Diclofenac pain pills side effects. Disapproving responses from people. Special instructions for use

Diclofenac tablets is a non-steroidal anti-inflammatory drug.

It has anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Most effective for inflammatory pain. It is used for symptomatic treatment of diseases of the musculoskeletal system, reduction of various types of pain syndrome.

On this page you will find all the information about Diclofenac: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Diclofenac tablets. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much do diclofenac tablets cost? The average price in pharmacies is at the level of 20 rubles.

Release form and composition

Tablet forms: tablets in a / r shell 25 mg, in a p / o shell 25 and 50 mg, retard 100 mg.

Composition of enteric-coated tablets: 25 or 50 mg Diclofenac sodium, dibasic calcium phosphate, starch, magnesium stearate, polyvinylpyrrolidone K30, purified talc, cellulose acetate, indoresin, diethyl phthalate, carmoisine varnish, titanium dioxide, Ponceau 4R varnish, iron oxide red and yellow .

Pharmacological effect

Suppresses the exudative and proliferative phases of inflammation. Reduces the amount of serotonin, histamine and bradykinin, increases the threshold for the perception of pain receptors; reduces the concentration of PG in the center of thermoregulation, increases heat transfer, reduces body temperature; inhibits platelet aggregation.

Indications for use

The tablet form of Diclofenac is prescribed to relieve pain during attacks of psoriatic, gouty, juvenile, injuries of the ligaments and articular apparatus of the knee joint.

Tablets can be used for pain in the spine. Arising as a result of degenerative changes in the intervertebral discs. It is used for tunnel syndrome of the wrist or elbow joint. It is indispensable in case of injury, sprain or dislocation, including for athletes and people working in physically difficult industries.

Contraindications

Contraindications to the use of tablets:

inflammatory bowel disease;
exacerbation of lesions of the gastrointestinal tract (erosive and ulcerative);
bleeding from the gastrointestinal tract;
severe insufficiency of kidney or liver function;
condition after coronary artery bypass grafting;
pregnancy and lactation;
"aspirin triad" - intolerance to NSAIDs in patients with bronchial asthma and nasal polyps;
children under 6 years of age for 25 mg tablets, other dosages are contraindicated under 18 years of age;
lactose intolerance, lactase deficiency, pathology of glucose-galactose absorption.

It is prescribed with caution in the following conditions: inflammatory bowel disease, alcoholism, chronic erosive and ulcerative diseases of the gastrointestinal tract (without exacerbation), diabetes, diverticulitis, inducible porphyria, bronchial asthma, anemia, congestive heart failure, edematous syndrome, arterial hypertension, liver or kidney failure , condition after serious surgical interventions, old age, systemic connective tissue pathologies.

Use during pregnancy and lactation

Contraindicated in the III trimester of pregnancy. In the I and II trimester of pregnancy, it should be used according to strict indications and at the lowest dosage.

Diclofenac passes into breast milk. If necessary, the appointment of the drug during lactation, breastfeeding should be discontinued.

Instructions for use

The instructions for use indicate that Diclofenac in the form of tablets should be taken orally, without chewing and drinking plenty of water, preferably 30 minutes before a meal (to achieve a quick therapeutic effect). It is also possible to take the drug before, during or after a meal.

For children over 15 years old and adults, Diclofenac is prescribed 2-3 times a day for 25-50 mg (maximum - 150 mg per day). After improvement, the dose is gradually reduced and switched to maintenance therapy - 50 mg per day.

In the treatment of juvenile rheumatoid arthritis, the daily dose can be increased to 3 mg/kg body weight.

For children, the drug is usually prescribed in the following doses (single / daily):

6-7 years (20-24 kg) - 25/25 mg;
8-11 years old (25-37 kg) - 25 / 50-75 mg;
12-14 years old (38-50 kg) - 25-50 / 75-100 mg.

How long can be applied?

Most of the pathologies and complications associated with the use of this drug occur against the background of the duration of treatment. How to take Diclofenac tablets to prevent unpleasant symptoms? First of all, the process must be controlled by a doctor. Adult patients are prescribed 2-3 tablets per day. The dose is reduced when improvements occur.

Duration of admission should not exceed 2 weeks, except in difficult cases.

Side effects

When taken orally, the following side effects are possible: dyspeptic symptoms, erosive and ulcerative lesions of the digestive canal, perforation of its walls, gastric and intestinal bleeding, increased drowsiness, dizziness, hypersensitivity reactions, irritability.

Overdose

Symptoms: hypotension, renal failure, convulsions, gastrointestinal irritation or respiratory depression may occur.

Treatment: There is no specific antidote. In acute poisoning, it is necessary to stop the absorption of the drug from the gastrointestinal tract as soon as possible. Gastric lavage, administration of activated charcoal and other symptomatic and supportive therapy are indicated. The use of forced diuresis, dialysis or blood transfusion is hardly justified, due to the fact that NSAIDs are highly protein bound and have an extensive metabolism.

special instructions

During the period of treatment with the drug, systematic monitoring of peripheral blood, liver and kidney function, and a study of feces for the presence of blood should be carried out.

Patients taking the drug should refrain from activities that require increased attention and rapid mental and motor reactions, alcohol consumption.

drug interaction

Reduces the effect of hypoglycemic agents.
Reduces the effects of antihypertensive and hypnotic drugs.
Acetylsalicylic acid reduces the concentration of diclofenac in the blood.
Increases plasma concentration of digoxin, methotrexate. lithium and cyclosporine.
Simultaneous use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac.
Cefamandol, cefoperazone, cefotetan, valproic acid and plicamycin increase the incidence of hypoprothrombinemia.
Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity.
Simultaneous administration with ethanol, colchicine, corticotropin and St. John's wort increases the risk of bleeding in the gastrointestinal tract.
Reduces the effect of diuretics, against the background of potassium-sparing diuretics, the risk of hyperkalemia increases; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) - the risk of bleeding (often from the gastrointestinal tract).
Diclofenac enhances the effect of drugs that cause photosensitivity Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.
Increases the likelihood of side effects of other NSAIDs and glucocorticosteroid drugs (bleeding in the gastrointestinal tract), methotrexate toxicity and cyclosporine nephrotoxicity.

Many patients are interested in which is better - Ketoprofen or Diclofenac, what is the difference between them. Both drugs are non-steroidal anti-inflammatory drugs.

Composition and properties of drugs

The impact of these drugs is based on a decrease in the formation of special enzymes - cyclooxygenase, which give rise to the body's reaction to pathological processes:

pain syndrome;
feverish state;
inflammatory process.

Ketoprofen is produced by the pharmaceutical industry in the form of tablets, gel, injection solution, capsules, suppositories. Diclofenac is also produced in the form of ointments and drops, but it is not available in the form of suppositories. The main active ingredient of Ketoprofen is ketoprofen, produced from propionic acid, and in Diclofenac, it is diclofenac sodium, produced from phenylacetic acid.

Ketoprofen tablets contain 100 mg or 150 mg of ketoprofen. The content in 2.5% Ketoprofen gel is 25 mg, and in 5% - 50 mg. The contents of 30 or 50 g of an aluminum tube with 2.5% gel are transparent, colorless, slightly shimmering, with 5% it may have a slightly yellowish tint. Capsules contain 50 mg of ketoprofen. Candles in their composition have 100 mg of ketoprofen. The solution for injection contains 100 mg of ketoprofen.

Diclofenac tablets contain 25 mg, 50 mg or 100 mg diclofenac sodium. The content in 1% and 5% diclofenac sodium gel is 10 mg and 50 mg, respectively.

0.1% drops have 1 mg diclofenac sodium. Candles in their composition have 50 mg or 100 mg of diclofenac sodium. Solution for injection contains 75 mg diclofenac sodium. 1% ointment contains 10 mg diclofenac sodium.

Indications for their use

Ketoprofen in tablets, suppositories and injection solutions is used for inflammatory diseases of the musculoskeletal system:

arthritis;
bursitis;
osteoarthritis;
spondyloarthritis.

Tablets and suppositories are prescribed to get rid of:

muscle pain;
various kinds of neuralgia;
spinal injuries;
when sprained ligaments;
dislocations;
bruises;
tendon ruptures;
ENT diseases.

The solution for injection is used as an additional treatment to suppress pain in:

neuralgia;
radiculitis;
otitis;
toothache and headache.

Ketoprofen in a gel dosage form helps with osteochondrosis, sciatica and arthritis.

Diclofenac in the form of a solution for injection is used for such pathologies:

neuralgia;
arthritis;
spondyloarthritis;
osteoarthritis;
rheumatism;
postoperative pain.

Candles and Diclofenac tablets are used for such diseases:

arthritis;
osteoarthritis;
bursitis;
migraine;
oncological diseases;
toothache;
neuralgia;
radiculitis;
ENT diseases.

Gel or ointment is used:

with pain in the muscles;
with dislocations;
with bruises;
with ligament injuries.

Drops are prescribed for cataract surgery, inflammatory processes of the organs of vision, conjunctivitis, erosion.

Candles are used to suppress fever that occurs with SARS or influenza.

Thus, in general, Ketoprofen and Diclofenac are used for almost the same diseases, with some exceptions.

Method of application and dosage

Ketoprofen and Diclofenac, depending on the dosage forms, have a certain dosage and method of application. However, in any case, this is established by the doctor, depending on the disease and age. Instructions for the use of Ketoprofen and Diclofenac, which are in the packages along with the drugs, contain the following recommendations:

Ketoprofen:

The gel is used topically up to 3 times a day, it is rubbed into the inflamed area of the body for no more than 10 days.
Ketoprofen tablets are taken orally regardless of the meal.
Ketoprofen in candles is used 1 piece 1 or 2 times a day.
Ketoprofen in ampoules is administered intramuscularly or intravenously (mainly in a hospital). It is allowed to use in conjunction with morphine, dissolving the mixture with saline. The resulting product must be used at intervals of 8 hours.

Diclofenac:

Solution for injection for intramuscular injection is used for 2 days.
Taking tablets is carried out for a quick effect before meals, and mainly during meals or immediately after it, swallowing and drinking plenty of water at room temperature.
Candles are administered during the day at a dosage of not more than 100 mg.
The gel and ointment are applied topically, rubbing them into the painful area three times a day for adults and twice a day for children.
Drops are used both before and after surgery.

Limitations and adverse reactions

Both drugs have side effects and contraindications for use. Studies have revealed a fairly long list of side effects from taking both drugs, manifested by almost all major human organs:

nausea;
heartburn;
vomit;
pain and bleeding in the stomach;
constipation;
diarrhea;
headache;
drowsiness;
dizziness;
the appearance of noise in the ears;
possible speech impairment;
anemia;
conjunctivitis;
skin rash;

In Diclofenac, it is additionally possible to manifest:

ulcers;
bloody discharge in the stool;
hepatitis;
necrosis or cirrhosis of the liver;
aseptic meningitis;
eczema;
dermatitis;
pneumonia;
cough;
heart attack.

As for contraindications, in which the use of these drugs is strictly prohibited, they are:

individual intolerance in the patient to any component of the drug;
the presence of hypersensitivity to non-steroidal drugs;
pregnancy;
lactation period;
bronchial asthma;
erosive and ulcerative lesions of the gastrointestinal tract;
stomach bleeding;
hemophilia;
heart, liver and kidney failure;
elderly age.

For injection solution - children under 18 years of age, for gel - 6 years, for tablets - 15 years.

What medicine to choose

Indications and contraindications for the use of these drugs are almost the same. Let's find out which drug has a stronger effect and is safer to use.

It can be immediately noted that the effectiveness of the use has been proven for both drugs, however, Ketoprofen has a more pronounced analgesic effect, and Diclofenac has an anti-inflammatory effect, therefore, Ketoprofen should be used to instantly relieve pain, and Diclofenac to reduce the inflammatory process.

Still, Ketoprofen is safer than Diclofenac, since the second drug is prescribed with caution to elderly patients due to its poor tolerability and the presence of serious side effects from the cardiovascular system.

Another difference between these drugs is their price: Diclofenac is a more affordable medication than Ketoprofen. However, here we should not forget about a fairly large number of manufacturers of these medicines, since some well-known manufacturers Diclofenac will cost even more than Ketoprofen.

Both drugs have many contraindications for use, side effects, so only a specialist should prescribe a specific drug for admission.

Which is better: injections of Diclofenac or Movalis?

For back pain, such as osteochondrosis, anti-inflammatory drugs can help. They are the basis of basic therapy for degenerative-dystrophic diseases of the spinal column. Those who often suffer from back pain know that these drugs are very effective. Movalis and Diclofenac are among these drugs, and many people have a question, which one is better to choose for back pain?

- Diclofenac and its properties
- The main properties of Movalis
- Interaction with other drugs and overdose
- Features of the use of Movalis

Anti-inflammatory drugs for osteochondrosis

Most of the pathogenetic links of the disease can be eliminated using anti-inflammatory drugs. When scientists create them, they expect to be able to cure osteochondrosis. In fact, when using non-steroidal anti-inflammatory drugs, there may be side effects that affect the functioning of the gastrointestinal tract.

The popularity of these drugs is high, this is due to several mechanisms of their action:

painkiller;
anti-inflammatory;
pathogenetic.

Almost everyone who often suffers from back pain, independently resorts to these remedies in the treatment. They are often prescribed by the attending physician and warns that these drugs should not be taken for more than 10 days in a row. After use, be sure to take a break so as not to harm your health. Do not give injections or drink pills with stomach ulcers. If used correctly, non-steroidal anti-inflammatory drugs, they effectively relieve pain.

Diclofenac and its properties

This drug is prescribed for rheumatic lesions and other diseases with severe pain. It has anti-inflammatory and analgesic effects on the body. Due to its positive action in most patients:

reduced pain in rheumatic diseases;
swelling and stiffness of the joints disappear in the morning;
improves mobility.

Take a drug such as Diclofenac should be strictly according to the instructions. You should be aware that this pain reliever can cause side effects. It should not be used if the patient has:

disorders in the liver and kidneys;
heart failure;
stomach ulcer;
work associated with increased attention;
period of pregnancy or lactation.

The main properties of Movalis

At its core, Movalis is an analogue of Diclofenac. It is considered one of the most effective non-steroidal drugs. Doctors often prescribe it in the treatment of diseases and disorders in the musculoskeletal system. Movalis is produced in several dosage forms:

ampoules for intramuscular injections;
tablets;
rectal suppositories.

As part of the drug, the main active ingredient is meloxicam. It has analgesic properties and stops the development of inflammatory processes. It is prescribed for the following problems:

Intramuscular injections Movalis can be used only during the first days of therapy. After that, you need to switch to other forms of drug release.

Due to its effective analgesic effect, Movalis quickly suppresses inflammatory mediators. The drug is well tolerated by patients, with the exception of those who have contraindications. These include:

allergy;
peptic ulcer;
taking anticoagulants;
severe hepatic or renal failure;
inflammation of the rectum;
old age and childhood.

The drug should not be taken during lactation and during pregnancy, as well as in the treatment of infertility.

Which is better: Diclofenac or Movalis?

To answer this question, you need to know about the clear benefits of Movalis and be aware of the side effects of both drugs.

Movalis belongs to the drugs of a new generation and differs from many other similar drugs in not very pronounced side effects. If we compare it with Diclofenac, then Movalis has a significant advantage - it can be used longer than other analogues. Treatment should be prescribed by the attending physician in order to complete the full course. Movalis is chondroneutral, so injections of the drug do not have a negative effect on cartilage tissue. This property is very important in many diseases of the spine and joints. Most often, such diseases are accompanied by pain and are characterized by metabolic processes in the body.

The drug Movalis is usually prescribed when the pain syndrome is mild. Moderate pain is usually associated with an inflammatory process. Scientists conducted research for six months to compare two drugs: Diclofenac and Movalis. For this purpose, more than 300 volunteers were selected to participate in the research. Most of them had problems with joints and spine.

During the study, both drugs showed high efficiency, but differed in the degree of side effects. According to the influence on the development of side effects, Movalis appeared in 11%, and Diclofenac in 14% of patients.

Interaction with other drugs and overdose

Before using Movalis for medicinal purposes, you should know that if it is used in conjunction with diuretics, you need to periodically check the kidneys. Drinking more fluids is also recommended. This medicine may affect and reduce the effectiveness of blood pressure medicines. Movalis can adversely affect the function of the intrauterine device.

It is not recommended to combine the use of Movalis and its analogues with alcoholic beverages, this is strictly prohibited. Such a combination can adversely affect the functioning of the liver and exacerbate hepatitis, peptic ulcer. It often happens that ignoring the recommendations in patients during treatment and alcohol consumption, severe pain appeared in the epigastric region.

Movalis tends to accumulate in body tissues, especially if the patient has been using the medicine for too long. When the patient experiences pain, then most often the dose of the drug is overestimated. If the dose of use is higher than the average, then this may cause an increase in side effects. In this case, it is recommended to clean the stomach with lavage, but only if the drug was taken less than 1 hour ago. In more severe cases, be sure to contact the ambulance service.

Features of the use of Movalis

The attending physician most often prescribes Movalis injections immediately after taking the patient. Its injection solution cannot be combined with solutions of other drugs in the same syringe. This is due to its potential incompatibility. Movalis can be used as an injection only intramuscularly. Injections have the most effective effect during treatment compared to tablets and suppositories.

Any dosage form has its pros and cons, so tablets are no exception. The main disadvantage is the negative impact on the digestive organs. Since the drug inhibits the synthesis of prostaglandins involved in the formation of inflammatory processes, it cannot affect the synthesis of similar prostaglandins in the gastric mucosa. In other similar non-steroidal anti-inflammatory drugs, the synthesis of all absolutely prostaglandins is suppressed.

Tablets, unlike other forms of drug release, have milder properties to act on the body. Their action is not so quickly manifested. Therefore, in case of pain, they are recommended to be used in conjunction with injections. If the pain is not very pronounced, then one pill is enough.

Suppositories are considered the most convenient to use, since when administered they are quickly absorbed and immediately begin to show their properties. They are actively used by many patients not only for back pain, but also in gynecology and urology.

As a result, we can say that Movalis is safer to use than Diclofenac. This is very important to know for patients who experience unstable health conditions while taking medication.

For centuries, scientists have searched for methods to effectively relieve pain. Despite the fact that there are many causes of pain syndrome, the mechanism of its occurrence is the same. Under the action of certain enzymes synthesized by inflamed tissues, pain receptors become especially sensitive. One of the standard drugs to cope with pain is Diclofenac.

Dosage forms

Several types of this drug are produced, among which the most popular is Diclofenac solution (25 mg of diclofenac sodium in 1 ml). It is sold in ampoules of 3 ml. Also available for sale:

Tablets 25 or 50 mg.
Long-acting tablets 75 or 150 mg.
Candles 25, 50 or 100 mg.
Ointment 1%.
Gel 1% or 5%.

The main component of all dosage forms is diclofenac sodium.

Pharmacology

Diclofenac is a non-steroidal anti-inflammatory drug based on phenylacetic acid. The mechanism of its action is the inhibition of cyclooxygenase, an enzyme that is directly involved in the formation of the inflammatory process, pain and fever. Medication therapy:

Relieves inflammation in the lesion.
Eliminates pathological pain.
Lowers temperature.

The active substance of the drug is well absorbed by the gastrointestinal mucosa. After an injection of Diclofenac, its maximum concentration is reached after 20 minutes, after rectal administration - within 1 hour, internal - after 2-4 hours.

Indications

Diclofenac is a modern drug that can be used to eliminate pain, inflammation, and swelling. It is prescribed in rheumatology, traumatology and orthopedics, neurology, gynecology.

Use in rheumatology

Due to its high analgesic ability, Diclofenac is the subject of choice in the treatment of various joint pathologies (arthrosis, arthritis, etc.). It allows:

Remove swelling.
Improve motor function of the joints.
Eliminate stiffness in the morning.
Reduce pain.

Diclofenac eliminates pain, but does not affect the cause of the disease.

Use in orthopedics and traumatology

Pain can occur as a result of pathological processes in the musculoskeletal system: inflammation, dysplasia, trophic disorders, degenerative disorders, trauma. The optimal therapeutic effect can be achieved by combining the general and external forms of Diclofenac. Indications for local use:

Extra-articular pathologies: rheumatism, bursitis, tendovaginitis.
Injury to tendons, ligaments, muscles and joints.

General forms (ampoules, tablets, suppositories) can be used for extensive injuries, fractures of large bones, during the rehabilitation period after complex surgical interventions.

Use in neurology

Diclofenac is actively used to prevent pain attacks of a neurological nature. So, indications for it are spinal pain, migraine attacks, tunnel neuropathy.

Indications for the use of one form or another of the drug depends on the location of the pain and its severity. With a mild syndrome that does not constrain motor activity, it is possible to prescribe external agents (gels, ointments). In acute pain that limits the patient's movements, it is advisable to inject Diclofenac.

Use in gynecology

Diclofenac can relieve the painful flow of menstruation. Indications for the drug are also inflammatory diseases of the pelvic organs, in particular, adnexitis.

In gynecological practice, Diclofenac suppositories are predominantly prescribed. They quickly dissolve in the vagina, providing a therapeutic effect.

Features of use

The undoubted advantage of Diclofenac is the possibility of using different dosage forms. This allows patients to decide how much to take the drug, and in what form, depending on the indication. The ability to combine different methods of application in one patient significantly minimizes the risk of adverse reactions.

Injection

Diclofenac injections allow you to quickly eliminate severe pain attacks. Injections are made over 2-3 days. The dose of the drug is prescribed by the attending physician, taking into account the severity of the patient's condition, his age.

If a long course of therapy with Diclofenac is necessary, the required number of injections is carried out, after which they switch to a tablet form or suppositories.

If the doctor has prescribed Diclofenac in ampoules, it is important to choose the right place where to inject the drug. For intramuscular injection, the syringe is inserted deep into the upper part of the gluteal muscle. Each next injection should be done in a different buttock.

According to the instructions, the drug should not be injected intravenously or subcutaneously.

Rectal suppositories

If oral administration of Diclofenac or injections is impossible, as well as in case of pathologies of the digestive system, patients are prescribed suppositories. They are easier to tolerate, do not cause local reactions (suppuration at the injection site, infiltrates, necrosis of muscle tissue).

A candle is inserted into the anus after a natural stool or a cleansing enema. For gynecological diseases accompanied by pain, a candle is inserted into the vagina.

Tablets

Diclofenac tablets are made in different dosages. For each patient, the doctor determines individually how much to take the medicine, taking into account the severity of the symptoms.

If it is necessary to relieve the pain syndrome that occurs at night or in the morning, suppositories can be prescribed in combination with the tablet form. They are used before bed. After achieving a positive result, they switch to a maintenance dosage of the drug.

Tablets are taken orally during meals, do not chew, washed down with water.

Delayed tablets

After taking prolonged-release tablets, the therapeutic effect occurs later, but lasts longer. This allows you to take the drug less often, while maintaining the required amount of the active substance in the body.

Retard tablets are indicated for chronic pain, when long-term therapy is necessary. The course of treatment can last several months.

How many tablets to take is indicated in the instructions, however, it is advisable to carry out treatment at the dosage indicated by the attending physician. With vivid symptoms, pain that occurs at night or in the morning, the tablets are drunk at bedtime.

Forms of topical application

When the drug is applied to the skin, the effect directly on the lesion occurs, thereby minimizing the negative effect on other organs and systems.

Dicolofenac gels and ointments are highly effective and are OTC drugs, which is why they are very popular. However, only a doctor can decide whether to use the drug and how long the therapy should last.

A small amount of medicine is applied to the affected area and rubbed into the skin.

Contraindications

The instructions for the medication indicate a rather extensive list of contraindications to Diclofenac. It is forbidden to inject Diclofenac and use its other dosage forms under the following conditions:

Pregnancy and lactation.
Children's age: up to 6 years for ointment and tablets, up to 12 years for suppositories and solution.
Individual intolerance to diclofenac and other components of the drug.
Individual intolerance to acetylsalicylic acid (aspirin triad).
Proctitis (for candles).
Ulcer disease.
Inflammation of the digestive tract.

Relative contraindications to Diclofenac are patient complaints about gastrointestinal dysfunction, suspected peptic ulcer, inflammation, and also:

Hemorrhagic disorders.
Autoimmune disorders of connective tissue.
Pathology of the liver and kidneys.
Increased blood pressure.
Disorders of the heart.
Rhinitis of an allergic nature;
Pathology of the upper respiratory tract.

In the conditions listed above, the medication should be prescribed with caution, and the treatment should be carried out under the close supervision of a doctor, since undesirable consequences are not excluded.

Side effects

Treatment with Diclofenac may cause side effects primarily from the digestive system. Depending on how long the therapy lasts and in what dosages the drug is prescribed, it can be epigastric pain, stool disorders, nausea and vomiting, and flatulence. It is not excluded the formation of erosion, the development of bleeding from the gastrointestinal tract, liver failure. Other side effects:

Colitis with hemorrhage.
Dizziness, sleep disturbances, lethargy, headache, anxiety.
Low hemoglobin, platelets, granulocytes, leukocytes.
Violation of the kidneys.
Skin manifestations: eczema, erythema, photosensitivity, erythroderma.

Sometimes visual impairment, mental disorders, baldness, a feeling of numbness of the skin, a nervous tic are possible.

After Diclofenac injections, local reactions may develop: fatty necrosis, infiltrate formation, discomfort at the injection site.

When applied externally, a rash may appear on the skin, redness and a burning sensation may occur.

With anal administration, local irritation, mucus with blood, and painful defecation are not excluded.

Despite a rather extensive list of side effects and contraindications, Diclofenac is well tolerated, even with prolonged therapy. People with predisposing factors tend to develop adverse reactions, which include:

Old age (over 65).
History of ulcer.
Combination with other NSAIDs.
The presence of bad habits (smoking, drinking alcohol).
Concomitant treatment with glucocorticoids.

special instructions

If diclofenac is needed for long-term therapy, it is used in conjunction with misoprostol - this will protect the gastric mucosa from the action of the drug.

Patients with hypertension during therapy with Diclofenac need to monitor fluctuations in blood pressure. In case of violations of the liver or kidneys, the drug is prescribed in the minimum allowable doses, monitoring the amount of liver enzymes.

The patient should inform the attending physician that he is taking other medicines in order to avoid unwanted complications during Diclofenac therapy. The instructions indicate that the drug:

Increases the plasma level of cyclosporine A, lithium, digoxin.
Enhances the toxicity of methotrexate.
Increases the likelihood of hyperkalemia when combined with diuretics.
Increases the likelihood of bleeding in conjunction with taking anticoagulants.
Reduces the therapeutic effect of hypnotics, antihypertensives, diuretics.

Exceeding the number of injections of Diclofenac and the recommended dosage of other drugs can cause acute poisoning. In this case, symptomatic treatment is carried out.

All dosage forms are stored in a dark, dry, cool place.

Diclofenac in the form of tablets can be taken for headaches, if a toothache. This drug has a rapid analgesic effect, as it belongs to non-steroidal anti-inflammatory drugs (NSAIDs).

Diclofenac - description

The drug Diclofenac- Representative of the NSAID group. The forms of release of the drug are varied - these are tablets, injection solution, ointment, eye drops, suppositories for rectal administration. The active composition of the drug is represented by sodium diclofenac, a derivative of phenylacetic acid. Tablets are sold with a dosage of 25.50 mg, they are round, convex on both sides, covered with a brown shell.

Additional components of tablets that are required to ensure the safety and the desired physical properties of the drug:

dimethyl sulfoxide;
starch;
benzene alcohol;
magnesium stearate;
calcium phosphate, etc.

The drug was developed in early 1966, it was originally intended for the treatment of inflammation in the joints. Later, the list of indications for Diclofenac expanded significantly. In a number of countries, the drug was discontinued due to the abundance of side effects, but with strict adherence to the course of treatment, it is recognized as quite safe. The price of the drug is very low - about 40 rubles for 20 tablets (50 mg). It is produced by Akri, Sintez, Obolenskoye and others.

pharmachologic effect

The effectiveness of tablets is much better than with treatment with Aspirin. The drug has a stronger anti-inflammatory, antipyretic, analgesic effect. The active substance inhibits the production of COX 1,2 - enzymes that are recognized as precursors of prostaglandins (the latter are "provokers" of the inflammatory reaction and pain).

The drug easily penetrates into the synovial fluid of the joints, while not harming the production of cartilage proteins.

The mechanism of action of Diclofenac includes two directions - central (prostaglandin inhibition) and local.

Due to this, the drug has a non-selective effect, working in any part of the body where there is an inflammatory reaction. Among other things, Diclofenac thins the blood, reducing the adhesion of platelets. A long course of use leads to a desensitizing effect.

How does the drug work in relation to the clinical manifestations of inflammatory pathologies:

helps reduce pain;
eliminates stiffness of the joints, especially in the morning;
reduces swelling, redness of the lesion site;
after injuries, operations - reduces pain, inflammatory edema.

The drug is rapidly absorbed, slightly slowing down the rate of absorption of its intake on a full stomach. Easily passes into breast milk. The half-life is 6 hours.

Indications for use

The remedy has only a symptomatic effect - it will not affect the causes of the disease. It is especially important to take into account this feature of all NSAIDs in infectious pathologies - the antipyretic effect of drugs can mask the symptoms of the disease.

As an anesthetic, Diclofenac tablets help with algomenorrhea - abnormally painful menstruation in women, and a feature often occurring in young girls. In gynecology, the drug is advised to drink with adnexitis, since this disease is accompanied by a pronounced pain syndrome.

The medicine can be taken with angina - if the sore throat is unbearable, as well as at high temperature against the background of influenza, SARS.

It is also prescribed for headache, toothache, discomfort with otitis, after injuries, operations.

Instructions for use

How long the course will continue, what dosage will help the patient, should be checked with a specialist. This is especially important for the upcoming course admission - it is impossible to carry out treatment without a doctor's prescription!

Tablets are taken 30 minutes before meals with plenty of water. This will guarantee a quick, prolonged and pronounced effect. People prone to diseases of the stomach and intestines should drink Diclofenac only after eating, and also after taking proton pump inhibitors (,).

Dosages will be as follows:

children from 15 years old, adults - 25-50 mg per single dose;
the number of receptions - up to three / day;
the maximum daily dose is 150 mg;
as health improves, they immediately switch to the lowest possible dosage - 25.50 mg / day.

With osteochondrosis, other inflammatory pathologies of the spine, joints, the course is usually not more than 10 days. Additionally, to protect the stomach, the doctor may recommend taking Almagel.

Against toothache, they drink 50 mg of the drug up to 3 times / day for 1-2 days. For headaches, a single dose of 25.50 mg is allowed. As an antipyretic, Diclofenac is taken randomly, but not exceeding the maximum dose.

Side effects, contraindications

During pregnancy, taking the drug is contraindicated, only one-time consumption in the second trimester is allowed according to strict indications. In the third trimester, during lactation, Diclofenac is strictly contraindicated.

Other prohibitions for admission will be:

Side effects are very common. Basically, they relate to dyspeptic reactions of the body - abdominal pain, flatulence, diarrhea, stomach pain, nausea, vomiting may appear. Long-term use can provoke gastritis, ulcers, erosive phenomena, bleeding. From the side of the heart, tachycardia, hypertension are possible, from the side of the kidneys - insufficiency of function, edema, blood in the urine. Also capable of appearing dizziness, drowsiness, apathy, rash on the body.

Analogues and other information

Among the analogues, one can name the majority of drugs based on NSAIDs, which are sold in a wide range in pharmacies.

"Diclofenac", what does this anti-inflammatory pain reliever help with? The drug occupies a leading position in the world among analgesics. Tablets, ointment and injections "Diclofenac" instructions for use prescribe to take with neuritis, lumbago, neuralgia, as well as other diseases and conditions accompanied by pain of varying intensity.

Varieties and composition

The drug is produced in tablet form, in the form of an external ointment, rectal suppositories, eye drops and an injection solution. The active element is sodium diclofenac, the content of which in enteric tablets is 25 or 50 mg. 1 ml of solution contains 25 mg of active ingredient.

Ointment "Diclofenac", from which the remedy for inflammation helps, there is 30 mg of the active ingredient. Better absorption of the drug (depending on the form) is facilitated by: starch, sodium metabisulphite, dimethyl sulfoxide, indoresin, benzene alcohol, macrogol, calcium phosphate, magnesium stearate, water for injection and other substances. Rectal suppositories (25, 50 and 100 mg) are often used in the treatment of pathologies of the reproductive system.

The ointment is available in 30 g aluminum tubes in a cardboard box with detailed instructions attached.

Pharmacological properties

The effect of the drug is manifested as a result of slowing down cyclooxygenase with diclofenac sodium, which helps to reduce the amount of prostaglandins in the area of inflammation. After application, the drug is resorbed without residue, reaching a maximum concentration after 2 hours. In terms of anti-inflammatory action and tolerability, the drug "Diclofenac", from which an effective remedy for the treatment of rheumatic pathologies, is significantly superior to indomethacin.

Diclofenac injections are used in the initial stages of diseases accompanied by pain. A stable therapeutic result from the use of injections is observed after 7-14 days. Tablets "Diclofenac" reduce swelling and pain in the joints during movement and rest.

The drug "Diclofenac": what helps

The drug does not affect the causes of the disease, eliminates only its pain symptoms, reduces the inflammatory process. Diclofenac tablets and suppositories are prescribed for the treatment of pain during the following ailments:

oncology;
ankylosing spondylitis;
sciatica;
adnexitis;
lumbago;
arthritis of various types;
algomenorrhea;
tonsillitis;
radiculitis;
osteoarthritis;
pain with flu and colds;
ossalgia;
tendovaginitis;
myalgia;
pharyngitis;
neuralgia;
migraine;
bursitis;
otitis;
arthralgia;
headache and toothache;
inflammation and pain after injuries and operations.

What helps "Diclofenac" injections

A solution for injection into muscle tissue is used for short-term therapy of pain of various origins, intensity and nature in case of ailments of the musculoskeletal organs, pelvic inflammation, and intervertebral hernia. Diclofenac injections are prescribed for:

rheumatism of soft tissues;
all types of arthritis;
adnexitis;
neuralgia;
osteoarthritis of the spine and joints;
algomenorrhea;
sciatica;
lumbago.

Ointment "Diclofenac" - from what

The medication helps with:

arthritis;
ankylosing spondylitis;
osteoarthritis;
rheumatic lesions;
muscle pain;
soft area injuries.

Eye drops

This form of the drug "Diclofenac" is used for therapy:

post-traumatic inflammation of the cornea;
photophobia after keratotomy;
keratoconjunctivitis;
corneal erosion;
conjunctivitis and other eye ailments.

The drug "Diclofenac": instructions for use

Tablets are drunk without chewing, with a sufficient amount of liquid half an hour before meals, which guarantees a quick therapeutic effect. It is acceptable to use the product after or during a meal. Adult patients and adolescents after 15 years of age "Diclofenac" instructions for use recommends taking in the amount of 25 - 50 mg up to 3 times a day. Do not exceed the daily dose - 150 mg. After improvement of the condition, maintenance treatment is prescribed at 50 mg per day.

Diclofenac injections are made into muscle tissue, deeply injected. A single volume for adults reaches 75 mg. You can repeat the injection no earlier than 12 hours later. Treatment is carried out for 2 days, then they switch to the use of tablets.

Rectal suppositories are administered 2-3 times a day. The daily dose reaches 150 mg. With prolonged use, the volume of the drug reaches 100 mg. For children after 14 years of age, Diclofenac suppositories are administered twice a day in a volume of 50 mg for 1 procedure.

The ointment is applied in a thin layer on the inflamed painful area up to 4 times a day. A day is enough to use 2-4 g of gel. Eye drops are injected into the conjunctival sac 5 times for 3 hours before surgery, 1 drop, after the procedure - 3 times. The scheme of treatment of other diseases - 1 drop up to 5 times a day. Treatment continues up to a month.

Contraindications

It is forbidden to use the medication for:

hypersensitivity to the composition;
inflammation of the digestive organs;
aspirin asthma and the triad;
ulcers, bleeding and ulcerations of the intestines and stomach;
pronounced deviations in the work of the liver, heart muscle and kidneys;
after recently performed coronary artery bypass grafting;
children under 6 years old;
during pregnancy and breastfeeding.

Ointment and gel "Diclofenac" can not be used for damage to the integrity of the skin, suppositories - for proctitis. Tablets for children and suppositories are prescribed only from the age of 14. In this case, the forms of the drug, in which 100 mg of the active substance is present, can only be taken by adult patients.

Side effects

The drug can provoke the following negative reactions of the body:

dyspepsia;
ulcers, bleeding and erosion of the digestive organs;
dizziness;
drowsiness;
irritability;
burning at injection sites.

Price and analogues

"Diclofenac" can be replaced by the following drugs: "", "Diklak", "", "Nise", "Nurofen", "Adolor", "Finalgel", "Ketonal", "Ketorol", "". You can buy injections for 40 - 60 rubles, ointment - 45 - 70 rubles. The price of Diclofenac tablets starts from 15 rubles, candles - from 80 rubles. You will have to pay 45 rubles for eye drops.

Vacation and storage conditions

Release forms for external use are dispensed without a prescription, tablets and solution - by prescription.

Store in a dark, dry place out of the reach of children at temperatures up to 25°C. Best before date:
Enteric-coated tablets and eye drops - 3 years;
Solution for intravenous administration, rectal suppositories, gel and ointment for external use - 2 years.
After opening the vial, eye drops can be used for 4 weeks.

Patient opinions

Patients about all forms of the drug "Diclofenac" leave positive reviews. This is a really effective remedy that quickly relieves inflammation and pain. Gel, tablets, injections help with bruises, sprains, pain in the back and joints. Negative reviews are associated with side effects that are observed quite often.

Diclofenac (diclofenac) - a new description of the drug, you can see contraindications, indications for use, Diclofenac (diclofenac). Reviews about Diclofenac (diclofenac) -

It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.
Drug: DICLOFENAC
The active substance of the drug: diclofenac
ATX encoding: M01AB05
CFG: NSAIDs
Registration number: P No. 010878/03
Date of registration: 21.10.05
The owner of the reg. Credit: IPCA LABORATORIES Ltd. (India)

Release form Diclofenac (diclofenac), drug packaging and composition.

Enteric coated tablets
1 tab.
diclofenac sodium
50 mg

Long-acting film-coated tablets
1 tab.
diclofenac sodium
100 mg

10 pieces. - non-cell packing contour (2) - packs of cardboard.
10 pieces. - packings without cells contour (10) - packs of cardboard.
Solution for intramuscular injection
1 ml
1 amp.
diclofenac sodium
25 mg
75 mg

3 ml - ampoules (5) - packs of cardboard.
3 ml - ampoules (10) - packs of cardboard.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All the information provided is provided only for familiarization with the drug, you should consult a doctor about the possibility of using it.

Pharmacological action Diclofenac (diclofenac)

NSAIDs, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through the suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits the synthesis of proteoglycan in cartilage.

In rheumatic diseases, it reduces pain in the joints at rest and during movement, as well as morning stiffness and swelling of the joints, and increases the range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory edema.

Suppresses platelet aggregation. With prolonged use, it has a desensitizing effect.

When applied topically in ophthalmology, it reduces swelling and pain in inflammatory processes of non-infectious etiology.

Pharmacokinetics of the drug.

After oral administration, it is absorbed from the gastrointestinal tract. Eating slows down the rate of absorption, while the degree of absorption does not change. About 50% of the active substance is metabolized during the "first pass" through the liver. When administered rectally, absorption is slower. The time to reach Cmax in plasma after oral administration is 2-4 hours, depending on the dosage form used, after rectal administration - 1 hour, intramuscular injection - 20 minutes. The concentration of the active substance in plasma is linearly dependent on the size of the applied dose.

Does not accumulate. Plasma protein binding is 99.7% (mainly albumin). Penetrates into the synovial fluid, Cmax is reached 2-4 hours later than in plasma.

It is largely metabolized to form several metabolites, of which two are pharmacologically active, but to a lesser extent than diclofenac.

The systemic clearance of the active substance is approximately 263 ml/min. T1 / 2 from plasma is 1-2 hours, from synovial fluid - 3-6 hours. Approximately 60% of the dose is excreted as metabolites by the kidneys, less than 1% is excreted unchanged in the urine, the rest is excreted as metabolites in the bile.

Indications for use:

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthrosis, periarthropathies), post-traumatic inflammation of soft tissues and the musculoskeletal system (stretching, bruises). Pain in the spine, neuralgia, myalgia, arthralgia, pain syndrome and inflammation after operations and injuries, pain syndrome with gout, migraine, algomenorrhea, pain syndrome with adnexitis, proctitis, colic (biliary and renal), pain syndrome with infectious and inflammatory diseases of the ENT -organs.

For local use: inhibition of miosis during cataract surgery, prevention of cystoid macular edema associated with removal and implantation of the lens, inflammatory processes of the eye of a non-infectious nature, post-traumatic inflammatory process with penetrating and non-penetrating wounds of the eyeball.

Dosage and method of application of the drug.

For oral administration for adults, a single dose is 25-50 mg 2-3 times / day. The frequency of administration depends on the dosage form used, the severity of the course of the disease and is 1-3 times / day, rectally - 1 time / day. For the treatment of acute conditions or the relief of an exacerbation of a chronic process, IM is used at a dose of 75 mg.

For children over 6 years of age and adolescents, the daily dose is 2 mg / kg.

Externally applied at a dose of 2-4 g (depending on the area of the painful area) to the affected area 3-4 times / day.

When used in ophthalmology, the frequency and duration of administration are determined individually.

Maximum doses: when taken orally for adults - 150 mg / day.

Side effects of diclofenac (diclofenac):

From the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea; in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - a violation of liver function. With rectal administration, in isolated cases, inflammation of the colon with bleeding, exacerbation of ulcerative colitis were noted.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, fatigue; rarely - paresthesia, visual disturbances (vagueness, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremor, mental disorders, depression.

On the part of the hematopoietic system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis.

From the urinary system: rarely - impaired renal function; edema is possible in predisposed patients.

Dermatological reactions: rarely - hair loss.

Allergic reactions: skin rash, itching; when used in the form of eye drops - itching, redness, photosensitivity.

Local reactions: at the site of the / m injection, burning is possible, in some cases - the formation of an infiltrate, abscess, necrosis of adipose tissue; with rectal administration, local irritation, the appearance of mucous secretions mixed with blood, and painful defecation are possible; for external use in rare cases- itching, redness, rash, burning; when applied topically in ophthalmology, a transient burning sensation and / or temporary blurred vision may occur immediately after instillation.

With prolonged external use and / or application to large body surfaces, systemic side effects are possible due to the resorptive action of diclofenac.

Contraindications to the drug:

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, "aspirin triad", hematopoietic disorders of unknown etiology, hypersensitivity to diclofenac and the components of the dosage form used, or other NSAIDs.

Use during pregnancy and lactation.

Use during pregnancy and lactation is possible in cases where the potential benefit to the mother outweighs the potential risk to the fetus or newborn.

Special instructions for the use of diclofenac (diclofenac).

It is used with extreme caution in diseases of the liver, kidneys, gastrointestinal tract in history, dyspepsia, bronchial asthma, arterial hypertension, heart failure, immediately after major surgical interventions, as well as in elderly patients.

With a history of allergic reactions to NSAIDs and sulfites, diclofenac is used only in urgent cases. In the process of treatment, systematic monitoring of liver and kidney function, peripheral blood patterns is necessary.

It is necessary to avoid getting diclofenac in the eyes (with the exception of eye drops) or on mucous membranes. Patients using contact lenses should apply eye drops no earlier than 5 minutes after removing the lenses.

During the period of treatment with dosage forms for systemic use, alcohol is not recommended.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, a decrease in the rate of psychomotor reactions is possible. If visual clarity worsens after using eye drops, you should not drive a car or engage in other potentially hazardous activities.

Interaction of Diclofenac (diclofenac) with other drugs.

With the simultaneous use of antihypertensive drugs with diclofenac, their action may be weakened.

There are isolated reports of the occurrence of seizures in patients taking NSAIDs and antibacterial drugs of the quinolone series at the same time.

With simultaneous use with GCS, the risk of side effects from the digestive system increases.

With the simultaneous use of diuretics, a decrease in the diuretic effect is possible. With simultaneous use with potassium-sparing diuretics, an increase in the concentration of potassium in the blood is possible.

When used simultaneously with other NSAIDs, the risk of side effects may increase.

There are reports of the development of hypoglycemia or hyperglycemia in patients with diabetes mellitus who used diclofenac simultaneously with hypoglycemic drugs.

With simultaneous use with acetylsalicylic acid, a decrease in the concentration of diclofenac in the blood plasma is possible.

Although clinical studies have not established the effect of diclofenac on the action of anticoagulants, isolated cases of bleeding have been described with the simultaneous use of diclofenac and warfarin.

With simultaneous use, an increase in the concentration of digoxin, lithium and phenytoin in the blood plasma is possible.

The absorption of diclofenac from the gastrointestinal tract is reduced with simultaneous use with cholestyramine, to a lesser extent with colestipol.

With simultaneous use, it is possible to increase the concentration of methotrexate in the blood plasma and increase its toxicity.

With simultaneous use of diclofenac may not affect the bioavailability of morphine, however, the concentration of the active metabolite of morphine may remain elevated in the presence of diclofenac, which increases the risk of side effects of the morphine metabolite, incl. respiratory depression.

With simultaneous use with pentazocine, a case of the development of a large convulsive seizure is described; with rifampicin - a decrease in the concentration of diclofenac in the blood plasma is possible; with ceftriaxone - increased excretion of ceftriaxone with bile; with cyclosporine - it is possible to increase the nephrotoxicity of cyclosporine.