Biseptol from which the suspension helps children. Biseptol: description, instructions and use for children. Negative effects, contraindications and overdose

Biseptol syrup does not belong to the group of antibiotics and is considered a drug of the sulfonamide category. The drug is used to treat many diseases accompanied by infectious and inflammatory processes. It is necessary to take the syrup in strict accordance with the instructions or recommendations of the doctor, having previously eliminated the risk of contraindications.

Syrup Biseptol is a combined drug from the group of bactericidal drugs. The drug has a wide range of bactericidal effects on the body. The drug is active against most of the existing pathogenic microorganisms. Biseptol is used to treat many diseases accompanied by infectious and inflammatory processes.

The mechanism of action of the drug is as follows:

• blocking the biosynthesis of folates in microbial cells;
• relief of the general condition of the body;
• inhibition of the vital activity of Escherichia coli;
• destruction of pathogenic microorganisms;
• blocking the metabolism of bacteria;
• reducing the risk of developing complications of an existing disease;
• strengthening the protective functions of the body;
• prevention of recurrence of an infectious disease;
• normalization of metabolic processes in the body;
• bactericidal effect.

Compound

The active active ingredients in Biseptol syrup are trimethoprim and sulfamethoxazole. These substances have a detrimental effect on pathogens and block their negative impact on the child's body. The action of active components is complemented by auxiliary elements.

Excipients:

Indications for use

Biseptol syrup is used to treat pathological conditions of the child's body caused by pathogens. Such diseases can affect the respiratory system, the genitourinary system, infectious processes of the skin and digestive organs. Syrup is prescribed for children older than one year.

Indications for the use of the drug are the following conditions:

• meningitis;
• bronchitis (read about);
• pneumonia;
• malaria;
• brain abscess;
• intestinal infections;
• paratyphoid;
• lung abscess;
• urethritis;
• cystitis (read the article about and its treatment);
• angina (for example,);
• pyelonephritis;
• typhoid fever;
• furunculosis;
• acne;

Contraindications and side effects

Side effects after taking Biseptol syrup occur in rare cases and are mild. Signs of incompatibility of the child's body with the components of the drug are digestive system disorders, headaches, bouts of dizziness and nausea. In severe cases, nephritis, neuropenia, leukopenia, or hematuria may occur.

Contraindications for the use of the drug are the following conditions:

• serious liver pathology;
• individual intolerance to the drug;
• children's age up to one year;
• pathology of the hematopoietic system;
• deviations in the work of the kidneys;
• severe pathologies of the cardiovascular system.

An overdose of the drug can provoke uncontrollable vomiting or dizziness. Symptoms are eliminated by gastric lavage and activated charcoal. If signs of an overdose persist for several days, then the child must be examined in a medical facility.

Method of application and dosage for a child

The dosage of Biseptol syrup and the duration of the course of treatment can be adjusted by the attending physician. It is not worth breaking the recommendations of an expert. Otherwise, not only a decrease in the effectiveness of therapy may occur, but there will also be a risk of complications. The duration of the course of treatment directly depends on the degree of development of the disease and the overall clinical picture of the child's health.

Scheme of taking Biseptol syrup for children:

• children from one to two years of age are recommended to take the drug 120 mg twice a day;
• children from two to six years old syrup is prescribed 180-240 mg twice a day;
• children over six years of age should take the drug at 240-480 mg twice a day;
• the time interval between doses of the drug should be at least twelve hours;
• the minimum course of treatment is five days.

special instructions

If the child has a tendency to allergic reactions or pathologies of the internal organs, treatment with Biseptol syrup should be carried out under the supervision of a specialist due to the high risk of side effects.

If after taking the drug there are any negative symptoms, then the therapy is canceled.

Special instructions for the use of the drug:

Analogues

Analogues of Biseptol syrup include drugs that have similar pharmacological properties and compositions. Such medicines are used to treat similar diseases and in most cases have identical contraindications. Method of application and dosage may vary.

Biseptol syrup analogues are the following medicines:

• Ingalipt(the composition includes identical active ingredients, the drug is available in the form of an aerosol, which facilitates its use for young children);
• Bactrim(antimicrobial drug with a wide spectrum of action);
• Asakol(antimicrobial agent with anti-inflammatory effect);
• Mekol(antibacterial ointment, used to treat infectious diseases of the skin);
• Ginalgin(antibacterial drug with antifungal action);
• Septocide(antimicrobial agent with antiseptic effect);
• Ingaflu(available as a spray, anti-inflammatory and antimicrobial agent for the treatment of infectious and inflammatory processes);
• Oriprim(belongs to the number of structural analogues of Biseptol syrup, has similar pharmacological properties and active ingredients);
• Procelan(antibacterial agent for external use).

Content

According to the pharmacological classification, Biseptol refers to antimicrobial combined agents containing sulfamethoxazole and trimethoprim. The antibacterial drug is produced by the Polish pharmaceutical company Polfa.

Composition and form of release

Biseptol (Biseptol) has three forms of release:

Biseptol - an antibiotic or not

The drug belongs to the combined antibiotics. It contains co-trimoxazole, a 5:1 mixture of sulfamethoxazole and trimethoprim. Sulfamethoxazole inhibits the synthesis of dihydrofolic acid, is a competitive antagonist with para-aminobenzoic acid, and exhibits a bacteriostatic effect. Trimethoprim is an inhibitor of the bacterial enzyme dihydrofolate reductase, has a bactericidal or bacteriostatic effect.

Biseptol is active against streptococci, staphylococci, neisseria, E. coli, salmonella, listeria, enterococci, klebsiella, proteus, mycobacteria, shigella, chlamydia, protozoa, pathogenic fungi. Corynebacteria, Pseudomonas, mycobacteria, treponemas, viruses are resistant to the drug. Within an hour after taking the medicine, the maximum concentration of active substances is observed.

Trimethoprim is a weak alkali with lipophilic properties, accumulates in bile, sputum. Half of its dose combines with plasma proteins, has a 13-hour half-life. Trimethoprim is excreted by the kidneys in the urine. Sulfamethoxazole is a weak acid that accumulates in bile, cerebrospinal, synovial and intracellular fluid. The active component is excreted by the kidneys, its clearance is reduced in the elderly.

Indications for Biseptol's use

Instructions for use indicate the following indications for the use of Biseptol:

• otitis media;
• typhoid fever, paratyphoid, gastroenteritis, dysentery, cholera;
• tonsillitis, bronchitis, bronchopneumonia, laryngitis, stomatitis;
• malaria, meningitis;
• pyelitis, pyelonephritis;
• sinusitis;
• cholangitis;
• scarlet fever;
• nocardiosis, brucellosis, toxoplasmosis;
• actinomycosis, South American blastomycosis.

Method of application and dosage

The concentrate for the preparation of the infusion solution is administered intravenously, shaken thoroughly before use. The formation of sediment or the appearance of crystals is unacceptable. 5 ml of the concentrate is diluted in 125 ml of solution for infusion. Solvents are dextrose 5 or 10%, Ringer's solution, saline, 0.45% sodium chloride solution with 2.4% dextrose solution. The infusion lasts 1-1.5 hours. If the patient cannot be given a lot of fluid, it is allowed to mix 5 ml of the concentrate with 75 ml of 5% dextrose.

Dosages for patients older than 12 years, depending on the disease:

The drug is taken after meals, washed down with water. For pneumonia, 100 mg of sulfamethoxazole per kg of body weight is prescribed with a 6-hour interval. The course of treatment does not exceed 2 weeks. For gonorrhea, take 2 g twice a day with a 12-hour interval. Adults and children over 12 years old are prescribed 960 mg twice a day for a course of 5-14 days.

In severe cases of the disease, the dose is increased by 30-50%. With prolonged therapy, manifestations of the pathological type are possible, in which case folic acid is prescribed. If a dose is missed, the drug is taken as soon as possible. In renal failure, the dosage is halved.

Biseptol for cough in the form of a suspension is taken at a dose of 6 mg of trimethoprim and 30 mg of sulfamethoxazole per kg of body weight per day. Patients over 12 years old are prescribed 20 ml every 12 hours. Therapy lasts 10-14 days, with shigellosis - 5. For lung infections, the dose is 120 mg / kg of body weight per day with a 6-hour interval for a course of 2-3 weeks. In case of impaired renal function, the dose is halved.

special instructions

It is useful to study the special instructions section in the instructions for use:

1. With long-term therapy, regular blood tests are recommended, there is a risk of folic acid deficiency.
2. After taking the remedy, diarrhea may develop. Sometimes it serves as a symptom of pseudomembranous colitis. In this case, antidiarrheal drugs are canceled.
3. When a skin rash appears, the injections are canceled.
4. The drug is not used during pregnancy, breastfeeding.
5. During therapy, driving and operating machinery should be avoided.

Biseptol for children

1 ml of solution accounts for 15 mg of benzyl alcohol, so the drug in this form is not used in premature babies, infants, children under 3 years old.

Biseptol for prostatitis

Biseptol can be prescribed for prostatitis by a doctor after tests and diagnostics. Treatment eliminates the inflammatory process in the tissues of the prostate, prevents the transition of the acute stage to the chronic one. The therapy lasts 3 weeks, repeats in a month. At the initial stage, an increased dosage is used: for 3 days the patient takes 6 tablets of the drug (divided into two doses). After 2-3 days of treatment, the first result is visible. Then take 2 tablets per day.

To prevent the development of recurrence of prostatitis, take 1 tablet per day for a course of 2 weeks. The daily dose of the drug should not exceed 960 mg. The components do not affect inflammation, but reduce the amount of pathogenic microflora. Tablets are allowed in the primary and chronic course of the disease.

drug interaction

The instructions for use describe the drug interaction of the drug:

1. The agent lowers the concentration of Cyclosporine in the blood, this combination leads to a transient deterioration in kidney function.
2. The solution is incompatible with bicarbonates.
3. The agent enhances the effect of Methotrexate, hypoglycemic agents, barbiturates, reduces the intensity of the metabolism of Phenytoin, Warfarin, reduces the half-life of Rifampicin, increases the concentration of Digoxin.
4. Caution should be exercised when taking potassium-sparing diuretics, other drugs that can cause hyperkalemia.
5. The combination of the drug with the antimalarial pyrimethamine can lead to megaloblastic anemia.
6. Benzocaine, Procainamide, Procaine are able to reduce the therapeutic effect of the drug.
7. Between diuretics, hypoglycemic sulfonylurea derivatives and antimicrobial sulfonamides there is a risk of cross-allergy.
8. The agent increases the concentration in the blood of Procainamide, Amantadine.
9. Salicylates can enhance the effect of the drug.
10. Hexamethylenetetramine, ascorbic acid can increase the risk of developing crystalluria.

Side effects

The antibiotic Biseptol can lead to the development of side effects:

• hallucinations, headache, depression, apathy, tinnitus, tremor, dizziness, convulsions, ataxia, neuritis;
• pulmonary infiltrates, bronchospasm, shallow breathing, cough;
• pancreatitis, gastritis, glossitis, cholestasis, liver necrosis, abdominal pain, hyperbilirubinemia, nausea, vomiting, hepatitis;
• hemolysis, leukopenia, eosinophilia, neutropenia, purpura, thrombocytopenia, methemoglobinemia, hypoprothrombinemia, anemia, agranulocytosis;
• hepatonecrosis, granuloma;
• nephritis, polyuria, anuria, crystalluria, oliguria, hematuria, nephropathy, hypercreatininemia;
• myalgia, arthralgia;
• systemic lupus erythematosus, serum sickness, periarteritis nodosa, allergic myocarditis, anaphylactic reactions, vasomotor rhinitis, hemorrhagic vasculitis, drug-induced fever;
• skin rash, photosensitivity, angioedema, allergies, dermatitis, erythema, necrolysis, redness of the sclera;
• hypoglycemia, anorexia, hyperkalemia, hyponatremia;
• candidiasis;
• thrombophlebitis.

Overdose

Symptoms of an overdose of the drug are vomiting, confusion, nausea. In severe cases, bone marrow depression is possible. With the development of such symptoms, treatment is canceled, liquid, electrolytes are introduced, if necessary, hemodialysis is performed.

Contraindications

The drug is prescribed with caution for alcohol dependence, bronchial asthma, in old age. Contraindications:

• intolerance to the components of the composition;
• damage to the liver parenchyma;
• porphyria;
• age up to 3 years for concentrate and tablets, up to 3 months for suspension;
• pregnancy, lactation.

Concentrate 5 ml 10 ampoules

Tablets 120 mg 20 pcs.

Suspension 80 ml

Video

Attention! The information provided in the article is for informational purposes only. The materials of the article do not call for self-treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment, based on the individual characteristics of a particular patient.

Suspension Biseptol combines a good therapeutic effect and a pleasant taste. The drug affects a large group of pathogenic bacteria, inhibits their vital activity and reproduction.

What does Biseptol suspension help children with, what are the contraindications and side effects of the children's drug, the instructions for use will tell.

Composition, active ingredients

100 ml of the drug contains 4 grams of sulfamethoxazole and 0.8 grams of trimethoprim. These substances are the main therapeutic components of the drug.

Auxiliary ingredients medicinal product:

• magnesium aluminum silicate;
• carmellose sodium;
• lemon acid;
• methylhydroxybenzoate (preservative E 218);
• propylhydroxybenzoate (preservative E 214);
• macrogol glyceryl hydroxystearate;
• sodium saccharin;
• maltitol (food additive E 965);
• sodium hydrogen phosphate dodecahydrate;
• strawberry flavor;
• propylene glycol;
• distilled water.

Description and release form

The suspension is in a dark glass bottle. closed with a screw plastic cap. The volume of the vial is 80 ml. A transparent plastic cup is put on the lid, designed for dosing the drug.

The drug is a liquid (suspension) of white or pale cream color with the smell of strawberries.

Detailed instructions are included with the suspension bottle. from drug manufacturers. The bottle and instructions are placed in a cardboard box.

When appointed

Biseptol treats many infectious inflammatory diseases of the lungs(pneumonia, including fungal) and bronchi (), genitals, ears, nose, larynx and throat, stomach, intestines (in particular, "travelers' diarrhea", typhoid fever, paratyphoid).

In combination with other means solution used in the treatment of cholera. This drug can be indicated for brucellosis, toxoplasmosis and a number of other diseases.

Contraindications

According to the instructions for use, Biseptol suspension for children is not prescribed if The following diseases have been identified:

• liver failure;
• kidney failure;
• some types of anemia and blood diseases;
• deficiency of glucose-6-phosphate dehydrogenase;
• prescribed taking one of the drugs for arrhythmia - dofetilide.

The drug is not prescribed to infants under 2 months of age., it can not be drunk with hypersensitivity to the main or auxiliary ingredients of Biseptol.

Under the close supervision of a pediatrician Biseptol can treat children with thyroid diseases, some hereditary diseases.

How and how long does the medicine work

The main components of the drug affect a large group of pathogenic microbes. The main component of the drug is sulfamethoxazole. Trimethoprim enhances and consolidates its action.

Both substances affect the bacteria, and they stop producing folic acid, which is necessary for the formation of their DNA. As a result, the reproduction of microorganisms stops, and eventually they die.

In this way, sulfamethoxazole and trimethoprim have a bacteriostatic effect on microbes.

In mild cases, recovery begins on the second or third day from the start of treatment, with moderate diseases - on the fourth or fifth day.

If you stop taking the suspension after a couple of days, bacteria will continue to multiply., and the therapeutic effect will be reduced to zero. Therefore, the drug is taken in courses, the duration of treatment is determined by the doctor.

Dosage and frequency of administration at different ages

The drug is prescribed for babies from 2 months of life. The exception is children born to HIV-infected mothers. The doctor can prescribe Biseptol suspension to them from the age of six weeks.

When selecting the required dose of the solution, calculate that per day the body should receive 36 mg of the drug for every kilogram of weight.

Based on this, in the instructions for use of the drug the following approximate dosage is given:

• for children from 2 to 5 months - 120 mg per dose;
• for children from 6 months to 5 years - 240 mg per dose;
• for children from 6 to 12 years old - 480 mg per dose;
• children over 12 years old are dosed in the same way as adults - 960 mg per dose.

The medicine is taken twice a day, after 12 hours. With a complex course of an infectious disease, the dose may be increased by a doctor.

The longer the treatment, the smaller doses of a single dose will be prescribed by the pediatrician. Depending on the type, form and severity of the disease the duration of the course is from 5-7 days to 3 months.

How to take, special instructions

The suspension is taken orally, for the exact dosage of the medicine, a measuring cup is used, which is put on the bottle cap.

If any adverse or allergic reactions occur, stop treatment and consult a pediatrician.

Biseptol is prescribed when the expected therapeutic effect of its effects outweighs the risks of possible side effects.

The attending physician, prescribing single doses of administration, takes into account the geographical location of the region, since bacteria can be active in different areas in different ways.

With prolonged treatment, the pediatrician should monitor the composition of the blood and urine of the child especially if he has previously had kidney failure.

With long courses, drug manufacturers recommend taking folic acid.

During treatment you need to drink a lot, since water prevents the formation of crystals in the urine (prevention of crystalluria).

The duration of the course should be as short as possible, while at the same time sufficient for a cure.

Interaction with other drugs

Biseptol can enhance the effect of some drugs and reduce the effect of others.

Only the attending physician can know all the subtleties of drug compatibility, therefore Biseptol should never be used for self-medication..

The suspension can be taken with some antibiotics, antivirals, painkillers and antipyretics (and).

Biseptol enhances the effect of a number of drugs necessary for diabetes, and indirect anticoagulants (substances that prevent thrombosis). The drug also enhances the effect and toxic effects of phenytoin (an epilepsy drug).

Dofetilide (a drug used for arrhythmias), with Biseptol is not prescribed. Taking the suspension along with pyrimethamine (a medicine for malaria and toxoplasmosis) can lead to the development of one type of anemia.

There is a large list of drugs with which Biseptol is prescribed with caution or not prescribed at all (for example, diuretics and antidepressants).

Overdose

In case of drug overdose the following states appear:

With prolonged overdose observed:

• thrombocytopenia (decrease in the number of platelets in the blood and bleeding);
• leukopenia (decrease in the number of leukocytes in the blood), megaloblastic anemia;
• yellowness of the skin.

With a single overdose, gastric lavage is done (induce vomiting) and a diuretic is given.

If it turned out that the overdose was allowed repeatedly, or some time has passed since taking the drug, the doctor prescribes drugs that reduce the effect of biseptol.

In severe cases the child may be prescribed a blood purification procedure - hemodialysis.

Side effects

Side effects of the drug can manifest themselves in different ways.. With individual intolerance to the usual doses of medication in children, the following symptoms may appear:

It must be said that side effects of the drug at the dosage prescribed by the doctor are extremely rare.

Prices in Russian pharmacies

Suspension Biseptol can be bought in almost all pharmacies in Russia, this drug can be ordered via the Internet in pharmacy chains.

The cost of the drug in pharmacies Moscow ranges from 119 to 124 rubles per bottle, St. Petersburg - from 122 to 134 rubles, in Krasnoyarsk, Abakan, Novosibirsk and Irkutsk the drug costs 122 - 140 rubles, in Vladivostok and Khabarovsk - 111-136 rubles, in Rostov- on-Don and Perm - 122-128 rubles.

The average price in Russia is 125 rubles.

Storage and holiday conditions, expiration date

The drug, according to the instructions, sold by prescription. But many private pharmacies and online stores offer to buy it without a prescription.

Store the medicine in a dark place, the storage temperature should be no more than plus 25 °.

Since the suspension has a sweetish taste and a pleasant smell, kids can take it for a treat, so the bottle should be hidden away from small children.

Closed, not unpacked medicine can be stored for three years from the date of issue. The instructions do not say anything about the time of using Biseptol after opening the bottle.

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

The drug Biseptol

Biseptol is active against the following pathogens: staphylococci, streptococci, pneumococci, dysentery bacillus, typhoid bacillus, proteus, E. coli, salmonella, pneumocystis, plasmodium, causative agent of leishmaniasis, meningococcus, vibrio cholerae, actinomycetes, Klebsiella, chlamydia, causative agent of diphtheria and some types of diphtheria mushrooms.

The drug is ineffective against Pseudomonas aeruginosa, the causative agent of leptospirosis, the causative agent of tuberculosis, spirochetes and viruses.
Biseptol also has an effect on microorganisms that are resistant to other sulfanilamide drugs.

Biseptol is rapidly and well absorbed from the stomach and reaches its maximum concentration in the blood 1-3 hours after ingestion. Therapeutic concentration of the drug is maintained up to 7 hours.

The drug penetrates well into biological fluids and tissues of the body: bile, saliva, cerebrospinal fluid, sputum, prostate gland, kidneys, lungs. It is excreted from the body mainly with urine.

Release forms

• 120 mg tablets (100 mg sulfamethoxazole and 20 mg trimethoprim);
• 480 mg tablets (400 mg sulfamethoxazole and 80 mg trimethoprim);
• Tablets "Bactrim forte" 960 mg (800 mg of sulfamethoxazole and 160 mg of trimethoprim);
• Syrup (or suspension) - for oral administration 100 ml (in 1 ml - 40 mg of sulfamethoxazole and 8 mg of trimethoprim);
• Concentrate for solution for injection 480 mg (in 1 ml of concentrate - 80 mg of sulfamethoxazole and 16 mg of trimethoprim).

Instructions for use Biseptol

Indications for use

• diseases of the respiratory tract (bronchitis in acute and chronic form; pneumonia; pleural empyema - purulent inflammation of the membranes of the lungs; abscess or abscess of the lung; bronchiectasis - expansion of the lumen of the bronchi due to the disease);
• ENT pathology (otitis media, or inflammation of the ear; sinusitis, or inflammation of the paranasal sinuses);
• intestinal infections (dysentery, paratyphoid A and B, cholera, typhoid fever);
• urinary tract infections (urethritis - inflammation of the urethra; prostatitis - inflammation of the prostate gland; pyelonephritis - inflammation of the renal pelvis and the kidney tissue itself; salpingitis - inflammation of the uterine appendages);
• gonorrhea (venereal disease);
• soft tissue and skin infections (pyoderma, or pustular skin lesions; acne; furuncle, or boil);
• meningitis (inflammation of the meninges) and abscess (abscess) of the brain;
• septicemia (a form of "infection" of the blood);
• infectious diseases: brucellosis, malaria, toxoplasmosis, borreliosis, scarlet fever;
• wound infections and osteomyelitis;
• prevention and treatment of pneumocystis pneumonia in HIV-infected patients.

Contraindications

• with severe cardiovascular insufficiency;
• with diseases of the hematopoietic organs;
• with severe renal failure;
• mothers when breastfeeding;
• with deficiency of glucose-6-phosphate dehydrogenase (hereditary disease);
• children under the age of 3 months and premature babies;
• with an increased level of bilirubin in children;
• with hypersensitivity to the components that make up the drug, or to other sulfanilamide drugs.

With caution, Biseptol can be used if the patient has previously been allergic to other drugs; with bronchial asthma; patients with folic acid deficiency; with diseases of the thyroid gland; in early childhood and old age.

Treatment with Biseptol should be carried out under medical supervision and blood tests should be carefully monitored.

Side effects

• From the side of the digestive system: in rare cases - diarrhea, abdominal pain, loss of appetite, nausea, vomiting; in isolated cases - colitis (inflammation of the intestine); reactive inflammation of the liver with bile stasis - cholestatic hepatitis; glossitis - inflammation of the tongue; stomatitis - inflammation of the oral mucosa; pancreatitis - inflammation of the pancreas.
• From the nervous system in some cases: dizziness, headache, depression, fine trembling of the fingers of the extremities.
• From the side of the kidneys in rare cases: an increase in the volume of urine, inflammation of the kidneys (nephritis), excretion of blood in the urine.
• On the part of the respiratory system: bronchospasm, cough, choking or a feeling of lack of air.
• On the part of the hematopoietic organs in isolated cases: a decrease in the number of leukocytes in the blood, a decrease in the number of neutrophils (a type of leukocyte that protects the body from infections), a decrease in platelets (platelets involved in blood clotting), folic acid deficiency anemia.
• On the part of the skin: rashes on the skin in the form of urticaria; itching; in isolated cases - Lyell's syndrome and Stevens-Johnson syndrome (the most severe variants of allergic manifestations on the skin and mucous membranes with necrosis and rejection); angioedema (local or diffuse swelling of the subcutaneous tissue and mucous membranes); hypersensitivity to ultraviolet rays.
• There have been isolated cases of chills and fever after taking Biseptol (drug fever).
• Pain in joints and muscles.
• Thrombophlebitis (at the injection site).
• Decreased levels of potassium, sodium and blood sugar.

With prolonged use (more than 5 days) and with the use of higher dosages, as well as with the appearance of changes in the blood test during treatment, folic acid should be taken at 5-10 mg per day.

drug interaction
Biseptol should not be taken simultaneously with Aspirin, Butadion, Naproxen.

Biseptol enhances the effect of drugs that reduce blood clotting, such as warfarin.

Biseptol enhances the effect of some antidiabetic drugs (Gliquidone, Glibenclamide, Glipizide, Chlorpropamide, Gliclazide).

Biseptol increases the activity of the antitumor drug Methotrexate and the anticonvulsant drug Phenytoin.

Biseptol is not recommended to be administered simultaneously with thiazide diuretics (Chlorothiazid, Diuril, Naturetin, Metolazone, Diukardin, Furosemide, etc.) - this contributes to increased bleeding.

Biseptol in combination with diuretics, as well as with the antidiabetic agents listed above, can cause an allergic cross reaction.

Hexamethylenetetramine, ascorbic acid and other drugs that acidify urine increase the risk of "sand" in the urine when used simultaneously with Biseptol.

Biseptol may increase the concentration of digoxin in the blood in elderly patients.

The simultaneous use of Biseptol and Pyrimethamine (an antimalarial drug) increases the risk of anemia.

Benzocaine, Procaine (drugs for local anesthesia) reduce the effectiveness of Biseptol.

Dosage of Biseptol
The dose of the drug and the duration of administration is prescribed by the doctor individually, depending on the severity of the condition and concomitant diseases.

Adult patients are usually prescribed 960 mg 2 times a day (2 tablets of 480 mg or 1 tablet forte 2 times) every 12 hours for 5-14 days.

If long-term treatment is necessary, 480 mg is prescribed 2 times a day (1 tablet 480 mg 2 times).

Suspension of Biseptol is prescribed to adults at 20 ml every 12 hours.

In the case of a severe course of the disease (sometimes with a chronic disease), the dose may be increased up to 50%.

And with a duration of treatment over 5 days, and with an increase in the dose of Biseptol, it is necessary to control the complete blood count.

But microbes adapt to drugs that are often used, and over time lose their sensitivity to these drugs; medicines stop working. So it happened with Biseptol. Therefore, the attitude towards the appointment of Biseptol for cystitis is very restrained at the present time.

The correct tactic in relation to the treatment of cystitis is the selection of medications in accordance with their sensitivity. For this purpose, urine culture is prescribed for microflora and its sensitivity to drugs. The doctor will receive the result 3-4 days after the test and select the correct treatment.

In some cases, the doctor initially prescribes Biseptol, and after receiving the result of the sensitivity of the flora to drugs, if necessary, changes the treatment. Sometimes Biseptol is prescribed due to intolerance to antibiotics or other drugs. Assign Biseptol in the usual dosage (2 tablets 2 times a day) for 5-10 days.

Biseptol's analogs and synonyms

Analogues are called drugs that have different active ingredients in their composition, differ in names, but are used in the treatment of the same diseases, because. have the same effect. Analogues may differ in strength of action, tolerability of the drug, contraindications, side effects.

Analogues of Biseptol are antibiotics of different groups, tk. they also have antimicrobial activity. Depending on the sensitivity of the pathogen and the spectrum of action, antibiotics are used to treat the same diseases as Biseptol.

Analogues of Biseptol are other sulfanilamide preparations:

• Asacol (active ingredient: mesalazine);
• Dermazin (active ingredient: sulfadiazine);
• Ingalipt (active ingredients: streptocide, sodium sulfathiazole);
• Ingaflu (active ingredient: streptocide) and other sulfa drugs.

Preparations-synonyms of Biseptol: Bactrim, Bacterial, Bactramin, Abatsin, Andoprim, Bactifer, Abactrim, Bactramel, Hemitrin, Bactrizol, Ectapprim, Berlocid, Bacticel, Doktonil, Ekspektrin, Gantrin, Falprin, Methomide, Infectrim, Primazol, Microcetim, Oradin, Potesept, Oribact, Resprim, Sumetrolim, Septocid, Uroxen, Bactecod, Trixazole, Trimexazole, Blackson, Vanadil, Aposulfatrin, Bactreduct, Groseptol, Cotrimol, Cotribene, Eriprim, Primotren, Sulfatrim, Rancotrim, Expazol, Novotrimed, Oriprim, Cotrimaxol, Cotrimaxazole, Sinersul, Sulotrim, Trimosul.