How to use aspirin cardio. Aspirin cardio - instructions for use. Influence on concentration

INN: Acetylsalicylic acid

Manufacturer: Bayer Pharma AG

Anatomical-therapeutic-chemical classification: Acetylsalicylic acid

Registration number in the Republic of Kazakhstan: No. RK-LS-5 No. 013404

Registration period: 13.03.2019 - 13.03.2029

KNF (drug is included in the Kazakhstan National Formulary of Medicines)

ALO (Included in the Free Outpatient Drug Supply List)

ED (Included in the List of drugs in the framework of the guaranteed volume of medical care, subject to purchase from a single distributor)

Limit purchase price in the Republic of Kazakhstan: 7.35 KZT

Instruction

Tradename

Aspirin cardio

International non-proprietary name

Acetylsalicylic acid

Dosage form

Enteric-coated tablets 100 mg and 300 mg

Compound

One tablet contains

active substance- acetylsalicylic acid 100 mg or 300 mg,

Excipients: cellulose powder, corn starch, eudragit L30D, polysorbate 80, sodium lauryl sulfate, talc, triethyl citrate.

Description

Round, biconvex, slightly rough, white tablets bevelled to the edge, at the break - a homogeneous mass of white, surrounded by a shell of the same color

Pharmacotherapeutic group

Anticoagulants. Platelet aggregation inhibitors excl. heparin. Acetylsalicylic acid

ATX code B01AC06

Pharmacological properties

Pharmacokinetics

After oral administration, acetylsalicylic acid (ASA) is rapidly and completely absorbed from the gastrointestinal tract.

During absorption and immediately after it, acetylsalicylic acid turns into the main active metabolite - salicylic acid.

The maximum concentration of acetylsalicylic acid in the blood plasma is reached after 10-20 minutes, the maximum concentration of salicylic acid - after 0.3-2 hours.

Due to the fact that the enteric coating of Aspirin Cardio® tablets is acid-resistant, the release of the active substance does not occur in the stomach, but in the alkaline environment of the intestine. Due to this, the absorption of acetylsalicylic acid is delayed by 3-6 hours compared to non-enteric coated tablets.

Acetylsalicylic and salicylic acids bind to a large extent with plasma proteins and are rapidly distributed in tissues.

Salicylic acid is secreted into breast milk and crosses the placental barrier.

Salicylic acid is metabolized mainly in the liver with the formation of metabolites - salicylurate, salicylic phenolic glucuronide, salicylacyl glucuronide, gentisic and gentisuric acids.

The excretion of salicylic acid is dose-dependent.

The half-life when taking the drug in low doses is 2-3 hours, when taking the drug in high doses - 15 hours. Salicylic acid and its metabolites are excreted mainly by the kidneys.

Pharmacodynamics

The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, since they are not able to re-synthesize cyclooxygenase.

It is believed that acetylsalicylic acid also has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.

Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs, and has analgesic, antipyretic and anti-inflammatory effects.

Higher doses are used to relieve pain and minor fevers such as colds and flu, to reduce fever, reduce muscle and joint pain, and in acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

Indications for use

To reduce the risk of death in patients with suspected acute myocardial infarction

To reduce the risk of morbidity and mortality in patients who have had a myocardial infarction

For secondary prevention of stroke

To reduce the risk of transient ischemic attack (TIA) and stroke in patients with TIA

To reduce morbidity and mortality in stable and unstable angina

For the prevention of thromboembolism after surgery and invasive interventions on the vessels (for example, percutaneous transluminal catheter angioplasty, coronary artery bypass grafting, carotid endarterectomy, arteriovenous bypass grafting)

For the prevention of deep vein thrombosis and pulmonary embolism during prolonged immobilization (for example, after major surgery)

To reduce the risk of acute myocardial infarction in the presence of cardiovascular risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, older age)

Dosage and administration

For oral administration.

Aspirin cardio enteric-coated tablets should be taken before meals with plenty of liquid.

To reduce the risk of death in patients with acute myocardial infarction

An initial dose of 100-300 mg (the first tablet must be chewed for faster absorption) should be taken by the patient as soon as possible after an acute myocardial infarction is suspected.

In the subsequent 30 days after the development of myocardial infarction, a dose of 100-300 mg / day should be maintained.

After 30 days, the need for further therapy should be considered to prevent the development of recurrent myocardial infarction.

To reduce the risk of morbidity and mortality in patients who have had a myocardial infarction

100-300 mg/day

For secondary prevention of stroke

100-300 mg/day

To reduce the risk of TIA and stroke in patients with TIA

100-300 mg/day

To reduce morbidity and mortality in stable and unstable angina

100-300 mg/day

For the prevention of thromboembolism after operations and invasive interventions on the vessels

100-300 mg/day

For the prevention of deep vein thrombosis and pulmonary embolism

100-200 mg/day or 300 mg every other day

To reduce the risk of developing acute myocardial infarction

100 mg per day or 300 mg every other day.

Side effects

The side effects listed below are based on spontaneous post-marketing reports and experience with all forms of Aspirin, including short and long-term oral forms.

In this regard, their presentation by frequency in accordance with the categories of CIOMS III is not possible.

Often:

Dyspepsia, abdominal and gastrointestinal pain

Rarely:

Inflammation of the gastrointestinal tract, ulcers of the mucous membrane of the stomach and duodenum (very rarely potentially leading to gastrointestinal bleeding and perforation with corresponding clinical and laboratory symptoms)

Rare - very rare:

Severe cases of bleeding, such as gastrointestinal bleeding, cerebral hemorrhage (especially in patients with uncontrolled arterial hypertension and / or receiving concomitant anticoagulant therapy), which in some cases may be life-threatening.

Very rarely:

Severe hypersensitivity reactions, including anaphylactic shock

Transient disorders of liver function with increased activity of "liver" transaminases

With unknown frequency:

Bleeding such as perioperative bleeding, bruising, epistaxis (nosebleeds), urinary tract bleeding, bleeding gums

Hemolysis and hemolytic anemia in patients with severe glucose-6-phosphate dehydrogenase deficiency

Renal dysfunction and acute renal failure

Hypersensitivity reactions with relevant clinical and laboratory manifestations (asthmatic syndrome, mild to moderate reactions from the skin, respiratory tract, gastrointestinal tract and cardiovascular system, including skin rash, urticaria, edema, pruritus, rhinitis, mucosal edema nasal membranes, cardio-respiratory distress syndrome)

Dizziness and ringing in the ears, which can also be a sign of an overdose of the drug.

Contraindications

- hypersensitivity to acetylsalicylic acid or other salicylates, or to any of the excipients of the drug

History of bronchial asthma induced by the intake of salicylates and substances of similar action, especially non-steroidal anti-inflammatory drugs (NSAIDs)

Acute period of peptic ulcer

Hemorrhagic diathesis

severe kidney failure

severe liver failure

severe heart failure

Combined use with methotrexate at a dose of 15 mg per week or more

Last trimester of pregnancy for aspirin cardio  100 mg (see Pregnancy and lactation section)

Pregnancy period (all 3 trimesters) for Aspirin cardio  300 mg (see Pregnancy and lactation section)

Drug Interactions

Contraindicated Interactions

Methotrexate at a dose of 15 mg/week or more

With the simultaneous use of ASA with methotrexate, the hematological toxicity of methotrexate increases due to the fact that NSAIDs reduce the renal clearance of methotrexate, and salicylates, in particular, displace it from its association with plasma proteins.

Combinations requiring caution

Ibuprofen

Ibuprofen, when used simultaneously with ASA, antagonizes its positive effect on platelets.

In patients with an increased risk of cardiovascular disease, the simultaneous use of ibuprofen and ASA leads to a decrease in its cardioprotective effect.

Anticoagulants, thrombolytic and other antiplatelet drugs

There is a risk of bleeding.

Other NSAIDs with high dose salicylates (3 g/day or more)

Due to the synergism of action, the risk of ulceration of the gastrointestinal mucosa and bleeding increases.

Selective serotonin reuptake inhibitors

Due to the synergy of action, the risk of bleeding from the upper gastrointestinal tract increases.

Digoxin

By reducing renal clearance, ASA increases the concentration of digoxin in the blood plasma.

Antidiabetic agents, eg insulin, sulfonylurea derivatives

High doses of ASA enhance the effect of hypoglycemic drugs due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from their association with plasma proteins.

Diuretics in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of a decrease in the synthesis of prostaglandins in the kidneys.

Systemic glucocorticosteroids (GCS), with the exception of hydrocortisone, used for replacement therapy of Addison's disease

During corticosteroid therapy, the level of concentration of salicylates in the blood decreases and there is a risk of developing an overdose of salicylates after stopping treatment, since corticosteroids increase the excretion of the latter.

Angiotensin-converting enzyme (ACE) inhibitors in combination with high doses of ASA

There is a decrease in glomerular filtration as a result of inhibition of prostaglandins that have a vasodilating effect, respectively, a weakening of the hypotensive effect.

Valproic acid

The toxicity of valproic acid increases due to its displacement from the connection with blood plasma proteins.

ethanol

There is an increased risk of damage to the gastrointestinal mucosa and an increase in bleeding time as a result of the mutual enhancement of the effects of ASA and ethanol.

Uricosuric drugs such as benzbromarone, probenecid

The uricosuric effect is reduced due to competitive renal tubular elimination of uric acid.

special instructions

The drug should be used with caution in the following conditions:

With hypersensitivity to analgesics, anti-inflammatory, antirheumatic drugs and other types of allergies

A history of gastrointestinal ulcers, including chronic or recurrent peptic ulcers or gastrointestinal bleeding

When used together with anticoagulants (See section "Drug Interactions")

In patients with impaired renal or circulatory function (eg, vascular disease of the kidneys, congestive heart failure, decreased blood volume, major surgery, sepsis, or severe bleeding), because acetylsalicylic acid may further increase the risk of developing kidney damage or acute renal failure. insufficiency

In patients suffering from severe deficiency of glucose-6-phosphate dehydrogenase (G6PD), acetylsalicylic acid can induce the development of hemolysis or hemolytic anemia. Factors that may increase the risk of hemolysis include, for example, high doses of the drug, fever, or the presence of acute infections.

In violation of liver function

Ibuprofen may interfere with the inhibitory effect of ASA on platelet aggregation. Patients receiving ASA treatment and taking ibuprofen for pain relief should inform their physician.

ASA can provoke bronchospasm, as well as cause asthma attacks and other hypersensitivity reactions. Risk factors are a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory disease, and allergic reactions to other substances (eg, skin reactions, itching, urticaria).

Due to the inhibitory effect on platelets, the use of Aspirin cardio  may be associated with an increased risk of bleeding. Due to this ability to inhibit platelet aggregation, which persists for several days after taking the drug, acetylsalicylic acid can lead to increased bleeding during and after surgical interventions (including minor surgical interventions, such as tooth extraction).

Bleeding can lead to the development of acute or chronic post-hemorrhagic/iron deficiency anemia (for example, due to latent microbleeding) with relevant clinical and laboratory signs and symptoms, such as asthenia, pallor of the skin, hypoperfusion.

ASA in low doses reduces the excretion of uric acid, which can provoke the development of gout in predisposed individuals.

Application in pediatrics

There is a relationship between Aspirin use and the development of Reye's syndrome when used in children with certain viral diseases. The risk may be increased with the combined use of drugs containing ASA, but a causal relationship has not been identified. The development of persistent vomiting in such diseases may be a sign of Reye's syndrome.

Reye's syndrome is a very rare disease that causes damage to the brain and liver and can be fatal.

In this regard, Aspirin cardio  should not be used in children and adolescents under 18 years of age unless specifically indicated.

Use during pregnancy

Inhibition of prostaglandin synthesis can have a negative effect on pregnancy and the development of the embryo or fetus. Data from epidemiological studies indicate an increased risk of malformations and malformations when using prostaglandin synthesis inhibitors in early pregnancy. It is believed that the risk increases with increasing dose and duration of treatment. Available data do not support any relationship between the use of acetylsalicylic acid and an increased risk of premature termination of pregnancy. The available epidemiological data regarding the development of malformations are contradictory, however, an increased risk of developing a defect - non-closure of the anterior abdominal wall cannot be ruled out. Prospective use of ASA in early pregnancy (1-4 months) in 14,800 women/children did not reveal any association with an increased incidence of malformations.

Preclinical data have shown reproductive toxicity. The appointment of drugs containing acetylsalicylic acid in the first and second trimesters of pregnancy is not indicated, until it is dictated by extreme necessity.

With this in mind, in the first and second trimesters of pregnancy, Aspirin cardio at a dose of 100 mg can be used only after a thorough assessment of the risk/benefit ratio by the doctor.

When using preparations containing acetylsalicylic acid by a woman at the time of conception, or in the first and second trimester of pregnancy, it is necessary to use the lowest possible dose of the drug and conduct a short course of treatment.

In the third trimester of pregnancy, all inhibitors of prostaglandin synthesis can cause the fetus:

cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension)

kidney dysfunction, which can progress to renal failure with oligohydramnios;

In mother and fetus at the end of pregnancy:

possible increase in bleeding time, antiplatelet effect that may occur even at low doses

suppression of the contractile activity of the uterus, which can lead to overmaturity or prolonged labor

In this regard, ASA is contraindicated for use in the third trimester of pregnancy.

Application during lactation

Salicylates and their metabolites are excreted in breast milk in small amounts. Accidental intake of salicylates during lactation does not require cessation of breastfeeding. However, if a doctor prescribes long-term use of the drug or taking acetylsalicylic acid in high doses, breastfeeding should be stopped.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Given the possible side effects, such as dizziness, care must be taken when driving a vehicle or potentially dangerous machinery.

Overdose

Salicylate intoxication (develops when taking ASA at a dose of more than 100 mg / kg / day for more than 2 days) may result from prolonged use of toxic doses of the drug as a result of improper therapeutic use of the drug (chronic intoxication) or a single accidental or intentional intake of a toxic dose of the drug adult or child (acute intoxication).

Symptoms of chronic overdose are nonspecific and often difficult to diagnose.

Chronic overdose of mild severity usually develops only after repeated use of large doses of the drug.

Symptoms: dizziness, tinnitus, hearing loss, increased sweating, nausea and vomiting, headache and confusion. The specified symptomatology disappears after reduction of a dose of drug. Tinnitus may appear at plasma ASA concentrations of 150 to 300 µg/mL. More severe symptoms appear at ASA concentrations greater than 300 µg/mL.

Acute intoxication

Symptoms: o The main manifestation of acute intoxication is a severe violation of the acid-base state, the manifestations of which may vary depending on the age of the patient and the severity of intoxication. In children, the most typical is the development of metabolic acidosis. The severity of intoxication cannot be assessed only by the concentration of ASA in the blood plasma. Absorption of ASA may be delayed due to slow gastric emptying, the formation of stones in the stomach, or as a result of taking enteric-coated tablets.

Treatment: is carried out in accordance with accepted standards and depends on the severity of intoxication and the clinical picture and should be aimed mainly at accelerating the elimination of the drug and restoring the water-electrolyte balance and acid-base state.

Mild to moderate overdose

Symptoms: tachypnea, hyperventilation, respiratory alkalosis (alkalemia and alkaluria), increased sweating, nausea and vomiting.

Treatment: gastric lavage, repeated intake of activated charcoal, forced diuresis with drugs for alkalinization of urine, restoration of water and electrolyte balance and acid-base status.

Moderate to severe overdose

Symptoms:

Respiratory alkalosis with compensatory metabolic acidosis (acidemia and aciduria)

Hyperpyrexia

Respiratory disorders: hyperventilation, non-cardiogenic pulmonary edema, respiratory depression, asphyxia

Cardiovascular system disorders: heart rhythm disturbances, arterial hypotension, cardiac depression (changes in blood pressure, electrocardiograms)

Disorders of water and electrolyte balance: dehydration, impaired renal function from oliguria up to the development of renal failure (hypokalemia, hypernatremia, hyponatremia)

Glucose metabolism disorders: hyperglycemia, hypoglycemia (especially in children), ketoacidosis

Tinnitus, deafness

Gastrointestinal bleeding

Hematological disorders: from inhibition of platelet aggregation to coagulopathy, prolongation of prothrombin time, hypoprothrombinemia

Neurological disorders: toxic encephalopathy and depression of the function of the central nervous system (drowsiness, confusion, coma, convulsions)

Treatment: immediate hospitalization in specialized departments for emergency therapy - gastric lavage, repeated intake of activated charcoal, forced alkaline diuresis, hemodialysis.

Restoration of water and electrolyte balance and acid-base status, symptomatic therapy.

Release form and packaging

14 or 10 tablets in a blister pack made of polypropylene film and aluminum foil.

2 blister packs containing 14 tablets or 3 blister packs containing 10 tablets are placed in a cardboard box along with instructions for use.

Shelf life

5 yearsDo not use after the expiration date.

Storage conditions

Store at a temperature not exceeding 25°C.

Keep out of the reach of children!

Holiday conditions Without a prescription

Manufacturer

Bayer Pharma AG, Leverkusen, Germany

Registration certificate holder

Bayer Pharma AG, Berlin, Germany

Packer

Bayer Bitterfeld GmbH, Germany

Address of the organization hosting on the territory of the Republic of Kazakhstan

claims from consumers on the quality of the product (goods)

Bayer KAZ LLP, st. Timiryazev, 42,

business center "Expo City", pav. fifteen

050057 Almaty, Republic of Kazakhstan,

tel. +7 727 258 80 40,

fax: +7 727 258 80 39, e-mail: [email protected]

Attached files

Content

It is important for every person to maintain the health of the heart, blood vessels and brain. The German drug Aspirin Cardio helps to normalize blood pressure, get rid of dizziness, and prevent stroke attacks - the instructions for use of which tell in detail about the features of the reception. The medicine contains acetylsalicylic acid, counteracts the formation of blood clots. In addition, the drug has the properties of the popular Aspirin, effective for inflammation, fever. Before using the tablets, it is important to read the instructions for the medication.

Heart Aspirin

This is how enteric Aspirin Cardio is called in everyday life. Tablets are produced on the basis of acetylsalicylic acid and are used to treat various diseases. Initially, the drug was used to reduce body temperature. Later, analgesic, anti-inflammatory, blood-thinning properties were discovered. Heart Aspirin is available in 50, 75, 100, or 300 mg salicylates. The drug belongs to anticoagulants (has an antithrombotic effect), antiaggregants (thinns the blood). The manufacturer of the tablets is the German company Bayer.

Composition and form of release

This drug is available in white, enteric-coated tablets. A detailed list of tablet components is presented in the table:

Pharmacodynamics and pharmacokinetics

Acetylsalicylic acid, which is part of the drug, inhibits the production of the cyclooxygenase enzyme, thereby eliminating inflammation and pain. Besides, cardiac aspirin provides the following effects:

• reduces the sensitivity of nerve endings;
• inhibits the development of prostaglandins, thereby reducing its effect on the thermoregulatory center;
• has a depressing effect on thromboxane, which prevents an increase in blood pressure and the development of thrombosis.

After entering the gastrointestinal tract, the components of the tablet are partially converted into salicylic acid, a metabolite and metabolic product. Aspirin in the shell is released only in the duodenum, under the influence of an alkaline environment. Acetylsalicylic acid is completely absorbed into the blood. The enteric coating of the drug increases its absorption up to 6 hours. The drug is completely excreted by the kidneys within 2-3 days.

Indications for use

This tool is used more for the prevention of cardiovascular disease than for treatment. Indications for taking cardiac aspirin tablets are as follows:

• stable/unstable angina;
• prevention of myocardial infarction (in the presence of provoking factors: age, bad habits, diabetes mellitus);
• prevention of thrombosis, circulatory disorders in the brain, stroke;
• prevention of thromboembolism after surgery.

Method of application and dosage

It is important to consult your doctor before using this medication. If Aspirin Cardio tablets are prescribed, the instructions for use will tell you how to take them. The medicine is designed for long-term course treatment. It is recommended to drink tablets before meals with water (up to 200 ml). Some patients are prescribed this remedy for life if there are no side effects. In any case, the course of therapy and regimen are determined by the doctor.

How to take for prevention

More often this medicine is used for prevention. Below is table with the regimen and doses, depending on the specific case:

special instructions

Cardiac Aspirin promotes platelet aggregation and significantly reduces the patient's blood clotting. In this regard, the drug is not prescribed in conjunction with other antiplatelet agents, anticoagulants, thrombolytics. With gout, the remedy can provoke relapses of the disease due to the production of a large amount of uric acid in the blood. With uncontrolled hypertension, the drug can cause hemorrhagic stroke.

drug interaction

To reduce the risk of side effects, When treating with this drug, it is not recommended to take the following drugs:

• Heparin;
• Ketoprofen;
• Timolol;
• Amitriptyline;
• Warfarin;
• Reviparin.
• Dexamethasone.

Cardiac Aspirin when used together increases the effects of methotrexate, heparin, indirect anticoagulants. The combination with valproic acid can lead to intoxication. If you take medicine with anti-inflammatory drugs, the risk of bleeding increases significantly. The use of the drug simultaneously with alcohol (preparations containing ethanol) leads to damage to the mucous membranes of the stomach and other internal organs, provokes bleeding. The effectiveness of diuretics from acetylsalicylic acid is reduced.

Side effects

The reviews confirm that if you break the regimen or do not take into account the contraindications of this medication, then The following side effects may occur during treatment:

• nausea;
• abdominal pain;
• violations of the liver;
• bleeding before and after surgery;
• hematomas;
• anemia;
• cerebral hemorrhage;
• bronchospasm;
• anaphylaxis;
• skin itching;
• swelling;
• nasal congestion.

Overdose

If you do not follow the instructions and exceed the daily dose (more than 10 mg when used for more than 2 days), then therapy can cause the patient to develop the following conditions:

• dizziness;
• sweating;
• hearing loss;
• confusion;
• respiratory alkalosis;
• pulmonary edema;
• hyperpyrexia (very high body temperature);
• arterial hypotension;
• heart failure;
• violation of the kidneys;
• damage to the gastric mucosa;
• depression of the functions of the central nervous system.

Contraindications

Before using cardiac Aspirin, you need to read the instructions. The medicine has the following contraindications:

• bronchial asthma;
• acute stomach ulcer;
• hemorrhagic diathesis;
• 1st and 3rd trimesters of pregnancy;
• age under 18;
• lactation;
• kidney failure;
• liver disease;
• allergy to acetylsalicylic acid;
• heart failure.

With caution, tablets should be used in the following conditions:

• hyperuricemia;
• gout;
• gastrointestinal bleeding;
• violations of the kidneys;
• atherosclerosis of the renal arteries;
• sepsis;
• respiratory diseases;
• 2nd trimester of pregnancy;
• before a planned surgical operation (including a minor one).

Terms of sale and storage

You can buy Aspirin Cardio in Russian pharmacies without a special prescription from a doctor. The rules for storing tablets are as follows:

• Air temperature up to 25°C.
• Shelf life - no longer than 5 years.
• The place is dark, inaccessible to children.

Analog

If this drug is not in the pharmacy, you can purchase a remedy similar in composition or action. Here known analogues of Aspirin Cardio:

• Thrombo ASS;
• Agrenox;
• Upsarin UPSA;
• ibuprofen;
• Polocard;
• Cardiomagnyl;
• Plagril;
• Lopirel.

Aspirin Cardio and Cardiomagnyl - what's the difference

Considering this remedy and its main analogue Cardiomagnyl, many patients have the question of how they differ. First of all, it is worth noting the price of cardiac Aspirin, which is much lower. Cardiomagnyl is more expensive because it is made in Denmark. The composition of the drugs is also different. Cardiomagnyl, in addition to acetylsalicylic acid, additionally contains magnesium hydroxide, which has a positive effect on the heart, which is confirmed by experts and patient reviews.

Price Aspirin Cardio

The cost of this drug depends on the region, the manufacturer and other factors. Below is table with drug prices in Moscow pharmacies:

Every year, cardiovascular diseases, such as stroke, myocardial infarction, angina pectoris, take the lives of many people of different ages. Scientists from different countries are working on the creation of drugs that can prevent the development of diseases of the heart and blood vessels, as well as reduce their symptoms. Among these drugs, the drug Aspirin Cardio, developed by the leading German company Bayer, has gained particular popularity.

Aspirin Cardio is a nonsteroidal anti-inflammatory drug (NSAID) with antiaggregatory, anti-inflammatory, analgesic, antipyretic effects.

Aspirin cardio - a popular drug with acetylsalicylic acid, is produced in tablets surrounded by a shell. It is a good medicine that counteracts the formation of blood clots. It has the properties of aspirin, a long-established reliable remedy for fever, inflammation and pain.

Aspirin Cardio 300 photo

Acetylsalicylic acid - the active ingredient in Aspirin Cardio tablets - reduces the ability of platelets to stick together and form blood clots. The drug has such an effect because it inhibits the synthesis of thromboxane A2 in platelets. This property of aspirin is called antiaggregatory action.

Acetylsalicylic acid was discovered by Felix Hoffmann, a staff chemist of the German company Bayer, back in 1899, the year that this world-famous trademark was born. Aspirin cardio is one of the representatives of the friendly family of "Bayer" aspirins, used, as its name implies, mainly in cardiology practice.

Aspirin cardio is available as enteric-coated tablets. 1 tablet of the drug contains acetylsalicylic acid 100 mg (0.1 g) or 300 mg (0.3 g).

Indications for use Aspirin Cardio

Indications for the use of Aspirin Cardio apply to all diseases in which there is a risk or excessive thrombus formation occurs:

• Pain syndrome of low and medium intensity of various origins, fever, inflammatory and rheumatic diseases;
• As an antiplatelet agent, it is used for unstable angina pectoris, acute myocardial infarction, as well as for the prevention of thrombosis and embolism after vascular surgery, transient cerebrovascular accident and ischemic stroke, secondary prevention of myocardial infarction.

Instructions for use Aspirin Cardio, dosage

To reduce mortality among patients with angina pectoris, with the threat of developing acute myocardial infarction, after myocardial infarction, as well as in the secondary prevention of stroke, Aspirin Cardio is prescribed at a dose of 100 mg / day.

The dose of Aspirin Cardio 300 mg/day is used only for therapeutic indications for short-term treatment.

It is advisable to take the tablets before meals with plenty of liquid. Tablets are taken 1 time / day. The drug is intended for long-term use. The duration of therapy is determined by the doctor.

Application features

There was no effect on the ability to drive a car and other mechanisms.

When taking aspirin, one should keep in mind the fact that its antiplatelet effect persists for several days, therefore, when planning a surgical intervention, it is necessary to stop taking the drug during this period.

To check the effect of the use of Aspirin Cardio, a coagulogram is prescribed (people suffering from problems associated with blood clotting are familiar with this study). If the result is satisfactory, the treatment is either weakened or stopped completely - at the discretion of the attending physician.

Features of taking Aspirin Cardio to combat fever or headaches additionally need to be agreed with a specialist.

Side effects and contraindications of Aspirin Cardio

Possible side effects when taking Aspirin Cardio:

• hepatitis, pancreatitis, pain and bloating, lack of appetite, stomach ulcers;
• headache and dizziness;
• allergic reactions on the skin;
• anemia, thrombocytopenia, agranulocytosis, leukopenia;
• various bleeding.

Overdose

Exceeding the dose of ASA is associated with a risk of gastrointestinal bleeding.

Overdose is especially dangerous in elderly patients.

Symptoms of an overdose of moderate severity: nausea, vomiting, tinnitus, hearing loss, dizziness, confusion.

Treatment is to reduce the dose of the drug.

Contraindications:

• drug allergy;
• diathesis;
• asthma;
• diseases of the liver and kidneys;
• acute heart failure.

The drug should be used only as directed by a doctor.

The drug should not be taken if the ulcer has worsened or the person has had a hemorrhagic stroke. It is not prescribed for those who have hypersensitivity to aspirin or diagnosed with renal, hepatic, heart failure. The drug is not prescribed to patients under 18. It is not recommended to drink Aspirin cardio in the 1st and 3rd trimesters of pregnancy.

Analogues of Aspirin Cardio, list

Analogues of Aspirin cardio are drugs whose active ingredient is also acetylsalicylic acid:

1. Aspecard;
2. Thrombo-ass-50;
3. Magnikor;
4. Cardiomagnyl Forte;
5. Cardiomagnyl;
6. Acetylsalicylic acid-darnitsa

Important - instructions for use of Aspirin Cardio, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Aspirin Cardio with an analogue, it is important to get expert advice, you may need to change the course of therapy, dosages, etc. Do not self-medicate!

According to the WHO, the introduction and use of drugs containing acetylsalicylic acid or aspirin in cardiology practice is one of the most significant facts in medicine in an era when cardiovascular diseases are one of the decisive factors determining the life expectancy of people in the developed countries of the world. Application of the drugin the prevention and treatment of this group of diseases has already made it possible to extend the lives of millions of people on Earth, and this figure is increasing every day.

Aspirin is probably the most studied drug in the world today. Its pharmacologically active substance - acetylsalicylic acid - was discovered by Felix Hoffmann, a staff chemist of the German company Bayer, back in 1899, which became the year of the birth of this world-famous trademark. Aspirin cardio is one of the representatives of the friendly family of "Bayer" aspirins, used, as its name implies, mainly in cardiology practice. The idea of ​​aspirin as an anti-inflammatory and pain reliever has long since been written off. Although, long after the discovery of the drug, knowledge of its properties was limited only to this. And only 50 years later, its antiaggregation abilities were discovered, which made it possible to use aspirin in the prevention of thrombosis. At the same time, for the first time, it was suggested that regular and long-term use of aspirin helps to reduce the risk of death from myocardial infarction and other fatal cardiovascular pathologies. In the future, this thesis was repeatedly confirmed, one might even say, carved in granite, in the course of many large clinical studies. And in 1994, as a result of summarizing data from more than 300 studies involving about 140,000 volunteers, an unambiguous conclusion was made: daily intake of low doses of aspirin can reduce mortality from cardiovascular disease by 100,000 people a year.

Despite more than a century of "age" of aspirin, understanding of its mechanisms of action did not come immediately. Moreover, to date, the question of the mechanism of action of acetylsalicylic acid remains debatable to a certain extent. To date, it is known for certain that aspirin inhibits the formation of the enzyme cyclooxygenase-1 (COX-1), thereby inhibiting the synthesis of prostaglandins.

In addition, the synthesis of enzymes that increase platelet aggregation and cause vasoconstriction, thromboxanes, is suppressed. Ultimately, this selective blocking of enzymatic activity leads to the development of three main pharmacological effects of aspirin: antithrombotic, analgesic and anti-inflammatory. It is curious that the degree of manifestation of each of them depends on the dose taken: small doses of aspirin contribute to the development of an antithrombotic effect, and with an increase in the number of tablets taken, the analgesic and anti-inflammatory effects begin to assert themselves louder. Summing up a brief digression into the pharmacological “labyrinths of the soul” of aspirin, it should be noted that this drug affects the key moment in thrombotic complications of cardiovascular pathology, which is aggregation (gluing) and adhesion (adherence to the vascular wall) of platelets. Despite the relatively short half-life of the drug in the body - about 20 minutes - its pronounced antithrombotic effect lasts 1-2 days and remains noticeable for another 7-10 days.

Aspirin cardio is available as enteric-coated tablets. The drug should be taken before meals, drinking plenty of water. Aspirin cardio is intended for regular and long-term use. Multiplicity of reception - 1 time per day. The specific dose of the drug is determined by the doctor depending on the goals of drug therapy. When taking aspirin, one should keep in mind the fact that its antiplatelet effect persists for several days, therefore, when planning a surgical intervention, it is necessary to stop taking the drug during this period.

Pharmacology

NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects, and also inhibits platelet aggregation. The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A decrease in the content of prostaglandins (mainly E 1) in the center of thermoregulation leads to a decrease in body temperature due to the expansion of skin vessels and an increase in sweating. The analgesic effect is due to both central and peripheral action. Reduces aggregation, adhesion of platelets and thrombosis by suppressing the synthesis of thromboxane A 2 in platelets.

Reduces mortality and the risk of myocardial infarction in unstable angina. It is effective in the primary prevention of diseases of the cardiovascular system and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it inhibits the synthesis of prothrombin in the liver and increases the prothrombin time. Increases plasma fibrinolytic activity and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). Increases hemorrhagic complications during surgical interventions, increases the risk of bleeding during anticoagulant therapy. Stimulates the excretion of uric acid (impairs its reabsorption in the renal tubules), but in high doses. Blockade of COX-1 in the gastric mucosa leads to inhibition of gastroprotective prostaglandins, which can lead to mucosal ulceration and subsequent bleeding.

Pharmacokinetics

When taken orally, it is rapidly absorbed mainly from the proximal small intestine and, to a lesser extent, from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.

It is metabolized in the liver by hydrolysis to form salicylic acid, followed by conjugation with glycine or glucuronide. The concentration of salicylates in plasma is variable.

About 80% of salicylic acid binds to plasma proteins. Salicylates easily penetrate into many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Small amounts of salicylates are found in the brain tissue, traces - in bile, sweat, feces. It quickly crosses the placental barrier and is excreted in small amounts in breast milk.

In newborns, salicylates can displace bilirubin from its association with albumin and contribute to the development of bilirubin encephalopathy.

Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.

When acidosis occurs, most of the salicylate turns into non-ionized acid, which penetrates well into tissues, incl. into the brain.

It is excreted mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. The excretion of unchanged salicylate depends on the pH of the urine (with alkalization of the urine, the ionization of salicylates increases, their reabsorption worsens, and excretion increases significantly). T 1/2 acetylsalicylic acid is approximately 15 minutes. T 1 / 2 salicylate when taken in low doses is 2-3 hours, with increasing doses it can increase up to 15-30 hours. In newborns, the elimination of salicylate is much slower than in adults.

Release form

Tablets, enteric-coated white, round, biconvex; on the transverse section - a homogeneous mass of white color, surrounded by a white shell.

Excipients: cellulose, powder - 10 mg, corn starch - 10 mg.

Shell composition: copolymer of methacrylic acid and ethacrylate 1: 1 (eudragit L30D) - 7.875 mg, polysorbate 80 - 186 μg, sodium lauryl sulfate - 57 μg, talc - 8.1 mg, triethyl citrate - 800 μg.

10 pieces. - blisters (2) - packs of cardboard.
14 pcs. - blisters (2) - packs of cardboard.
14 pcs. - blisters (4) - packs of cardboard.

Dosage

Individual. For adults, a single dose varies from 40 mg to 1 g, daily - from 150 mg to 8 g; multiplicity of application - 2-6 times / day.

Interaction

With the simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of acetylsalicylic acid.

With the simultaneous use of calcium channel blockers, agents that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.

With simultaneous use with acetylsalicylic acid, the effect of heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulins, methotrexate, phenytoin, valproic acid is enhanced.

With simultaneous use with GCS, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.

With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.

With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid may reduce plasma concentrations of indomethacin, piroxicam.

When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.

With simultaneous use, the effectiveness of uricosuric agents (including probenecid, sulfinpyrazone, benzbromarone) decreases.

With the simultaneous use of acetylsalicylic acid and sodium alendronate, severe esophagitis may develop.

With the simultaneous use of griseofulvin, a violation of the absorption of acetylsalicylic acid is possible.

A case of spontaneous hemorrhage in the iris is described when taking ginkgo biloba extract against the background of long-term use of acetylsalicylic acid at a dose of 325 mg / day. It is believed that this may be due to an additive inhibitory effect on platelet aggregation.

With the simultaneous use of dipyridamole, an increase in Cmax of salicylate in plasma and AUC is possible.

With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in the blood plasma increase.

With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.

Acetylsalicylic acid at doses less than 300 mg / day has little effect on the effectiveness of captopril and enalapril. When using acetylsalicylic acid in high doses, it is possible to reduce the effectiveness of captopril and enalapril.

With simultaneous use, caffeine increases the absorption rate, plasma concentration and bioavailability of acetylsalicylic acid.

With simultaneous use, metoprolol can increase the Cmax of salicylate in plasma.

When using pentazocine against the background of long-term use of acetylsalicylic acid in high doses, there is a risk of developing severe adverse reactions from the kidneys.

With the simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.

With simultaneous use, ethanol can enhance the effect of acetylsalicylic acid on the gastrointestinal tract.

Side effects

From the digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely - the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, impaired liver function.

From the side of the central nervous system: with prolonged use, dizziness, headache, reversible visual impairment, tinnitus, aseptic meningitis are possible.

From the hemopoietic system: rarely - thrombocytopenia, anemia.

From the blood coagulation system: rarely - hemorrhagic syndrome, prolongation of bleeding time.

From the urinary system: rarely - impaired renal function; with prolonged use - acute renal failure, nephrotic syndrome.

Allergic reactions: rarely - skin rash, Quincke's edema, bronchospasm, "aspirin triad" (combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs).

Others: in some cases - Reye's syndrome; with prolonged use - increased symptoms of chronic heart failure.

Indications

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis; fever in infectious and inflammatory diseases; pain syndrome of low and medium intensity of various origins (including neuralgia, myalgia, headache); prevention of thrombosis and embolism; primary and secondary prevention of myocardial infarction; prevention of cerebrovascular accidents by ischemic type.

In clinical immunology and allergology: in gradually increasing doses for prolonged "aspirin" desensitization and the formation of stable tolerance to NSAIDs in patients with "aspirin" asthma and the "aspirin triad".

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding, "aspirin triad", a history of indications of urticaria, rhinitis caused by taking acetylsalicylic acid and other NSAIDs, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, dissecting aortic aneurysm, portal hypertension, vitamin K deficiency, liver and / or kidney failure, glucose-6-phosphate dehydrogenase deficiency, Reye's syndrome, children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases), I and III trimesters of pregnancy, lactation period , hypersensitivity to acetylsalicylic acid and other salicylates.

Application features

Use during pregnancy and lactation

Contraindicated for use in the I and III trimesters of pregnancy. In the II trimester of pregnancy, a single dose is possible according to strict indications.

It has a teratogenic effect: when used in the first trimester, it leads to the development of a splitting of the upper palate, in the third trimester it causes inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.

Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function, therefore, acetylsalicylic acid should not be used in the mother during lactation.

Application for violations of liver function

Contraindication: liver failure.

Use with caution in patients with liver disease.

Application for violations of kidney function

Contraindication: renal failure.

Use with caution in patients with kidney disease.

Use in children

special instructions

Use with caution in patients with diseases of the liver and kidneys, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, with increased bleeding or while conducting anticoagulant therapy, decompensated chronic heart failure.

Acetylsalicylic acid, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When carrying out long-term therapy and / or the use of acetylsalicylic acid in high doses, a doctor's supervision and regular monitoring of hemoglobin levels are required.

The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 g is limited due to the high likelihood of side effects from the gastrointestinal tract.

Before surgery, to reduce bleeding during surgery and in the postoperative period, salicylates should be discontinued 5-7 days in advance.

During long-term therapy, it is necessary to conduct a complete blood count and a study of feces for occult blood.

The use of acetylsalicylic acid in pediatrics is contraindicated, since in the case of a viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days as an antipyretic.

During the treatment period, the patient should refrain from drinking alcohol.

Latin name: Aspirin ® Cardio
ATX code: B01FC06
Active substance: acid acetylsalicylic
Manufacturer: Biterfield (Switzerland)
Pharmacy leave condition: Without recipe

According to the World Health Organization, diseases of the heart and blood vessels rank first among all known pathologies. In order to prevent strokes and heart attacks, many drugs have been created, one of which is cardiac Aspirin Cardio or Cardiomagnyl - its analogue. Both medications are actively used in cardiology practice, are produced by a foreign manufacturer and have almost the same list of indications. In addition, the main active ingredient of both drugs is acetylsalicylic acid. This substance has aggregant, antipyretic and analgesic properties.

Indications

The anti-inflammatory drug Aspirin Cardio is intended for the prevention and treatment of a number of diseases related to cardiology:

• Strokes
• myocardial infarction
• Violation of cerebral circulation
• Thromboembolism
• Obesity
• Diabetes
• Hyperlipidemia
• Before and after surgical interventions on blood vessels and the heart
• Ischemic attacks
• Arterial hypertension
• Advanced age of the patient and weakened heart
• To reduce the risk of death in patients who have had a heart attack or stroke
• Arthritis
• Respiratory and colds.

Compound

The imported drug is produced in solid form, contains one tablet of aspirin as the main active ingredient and several auxiliary components:

• Methacrylic acid ester - emulsifier and copolymer
• Oxyethylated non-ionic sorbitan - fat solubilizer
• Cellulose, talc and starch are the elements needed to solidify a drug.
• Triethyl citrate foaming agent of natural origin
• Sodium dodecyl sulfate is a lysis buffer.

Patients suffering from diseases of the heart and blood vessels or having a large body weight and taking various means for the prevention of pathologies often ask the question: Aspirin Cardio and Cardiomagnyl, what is the difference. The difference between these medicines is that the latter, in addition to all similar components, also contains magnesium hydroxide. But both drugs belong to the group of non-steroidal anti-inflammatory substances.

Pharmacological properties

The drug is intended for oral use. Once in the digestive system, it is converted into acetylsalicylic acid. Aspirin for the heart plays the role of an analgesic, it relieves fever, eliminates inflammation. For the first time, this element was synthesized back in the 19th century, and only 50 years later, chemists discovered its new properties.

Studies of the element have shown that it is effective for the treatment of cardiac and vascular pathologies, since cardio acetylsalicylic acid is able to suppress the production of platelet compounds. It acts as an inhibitor of cyclooxygenase, a substance advising the action of prostaglandins and thromboxanes.

Aspirin contains acetic acid and salicylic acid. Since a thrombus forms at the site of damage to the vessel, the walls become prone to sticking together. The expansion process involves prostacyclin, which is produced simultaneously with thromboxane. When the balance in the synthesis between these elements is disturbed, blood flow slows down, which can lead to heart damage. The acids in the composition of Cardio Aspirin 100 prevent the negative process and do not allow blockages to form.

The use of the drug gives a good antipyretic effect, helps to eliminate fever, relieve rheumatic pain syndrome. Since the element lowers the production of hyaluronidase, it is able to remove inflammation. Also, aspirin is responsible for the permeability of capillaries, reduces their fragility, and inactivates the function of prostaglandins. Due to this, more adenosine triphosphate can be produced, which uses energy resources to help acid.

The drug affects the centers of thermoregulation located in the hypothalamus. Thus, it reduces high temperature, relieves a person of fever and chills that accompany respiratory diseases and manifestations of arthritis and rheumatism. The peptide that causes pain, bradykinin, on the one hand, has a positive effect by dilating blood vessels. But on the other hand, it acts as a plasma algogen, which acts on nerve receptors and increases sensitivity.

In addition, it releases prostacyclin, a metabolite of arachidonic acid, which prevents the formation of blood clots. Such a dual effect is selectively regulated by acetylsalicylic acid, allowing the substance to participate in processes that prevent the formation of blockages, but do not allow signaling to pain receptors. Thus, the analgesic properties of the drug are provided. Thanks to the blood-thinning functions, intracranial pressure is reduced, which is an exhaustive answer to the question of what the remedy helps with.

The maximum concentration of the composition is created 20 minutes after ingestion. Since the drug is produced in a shell, it begins to dissolve in the intestines without adversely affecting the gastric mucosa. The doctor at the appointment will explain how to take it correctly and when you can take the pills. The drug is excreted through the kidneys, after 2-15 hours, depending on the dosage.

Despite the fact that aspirin is a well-studied compound, the development of medicines with its participation is one of the most expensive and complex areas in the field of pharmacological research. In this case, all factors should be taken into account: the optimal combination of different elements, their interaction and effect on the body, adverse reactions and the degree of toxicity. Thanks to IT technologies, digital tools have appeared that make it possible to create new drugs more productively and in a short time and reduce the testing period. Now the analysis of all data is carried out not in the traditional way, but on the basis of the Microsoft cloud platform. Therefore, improved tools, such as Aspirin Cardiomagnyl or Thrombo Ass, are highly effective.

Release forms

Cost: tab. 100 mg No. 28 - 150-200 rubles. No. 56 - 270-300 rubles. 300 mg No. 20 - 85-90 rubles.

The drug is produced only in tablet form. Unit weight - 100 or 300 mg. The shell is glossy, smooth, without impurities. Color - white, no smell. They can be swallowed whole, and when chewed, a sour-bitter taste is felt. The tablets are packed in polyethylene-paper strips or aluminized blisters with a transparent surface. In a white-blue pack with a red stripe there are 20, 28 or 56 pieces and Aspirin Cardio instructions for use. The price is quite reasonable.

Application methods

For the prevention of diseases of the heart and blood vessels, rheumatic pathologies, you can take 100 mg per day without violating the treatment regimen. For therapeutic purposes, it is recommended to use the drug at 100-300 mg per day, depending on the patient's condition. The duration of the course of treatment is a month. If necessary, it can be extended, but only after a two-week break.

It is better to take the drug as a whole, half an hour after a meal, drinking plenty of liquid, which will reduce its negative impact on the mucous digestive systems. Chewing the remedy is allowed only in extreme cases, for example, with unstable angina. It is not recommended to give medication to children with fever during acute manifestations of a cold, as it can cause a worsening of the condition.

Application during pregnancy

Since the composition easily passes through all barriers, including the placental one without difficulty, it is contraindicated in the 1st and 3rd semesters. During the second semester, the drug is prescribed only after realistically evaluating the ratio of the therapeutic effect for the mother and the possible danger to the development of the fetus. At the time of lactation, you can not take the drug or cancel breastfeeding for the entire period of therapy.

Contraindications

The pharmaceutical agent is not prescribed for the following diseases and conditions:

• Aspirin-type asthmatic syndrome
• Acute heart failure
• Diathesis
• Allergic manifestations
• Severe pathologies of the liver and kidneys
• Component intolerance.

Despite the fact that the drug is produced in a shell, its effect on the mucous membrane is minimal, with ulcerative lesions, gastritis and colitis, care must be taken.

Combination with other formulations

Since aspirin may enhance the effects of some drugs and minimize the effects of others, a physician's consultation is required to determine interactions. It should be borne in mind that while taking acetylsalicylic acid, it can manifest itself in different ways:

• The composition enhances the properties of anticoagulants, thrombolytics and antiplatelet agents
• When using hypoglycemic drugs, patients with diabetes need to control hormone levels
• The action of diuretics is weakened
• Systemic corticosteroids and anti-inflammatory agents decrease aspirin function
• When interacting with other drugs containing a similar active element, bleeding may increase after surgical interventions.

Side effects

The information is based on data on adverse reactions after taking all groups of drugs containing aspirin:

• On the part of digestion: dyspeptic disorders, gag reflex, nausea. Epigastric pain and erosive lesions. In rare cases, hemorrhages and perforation of the mucosa.
• The risk of bleeding from the nose, gums and after surgery. The danger is especially increased for patients with uncontrolled arterial hypertension and for people taking antihemostatics.
• Asthenia, iron deficiency anemia, hypoperfusion.
• Impaired kidney function.
• Asthmatic condition and respiratory failure.
• Skin manifestations in the form of a rash and redness.

Overdose

Exceeding the amount mainly entails an increase in side effects. Perhaps the toxic effect of salicylates due to chronic intoxication. Manifestations are hidden with a moderate overdose. In other cases, the symptoms are expressed in tinnitus, acid and alkaline imbalance. Some patients have experienced metabolic acidosis and calculus formation. Therapy is based on the clinical picture, determined by the severity, is to eliminate signs of poisoning and restore electrolyte balance. The patient's condition stabilizes, after which he is transferred to maintenance and restorative treatment regimens.

Storage rules

Means is suitable for use within 5 years. Avoid exposure to light and moisture. Access to children should be restricted.

Analogues

Manufacturers offer a group of drugs with aspirin as the main active ingredient. This list includes the following medicines:

Cardiomagnyl

Manufacturer: Nycomed (Denmark)

Price: 75 mg No. 30 - 130-150 rubles. No. 100 - 250-300 rubles. 150 mg No. 100 - 400-430 rubles.

The composition of the drug includes acetylsalicylic acid and magnesium hydroxide. According to the principle of impact on the body, it does not differ from analogues, so only a doctor can decide which is better, Aspirin Cardio or Cardiomagnyl. The tool relieves pain, lowers the temperature, helps with fever and chills. The main active element inhibits the synthesis of cyclooxygenases, thereby preventing the formation of platelets. Which has a positive effect on the rheological characteristics of the blood. The magnesium contained in the preparation is intended for the irritating effect of aspirin on the gastric mucosa.

The composition is absorbed in full, reaching maximum concentrations three hours after ingestion. Bioavailability can reach almost 95%. A medication is prescribed for chronic ischemic syndrome, heart failure, unstable angina pectoris. Suitable for the prevention of obesity in diabetes, thrombosis, treatment of arterial hypertension. Contraindicated in peptic ulcer lesions, cardiac decompensation, status asthmaticus.

It goes on sale in tablet form, made in the form of white hearts. Each unit has a dividing strip. The medicine is packaged in opaque brown glass jars with a polypropylene lid of 30 or 100 pieces. The smell is absent, the taste when biting through is specific. The dosage for treatment is 75 mg per day, for prophylactic purposes - 150-450 mg per day, depending on the purpose and condition of the patient. The course of therapy is determined by the doctor, but for some patients, the duration of admission can be lifelong.

Advantages:

• Acceptable price
• The drug relieves acute symptoms in cardiac and vascular dysfunctions.

Flaws:

• The composition is prohibited for use by children
• There is a long list of adverse reactions.

Manufacturer: Lannacher (Austria)

Price: tab. 50 mg No. 28 - 45-50 rubles. No. 100 - 150-170 rubles.

An agent characterized by fibrinolytic plasma activity and reducing blood coagulation factors. The main active ingredient in Thrombo Ass is aspirin. Antigregant properties develop slowly, with small doses of use. The composition eliminates pain, removes the feeling of heaviness in the lower extremities, relieves fever and inflammation. Once in the body, the drug releases acids that are most actively associated with proteins. Thanks to this, the formation of blood clots is prevented, capillary permeability is controlled. Damaged vessels regenerate faster, the effect of sticking stops.

The medicine is indicated for varicose veins, heart attacks, ischemic status, thromboembolism. It helps with angina pectoris, prevents the development of repeated strokes. Controls blood pressure and heart activity. It is forbidden to prescribe the composition for polliposis in the nasal sinuses, hemorrhagic diathesis, aspirin asthma. With caution, it is given to patients with impaired rheology and a tendency to bleeding. There is a long list of side effects. In addition, the drug is not compatible with some formulations, so consultation with a cardiologist or therapist is required.

The drug goes on sale in metallized blisters with an opaque matte surface, in which white round tablets are packed. They are recommended to be swallowed with plenty of water, at least one hour after a meal. If necessary, the remedy can be bitten or chewed, ground into powder, but provided that there are no problems with the digestive system. There will be a slight sour aftertaste with bitterness, but it is insignificant. The average dosage is 50-100 mg per day. The duration of therapy is determined on the basis of the diagnosis.

Advantages:

• Relieves pain from varicose veins
• Helps with blockage of blood vessels.

Flaws:

• Produced in only one form
• Prohibited for children and pregnant women.