Antiulcer drug Famotidine - instructions for use. Famotidine tablets - instructions for what they help

Nowadays, more and more people suffer from diseases of the digestive system. This causes severe discomfort, interferes with a full-fledged active life. In addition, if such ailments are not treated, then this can be fraught with the appearance of serious complications. What provokes the occurrence of these unpleasant diseases?

Inflammatory processes in the stomach can cause stress, lack of sleep, malnutrition, weakened immunity, etc. If timely measures are not taken for treatment, the mucous membrane is affected, which leads to ulcers. Discomfort in the stomach and digestive disorders are a reason to seek help from a specialist. Therapy of diseases of the gastrointestinal tract should be carried out in a complex with diet and maintaining a healthy lifestyle.

In this article, we will consider the drug "Famotidine", reviews will also be given.

In order for drugs to treat gastritis or ulcers to give a positive result, it is necessary to lower the acidity of the stomach, since the most common bacterium, Helicobacter pylori, just multiplies in an acidic environment. Low acidity reduces bacterial activity, and in ulcers, acid interferes with wound healing.

What helps "Famotidine"?

The drug has an anti-inflammatory effect by suppressing the production of excessive amounts of acid. This drug is freely available in pharmacies, is well accepted by the body and helps to cure many diseases of the gastrointestinal tract. However, it must be understood that Famotidine alone cannot cure gastritis or an ulcer, it only helps to reduce symptoms and make life easier for the patient.

Instruction

According to reviews, "Famotidine" helps in the treatment of stomach ulcers by reducing the level of acid formation. It relieves pain and eliminates heartburn. The drug is suitable for the treatment of acute forms of diseases, as well as the prevention of inflammation in the stomach. It begins to act very quickly, one and a half hours after ingestion, while one dose retains its effect for up to a day. Thus, just one tablet per day is sufficient.

Release form

The drug is presented in the form of tablets of different dosages of the active substance (20 and 40 mg, respectively), as well as in the form of a powder for injection. Produced in Ukraine, Russia, Serbia, Bulgaria and Belarus. Packed tablets of 20 and 30 pieces in one package.

How to take "Famotidine" - before meals or after? More on this later.

The active substance of the drug itself is famotidine, which blocks histamine receptors, thereby greatly reducing the production of acid in the stomach. This substance makes the mucous membrane stronger, reduces the amount of gastric juice, relieves heartburn, belching and pain, helps the healing of ulcers and stops bleeding.

When to apply?

According to reviews, "Famotidine" is prescribed as part of complex therapy in the treatment of the following diseases:

1. Exacerbation of gastritis.
2. Removal of exacerbation and prevention of recurrence of peptic ulcer of the stomach and duodenum.
3. Violation of the digestive tract (dyspepsia).
4. Spontaneous release of gastric juice into the esophagus (gastroesophageal reflux disease).
5. Pancreas cancer.
6. Prevention of inflammatory processes against the background of taking non-steroidal anti-inflammatory drugs.
7. Gastroduodenitis (inflammation of the mucosa, accompanied by erosion).
8. Hemorrhagic syndrome in the gastrointestinal tract.

Dosage

Tablets must be swallowed whole and must not be chewed or cut. You need to drink the medicine with a small amount of water. The daily dose in the treatment of ulcers, gastritis or gastroduodenitis is 40 mg (taken twice a day or once at bedtime). It is permissible to increase the dosage, but only with the consent of the attending physician. The duration of the course of treatment is approximately two months.

To receive "Famotidine" indications must be strictly observed, uncontrolled use is fraught with consequences.

For the prevention of peptic ulcer, 20 mg per day at bedtime is sufficient. Gastrointestinal disorders will also require a dosage of 20 mg per day. This will be enough to reduce the amount of acid produced by the stomach. With Zollinger-Ellison syndrome (pancreatic tumor), the drug is drunk three times a day, 20 mg each. 40 mg is prescribed at night and in the morning to patients before general anesthesia.

drug interaction

According to reviews, "Famotidine" can not be taken together with other drugs, you need to observe an interval of about two hours. It is compatible with sodium bicarbonate, dextrose and saline. This drug reduces the absorption of antifungal drugs such as Itraconazole and Ketoconazole. Antacids (Almagel), on the contrary, stop the action of Famotidine, since they chemically reduce acidity.

Do not take this drug along with drugs that depress the bone marrow, as this can lead to neutropenia (weakened immunity due to a decrease in the level of neutrophils in the blood). It affects liver metabolism, inhibits the action of diazepam, caffeine, lidocaine, theophylline, hexobarbital, phenytoin, antidepressants and metronidazole.

This confirms the instruction to the Famotidine remedy.

Side effects

This drug rarely causes side effects. The most common of these are allergic reactions and headaches. If you take the drug for a long time and in high dosages, the following symptoms may appear:

1. Allergy in the form of a skin rash, urticaria, which is accompanied by itching, spasm in the bronchi, dry skin and acne, as well as anaphylactic shock.
2. On the part of the cardiovascular system, hypotension (lower blood pressure) and bradycardia (slow heart rate) may occur.
3. The digestive organs may respond to the drug with an upset, dry mouth, pancreatitis, hepatitis and decreased appetite.
4. In the blood, the number of leukocytes, platelets and granulocytes decreases. Sometimes all blood counts drop sharply (pancytopenia).
5. The central nervous system can make itself felt while taking Famotidine with weakness, migraines, dizziness, insomnia, hallucinations.
6. Soreness in muscles and joints.
7. Blurring of the visual perception of the picture, ringing in the ears and the so-called temporary myopia.
8. Long-term use can also lead to an increase in prolactin in the blood, which causes the growth of the mammary glands, a violation in the monthly cycle and a decrease in libido in women.

As can be seen from the impressive list of side effects, Famotidine tablets should be taken only after the appointment of the attending physician. Self-administration of it can lead to irreversible health consequences or erase the picture when diagnosing a more serious illness.

special instructions

The drug should be taken with great caution in the elderly, with hepatic or renal insufficiency, as well as in case of a sharp decrease in immunity. Before you buy it, you should exclude from the anamnesis of a tumor in the gastrointestinal tract, since this drug can hide the symptoms of cancer.

The action of "Famotidine" is quite strong.

It is important not to skip pills to avoid sudden changes in stomach acid levels. However, doubling the amount after a missed pill while taking the next one is not worth it. Famotidine treatment should be combined with a special diet. It is necessary to exclude from the diet those foods that can irritate the gastric mucosa.

Overdose

Overdose symptoms are vomiting, overexcitation of the nervous system, tremor, tachycardia and hypotension. In this case, you need to do an immediate gastric lavage and seek qualified help in the hospital.

It is impossible to take Famotidine tablets during pregnancy, since the active substance enters the placenta, and its intrauterine effect has not been studied.

This drug does not require special storage conditions. The shelf life is two years from the date of production.

An attractive point is the very low price of Famotidine - about 30 rubles per pack.

Analogues of the drug "Famotidine"

Similar in action and active substance are drugs such as Kvamatel, Gastromax, Famosan, Ulfamid, Famatel, Gastrotide, Famodingexal and Pepsidin. However, it is not recommended to change the drug for analogues on its own. It can be changed only with the permission of the attending physician.

Presented are analogues of the drug famotidine, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more identical active substances. When choosing synonyms, consider not only their cost, but also the country of origin and the reputation of the manufacturer.

Description of the drug

List of analogues

Note! The list contains synonyms of Famotidine, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

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Official instructions for use

famotidine

Pharmacological properties

Indications for use

Contraindications

Dosage and administration

Side effects

Overdose

Interaction with other drugs

special instructions

Release form

Storage conditions

Best before date

Holiday conditions

Manufacturer

The information on the page was verified by the therapist Vasilyeva E.I.

pharmachologic effect
Pharmacodynamics
Blocker of H2-histamine receptors of the III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces the activity of pepsin. Strengthens the protective mechanisms of the gastric mucosa, promotes the healing of its damage associated with hydrochloric acid (including scarring of stress ulcers) and the cessation of gastrointestinal bleeding by increasing the formation of gastric mucus, the content of glycoproteins in it, stimulating the secretion of bicarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration. Significantly does not change the level of gastrin in plasma. Weakly inhibits the cytochrome P450 oxidase system in the liver.
After oral administration, the action begins after 1 hour, reaches a maximum within 3 hours. The duration of action of the drug in a single dose depends on the dose and ranges from 12 to 24 hours.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the gastrointestinal tract, the maximum plasma concentration is reached within 1-3.5 hours. Bioavailability - 40-45%, increases when taken with food and decreases when taking antacids. Communication with plasma proteins - 15-20%.
30-35% of famotidine is metabolized in the liver (with the formation of S-oxide). Penetrates into the cerebrospinal fluid, through the placental barrier, excreted in breast milk.
Elimination mainly occurs through the kidneys: 27-40% of the drug is excreted in the urine unchanged. The half-life is 2.5-4 hours, in patients with creatinine clearance below 30 ml / min, it increases to 10-12 hours. In patients with severe renal insufficiency (creatinine clearance below 10 ml / min), the half-life increases to 20 hours.

Indications for use
Peptic ulcer of the stomach and duodenum in the acute phase, prevention of relapses.
Treatment and prevention of symptomatic gastric and duodenal ulcers (associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), stress, postoperative ulcers).
Erosive gastroduodenitis.
Functional dyspepsia associated with increased secretory function of the stomach.
Reflux esophagitis.
Zollinger-Ellison syndrome.
Prevention of recurrent bleeding from the upper gastrointestinal tract.
Prevention of aspiration of gastric juice during general anesthesia (Mendelssohn's syndrome).

Contraindications
Hypersensitivity to the components of the drug. Children's age (for this form of release).

Carefully
Hepatic and / or renal failure, cirrhosis of the liver with portosystemic encephalopathy (history), immunodeficiency, old age.

Use during pregnancy and lactation
Penetrates through the placenta. Use during pregnancy is possible only if the benefit to the mother outweighs the risk to the fetus.
Penetrates into breast milk; if necessary, use during lactation should either stop using the drug, or breastfeeding.

Dosage and administration
inside. Tablets should be swallowed without chewing, drinking plenty of water.
With peptic ulcer of the stomach and 12 duodenal ulcer in the acute phase, symptomatic ulcers of the stomach and 12 duodenum (associated with taking NSAIDs, stress, postoperative ulcers), erosive gastroduodenitis is usually prescribed 0.02 g 2 times a day or 0, 04 g 1 time per day at bedtime. If necessary, the daily dose can be increased to 0.08-0.16 g. The course of treatment is 4-8 weeks.
In case of dyspepsia associated with increased secretory function of the stomach, 0.02 g is prescribed 1-2 times a day.
In order to prevent recurrence of peptic ulcer, bleeding from the upper gastrointestinal tract, the prevention of symptomatic ulcers (associated with the use of NSAIDs, stress, postoperative ulcers), 0.02 g is prescribed 1 time per day before bedtime.
With reflux esophagitis - 0.02-0.04 g 2 times a day for 6-12 weeks.
With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 0.02 g every 6 hours and may be increased to 0.160 g every 6 hours (severe forms of the syndrome).
To prevent aspiration of gastric juice during general anesthesia, 0.04 g is prescribed the night before and / or in the morning before surgery.
In renal failure, if creatinine clearance is less than 30 ml / min or serum creatinine is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 0.02 g.
If a dose is missed, it must be taken as soon as possible; do not take if it is time for the next dose; do not double doses.

Side effect
From the digestive system are possible: dry mouth, nausea, vomiting, abdominal pain, rarely - loss of appetite, increased activity of "liver" transaminases, constipation, diarrhea, jaundice, hepatocellular, cholestatic or mixed hepatitis, in some cases, acute pancreatitis may develop.
From the nervous system: headache, dizziness; asthenia, drowsiness, insomnia, anxiety, nervousness, depression, psychosis; cases of the development of hallucinations, confusion, blurred visual perception, hyperthermia are described.
From the side of the cardiovascular system: very rarely - lowering blood pressure, bradycardia, atrioventricular blockade, arrhythmia, vasculitis.
Allergic reactions: skin rash, itching, bronchospasm, angioedema, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock.
From the side of the hematopoietic organs: rarely - neutropenia, leukopenia, thrombocytopenia, hemolytic anemia; in isolated cases - agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.
From the reproductive system: with prolonged use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.
Others: rarely - fever, arthralgia, myalgia, tinnitus, dry skin, alopecia.

Overdose
Symptoms: vomiting, motor excitation, tremor, lowering of arterial pressure, tachycardia, collapse.
Treatment: gastric lavage, symptomatic and supportive therapy, hemodialysis.

Interaction with other drugs
Due to an increase in the pH of the contents of the stomach, while taking it, the absorption of ketoconazole, itraconazole, atazanavir, cefuroxime, dasatinib may decrease.
With simultaneous use with antacids, sucralfate, there is a decrease in the intensity of absorption of famotidine.
It inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, lidocaine, phenytoin, theophylline, indirect anticoagulants, glipizide, buformin, metronidazole, caffeine, "slow" calcium channel blockers.
Increases the absorption of amoxicillin and clavulanic acid.
With simultaneous use, an increase in serum concentrations of saquinavir is possible.
With simultaneous use, a decrease in serum concentrations of fosamprenavir is possible. Medicines that depress the bone marrow increase the risk of developing neutropenia.

special instructions
Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.
Famotidine, like all H2-histamine receptor blockers, is undesirable to abruptly cancel (rebound syndrome).
With long-term treatment in debilitated patients, under conditions of stress, bacterial lesions of the stomach are possible, followed by the spread of infection.
The drug should be taken 2 hours after taking itraconazole, ketoconazole, atazanavir, cefuroxime, dasatinib in order to avoid a significant decrease in their absorption.
The break between taking antacids, sucralfate and famotidine should be at least 1-2 hours.
H2-histamine receptor blockers can counteract the effect of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within the 24 hours preceding the test, the use of H2-histamine receptor blockers is not recommended.
H2-histamine receptor blockers can suppress the skin reaction to histamine, leading to false negative results (it is recommended to stop using H2-histamine receptor blockers before performing diagnostic skin tests to detect an allergic skin reaction of an immediate type).
During treatment, you should avoid eating foods, drinks and other medicines that can irritate the gastric mucosa.
Patients with burns may need to increase the dose of the drug due to increased clearance.
The effectiveness of the drug in inhibiting nocturnal acid secretion in the stomach may be reduced as a result of smoking.

Influence on the ability to drive vehicles and control mechanisms
Given the possibility of developing side effects from the central nervous system, the question of the possibility of engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions should be decided only after assessing the patient's individual response to the drug.

Release form
Film-coated tablets, 20 mg and 40 mg.
10 tablets in a blister pack made of PVC film and aluminum foil.
1, 2 or 3 blister packs together with instructions for use in a cardboard pack.

Storage conditions
List B. In a dry, dark place, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Best before date
3 years.
Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies
On prescription.

Manufacturer/organization accepting claims
CJSC "MAKIZ-PHARMA"
109029, Moscow, Automobile passage, 6

Quick Stomach Relief

Advantages: fast action, low price

Cons: Potential side effects

Student time is wonderful, no doubt, but it also has a downside. Eating somehow and where necessary, I planted my stomach, it came to gastritis, well at least not to an ulcer. The doctor prescribed the drug Famotidine, it costs a penny, even poor students can afford it. Helps really quickly despite the ridiculous price. I drank one tablet twice a day, in the morning and in the evening for one month. The drug begins to act within an hour after ingestion. During treatment, it is desirable to follow a sparing diet that does not irritate the stomach. After a month of taking, I reduced the dose to one tablet in the evening for prevention. Now I take this medicine one-time only for severe pain in the stomach. Such a good medicine is necessary in the home first aid kit.

It treats the gastrointestinal tract well, and can be taken for prevention purposes.

Benefits: Treats the gastrointestinal tract, cheap, readily available.

Cons: none

It is no secret to anyone that drugs for the treatment of the gastrointestinal tract are not cheap. There were also cases when expensive imported medicine did not help me at all. But it was Famotidine that turned out to be very effective. By the way, the medicine was not recommended to me by a doctor, but by a pharmacist in a pharmacy, for which I am very grateful to him. I took the drug only twice a day and after a month I completely forgot about problems with my stomach, pain, nausea, heartburn disappeared, but still, for prevention, I periodically took one tablet at night for two weeks. Yes, the medicine is not cheap, but the effect of it is simply amazing.

Saved a child from stomach pain

Pros: Inexpensive and effective

Cons: None

I learned about Famotidine tablets only a year ago when I went to buy a remedy for tummy pain for my child. I asked them to give me something effective and not too expensive, and the pharmacist girl offered it to me, assuring me that the pain and heaviness would pass quickly, and there would be no side effects guaranteed. Just in case, I called a familiar pediatrician to consult, he confirmed everything that they told me in the pharmacy, after that I already made a purchase with confidence. Since the pains were associated with overeating all sorts of things at the holiday, it was enough to drink a few tablets in the evening and in the morning, and the state of his stomach returned to normal. Now this is the number 1 tool for us.

Famotidine for stomach ulcers

Benefits: Really effective

Cons: side effects

For those who suffer from stomach or duodenal ulcers, it is quite obvious that finding a worthwhile medicine that does not kill the family budget is very difficult. What can I say about Famotidine, which was prescribed to me by a doctor after examining my medical history? The drug really helps, all my clinical results have improved by an order of magnitude already in a month or two. But the side effects are somewhat frustrating. Firstly, immediately after taking it, dryness in the mouth begins to be felt, appetite disappears. Secondly, problems with a chair begin. The instructions even say that libido disappears if you take this drug for a long time.

Cheap and efficient

Advantages: price, effect

Cons: addictive

I have been suffering from a stomach ulcer for a long time, I am being treated, but exacerbations constantly occur, and require more thorough treatment. The gastroenterologist this time prescribed me Famotidine. Arriving at the pharmacy, I was pleasantly surprised by the price, the medicine turned out to be very cheap. I took 14 days, the first seven, 2 pieces a day, the second - one at a time. Tablets very quickly help with exacerbations of the ulcer, the pain disappears in just a few days, but the course must be drunk to consolidate the effect. For the course of treatment, it took me 2 packs of the drug. Of the minuses, it is addictive, and exaggeration of the recommended dosage leads to negative consequences.

I didn’t expect such a cheap drug to help so much! I have an ulcer, which is caused by Helicobacter, and even increased acidity to boot. The doctor prescribed me only two drugs for treatment - an antibiotic against Helicobacter (Clorithromycin) and Famotidine - to reduce acidity and to heal the ulcer. It was somehow hard to believe that a drug for 80 rubles (30 tablets there) could not only lower acidity, but also have a healing effect. But an attempt is not torture, so I decided, as it is written, to drink an antibiotic with this drug for a week, and then only Famotidine for another 3 months - so that the acid does not damage the wound that has begun to heal. I took 40 mg (2 tablets of 20 mg each) in a day. The drug is really effective, I have heartburn after every meal, and it’s very strong, but here after the first pill for the first time in a long time there was no heartburn. After drinking the first week, I was pleasantly surprised, because the effect is the same as that of expensive drugs - you drink before meals, preferably 20 minutes before, and you don’t know any heartburn until the next dose. Yes, exactly - just two tablets were enough to avoid heartburn during the day. I drank for a week, passed the test, found out that Helicobacter pylori was eliminated. I began to drink Famotidine further, and then I realized which drug was giving side effects. I often had diarrhea, despite the fact that I drank Linex in parallel, and then I realized that it was not the antibiotic that harmed the body, but Famotidine. Diarrhea was not strong, but frequent, and even nausea and a complete lack of appetite were added to this. It was impossible to live a normal life, the pills against diarrhea helped for a short time. She held on, drank for another two weeks, but began to feel that another problem had appeared - the stomach often began to “freeze” and digest food poorly ...

With malnutrition, stress, lack of sleep, weakened immunity, inflammatory diseases of the stomach can develop.

If they are not treated in time, the mucous membrane is affected - ulcers appear. With frequent discomfort in the stomach, indigestion, you should consult a doctor for examination.

Treatment of gastric problems is always complex. And it starts with diet and a healthy lifestyle.

With gastritis, ulcers and other inflammatory diseases, in order for drugs to work, acidity must be reduced. For example, Helicobacter pylori requires an acidic environment for life and reproduction.

At a low level of acidity, the bacterium reduces its activity. And with peptic ulcer - acid prevents scarring of wounds.

The drug Famotidine has an anti-inflammatory effect due to the suppression of acid production. The drug is available to everyone, well tolerated and helps with most diseases of the stomach.

It is important to understand that it is impossible to cure an ulcer or gastritis with Famotidine alone. The drug is effective as part of drug therapy.

1. Instructions for the drug

Famotidine has an anti-ulcer effect by reducing the level of acidity. Effective for treating heartburn and stomach pain.

Suitable for the treatment of acute phases and the prevention of inflammatory diseases of the stomach.

The drug is effective within 60-90 minutes after administration(maximum after 3 hours), and the effect of a single dose lasts from 12 hours to a day. This allows you to take Famotidine once a day.

Composition and form of release of the drug

The drug is available in the form of tablets of 20 and 40 mg of the active substance and powder for the preparation of a solution for injection - lyophilisate. Producing countries: Ukraine, Russia, Belarus, Serbia, Bulgaria.

Tablets in plates of 10 pieces. In cardboard packs of 2 and 3 plates.

The active substance of the drug is famotidine. The substance blocks histamine receptors, which significantly reduces the amount of acid produced.

Provides the following actions:

• Enhances the protective properties of the mucosa due to increased production of mucus;
• reduces acidity in the stomach;
• eliminates heartburn, sour belching, stomach pain with increased acidity;
• promotes scarring of wounds and stop bleeding in the stomach.

Excipients: starch, cellulose, croscarmellose sodium, magnesium stearate, silicon dioxide.

Shell composition: dye, macrogol, titanium dioxide, hypromellose.

Application area

Famotidine is prescribed for the following diseases:

Mode of application

Tablets cannot be divided or chewed. Take orally with a glass of water.

With an ulcer, gastroduodenitis, gastritis in the acute stage, the daily dose is 40 mg, which can be divided into 2 doses or drunk once at night. It is possible to increase the dose by 2-4 times (as directed by a doctor). The duration of treatment is up to 2 months.

As a prophylaxis of peptic ulcer, it is enough to take 20 mg at night.

For disorders of the stomach, which are accompanied by increased production of acid: 20 mg 1 or 2 times a day.

Zollinger-Ellison Syndrome: Start at 20 mg at a time, taken thrice a day, 6 hours apart. According to indications, a single dose can be increased to 160 mg.

Reflux esophagitis : Daily dose of 40-80 mg divided into 2 doses. The course of treatment is from 1.5 to 3 months.

Before anesthesia, a dose of 40 mg of the drug is prescribed for the night before and in the morning on the day of surgery.

Interaction with other drugs

It is advisable to observe the interval between different drugs from two hours.

The drug is compatible with physiological saline and solutions of dextrose and sodium bicarbonate.

Famotidine reduces the absorption of some antifungal drugs (ketoconazole, itraconazole).

Antacids (reduce the acidity of the contents of the stomach by chemically neutralizing the acid) reduce the absorption of famotidine.

Taking Famotidine with drugs that depress the bone marrow contributes to the development of neutropenia (decrease in the level of neutrophils in the blood, immunity is significantly weakened).

Famotidine inhibits the metabolism of caffeine, diazepam, lidocaine, indirect coagulants, theophylline, phenytoin, hexobarbital, tricyclic antidepressants, metronidazole in the liver.

2. Side effects

The drug rarely causes unwanted manifestations. Common side effects include headaches and allergic reactions. When taking the drug in high dosages for a long period, you may experience:

• allergic reactions: skin rash accompanied by itching, urticaria, dry skin, acne, bronchospasm, anaphylactic shock.
• The cardiovascular system: hypotension (lowering pressure), slow heartbeat (bradycardia).
• Digestive system: loss of appetite, indigestion, feeling of dry mouth, hepatitis, pancreatitis.
• Hematopoietic system: a decrease in the number of leukocytes, granulocytes, and platelets in the blood, or a sharp decrease in the number of all cells in the blood - pancytopenia.
• Nervous system: dizziness, weakness, headache, insomnia, impaired consciousness, hallucinations.
• Musculoskeletal system: Pain in muscles and joints.
• sense organs: fuzzy picture with visual perception, false myopia, ringing in the ears.

When taking significant doses of Famotidine for a long time, an increase in the level of prolactin in the blood, an increase in the mammary gland in men, the absence of menstruation in women, and a decrease in sexual desire are observed.

Contraindications and features of admission

Medications should be taken as directed by a doctor. Self-medication can harm or hide the symptoms of a serious illness.

With pathological disorders of the kidneys and liver, in old age and with weakened immunity, use with caution. The daily dose is not more than 20 mg.

Before taking Famotidine, it is necessary to exclude the presence of tumors in the digestive organs. Because the drug relieves the symptoms.

Can't miss an appointment so that there are no jumps in the level of acidity in the stomach. But if the dose is not taken, and it is already time to take the next one, there is no need to double the amount.

It is important to combine treatment with diet. It is impossible to use foods that irritate the gastric mucosa while taking Famotidine.

Overdose signs of excitation, vomiting, tremor, hypotension, tachycardia are observed. An urgent gastric lavage is required. In severe cases, seek medical attention.

During pregnancy

Famotidine crosses the placenta. The effect on the fetus has not been studied. Therefore, you can not take the drug during pregnancy.

3. Storage of the drug

Famotidine can be stored at room temperature (15-25 degrees) in a place protected from light. The drug is valid for 2 years.

4. Price

Average price in Russia for 20 tablets of 20 mg - 30 rubles.

Average cost in Ukraine- 7 hryvnia for 20 tablets of 20 mg.

Video on the topic: Causes of heartburn

5. Analogues

Medicines with the same active ingredient: chewable tablets Gastromax, Kvamatel, Ulfamid, Famosan, Famatel, Famodingexal, Gastrotide, Pepsidin.

6. Reviews

Patients note a rapid relief of the condition during exacerbations of stomach diseases. After a few doses, improvement occurs: pain, heartburn go away, digestion normalizes. The effect is noticeable even with a single dose of the drug at night.

The drug also helps with pain in the stomach associated with malnutrition. It is used to quickly relieve symptoms before contacting a doctor. An impressive list of side effects is alarming. But in fact, sometimes there are complaints of headache while taking the drug.

Patients indicate that it is necessary to stop taking Famotidine gradually so that the level of acidity does not change sharply, but gradually.

Additional reviews about the drug can be read after the article.

Famotidine reduces the level of acidity of gastric juice. It is used for diseases of the stomach and duodenum, which are accompanied by inflammation of the mucosa. It is prescribed as part of complex treatment. Famotidine can hide the symptoms of the disease, making it difficult to diagnose.

Engaged in the prevention, diagnosis and treatment of diseases of the stomach, esophagus and 12 duodenal ulcers, diseases of the pancreas and liver of alcoholic etiology. Treats intestinal dysbacteriosis and constipation.

Pharmacodynamics

Famotidine is considered a competitive histamine antagonist. Acting on histamine H2-sensors of parietal cells, it significantly reduces the secretion of hydrochloric acid in gastric juice stimulated by various pathogens. The basic release of hydrochloric acid also decreases. Stimulation of pepsinogen is suppressed to the least extent. Generates inhibition of the product of hydrochloric acid and a decrease in the initiative of pepsin. Almost does not change the degree of gastrin in plasma.

The duration of exposure to the components of the drug depends on the dose and lasts from 12 to 24 hours.

Pharmacokinetics

After taking famotidine is rapidly absorbed. His work begins within an hour after admission. The highest concentration is reached after three hours. Plasma protein binding up to 20%.

Famotidine is best taken with food at mealtimes. This enhances the bioavailability of the drug. Up to 40% of famotidine is excreted from the body in the urine. The half-life depends on the state of the organism. It takes from two and a half to twenty hours.

Indications and contraindications

The terms of use for famotidine are as follows:

• stomach ulcer and 12 duodenal ulcer;
• treatment and prevention of consequences caused by the use of anti-inflammatory drugs, manifested in the form of ulcers on the mucous membranes of the stomach and duodenum;
• gastroduodenitis with erosive signs;
• dyspepsia resulting from exceeding the normative indicators of gastric secretion;
• Mendelssohn's syndrome (some anesthetists instruct not to feed patients before surgery in order to avoid the appearance of Mendelssohn's syndrome. This is a mistake. It is as a result of operations performed on an empty stomach that acid aspiration syndrome often appears);
• prevention of bleeding after surgery.

additional information

During pregnancy and lactation, the drug should not be used. It is possible only in exceptional cases, when the risk to the life of the mother outweighs the risk to the fetus.

A very careful approach is needed during breastfeeding, as the drug passes into breast milk. It is better to stop feeding the child while taking the drug.

In the initial period of drug treatment, it is imperative to exclude the possibility of malignant neoplasms in the patient's body in the esophagus, stomach or duodenum.

Famotidine should not be discontinued abruptly, as disease symptoms may return. In addition, if the drug is taken for a long time, especially weakened patients may experience various bacterial lesions in the stomach area with further spread to nearby areas.

At the time the drug is taken, you will have to give up foods, drinks and drugs that can irritate the mucous membrane in the gastric region.

Under what conditions is it released from pharmacies: They sell medicine without a prescription.

While watching the video, you will learn about three tests on the stomach.

The effectiveness of the drug is absolutely undeniable. famotidine, the absence of serious undesirable effects of the drug and ease of use make the drug indispensable in the treatment of gastric and duodenal ulcers.