group of drugs, but is a drug for combating a variety of harmful bacteria. Inflammation of the respiratory system, intestinal and other bacterial infections may be indications for the use of Biseptol for

Composition and pharmacological properties

Biseptol belongs to the sulfanilamide group of bacterial preparations, but it has an effect even on bacteria resistant to sulfanilamide. This is because it includes two components that enhance each other's action. These are trimethoprim and sulfamethoxazole, with the latter in the composition five times more. This combination is also called co-trimoxazole. In such proportions, they perfectly destroy gram-positive and gram-negative bacteria and microorganisms. Substances in turn block the metabolism in the cells of microbes and they die. First, sulfamethoxazole prevents the synthesis of dihydrofolic acid, and trimethoprim prevents it from turning into tetrahydrofolic acid. It is the latter that is necessary for the development of bacteria.

From the action of Biseptol, intestinal, dysentery and typhoid bacilli, salmonella, staphylococci, streptococci and other harmful microorganisms die. It does not have an antiviral effect, does not kill anaerobic and mycobacteria. The drug has a systemic effect, that is, it is absorbed into the blood fairly quickly. Its maximum amount is reached within three hours, and the action lasts seven. After that, it is excreted in the urine during the day.

In a milliliter of suspension, sulfamethoxazole is 40 mg, and trimethoprim is five times less, that is, 8 mg. The excipients that make up the composition are common for syrup. Among them are polypropylene glycol, citric acid, strawberry flavor, water. In addition to the suspension, there is also a tablet form of the drug, but it is prescribed only for adults and children after twelve years of age.

Did you know? Doctors have calculated that there are now about 1,400 independent infectious diseases.

Indications for use

From 6 months to 3 years

For children after six months and up to three years, the attending physician may increase the dose of the drug from 2.5 to 5 ml. You need to take it the same way, after twelve hours.

3-6 years old

From the age of three to six years, 5 to 10 ml of the drug is prescribed every half a day.

6-12 years old

After six years and up to twelve, the maximum single dose of Biseptol is 10 ml with the same intake frequency.

Over 12 years old

After twelve years, you can take not 20 ml of the drug twice a day. The doctor, observing a sick child, decides how many days to give the child Biseptol. As a rule, the course of treatment lasts from five to seven days for acute forms of infection.

Precautionary measures

The drug should be used with caution if there are diseases of the liver, kidneys, hematopoietic system and asthma. If any reactions occur in the form of a rash or blisters on the skin, you should immediately stop taking the medicine and consult a doctor. This may be a symptom of Steven-Johnson syndrome. While taking Biseptol, it is necessary to do laboratory and monitor indicators.

Did you know? After using penicillin, Australian Ashley Morris developed an allergy to water. This is the only case in the world.

Carefully need to take the drug along with other medicines. With simultaneous use with hypoglycemic agents, warfarin and phenytoin, their effect is enhanced. If you take Biseptol with diuretics, then the risk of bleeding increases. It is necessary to strictly observe the dosage of the drug.

Contraindications and side effects

There are contraindications when taking Biseptol suspension, namely:

• individual intolerance to any component of the drug;
• serious violations of the kidneys and liver;
• serious diseases of the heart and blood vessels;
• anemia;
• very low levels of glucose-6-phosphate dehydrogenase in the blood;
• violations of the function of blood formation;
• the drug is contraindicated in combination with dofetilide;
• should not be taken by children under three months of age.

For many years, Biseptol suspension has been a proven and reliable tool in the fight against various childhood infections. It must be remembered that the instructions for use are informative in nature and only a doctor can prescribe the dose and time of taking the drug. T Since the medicine has a pleasant taste, it must be kept out of the reach of children.