Cinnarizine - instructions for use, indications, composition, side effects, analogues and price. Vasodilator drug Cinnarizine: pharmacological characteristics and instructions for use

Atherosclerosis of cerebral vessels, dementia of vascular origin, after a stroke, traumatic brain injury, etc.) and peripheral circulation (for example, trophic ulcers, numbness in the extremities, obliterating endoarteritis, diabetic angiopathy, etc.), as well as kinetosis (seasickness, etc.).

Varieties, names, forms of release and composition of Cinnarizine

• Cinnarizine;
• Cinnarizine-Milve;
• Cinnarizine Sopharma.

The fact is that the production of Cinnarizine was launched back in the USSR. And in the Soviet Union there was no concept of a commercial patented drug with a unique name within the country. This means that different pharmaceutical factories produced the same drugs under exactly the same names using a single technology developed at research institutes. That is, Cinnarizine was produced under the same name both by the Tomsk pharmaceutical factory, and by the Ozone, Biosynthesis, etc. factories.

However, after the privatization of each pharmaceutical plant, it became necessary to register the drug under its own unique name, which would distinguish it and allow you to quickly find out that it was manufactured in a specific factory. To do this, some pharmaceutical factories have registered ordinary Cinnarizine under new unique names, adding an abbreviation from the name of their own enterprise to the word "Cinnarizine". This is how the names "Cinnarizin Sopharma" and "Cinnarizin-Milve" came about. But these drugs are made according to the old technology, and therefore differ from just Cinnarizine only in names.

Since all varieties of the drug are exactly the same drugs, we will use the common name "Cinnarizine" to designate them in the further text of the article.

Cinnarizine is available in a single dosage form - oral tablets. As an active substance, the drug contains cinnarizine, by the name of which the drug itself received its commercial name. Cinnarizine tablets are available in a single dosage - 25 mg of the active substance.

As auxiliary components, Cinnarizine tablets contain the following substances:

• Aerosil 200;
• Microcrystalline cellulose;
• lactose monohydrate;
• Polyvinylpyrrolidone K25;
• wheat starch;
• magnesium stearate.

Cinnarizine tablets are round, biconvex, white or almost white in color and are available in packs of 50 or 56 pieces. The tablets are quite large - their size reaches 7 mm in diameter.

What is the drug prescribed for? (therapeutic action)

Due to the expansion of the lumen of small vessels, blood flow through them is facilitated, which, in turn, leads to a significant improvement in microcirculation and blood supply to peripheral tissues with oxygen and nutrients. It is due to the expansion of the lumen of small vessels that Cinnarizine improves the blood supply to the brain, kidneys and limbs. Also, the drug reduces blood viscosity and increases the elasticity of erythrocyte membranes, which also improves the blood supply to peripheral tissues, in which numerous small vessels pass.

The effect of relaxation of blood vessels, which arose under the action of Cinnarizine, is not eliminated by biologically active substances that usually have a pronounced vasoconstrictive effect, such as adrenaline, norepinephrine, dopamine, angiotensin and vasopressin.

In addition, Cinnarizine has a moderate antihistamine activity, due to which it reduces the excitability of the vestibular apparatus and the tone of the sympathetic nervous system. Also, the drug enhances the resistance of tissues to oxygen starvation (hypoxia).

Summarizing the above, we can conclude that Cinnarizine improves cerebral and peripheral circulation, reduces the excitability of the vestibular apparatus and increases the resistance of tissues to oxygen starvation. That is why Cinnarizine is effective in the treatment of cerebrovascular insufficiency, cerebral atherosclerosis, focal post-stroke changes, as well as to improve peripheral circulation in various diseases, including endarteritis, Raynaud's syndrome, diabetic angiopathy, coronary artery disease, etc.

Cinnarizine - indications for use

2. Cerebral circulation disorders:

• Post-stroke focal disorders;
• Atherosclerosis of cerebral vessels;
• The period of rehabilitation after a traumatic brain injury;
• Encephalopathy;
• Senile vascular dementia (dementia).

4. Prevention of kinetosis (sea and air sickness).

5. Prevention of migraine attacks.

6. Peripheral circulatory disorders (prevention and treatment):

• "Intermittent" lameness;
• Raynaud's disease;
• Diabetic angiopathy;
• Trophic or varicose ulcers;
• Obliterating endarteritis;
• thromboangiitis obliterans;
• Nonspecific aorto-arteritis;
• Leriche's syndrome;
• Paresthesia (sensation of crawling, tingling, numbness, etc.);
• Night spasms of arms and legs;
• Cold extremities;
• Acrocyanosis.

Therapeutic action, indications for use - video

Cinnarizine - instructions for use

How to use?

The dosage of Cinnarizine depends on the disease or condition for which the drug is being taken. Adults and adolescents over 12 years of age should take the drug in the following dosages for various diseases:

• With disorders of cerebral circulation , chronic cerebrovascular insufficiency and migraines Cinnarizine should be taken at 25-50 mg (1-2 tablets) 3 times a day;
• In case of violations of the vestibular apparatus Cinnarizine should be taken 25 mg (1 tablet) 3 times a day;
• For the prevention of kinetosis (sea and air sickness) Cinnarizine 25 mg (1 tablet) should be taken half an hour before the start of a trip or flight. If necessary, during the trip or flight, you can take Cinnarizine every 6 hours;
• With disorders of the peripheral circulation Cinnarizine should be taken at 50-75 mg (2-3 tablets) 3 times a day.

The maximum allowable daily dosage of Cinnarizine for adults and adolescents over 12 years old is 225 mg, which is equivalent to 9 tablets, and for children 5 to 11 years old, respectively, 112.5 mg (4.5 tablets).

Cinnarizine therapy is long-term, and the course of treatment usually lasts from several weeks to 2 to 3 months. The duration of therapy in each case is determined individually by the doctor based on the condition of the person, as well as the dynamics of improvements.

Courses of therapy for disorders of cerebral and peripheral circulation are periodically repeated throughout a person's life, maintaining intervals between them of at least 1 month.

Use during pregnancy and breastfeeding

special instructions

People prone to lowering blood pressure should constantly monitor the value of their pressure during the entire period of use of Cinnarizine.

Cinnarizine can cause irritation of the gastric mucosa and is therefore recommended to be taken after meals to reduce the chance of stomach discomfort.

Cinnarizine can provoke false-positive doping tests in professional athletes.

With prolonged use, you should regularly (1 time in 1 - 2 weeks) monitor the condition of the liver, kidneys and peripheral blood. To do this, it is necessary to take a blood test to determine the activity of AST, ALT, alkaline phosphatase (AP), as well as the concentration of urea and creatinine. In addition, in the general blood test, it is imperative to calculate the leukoformula.

Since Cinnarizine has an antihistamine effect, skin allergy tests performed while taking it may be false negative. Therefore, before conducting allergy tests, Cinnarizine should be canceled 4 days before the study.

Influence on the ability to control mechanisms

Overdose

• Drowsiness;
• Tremor;
• Hypotension (strong decrease in blood pressure);

Compatibility with other drugs

• Alcohol, including as part of other drugs;
• Sedatives (valerian, Novo-Passit, Validol, Corvalol, etc.);
• Antihypertensive agents (Anaprilin, Metoprolol, Nifedipine, Verapamil, Captopril, Losartan, Aldefan, etc.);
• Vasodilators (Eufillin, Actovegin, Trental, Berlition, Vinpocetine, Piracetam, etc.);
• Nootropics (Piracetam, Oxiracetam, Meclofenoxate, Biotredin, Aminalon, Picamilon, Idebenone, Cortexin, Cerebrolysin, etc.);
• Tricyclic antidepressants (Imipramine, Desipramine, etc.);
• Hypnotics (Nitrazepam, Flurazepam, Zaleplon, Doxylamine, Melatonin, Zolpidem, Zopiclone, etc.).

Cinnarizine reduces the effect of drugs for the treatment of low blood pressure (for example, Mezaton, Digoxin, Angiotensinamide, Cordiamin, etc.).

The effect of Cinnarizine itself is reduced when taken simultaneously with phenylpropanolamine.

Cinnarizine for children

As a rule, Cinnarizine is prescribed to children in order to improve the blood supply to the brain, in order, as doctors say, to "feed the brain." This wording usually means the desire to improve the development of the child, that is, to help him quickly master speech, acquire a good concentration of attention, memory, quick wits, coordination of movements, etc. In addition, the drug is prescribed for recovery after a traumatic brain injury or to eliminate the insufficiency of cerebral blood supply.

Among the indicated reasons for the use, only two are justified - this is the elimination of cerebral circulatory insufficiency and recovery after a traumatic brain injury. The remaining options for the use of Cinnarizine "for nourishing the brain" of a normal healthy child are nothing more than an extra burden on his body with a dubious effect. Remember that the development of the brain is provided not by drugs that improve blood circulation, but by a variety of activities and games.

But it is impossible to use the drug routinely, for healthy children, since there is a desire to "improve brain nutrition". With this "feeding" parents are trying to accelerate the development of the child and make him smarter, which is simply impossible. And the appointment of Cinnarizine with similar goals is just a myth. Remember that the intelligence and abilities of a child are determined mainly by his genetics, and if the mother and father, roughly speaking, are not Einsteins, then the child is also unlikely to be a genius. After all, if a child has inherited average intelligence from his parents, then no drugs, including Cinnarizine, designed to "feed the brain", will not make him a genius, or at least a person with abilities above the average level. Therefore, if the baby does not lag behind in development and does not have cerebrovascular insufficiency, it is not necessary to use Cinnarizine.

Of course, if a child lags behind in development, he needs not only classes in special programs, but also drug therapy aimed at improving the functioning of his brain and, accordingly, accelerating the assimilation of new material. In such situations, Cinnarizine can indeed be useful.

That is why it is recommended to use Cinnarizine only if there are indications indicated in the official instructions for use, and not on the basis of dubious goals like “brain nourishment”, etc. After all, Cinnarizine is not only useless when not used according to indications, but also quite dangerous, since it can cause severe side effects, such as lowering blood pressure, impaired kidney and liver function, drowsiness and extrapyramidal disorders (tics, tremor, difficulty maintaining balance and etc.).

Cinnarizine for babies

For example, tremors, the so-called increase in muscle tone in infants, crossing the legs during support, Graefe's symptom (rolling eyes), bulging eyes, walking on tiptoe, trembling of the baby when viewed in a cold room or his lethargy when overheated, as well as a number of others conditions diagnosed by neurologists as pathology are actually variants of the norm. And in all these conditions, Cinnarizine is often prescribed, supposedly to improve the blood supply to the brain and eliminate these "pathologies". In fact, there is no pathology, and all these symptoms will pass in the child on their own, without any treatment.

Also, such conditions as expansion of the interventricular fissure, accumulation of fluid in the ventricles of the brain, "hydrocephalic syndrome", "increased intracranial pressure", etc., detected in infants massively during instrumental studies (ultrasound, ECHO-EG, computer tomography, etc.). The fact is that a wide interventricular gap and fluid in the ventricles is the norm, not only for children, but also for adults. The disease "hydrocephalic syndrome" does not exist, and if the child has hydrocephalus, then this is an indication for hospitalization and treatment in a hospital. Increased intracranial pressure in an infant is a life-threatening condition, and therefore requires urgent hospitalization.

Remember that the data of any examinations cannot be considered in isolation from clinical manifestations. And with regard to infants, the following rule is true - no examination data indicate pathology if the development of the child corresponds to the age norm, since a real pathology of the central nervous system will lead to a developmental delay.

Thus, it is obvious that almost all non-existent neurological "pathologies" are variants of the norm, which means that they do not need to be treated with any drugs, including Cinnarizine. And in the presence of really severe pathologies of the central nervous system, therapy with only Cinnarizine, even if carried out for a long time, will not help, since in such cases other qualified treatment is necessary, often in a hospital setting.

That is why it is not recommended to give Cinnarizine to infants with doubtful, non-existent and unconfirmed diagnoses. If there is a suspicion of a neurological disease, then the diagnosis is made only on the basis of several examinations separated in time by at least 2 months. Since if the "symptoms" have completely disappeared in 2 months or their severity has decreased, then we are talking about a variant of the norm, and the child does not have a suspected pathology. If the symptoms persist, then an additional examination is carried out and a diagnosis is made, for example, epilepsy, cerebral palsy, etc. And in this case, complex treatment is necessary, and only Cinnarizine will not be able to cope with the disease.

However, if parents, despite the above arguments, give babies Cinnarizine, you should carefully observe the movements of the baby. If movement disorders appear (tics, tremors, wave-like movements of the fingers, leg movements, as if a child is sitting on a motorcycle and pressing the gas pedal, etc.), then Cinnarizine should be canceled immediately.

• Celiac disease (gluten enteropathy);
• Lactase deficiency, galactosemia or glucose-galactose malabsorption syndrome.

Cinnarizine - analogues

Synonyms of Cinnarizine on the pharmaceutical market of the countries of the former USSR are the following drugs:

• Vertizin tablets;
• Stugeron tablets and capsules;
• Cinedil tablets;
• Cinnaron tablets;
• Cinnasan capsules.

• asniton tablets;
• Betaver tablets;
• betahistine tablets;
• Betahistine-SZ tablets;
• Betacentrin tablets;
• Denoise tablets;
• Microzer tablets and drops for oral administration;
• Neuroximet tablets;
• Neurotropin solution for injection;
• Mexidol tablets and solution for injection;
• Memorin oral solution;
• Tanakan tablets and oral solution;
• Cerebrovital capsules;
• Enerion tablets.

The drug "Cinnarizine" has a mild vasodilating property, which allows it to be used as part of a complex treatment for high blood pressure. A popular medication not only effectively reduces high blood pressure, but also copes with various types of encephalopathy. You can take "Cinnarizine" only after consulting with a specialized physician, as well as after studying the attached instructions.

Composition and properties

Medication "Cinnarizine" contains the following components:

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• cinnarizine;
• milk sugar;
• potato starch;
• food emulsifier E572;
• aerosil;
• povidone.

The medicine provides cerebral blood circulation, helps to restore the constant movement of blood during vasospasm, and also relieves a person from headaches, nausea, and bad mood. "Cinnarizine" restores elasticity to the vessels and lowers the viscosity of the blood fluid, by minimizing the accumulation of K ions in them. The vasodilating property of the drug is due to the enrichment of the blood with carbon dioxide, which prevents narrowing of the lumen of the vessels, and leads to a decrease in high pressure indicators. As a result of the use of the described drug in the human body, the following changes are observed:

• blood is thinned by increasing the plasticity of erythrocytes;
• blood vessels expand;
• a mild sedative effect is manifested;
• all parts of the brain are supplied with blood;
• relieves spasms;
• exhibits a mild antihistamine effect.

Indications and contraindications

Side effects

Taking the drug "Cinnarizine" can cause such negative effects:

• increased fatigue;
• drowsiness;
• headache;
• tremor of the limbs;
• dryness in the mouth;
• increased muscle tone;
• abdominal pain;
• disorders of the digestive system;
• excessive sweating;
• rashes on the dermis;
• yellowness of the skin;
• lowering blood pressure;
• weight gain.

Mode of application

The vasodilator medication "Cinnarizine" is prescribed by the doctor individually for each patient, depending on the diagnosis and his well-being. The usual dosage is 25-75 mg three times in 24 hours. It is recommended to take the medicine after or before a meal. It is important to swallow the tablets whole, without chewing or crushing, but it is better to drink a glass of water. To achieve greater efficiency, treatment with "Cinnarizine" should be continuous until the therapeutic effect occurs. The advantage of the drug is the possibility of its use for a long time, sometimes treatment can last more than 3 months.

To stop vasospasm, improve blood flow to the brain, appoint 25-50 mg three times a day. To normalize the peripheral blood circulation, it is recommended to drink 50-75 mg of the substance per day. "Cinnarizine" lowers blood pressure, if you take it 1-2 tablets 2-3 times a day for a month, or even longer. A more accurate dosage is prescribed by the attending physician.

Features of the use of "Cinnarizine" at high pressure

In childhood

Small patients from 5 to 11 years old are prescribed "Cinnarizine" at a dosage 2 times less than an adult. The maximum allowable dose of the drug is 9 tablets / 24 hours. The duration of the therapeutic course is determined on an individual basis, and usually lasts up to 3 months, after which a 30-day break is made and treatment is resumed until the desired effect of the treatment is achieved.

Cinnarizine is a drug that blocks the so-called. "slow" calcium channels, mainly in cerebral vessels. The drug inhibits the process of calcium entry into cells, reduces their concentration in plasma membrane depots, has a relaxing effect on the smooth muscle frame of small arteries, and potentiates the vasodilating effect of carbon dioxide. Directly acting on the smooth muscles of blood vessels, it reduces their sensitivity to biogenic vasoconstrictor compounds (catecholamines). It shows a vasodilating effect (especially in relation to cerebral vessels), while practically not affecting the blood pressure index. Shows the properties of an antihistamine, reducing the reactivity of the vestibular apparatus and sympathetic tone. Cinnarizine is effective in patients with latent cerebrovascular insufficiency, just emerging atherosclerosis of cerebral vessels, chronic vascular diseases and signs of post-stroke focal lesions. In patients with peripheral vascular lesions, cinnarizine improves blood supply to affected organs and tissues (including the heart), and enhances postischemic vasodilation. The drug increases the elasticity of erythrocyte membranes, their deformability, improves the rheological characteristics of the blood, increases the resistance of muscles to oxygen starvation. The maximum concentration of the active substance in the blood after oral administration is reached after 1-3 hours. The drug is completely metabolized by microsomal liver enzymes. The half-life of cinnarizine is 2-4 hours. Excreted by the intestines (most) and kidneys.

Cinnarizine is available in tablets. The drug should be taken after meals. In case of cerebral circulation disorders - 25-50 mg three times a day, in case of circulatory disorders in peripheral vessels - 50-75 mg three times a day, with labyrinth-vestibular dysfunctions - 25 mg three times a day, with kinetosis before the planned trip, adults take 25 mg with the possibility of taking an additional dose after 6 hours, children take half of the indicated dose.

The maximum daily dose of cinnarizine is 225 mg. With increased sensitivity to the drug, the drug course begins with a half dose, gradually increasing it until an optimal therapeutic response is obtained. The duration of pharmacotherapy varies from 2-3 weeks to several months. At the initial stage of treatment, you should stop taking ethanol in any form. Due to the presence of antihistamine activity in cinnarizine, the drug can give a positive result in a doping test in athletes, as well as mask the positive reactions of diagnostic skin tests (in this regard, treatment should be interrupted 4 days before the study). During prolonged drug courses, it is recommended to periodically monitor the functional parameters of the liver and kidneys, as well as the picture of peripheral blood. Patients suffering from Parkinson's disease should be given cinnarizine with extreme caution. The drug potentiates the action of ethanol, sedatives and antidepressants. When used together with nootropics, vasodilators and antihypertensives, cinnarizine enhances their effect. The drug plays a particularly important role in geriatric practice. Progressive cerebrovascular insufficiency with age interferes with the normal blood supply to brain tissues, resulting in the gradual death of brain neurons. One of the reasons on which the severity of disorders of brain functions depends is atherosclerotic vascular changes. In some cases, this factor begins to play a decisive role, as, for example, in senile dementia. The goal of treating elderly patients is to slow down age-related structural and functional changes. Given the direct effect of cinnarizine on the vessels of the brain, it is one of the most prescribed drugs for patients of this profile.

Pharmacology

Cinnarizine is a selective blocker of "slow" calcium channels, reduces the entry of calcium ions into cells and reduces their concentration in the depot of plasma membranes, reduces the tone of the smooth muscles of arterioles, and enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, reduces their response to biogenic vasoconstrictor substances (adrenaline and norepinephrine). It has a vasodilating effect (especially in relation to cerebral vessels), without significantly affecting blood pressure. Shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. It is effective in patients with latent cerebrovascular insufficiency, initial atherosclerosis of the cerebral vessels and chronic diseases of the cerebral vessels with post-stroke focal symptoms. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including myocardium), and enhances postischemic vasodilation. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity. Increases muscle resistance to hypoxia.

Pharmacokinetics

Cmax in plasma is achieved after ingestion after 1-3 hours. Communication with plasma proteins is about 91%. Completely metabolized in the liver by dealkylation. T 1/2 - 4 hours. It is excreted in the form of metabolites: 1/3 - by the kidneys, 2/3 - by the intestines.

Release form

Tablets white or white with a creamy tint, flat-cylindrical, with a chamfer.

Excipients: aerosil, calcium stearate, potato starch, lactose, low molecular weight medical polyvinylpyrrolidone.

50 pcs. - cans (1) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.

Dosage

Inside, after eating. In violation of cerebral circulation - 25-50 mg 3 times a day; with violations of peripheral circulation - 50-75 mg 3 times a day; with labyrinth disorders - 25 mg 3 times a day; with sea and air sickness, before the upcoming trip for adults - 25 mg, if necessary, the dose is repeated after 6 hours. Children are prescribed half the dose for adults. The maximum daily dose should not exceed 225 mg.

With high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually. The course of treatment is from several weeks to several months.

Overdose

Symptoms: vomiting, drowsiness, tremor, excessive decrease in blood pressure, coma. In case of an overdose, there is no specific antidote, it is necessary to do a gastric lavage and take activated charcoal.

Treatment: symptomatic.

Interaction

Pharmaceutical: Chemical incompatibilities are not known.

Pharmacodynamic: Enhances the effect of alcohol, sedatives and antidepressants. When used simultaneously with nootropic, antihypertensive and vasodilators, it enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, it reduces their effect.

Pharmacokinetic: no data available.

Side effects

From the nervous system: drowsiness, fatigue, headache, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia), depression.

From the digestive system: dry mouth, pain in the epigastric region, dyspepsia, cholestatic jaundice.

On the part of the skin: increased sweating, lichen planus (extremely rare).

Allergic reactions: skin rash.

Others: decrease in blood pressure, weight gain, development of a lupus-like syndrome.

Indications

• the period of convalescence after an ischemic and hemorrhagic stroke, traumatic brain injury;
• encephalopathy;
• labyrinthine disorders (including maintenance therapy for dizziness, tinnitus, nystagmus, nausea, vomiting of labyrinthine origin);
• migraine (prevention of attacks);
• Meniere's disease;
• sea ​​and air sickness (prevention);
• peripheral circulatory disorders (prevention and treatment) - obliterating endarteritis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders, trophic and varicose ulcers, preganrenous conditions, paresthesia, night spasms and coldness in the extremities.

Application for violations of kidney function With prolonged use, it is recommended to conduct a control examination of kidney function.

Use in children

special instructions

At the beginning of treatment, you should refrain from taking ethanol.

Due to the presence of an antihistamine effect, cinnarizine can affect the result of the study during anti-doping control of athletes (false positive result), as well as neutralize positive reactions during diagnostic skin tests (treatment should be canceled 4 days before the study).

Influence on the ability to drive vehicles and control mechanisms.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Cinnarizine is a powerful drug that blocks calcium channels (blocker). It is widely used for the treatment and prevention of various circulatory disorders of the brain.

It perfectly dilates blood vessels, increases resistance to hypoxia, reduces blood viscosity, without lowering blood pressure. It reduces the excitability of the vestibular apparatus and the nervous system, has the ability to positively affect peripheral blood circulation and improve brain activity by improving the supply of oxygen to cells and tissues.

The drug gives a slight antispasmodic effect, acting on the vessels, reducing their response to nutrients. It has an antihistamine effect, suppressing the increased activity of the eyeballs. Does not affect heart rhythms and conduction (coronary tone). Improves well-being, relieves headaches and tinnitus.

Why is cinnarizine prescribed, indications for use

It is prescribed as a cerebrovascular and nootropic agent. Most in demand for:

Adverse effects associated with brain injury (concussion), vomiting, nausea, dizziness, encephalopathy;
cervical osteochondrosis, atherosclerosis;
disturbances in thinking (decreased concentration and / or memory loss);
meniere's disease;
nystagmus;
vestibular disorders;
headache, migraine;
circulatory disorders, ischemic disease etc.

Composition, cost

The tablets contain 25 mg of the active substance of the same name, as well as: magnesium, lactose, cellulose, polyvinylpyrrolidone, aerosil, corn starch, etc. These substances have an auxiliary effect. For manufacturers of different companies, the concentration and composition may vary slightly, so we recommend that you carefully read the annotation for the drug, the composition is usually indicated in Latin.

The price of a medicine depends on several factors: the region and markups in pharmacies, but on average in Russia the cost ranges from 30 to 50 rubles. Release form - tablets (50 pieces per pack)

Analogues are cheap

You can replace cinnarizine with drugs similar in mechanism of action or synonyms (similar composition with different concentrations):

Vinpocetine;
cavinton;
betahistine;
glycine;
nimodipine;
mexidol;
Phezam;
cerebrolysin;
picamilon;
vasebral;
stearate;
betaserk;
nootropil etc.

Stugeron or cinnarizine which is better?

Stugeron differs from cinnarizine: pricing policy (imported production dictates its cost), fewer side effects and the quality of raw materials. In general, these are interchangeable drugs. By the way, cinnarizine is banned in the USA, experts have long preferred to replace it with softer analogues with regard to the negative impact.

Cinnarizine or Piracetam?

These drugs are not analogues, rather complement each other's effectiveness, so cinnarizine is often prescribed and used in combination. A joint course is also possible with Phezam and other drugs of the same pharmacological group, however, the appointment is made exclusively by doctors.

Instructions for use cinnarizine

Children over 12 years of age and adults take the tablets after meals with plenty of liquid. It is prescribed for oral administration of 1 tab. three times a day. In some cases, 2-3 tablets are prescribed at a time. The maximum dose is 9 tablets (225 mg) per day. The course of admission and how to drink it are controlled by doctors.

For children, babies, newborns

The instructions for the drug indicate that the appointment of children under 5 years of age is not recommended. Therefore, experts prefer a wide range of diuretics. However, in rare cases, specialists take a risky step, mainly if the risks are justified by a complex diagnosis and write a prescription for children under one year old.

Cinnarizine instructions for use injections in ampoules

The release form of the drug is tablets. Other forms (ampoules, injections, capsules, etc.) are not provided by the manufacturer.

Cinnarizine sopharma instructions for use

The instructions for use do not depend on the manufacturer: sopharma, avexima, forte plus, etc. But in any case, we do not recommend self-medicating and contacting a specialist for an appointment and strictly follow his recommendations. Only he can increase or, on the contrary, reduce the amount of the drug, replace it with other means, or completely stop treatment, etc.

Cinnarizine is a drug that positively affects the blood circulation system of the cerebral, coronary, peripheral zones, improves microcirculation processes.

Normalizes the supply of cellular tissue with oxygen, increases hypoxic resistance. Increases the plasticity of erythrocytes, has a thinning effect on the blood. Actively reduces the spasmodic effects of blood vessels, reduces the results of their response to narrowing drugs.

During the use of the drug, there is a removal of spasms of the smooth muscles of the vessels and a decrease in their susceptibility to drugs, as well as other substances that have vasoconstrictive effects. There is also a slight blocking of histamine receptors (located mainly in the central nervous system).

Clinical and pharmacological group

Calcium channel blocker with a predominant effect on the vessels of the brain.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Cinnarizine cost in pharmacies? The average price is at the level of 55 rubles.

Composition and form of release

Dosage form of Cinnarizine - tablets: round, flat-cylindrical, with a chamfer, marked R on one of the sides (or without it); color - from white to white with a creamy tint (10 pcs in blister packs, in a cardboard bundle 1-5 or 10 packs; 10, 20, 30, 40, 50 or 100 pcs in polymer / orange glass jars, in a cardboard box 1 bank).

1 tablet contains:

• active ingredient: cinnarizine - 25 mg;
• auxiliary components: lactose, calcium stearate, povidone, aerosil, potato starch, vaseline oil.

Pharmacological effect

Cinnarizine improves peripheral and cerebral circulation by blocking calcium channels. Treatment with this drug promotes the expansion of cerebral vessels without causing a decrease in blood pressure. Instructions for use Cinnarizine describes in detail the pharmacological properties of the drug. The drug also lowers the excitability of the vestibular apparatus and the tone of the nervous system. The highest concentration of the drug is observed 2-3 hours after ingestion.

The drug actively inhibits the flow of calcium ions into the cells of the body. This increases the ability of erythrocytes to plasticity and significantly reduces blood viscosity. The lack of oxygen supply to tissues stops, which contributes to a significant improvement in the general well-being of a sick person. The drug effectively relieves spasms, having an antispasmodic effect on the vessels and reducing their response to nutrients. Does not affect the conduction of the heart and heart rate. The drug also has an angistaminic activity and suppresses the involuntary movement of the eyeball.

By itself, this drug is a white tablet, each of which contains 25 mg of cinnarizine. The composition of the drug also includes lactose monohydrate, wheat starch, magnesium stearate, microcrystalline cellulose, aerosil, polyvinylpyrrolidone. These substances are auxiliary.

Indications for use

What helps? Indications for Cinnarizine are the following ailments:

1. Nystagmus.
2. Problems with concentration.
3. Decrease or loss of memory.
4. Prevention of kinetosis (air and sea sickness).
5. Circulatory disorders in the brain (, dyscirculatory encephalopathy, atherosclerosis, consequences and craniocerebral injuries).
6. Violation of peripheral circulation (syndrome of "intermittent" claudication, diabetic angiopathy, thrombophlebitis).
7. Noise in the ears of a labyrinthine origin, nausea or vomiting.
8. Senile dementia.
9. Meniere's disease.
10. Violation of thinking.
11. Prevention of migraine attacks.

Another indication for Cinnarizine is the symptomatic treatment of cerebrovascular pathologies, which are accompanied by dizziness, headaches, tinnitus and bouts of irritability.

Contraindications

Absolute:

• pregnancy and breastfeeding (lactation);
• children's age up to 5 years;
• increased individual sensitivity to cinnarizine and other components of the drug.

Relative contraindications: the drug is taken with caution in Parkinson's disease.

Appointment during pregnancy and lactation

For lactating women, it is allowed to take the drug after refusing to breastfeed. The decision on the possibility of taking Cinnarizine by pregnant women is made by the attending physician after a thorough assessment of the potential benefits and possible risks.

Cinnarizine for children

In pediatric practice, Cinnarizine for children is allowed from the age of over 5 years. Some pediatricians may prescribe the use of tablets for babies under this number, because there is a positive experience of treatment without side effects. Also, under the influence of the drug, the child's condition improves. Indications for the use of the drug are circulatory disorders of the brain, developmental delay in terms of mastering speech, good concentration, memory, coordination of movements, quick wits.

The instruction allows the use of the drug for children with craniocerebral injuries, to eliminate circulatory failure in the brain. It is considered a gross mistake to use the drug by parents to increase the intellectual abilities of the child or for "feeding". Cinnarizine is not capable of this, and its use without indications threatens with the manifestation of side effects (lowering pressure, disruption of the liver and kidneys, tremor).

Dosage and method of application

As indicated in the instructions for use, Cinnarizine is administered orally, after meals.

1. in violation of cerebral circulation - 25-50 mg 3 times a day;
2. with violations of peripheral circulation - 50-75 mg 3 times a day;
3. with labyrinth disorders - 25 mg 3 times a day;
4. with sea and air sickness, before the upcoming trip for adults - 25 mg, if necessary, the dose is repeated after 6 hours.

Children are given half the adult dose.

The maximum daily dose should not exceed 225 mg.

With high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually. The course of treatment is from several weeks to several months.

Adverse reactions

The use of the drug may cause side effects in humans. In the instructions for use, negative reactions are highlighted:

• Parkinson's syndrome, depression;
• pressure drop, hypertension;
• increased sweating, lupus-type reactions, lichen planus;
• allergic reactions: urticaria, itching, skin rash, irritation;
• weight gain;
• discomfort in the stomach, intestines, dry mouth, abdominal pain, cholestatic jaundice, dyspepsia (constipation, belching, bloating, diarrhea);
  drowsiness, headaches, increased fatigue, dyscirculatory tics, wave-like movements of the fingers, tremor of the extremities, imbalance, increased muscle tone, disorientation.

Overdose

An overdose of Cinnarizine is possible and is manifested by the following symptoms:

1. Vomit;
2. Drowsiness;
3. Tremor;
4. Hypotension (strong decrease in blood pressure);
5. Coma.

If signs of an overdose of Cinnarizine appear, the stomach should be washed and a sorbent should be taken within an hour (for example, activated charcoal, Polyphepan, Polysorb, Filtrum, Enterosgel, etc.). After that, symptomatic therapy is carried out, aimed at maintaining the normal functioning of vital organs and systems.

special instructions

At the beginning of treatment, you should refrain from taking ethanol.

Due to the presence of an antihistamine effect, cinnarizine can affect the result of the study during anti-doping control of athletes (false positive result), as well as neutralize positive reactions during diagnostic skin tests (treatment should be canceled 4 days before the study).

Compatibility with other drugs

Cinnarizine enhances the effect of nootropics, sedatives, vasodilators, antihypertensives, ethanol. Reduces the effective effect of hypertensive drugs.