Buserelin long and depot what is the difference, side effects. Buserelin Long: instructions for use of the antitumor agent Buserelin imported analogue

Buserelin is an agent for fighting malignant tumors. The drug is used if the growth of the neoplasm depends on the production of hormones. In the treatment of such tumors, synthetic analogues of pituitary releasing hormones are used. Buserelin is one such analogue of natural hormones. Buserelin long is a prolonged form of the drug. Due to the long action, it is used once every few weeks.

In contact with

The composition of the drug

The medicinal substance of the drug is Buserelin acetate. The composition of the drug also includes copolymer compounds of lactic and glycolic acids, carmellose sodium, polysorbate-80 and d-mannitol. Busereling Long is available as a powder. It is diluted in a solvent and injected intramuscularly. The powder bottle contains 3.75 mg of the active ingredient - Buserelin acetate. One package of Buserelin Long contains a bottle of powder, a solvent in an ampoule, a syringe, 2 needles (for solvent and for injection), 2 napkins and a knife for opening the ampoule.

The medicinal effect of the drug

At the first stage of treatment with the drug, the content of gonadotropins and sex hormones increases. This increase in hormonal levels is temporary.

14 days after the injection of Buserelin long production of gonadotropins by the pituitary gland is blocked. In women, the production of pituitary hormones responsible for the maturation of follicles in the ovaries stops. As a result, the level of female sex hormones is sharply reduced. The content of estrogen in young women falls to the levels characteristic of the menopause. Doctors call this condition medical pseudomenopause.

In men, the action of the drug leads to a sharp drop in the level of androgens (male sex hormones). The indicators of sex hormones fall to the level of the post-castration period. Doctors call it pharmacological castration. Patients need to remember that during treatment with Buserelin Long, the decrease in estrogen and androgen levels is reversible. After cessation of therapy, the content of sex hormones returns to normal levels.

For what diseases is the drug used?

Instructions for use Buserelin long speaks of the following indications for treatment drug:

• diseases of the uterus caused by an excess of estrogens (uterine fibroids, endometriosis, endometrial hyperplasia);
• breast tumors (with intact menstrual function and intact estrogen and progesterone receptors);
• before and after operations for endometriosis (the drug reduces endometriosis lesions and the formation of adhesions after surgery);
• hormone-dependent forms of prostate cancer;
• before in vitro fertilization (IVF) - the drug suppresses the natural synthesis of estrogens, which makes it possible to create an artificial hormonal status necessary for embryo replanting.

Who should not take Buserelin Long?

Buserelin long is a potent drug that greatly changes the hormonal status of a person. That's why Not every patient is shown such a tool:

Possible side effects when taking the drug

When treated with such a potent drug side effects not excluded.

• From the side of the central nervous system, dizziness, headache, insomnia, memory loss and absent-mindedness, fatigue are possible. Those suffering from depressive disorders may worsen their mental state.
• On the part of the sense organs, hearing and vision impairment, tinnitus, a feeling of pressure on the eyes are possible.
• The cardiovascular system may also respond to the drug. Possible increase in blood pressure, tachycardia.
• Manifestations from the digestive organs are expressed in dyspeptic symptoms, impaired appetite.
• In patients prone to allergies, skin rashes and itching are possible. Bronchospasm, anaphylactic shock, and edema are very rarely observed.
• Very often there are side effects from the endocrine organs, since the drug is an analogue of pituitary hormones. Many women complain of flushing to the face, increased sweating, decreased libido, pain in the lower abdomen, increased bone fragility, dryness in the vagina. This is due to the ability of Buserelin long to dramatically reduce the level of female sex hormones. In men, due to a low level of androgens, there is an increase in the mammary glands (gynecomastia), a decrease in potency, rare and difficult urination.
• In patients undergoing treatment for prostate cancer, symptoms may worsen in the first days of treatment with the drug.
• All side effects are aggravated by the use of alcohol during the course of treatment.

During therapy with Buserelin long, changes in the blood test are possible: a decrease in leukocytes and platelets, an increase in glucose levels, changes in the lipid composition of the blood.

Buserelin long treatment regimen

This drug belongs to potent drugs, so its use is permissible only as directed by a doctor.

In the treatment of malignant tumors of the breast and prostate make 1 injection (3.75 mg) intramuscularly 1 time in 4 weeks. The course of treatment takes a long time and is carried out under close medical supervision.

In the treatment of pathologies of the female genital organs associated with an excess of estrogen (endometriosis, fibroids, endometrial hyperplasia), also give 1 injection every 4 weeks. According to the instructions for the drug, treatment begins in the first 5 days of the menstrual cycle. The course of treatment lasts from 3 to 6 months. Therapy before surgery for uterine fibroids should last about 3 months.

Before the IVF procedure the first injection of Buserelin long is done either on the second day of the menstrual cycle, or in the period from the 21st to the 24th day. Two weeks after the injection, the level of estrogen decreases by 2 times. After that, an ultrasound examination is done to exclude ovarian cysts. Then, with the help of gonadotropic hormones, superovulation is stimulated under ultrasound monitoring.

special instructions

The instructions for the drug indicate features of the use of Buserelin long.

Interaction of buserelin with other drugs

The drug is not recommended for use together with estrogenic agents. Simultaneous use of Buserelin and estrogens can cause ovarian hyperstimulation and cyst formation. Buserelin may reduce the effect of the use of hypoglycemic drugs. This should be borne in mind by diabetic patients taking medication.

Many patients are interested in the cost per bottle of Buserelin Long. The price of this medicine in pharmacies can be from 3500 to 5500 rubles. Analogues of the drug for the active substance are:

The closest remedy is Buserelin depot. Both drugs are generics of the same drug.

This page provides a list analogues Buserelin- these are interchangeable drugs that have similar indications for use and belong to the same pharmacological group. Before you buy analogue Buserelin, it is necessary to consult with a specialist regarding the replacement of the drug, study in detail, read and a similar drug.

• Endorm

  A drug Endorm shown at:
  - Hypothyroidism
  - Hyperthyroidism (thyrotoxicosis)
  - Autoimmune thyroiditis
  - Euthyroid goiter (diffuse, nodular, multinodular)
  - endemic goiter
  - Prevention of thyroid diseases
  - climacteric syndrome
  - Comprehensive treatment of hyperplastic diseases of the female reproductive system (mastopathy, endometriosis, endometrial hyperplasia, etc.)
  - Comprehensive treatment of metabolic syndrome

• Gynekol Evalar

  Ginekol- a biologically active food supplement - an additional source of arbutin, salidroside - the main active substances, which, acting in combination, contribute to the maintenance of a woman's reproductive health, prevent the exacerbation of inflammatory diseases of the genitourinary system.
  

• Vitazenova

  Vitazenova recommended as a biologically active food supplement for women - an additional source of vitamins: B1, B2, B5, B6, B12, E, A, PP, D3, K, folic acid, biotin, coenzyme Q10; magnesium, iron, zinc, manganese, copper.
  Vitazenova is a dietary supplement, a vitamin-mineral complex, which contributes to the normal course of physiological processes in the body and the maintenance of a woman's reproductive health.
  

• Emzenova

  A drug Emzenova recommended as a biologically active food supplement for women - a source of isoflavones, an additional source of vitamins B1, B6 and B12, magnesium, iron, zinc, selenium, glutathione.
  

• Bust Formula Forte

  Bust Formula Forte recommended for use as a dietary supplement for women. Contributes to the normalization of the functions of the genital organs and the state of the mammary glands with symptoms associated with an imbalance of female sex hormones (premenstrual syndrome, mastopathy, endometriosis, uterine fibroids, menopausal disorders).
  It can be used to correct the mammary glands (increase the firmness of the breast, its tone and elasticity, including after childbirth), with human papillomavirus infection.
  Reduces the risk of complications during hormone replacement therapy.
  

• COENO QHL

• SOLGAR BERRIES WITH PALMETTO

• DETRIMAX

• SERENOA

• PROXID WOMAN

• INOFOLIK

• Quinol

  Quinol It is used for diseases of the female reproductive system, the development of which is based on the processes of pathological cell proliferation.
  Quinol can be used to prevent hormonal disorders and hormone-dependent diseases:
  - Mastopathy;
  - Endometriosis, adenomyosis;
  - Myoma (fibromyoma) of the uterus;
  - Ovarian cysts;
  - Dysplasia of the cervix;
  - Premenstrual syndrome;
  - Papillomatosis of the organs of the female reproductive system, papillomavirus infection (papillomas, genital warts).

• Stella

  A drug Stella recommended as an adjunct in the complex therapy of hormone-dependent diseases of the female reproductive system: uterine fibroids, fibrocystic mastopathy, cervical dysplasia, endometriosis, endometrial hyperplasia, etc. in order to normalize estrogen metabolism.
  In the prevention of recurrence (recurrence of the disease) of fibroadenomas after surgical treatment.
  To reduce the risk of hormone-dependent diseases of the female reproductive system (uterine fibroids, fibrocystic mastopathy, cervical dysplasia, endometriosis, endometrial hyperplasia, etc.).
  In the prevention of diseases associated with the human papillomavirus (HPV), such as cervical dysplasia, genital warts, papillomatosis, as well as in the prevention of cervical cancer, breast cancer.
  As a means of improving the functional state of the female reproductive system.
  

Latin name: Buserelin Long
ATX code: L02AE01
Active substance: Buserelin
Manufacturer: F-Sintez, Russia
Pharmacy leave condition: On prescription

Buserelin Long is one of the antitumor drugs, it is a synthetic analogue of the hormone gonadotropin-releasing.

Indications for use

The use of drugs is indicated for the treatment of hormonal dysfunctions that are caused by hyperestrogenism (both absolute and relative):

• Endometriosis (medical therapy before and after surgery)
• Hyperplastic changes in the endometrial layer of the uterus
• The presence of myomatous nodes.

Buserelins may be prescribed for in vitro fertilization (IVF) during infertility treatment.

Compound

The lyophilisate contained in the ampoules contains Buserelin Long - 3.75 mg. Additional components include the following substances:

• Dl-lactic and glycolic acid - 200 mg
• D-mannitol - 85 mg
• Carmellose sodium - 30 mg
• Polysorbate - 2 mg.

To dissolve the lyophilizate, mannitol (0.8% solution) is used in 1 ml of purified water.

Medicinal properties

Buserelin Long FS is a highly effective anticancer drug, similar to natural GRF. The effect on the body of buserelin is based on a temporary stimulation of the growth of sex hormones in the blood, it is due to this that there is a competitive connection with specific receptors of cells located on the surface of the anterior pituitary gland.

If the drug is used exclusively in therapeutic dosages, there is a blockage of gonadotropic pituitary activity (usually after (12-14 days). Buserelin reduces the production of testosterone, LH and FSH, which subsequently helps to inhibit the synthesis of sex hormones inside the gonads. in women, the level of estradiol is equal to the post-menopausal indicator, in men, the average testosterone value decreases to a level characteristic of the post-castration period.

During the continuous use of the drug Buserelin Long FS for 2-3 weeks. the testosterone index decreases significantly, thereby achieving the state of orchiectomy (the so-called pharmacological castration is observed).

After injection into the muscle, the bioavailability of drugs is quite high.

The highest concentration of the active substance of the drug is observed after 2-3 hours after the injection (dose - 3.75 mg), then it remains at the level necessary to inhibit the production of gonadotropins by the pituitary gland (at least 4 weeks).

Release form

Price from 3400 to 4400 rubles.

Buserelin Long FS in the form of a lyophilizate is available in 10 ml dark glass bottles, an additional solvent (2 ml) is supplied in neutral glass ampoules with instructions. Inside the cell package are placed:

• bottle of buserelin longa
• ampoule of solvent
• syringe for single use (5 ml)
• scarifier
• 2 wipes soaked in alcohol.

Buserelin Long: instructions for use

Buserelin Long should only be administered intramuscularly. There is no significant difference at what time of day the injection is given.

The preparation of a medicinal suspension with buserelin is carried out before its administration using the supplied solvent.

A health worker should prepare the solution and inject drugs.

Treatment with this drug is prescribed depending on the type of disease:

• Oncoprocesses in the prostate (hormone-dependent) - 1 in. into the muscle (3.75 mg) with a time interval of 4 weeks.
• Hyperplastic changes in the endometrial layer and endometriosis - therapeutic therapy begins on the 5th day of MC in a single dose of 3.75 mg, the drug is administered every 4 weeks, the course of therapy is 4-6 months.
• Uterine fibroids - a single injection into the muscle with a dosage of 3.75 mg, it is necessary to re-inject drugs after 4 weeks. Treatment should be started within 5 days. from the day of the onset of MC, before surgery, therapy is carried out for 3 months, in other cases - 6 months. (in combination with various drugs).
• Treatment of infertility - the introduction of 1 in. into the muscle for 2 days. MC (the possibility of an injection for 21-24 days. MC is not excluded) before the hyperstimulation procedure. After the level of estrogen decreases by 2 times, gonadotropic hormones are prescribed. Therapeutic therapy for infertility with other drugs is carried out in the absence of cystic changes in the ovaries and with regular monitoring of the estradiol index and ultrasound.

Use during pregnancy and breastfeeding

Not assigned to this group of patients.

Contraindications

• Increased susceptibility to buserelin
• Pregnancy, GW.

Precautionary measures

To prevent the development of adverse reactions in men in the first phase of the drug, it is recommended to combine the use of this drug with androgenic drugs (2 weeks before the administration of buserelin and 2 weeks after the injection).

With signs of the development of depression during anticancer therapy, it is best to provide the patient with constant medical supervision.

To achieve good results in the treatment of infertility (IVF procedure), it is necessary to control the induction of ovulation against the background of the use of buserilin.

Usually, the drug of a domestic manufacturer is well tolerated, but in some cases, the growth of ovarian cysts can be diagnosed.

Prior to therapy, it is necessary to exclude the onset of pregnancy and replace the COCs taken with a drug that differs in a different content of hormones (the first 2 months of treatment therapy).

After the complete discontinuation of the drug Buserelin Long FS, restoration of ovarian function is observed (after 3 months), there are no differences in their activity in comparison with the period before treatment.

Special care must be taken when driving a car and when working with precision mechanisms.

It is not recommended to purchase the drug outside the pharmacy network, paying attention to the ads "I sell or sell Buserelin Long at a low price." The difference between medicines purchased in the pharmacy chain and "from the hands" can be significant, because the acquisition of a fake cannot be ruled out.

Cross-drug interactions

It is worth paying attention to the interaction of buserelin with other drugs, which include different sex hormones. It cannot be said that they are not compatible with Buserelin Long FS, but against the background of complex administration, ovarian hyperstimulation syndrome may develop.

The drug can reduce the therapeutic effect of the use of hypoglycemic drugs.

If we talk about compatibility with other drugs, then at the moment there is no reliable information.

Alcohol compatibility

Buserelin and alcohol should not be combined. During treatment, it is necessary to completely abandon the use of alcoholic beverages. There is a negative effect of alcohol on the functioning of the reproductive system. Under the influence of alcohol, metabolic processes are disturbed, the synthesis of sex hormones slows down.

Side effects

Although the drug is characterized by good medicinal properties, adverse reactions may occur during therapy.

For men:

• Exacerbation of the course of oncological processes in the prostate
• Gynecomastia
• Erection deterioration
• Severe rush of blood to the head
• Excessive sweating
• An increase in the level of androgens in the blood
• Swelling of the extremities as well as the face
• Weakness in the muscles
• Difficulty passing urine
• The development of obstruction of the ureters, rarely - a violation of the activity of the spinal cord.

Among women:

• Breakthrough bleeding by type of menstruation
• Development of a depressive state
• Severe headaches
• Sleep quality disorder
• Change in emotional state
• Feeling of dryness inside the vagina
• Feeling "tides"
• Pain in the lower abdomen
• Increased sweating
• Decline in libido.

General symptoms may also be observed:

• Hyperemia of the skin
• Rash like urticaria
• Demineralization of bone tissue
• Rarely - the development of dyspeptic phenomena, the development of thromboembolism of one of the arteries of the lungs.

Storage conditions and shelf life

The antitumor agent Buserelin Long FS should be stored at a temperature not exceeding 25 C. The shelf life is 2 years.

Analogues

Pharmsintez, Russia

Price from 3624 to 4611 rubles.

Buserelin Depot is an excellent drug with antitumor properties, the active ingredient is buserelin. It is prescribed for the treatment of oncological diseases of the genitourinary system in men and women, and is used in the treatment of infertility. Produced in the form of a lyophilisate.

Pros:

• Has good antiandrogenic properties
• Used to treat endometriosis
• High efficiency in the treatment of malignant neoplasms of the breast.

Minuses:

• Expensive
• Released by prescription
• High risk of adverse reactions.

Buserelin is used for the complex treatment of hormone-dependent malignant tumors in men and women. This remedy is available in the form of a nasal spray or solution for intramuscular injection. In a pharmacy, the medicine may be called: Buserelin-depot, Buserelin-long and simply Buserelin. This synthetic analogue of natural gonadotropin-releasing hormone is especially helpful in the treatment of endometriosis (the main complication of which is infertility).

The combination of a course of conservative treatment with Buserelin with surgical intervention for endometriosis significantly reduces blood loss during surgery and its duration. During the recovery period, the use of these hormones suppresses the development of the remaining foci of inflammation, improves the processes of tissue repair and regeneration.

Pregnancy after Buserelin depot or long can occur in 2-4 months. In addition to endometriosis, buserelin is used in the treatment of prostate cancer in men, breast cancer in women, and uterine fibroids.

Comparison of the types of manufactured drugs

Buserelin long and depot - what is the difference can be seen in the comparative table. And only the attending physician can tell which form is better to choose for successful treatment.

Each drug is developed and manufactured according to certain technologies and principles. The substances included in its composition may, in combination with other pharmaceuticals, give undesirable results. Preparations containing buserelin should not be used in parallel with drugs that lower blood sugar levels and with sex hormones (during ovulation stimulation).

What diseases can prescribe Buserelin

Treatment with this drug is carried out with pathological diseases of the reproductive system:

• uterine fibroids;
• hyperplastic changes in the endometrium;
• ovarian tumors;
• mammary cancer;
• prostate cancer.

Buserelin has proven itself well in the treatment of infertility using in vitro fertilization. It suppresses the work of the hormonal system of the woman herself and makes it possible to artificially control the processes of maturation of the egg, its fertilization and implantation in the uterus. It helps a woman to successfully conceive.

What happens in the body under the influence of buserelin

Buserelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH for short). It belongs to stimulating hormones and effectively stimulates the pituitary gland. The active work of this endocrine gland turns off the production of follicle-stimulating and luteinizing hormones and completely stops ovulation in women. During treatment, the content of estradiol in the blood is very low - at the level of postmenopausal values, and the physical and psychological state of patients corresponds to the period of sexual extinction (mood swings, hot flashes and strong heartbeat).

Under what circumstances is the drug contraindicated?

Buserelin should not be taken alone (without a doctor's prescription). The doctor will definitely check the amount of hormones in the blood, conduct an ultrasound examination of the internal organs and other necessary tests.

A hormonal preparation containing the substance buserelin is not prescribed if:

• The woman is pregnant. The use of medication while carrying a child can lead to a delay in the development of the embryo or miscarriage. Immediately after childbirth, it is also impossible to undergo a course of treatment if the woman is breastfeeding the baby. The drug has the ability to penetrate into milk and affect the baby.
• The woman began her menopause.
• The patient is experiencing depression. Taking Buserelin may worsen the psychological state.
• The diagnosis is diabetes mellitus or high blood pressure. Vessels in these diseases become fragile and can not withstand the additional load.
• The patient has not reached puberty (so as not to destroy the emerging hormonal background).
• With individual intolerance to the components of the drug.

How does the body as a whole respond to treatment?

The brain controls all processes inside a person, producing certain hormones. Any interference in this complex process causes deviations in the work of all organs. That is why Buserelin is taken only under the supervision of a doctor: in order to control and timely minimize negative manifestations. Patients describe the following side effects:

Nasal spray Buserelin

Endometriosis is most often treated with drops. They have a more affordable price than the drug for intramuscular injection. The daily norm (900 mcg) is divided into three doses. From one spray, the body receives 150 mcg of the drug. The scheme of reception is as follows: one injection into each nostril three times a day. The nose must be clean so that all the medicine gets to its destination. Runny nose is not a contraindication to the course of treatment. The main thing is to monitor the cleanliness and patency of the sinuses. Salt solutions can be used to pre-cleanse the nose from accumulated mucus.

The main disadvantage of this form of administration is the exact observance of time intervals. Between doses (injections) can take from 6 to 8 hours. Even a night's rest will have to be adjusted according to the medication schedule. The course lasts 3-6 months and, according to patients, requires a lot of patience and self-discipline.

The use of the drug in ampoules

In the form of injections, Buserelin therapy follows a simpler scheme than with a spray: an intramuscular injection is given every 28 days. For each diagnosis, there is a specific method of taking the drug:

• If treatment is being carried out for endometriosis, uterine fibroids or endometrial hyperplastic processes, then the first injection is given in the period from 1 to 5 days from the onset of menstruation. Subsequent injections are given at intervals of 4 weeks. The course of therapy is from 3 to 6 months.
• Men with prostate cancer and women with breast cancer are given injections in a similar way.
• In the treatment of infertility or in order to prepare for IVF, the first injection can be given on the second day of the cycle (the follicular phase is just beginning) or in the period from 21 to 24 days (luteal phase in the middle). 2 weeks after the administration of the drug, the amount of estrogen in the blood plasma will be halved, and if the ultrasound examination did not show problems in the uterus and ovaries in the form of a cyst, then the doctor prescribes stimulation of the ovulation process (gonadotropic hormones are used). This complex procedure is performed under ultrasound monitoring. During therapy, the level of estradiol is constantly monitored, and the doctor can change the dose of Buserelin depending on the situation.

How to prepare a solution for injection

Pharmacy packaging of the drug for intramuscular injection contains a pair of vials and a syringe with two needles. In one vial is the drug, and in the second - the solvent. Needles are needed: one for mixing the medicine, the other for injection. The solvent is drawn up with a syringe and injected into the capsule with the main suspension. Shake the mixture thoroughly and allow the drug to dissolve completely. The needle on the syringe is then changed and the injection can be performed.

The medication is prepared immediately before the introduction into the body strictly according to the instructions. To avoid accidents with an intramuscular injection, an injection should be made in a treatment room.

Malignant neoplasms currently occupy one of the leading places in terms of mortality among the population almost all over the world. The longer a person puts off seeing a doctor, the harder and longer the road to recovery will be. It is in this direction of medicine that the words that lost time are equivalent to life will be as true as possible.

In the arsenal of modern pharmacology, there are now a lot of medicines designed to fight malignant tumors that affect various organs of the human body. For the treatment of hormone-dependent malignant neoplasms, medicines are widely used today - analogues of the hormones of the hypothalamus (the part of the brain responsible for the functioning of the neuroendocrine system). One of these medications is Buserelin-Long.

Composition and forms of release

The main active ingredient of the drug is buserelin acetate. Among the auxiliary drugs, the drug includes copolymers of lactic and glycolic acids, polysorbate-80, carmellose sodium, d-mannitol.

Today, the pharmacy chain of the Russian Federation offers its consumers this antitumor drug in two forms of release. One is a nasal spray (for administration through the nose), the second is a powdered composition for preparing a solution, which is then injected intramuscularly. Actually, the second form (solution) is called Buserelin-Long. Instructions for use contains detailed information on the principle of pharmacological effects on the human body.

Usually, in a blister pack enclosed in a cardboard box, there is a medicine bottle, an ampoule with a solvent, a disposable syringe (volume - 5 ml), 2 sterile needles (for solvent and for injection), a scarifier or a knife for opening the ampoule and 2 alcohol napkins.

Pharmacodynamics

At the initial stage of the use of this drug, there is a process of increased release of gonadotropins (hormones whose main function is to regulate the functions of the gonads). During this period, in the blood of patients, an increase in the amount of sex hormones can be observed for a short time.

After 12-14 days, the action of the drug causes a blockage of the gonadotropic function of the pituitary gland, which is characterized by the cessation of the secretion of hormones that stimulate the maturation of follicles and the production of lutein. The result is inhibition of the synthesis of sex hormones in the ovaries, and, as a result, the level of estradiol (the main female hormone) in the blood plasma drops to the levels characteristic of the postmenopausal period. A condition develops, called by medical workers "medicated pseudomenopause."

If this drug is used for a sufficiently long time for the treatment of prostate cancer, the result may be a significant decrease in the plasma concentration of testosterone (the main male hormone). In the medical community, this condition is called "pharmacological castration."

Taking drugs based on buserelin in the period preceding surgery for endometriosis will help reduce the size of the pathology foci, reduce their blood supply, and attenuate inflammatory processes. In the postoperative period, the effect of the drug will reduce the process of adhesion formation and reduce the frequency of relapses.

Patients need to know that the effect of the drug is reversible. After the drug is discontinued, the level of male and female sex hormones in the blood will gradually return to normal.

To whom is the application indicated?

"Buserelin-Long" instructions for the medication recommend taking with hormone-dependent pathological processes of the human reproductive system caused by absolute or relative hyperestrogenism. Sufficient reasons for the use of this drug in women can be considered diseases such as uterine fibroids, endometriosis, endometrial hyperplastic changes.

In addition, the medication is prescribed for malignant neoplasms of the prostate gland (hormone-dependent form, stages 3 and 4), for breast cancer (if the menstrual cycle is preserved, and progesterone and estradiol receptors are available).

Also, this medication is widely used in in vitro fertilization (IVF) procedures. The main function of the drug in this case is to suppress the effects of the woman's own hormonal system. Thus, an artificial controlled hormonal system is “formed”, which allows implanting an already fertilized egg in a woman. In the treatment of infertility, buserelin-containing drugs stimulate the ovulation process.

Contraindications for taking Buserelin-Long

It goes without saying that patients suffering from hypersensitivity to the main or auxiliary components of the drug should not take Buserelin-Long. It is also unacceptable to take this drug to pregnant women and nursing mothers.

Cautious and attentive to their well-being should be people who have a history of urinary tract obstruction. Patients in whom a malignant tumor of the prostate gland has metastasized to the spine should behave in the same way. At the initial stage of treatment in such patients, the likelihood of developing an exacerbation of the underlying disease increases.

Patients diagnosed with arterial hypertension, depression, diabetes mellitus should also be under the close attention of the attending physician, at least at the initial stage of taking the drug.

Possible side effects

On Buserelin, as on any complex drugs dispensed by prescription, negative reactions from various systems and human organs are possible.

The central nervous system can react to the drug with deviations in the processes of sleep and wakefulness, headaches and dizziness, a decrease in the ability to remember information and concentration, fatigue and neuropsychic instability. Perhaps the development of depression or deterioration of health in its presence.

Probable deviations from the sensory organs may be hearing and vision impairment (feeling of blurring), tinnitus. Sometimes patients report a feeling of increasing pressure on the eyes.

Perhaps the appearance of deviations of the endocrine nature. Most often you can hear about the “hot flushes” of blood to the face and upper chest, increased sweating, reduced sexual desire, feelings of vaginal dryness in women, pain in the lower abdomen, and mineral depletion of bones. Not often, but you can read reviews of patients (women) about Buserelin-Long, stating that during the first weeks of using the drug, bleeding similar to menstrual flow was observed.

Possible deviations from the cardiovascular system include tachycardia and an increase in blood pressure in patients diagnosed with hypertension. The response of the gastrointestinal tract to the drug may be nausea, vomiting, diarrhea, constipation, noticeable fluctuations in one direction or another in body weight, and appetite disturbances.

Possible allergic reactions to new drugs containing buserelin as the main component (urticaria, itching, hyperemia of the skin). Not often, but we can talk about the development of bronchospasm, shock (anaphylactic, anaphylactoid), edema of angioedema.

There is a possibility of changes in some physiological parameters evaluated in the laboratory: hyperglycemia, decreased susceptibility to glucose, thrombocytopenia, leukopenia, increased activity of serum transaminases, abnormalities in the lipid spectrum.

Sometimes you can hear from patients about the appearance of edematous zones in the ankles and feet, about nosebleeds, about the activation of hair growth on the body and head.

In male patients during therapy for prostate cancer, honey. preparations based on buserelin for 2-3 weeks after the first injection can provoke a relapse of the underlying disease, its progression. There is a risk of developing gynecomastia, increased sweating, reduced potency, urinary retention. If bone pain occurs during the initial period of treatment, the instruction recommends symptomatic therapy.

Application: dosing regimen and treatment regimen

Medicines like Buserelin should only be prescribed by the attending physician. In the treatment of hormone-dependent oncological diseases of the mammary or prostate glands, the drug is prescribed for intramuscular use at a dosage of 3.75 mg (1 injection). Injections are made at intervals of 4 weeks. The course of therapy takes a long period of time and should be under the supervision of the attending doctor.

If therapy is carried out for endometriosis, hyperplastic changes in the endometrium, the therapeutic course is the same as for oncological problems (1 injection with a frequency of 4 weeks). To start treatment with the use of the drug "Buserelin-Long" the instruction regulates within 5 days from the beginning of the menstrual cycle. The course of therapy, as a rule, lasts from 4 months to six months.

The treatment regimen and dosing regimen for uterine myoma - 1 injection with a frequency of 4 weeks. The beginning of the therapeutic course should be timed to coincide with the first 5 days of the menstrual cycle. The duration of therapy before surgery is at least 3 months. Conservative treatment usually lasts about six months.

The scheme of using a medication in the treatment of infertility using the IVF technique looks somewhat different. The first injection of Buserelin-Long is given either on the second day of the menstrual cycle (the beginning of the follicular phase), or in the period from the 21st to the 24th day (the middle of the luteal phase). After 12-15 days after the injection, the amount of estrogens contained in the blood serum will fall to half of the original (blocking the pituitary function). Further, if the patient does not have cysts on the ovaries (ultrasound studies), and the thickness of the endometrial layer does not exceed 5 mm, you can start stimulating superovulation with the help of gonadotropic hormones. These activities are carried out under ultrasound monitoring with mandatory control of the level of estradiol. The dose of Buserelin-Long can be adjusted in one direction or another.

Before starting a course of therapy with the use of Buserelin-Long, it will not be superfluous to familiarize yourself with some of the special recommendations that are contained in the instructions for use of the drug.

Patients-women suffering from any form of depression, in the process of treatment with the drug should be under the close attention of the attending physician. Also, strict medical control requires the procedure for induction of ovulation. Women should be aware that in the initial period of using the drug, there is a possibility of developing an ovarian cyst.

Before starting therapy with Buserelin, patients should stop taking hormonal contraceptives, but use non-hormonal methods to prevent pregnancy for 2 months from the start of the course.

• Important! Women, before starting treatment with medication, it is recommended to exclude the fact of pregnancy.

At the end of the course of therapy, the functioning of the ovaries will be restored. The first menstruation usually comes 3 months after the completion of treatment.

As for male patients, in order to avoid the development of negative manifestations at the beginning of Buserelin therapy, it is recommended to start taking antiandrogens at least 2 weeks before the first injection and take them for a crescent after the injection.

In addition, if you study the reviews of health workers about the antitumor drug "Busereling-Long" or at least carefully read the instructions, you can find out that those patients who, by the nature of their work, drive vehicles or are related to work that requires a high concentration of attention and the speed of psychomotor reactions, you should be especially careful when taking the medicine.

Interaction with other substances and drugs

As part of our article, it remains to consider a few more points regarding the Buserelin-Long drug. The price of the drug, its interaction with other medicines, analogues and patient reviews - any of these issues are of interest to people who are going to purchase the said medicine. Below we will dwell on each of them in more detail.

Like any modern medicine developed using high technologies, Buserelin-Long obeys certain principles, interacting with other medicinal substances. For example, the simultaneous use in the treatment of the medication we are considering and drugs that have sex hormones in their composition during the period of ovulation induction can cause the development of a condition called ovarian hyperstimulation syndrome by doctors.

And the parallel intake of Buserelin-Long and hypoglycemic drugs reduces the effectiveness of the latter.

Price range. Analogues

How much does Buserelin-Long cost? The price of the drug can make you think. In the pharmacy chain of Moscow, consumers can purchase this drug for an amount ranging from 3,500 to 5,500 thousand rubles. One must think that in remote regions of Russia, the drug is even more expensive. However, the effectiveness of the drug fully justifies its relatively high cost.

Spray "Buserelin" is cheaper than the drug in vials ("Buserelin-Depot" - from 3900 to 7000 rubles), and costs approximately 800-900 rubles.

As for similar antitumor drugs, the Buserelin-Long drug has analogues (structural) for the active substance - these are Buserelin-FSintez (spray), Buserelin-Depot (lyophilisate for making a suspension, administration - intramuscularly), " Buserelin acetate" (bottle 0.2%), "Suprefact" and "Suprefact-Depot".

The opinion of patients about the drug "Buserelin-Long"

Like any modern drug, Buserelin-Long patient reviews are both positive and negative. Those who have a positive experience of treatment with drugs containing buserelin report good results. A certain percentage of women claim that there are mild hot flashes, some have a small discharge. After the end of therapy within 1-2 months, the menstrual cycle is restored. In male patients, after stopping treatment with Buserelin, both sexual desire and potency are fully restored.

Another part of the patients was dissatisfied with the treatment, because, according to their comments, the drug provoked the development of a whole list of side effects. Someone talks about poor skin condition, severe headaches, dizziness and constant nausea. In such cases, there may be several reasons. It is impossible to discount the presence of individual intolerance to buserelin. There is only one way out - to change the drug (naturally, only at the direction of the attending physician). Non-compliance with the medication regimen developed by a specialist and a change in the dosage of the drug taken can lead to negative consequences.

In any case, no matter how good or bad the patient reviews describing honey. drugs ("Buserelin-Long" and the like), the decision to prescribe the drug should be made only by the attending doctor, who will take into account all the individual characteristics of the course of the disease in each individual patient. Only in this case can we hope to achieve positive results of therapy without the risk of causing serious damage to health.