Tanakan contraindications side effects. Tanakan heals the vascular and nervous systems of the body. Interaction with other drugs

Composition per 1 tablet

Active ingredient:

Ginkgo biloba extract standardized (EGb 761):

24% Ginkgo heterosides and

6% ginkgolides-bilobalides 40,000mg

Excipients:

Lactose monohydrate 82,500mg

Cellulose microcrystalline 50,000mg

Corn starch 37,000mg

Silicon dioxide 28,000mg

colloidal anhydrous

Talc 11,250mg

Magnesium stearate 1,250mg

Total: 250,000 mg

shell

Macrogol 400………………………………………………………………………… 1,500 mg

Hypromellose 6,000mg

Macrogol 6000 1,500mg

Titanium dioxide 1.025mg

Iron oxide red 0.650mg

Total weight: 260.675 mg

Description

round, biconvex, red-brown film-coated tablets.

Pharmacotherapeutic group

INN: Ginkgo folium

ATC code: N06DX02. Other drugs for the treatment of dementia.

Pharmacodynamic properties

The mechanism of action of the drug has not been established.

In clinical studies of a standardized extract of ginkgo biloba, increased cerebral activity was demonstrated according to electroencephalogram data, a decrease in blood viscosity and platelet aggregation, an increase in perfusion in certain areas of the brain in healthy individuals aged 60-70 years. Vasodilating effects were also found in the study of the blood vessels of the forearms, which led to an increase in regional blood flow.

Indications for use

Symptomatic treatment of cognitive disorders in elderly patients, with the exception of patients with a confirmed diagnosis of dementia, Parkinson's disease, cognitive disorders of iatrogenic origin or secondary cognitive disorders due to depression or metabolic disorders.

Dosage and administration

Contraindications

Hypersensitivity to the active substance or to the components of the medicinal product.

Pregnancy.

breastfeeding period.

Children's age up to 18 years.

Special instructions and precautions for use

Before starting the drug, consult your doctor.

With caution, the drug should be prescribed simultaneously with other drugs, the metabolism of which is realized through cytochrome P450-3A4 (CYP3A4).

Since the drug contains lactose, it should not be prescribed to patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or lactase deficiency.

The use of the drug is contraindicated in children and adolescents under 18 years of age due to the lack of sufficient data.

Patients with an increased risk of bleeding (hemorrhagic diathesis), as well as patients taking anticoagulant and antiplatelet agents, should consult a doctor before taking the drug.

Medicines containing ginkgo biloba may increase the risk of bleeding. The drug should be stopped 3-4 days before surgery.

In patients with epilepsy, taking ginkgo biloba preparations can provoke the development of a seizure.

If symptoms persist or worsen while taking the medicine, consult a doctor.

Interaction with other drugs and other forms of interaction

The results of clinical trials of drug interactions of EGb761 with other drugs have demonstrated either an increase or an inhibition of the activity of cytochrome P450 isoenzymes. So the levels of midazolam changed after the introduction of EGb 761, presumably due to their mutual effect on CYP3A4. Ginkgo biloba preparations should be used with caution with drugs metabolized through CYP3A4, as well as with drugs that have a narrow therapeutic index.

Drugs based on ginkgo biloba, when taken simultaneously with anticoagulant agents (for example, phenprocoumon, warfarin) or antiplatelet agents (for example, clopidogrel, acetylsalicylic acid and other non-steroidal anti-inflammatory drugs), can cause a change in their action.

The conducted studies did not reveal the interaction of ginkgo biloba preparations with warfarin, however, when they are taken together, it is recommended to carry out adequate monitoring of blood coagulation parameters at the beginning of the intake, when changing the dose, stopping the intake, or when replacing the ginkgo biloba preparation.

Interaction studies with talinolol have shown that ginkgo biloba preparations can inhibit P-glycoprotein in the gut. This may lead to increased exposure to drugs whose metabolism is dependent on P-glycoprotein, such as dabigatran etexilate. Caution should be exercised when ginkgo biloba and dabigatran are coadministered.

Ginkgo biloba can increase the Cmax of nifedepine (in some individuals up to 100%), which is accompanied by dizziness and increased hot flashes.

Co-administration of ginkgo biloba and efavirenz is not recommended as plasma concentrations of efavirenz may be reduced due to CYP3A4 induction.

In the case of simultaneous use of other medicines, including those sold without a doctor's prescription, you should consult a doctor.

Pregnancy and lactation

Pregnancy

There may be an increased risk of bleeding. The drug is contraindicated in pregnancy.

Lactation

There is no information on the penetration of the components of the drug into breast milk. The drug should not be taken during breastfeeding due to lack of adequate data.

The effect of the drug on the ability to drive vehicles and work with moving mechanisms

Studies on the effect of taking the drug on the ability to drive a vehicle and work with mechanisms have not been conducted.

Side effects

According to the results of a five-year clinical trial conducted to evaluate the efficacy and safety of Tanakan at a dose of 120 mg twice a day in patients over 70 years of age (2-31-00240-011), the most common adverse reactions (> 5%) were abdominal pain , diarrhea and dizziness.

There have been reports of the development of bleeding of various localization (eye, nasal, cerebral, gastrointestinal) while taking ginkgo biloba preparations, their frequency is unknown.

Identified adverse reactions are classified according to the frequency of their occurrence: very often: ≥ 1/10, often: from ≥ 1/100 to

Nervous System Disorders

Common: dizziness, headache, fainting

Immune System Disorders

Common: hypersensitivity reactions, dyspnoea

Uncommon: urticaria

Rare: angioedema

Gastrointestinal disorders

Common: Abdominal pain, diarrhea, dyspepsia, nausea

Skin and subcutaneous tissue disorders

Common: eczema, itching

Uncommon: rash

In the event of adverse reactions, including those not listed in this leaflet, you should stop taking the drug and consult a doctor.

Reporting suspected adverse reactions

Reporting adverse reactions after drug registration is important. This allows continuous monitoring and evaluation of the benefit / risk ratio of the drug. Health care professionals should report all cases of adverse drug reactions through the national reporting system.

Manufacturer

BOFUR IPSEN INDUSTRY

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

Leave conditions:

Without recipe

Package:

Tablets, coated film coated, 40 mg: 30 or 90 pcs.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Tanakan drug

The active components of Tanakan (flavonoid glycosides, bilobaids, terpene substances and gynoclides) are able to have a number of positive effects on the state of the nervous and vascular systems. They affect the metabolic processes in cells, improve blood microcirculation and its rheological properties. The drug has vasomotor properties, improving the tone of all vessels of the body, including the smallest vessels of the brain. The components of Tanakan have anti-edematous and antioxidant effects on the tissues of many organs.

Tanakan is successfully applied in 60 countries of the world.

Release form

Composition of 1 tablet:

• excipients - lactose monohydrate, microcrystalline cellulose, corn starch, silicon dioxide, magnesium stearate.

100 ml of solution contains:

• extract of leaves of ginkgo biloba - 40 mg;
• excipients - sodium saccharinate, orange and lemon flavor, ethanol, purified water.

Instructions for use Tanakan

Indications for use

• Violations of cerebral circulation of various origins (except for Alzheimer's disease and senile dementia);
• decreased visual acuity and visual impairment of vascular origin;
• movement coordination disorders, hearing impairment and dizziness due to vascular pathology;
• consequences of traumatic brain injury and stroke (impaired memory, attention, sleep);
• asthenic conditions caused by trauma or depression of a neurotic or psychogenic nature;
• Syndrome or Raynaud's disease.

Contraindications

• Hypersensitivity to the components that make up the drug;
• age up to 18 years;
• exacerbation of peptic ulcer of the duodenum and stomach;
• exacerbation of erosive gastritis;
• lactose deficiency or intolerance, congenital galactosemia, (for tablets) malabsorption syndrome (malabsorption) of galactose or glucose;
• decreased blood clotting.

Side effects

• allergic reactions - rash, redness, swelling, itching of the skin.
• From the side of the blood - a decrease in blood coagulability, a predisposition to bleeding with prolonged use.
• From the side of the skin - eczema.
• From the digestive tract - abdominal pain, indigestion, diarrhea (diarrhea), vomiting, nausea.
• From the CNS- Headache, dizziness, tinnitus.

Tanakan treatment

The doctor must warn the patient that the tablet form of the drug contains lactose, so Tanakan tablets should not be taken by people with congenital galactosemia, lactase deficiency, glucose or galactose malabsorption syndrome. Such patients are advised to take Tanakan's solution.

While taking an alcoholic solution of this drug, you should be careful when working with complex mechanisms, when engaging in potentially hazardous activities or when driving.

Dosage of Tanakan

• Tablets - 1 tablet 3 times a day, during meals, drinking plenty of water.
• Solution - 1 dose (1 ml), 3 times a day during meals (previously dissolve the dose in 1/2 glass of water).

Tanakan for children

The use of this tool in pediatrics is possible only according to individual indications. Before prescribing Tanakan, a child must undergo a comprehensive neurological examination, including neurosonography and Doppler ultrasound of the brain.

The drug should only be taken under constant medical supervision. The dosage of Tanakan and the duration of its administration in pediatric practice is determined individually: depending on the severity of the disease and the age of the child.

Interaction of Tanakan with other drugs

Trade name of the drug:

International non-proprietary name:

Dosage form:

Compound:

Oral solution 40 mg / ml (composition per 100 ml):
active substance: Ginkgo biloba leaf extract (EGb 761 ®): 24% flavonol glycosides and 6% ginkgolides-bilobalides - 4000.00 mg
Excipients: sodium saccharinate - 500.00 mg, orange flavor - 0.75 ml, lemon flavor - 0.75 mg, ethanol (96%) - 59.00 ml, purified water - up to 100.00 ml.

Description:

The solution is brownish-orange in color with a characteristic odor.

Pharmacotherapeutic group:

Angioprotective agent of plant origin

ATX code:

Pharmacological properties

Pharmacodynamics
A standardized and titrated preparation of plant origin, the action of which is due to the influence on the metabolic processes in cells, the rheological properties of the blood, as well as the vasomotor reactions of blood vessels.
The drug improves the supply of oxygen and glucose to the brain. Normalizes the tone of arteries and veins, improves microcirculation. Helps improve blood flow, prevents erythrocyte aggregation. It has an inhibitory effect on platelet activating factor. Improves metabolic processes, has an antihypoxic effect on tissues. Prevents the formation of free radicals and lipid peroxidation of cell membranes. It affects the release, reuptake and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.
Ginkgolides A and B and bilobalides have an 80% to 90% oral bioavailability. The maximum concentration is reached in 1-2 hours; the half-life ranges from 4 hours (ginkgolide A and bilobalide) to 10 hours (ginkgolide B). The main route of excretion is the kidneys.

Indications for use

• cognitive and neurosensory deficits of various origins (with the exception of Alzheimer's disease and dementia of various etiologies);
• intermittent claudication in chronic obliterating arteriopathy of the lower extremities;
• visual disturbances of vascular origin, a decrease in its sharpness;
• hearing impairment, tinnitus, dizziness and movement coordination disorders, predominantly of vascular origin;
• Raynaud's disease and syndrome.

Contraindications

Age up to 18 years.
Hypersensitivity to any of the components of the drug, erosive gastritis in the acute stage, peptic ulcer of the stomach and duodenum in the acute stage, acute cerebrovascular accident, acute myocardial infarction, pregnancy and lactation, reduced blood clotting.
Carefully
Since the drug in the form of a solution contains 0.45 g of ethyl alcohol per dose (one dose), it should be used with caution in patients with alcoholism, liver diseases, traumatic brain injuries and brain diseases.

Use during pregnancy and during breastfeeding

Due to the lack of clinical experience, data on the use of the drug during pregnancy and during breastfeeding have not been accumulated, and the use of the drug in this group of patients is contraindicated.

Dosage and administration

Inside adults, 1 ml of solution 3 times a day with meals.
Pre-dissolve in ½ glass of water, use the supplied dosing pipette, 1 dose = 1 ml of solution.
The minimum course of treatment is 3-6 months.

Side effect

Not often (> 0.1% -<1%): головная боль, головокружение, тошнота, абдоминальная боль, сыпь, зуд, экзема.
Experience with the drug in routine practice (with a frequency that cannot be estimated based on the available data): allergic reactions (redness, skin rash, swelling, itching), dyspepsia, diarrhea, urticaria, decreased blood clotting and the possibility of bleeding (with prolonged application).
In case of any adverse events, the drug should be discontinued and consult your doctor.

Overdose

Cases of drug overdose are not known.

Interaction with other drugs

In clinical studies with EGb 761, both inhibition and potentiation of cytochrome P450 enzymes have been identified. When EGb 761 was co-administered with midazolam, the level of the latter changed, presumably due to an effect on CYP3A4. Therefore, caution should be exercised when EGb 761 is co-administered with drugs metabolized by CYP3A4.

Since the drug in the form of a solution contains 0.45 g of ethyl alcohol per dose (one dose), it is necessary to avoid simultaneous use with drugs of the following groups due to the possible occurrence of such reactions as hyperthermia, flushing of the skin, vomiting, heart palpitations:

• antibiotics - cephalosporins (cefamandol, cefoperazone, latamoxef);
• gentamicin;
• chloramphenicol;
• disulfiram;
• thiazide diuretics;
• anticonvulsants;
• antidiabetic hypoglycemic agents (chlorpropamide, glibenclamide, glipizide, tolbutamide, metformin (may develop lactic acidosis));
• fungicides (griseofulvin);
• 5-nitroimidazole (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole;
• cytostatics (procarbazine);
• tricyclic antidepressants;
• tranquilizers.

Do not use the drug in patients who systematically use acetylsalicylic acid, warfarin.

special instructions

Before using the drug, a doctor's consultation is necessary. Improvement of the condition is manifested 1 month after the start of treatment.
One single dose contains 0.45 g of ethyl alcohol (57% V / V), in the maximum daily dose - 1.35 g of ethyl alcohol.

Influence on the ability to drive vehicles and mechanisms

During the period of taking the drug, it is not recommended to perform potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms) (since the drug may cause dizziness and contains ethyl alcohol).

Release form

Oral solution 40 mg/ml:
30 ml in a dark glass bottle with a plastic screw cap. The vial and pipette dispenser in a plastic container with a capacity of 1 ml, together with instructions for use, are placed in a cardboard box.

Storage conditions

At a temperature not exceeding 25 ° C, out of the reach of children.

Best before date

3 years.
Do not use after the expiry date stated on the packaging.

Holiday conditions

Released without a prescription.

Manufacturer

Bofur Ipsen Industry
France, 28100 Dreux

If necessary, consumer claims should be sent to the representative office in the Russian Federation:
109147, Moscow, Taganskaya st., 19

Tanakan is a drug with a positive effect on the nervous and vascular systems.

The drug is made on a plant basis. The course of therapy should be started only after discussion with the doctor.

And it is useful to carefully read the description of the medicine.

Characteristics of the drug according to the instructions

Tanakan has angioprotective properties. It is developed on the basis of an extract of the leaves of a tree called "Ginkgo biloba biloba".

How the medicine works can be found in the reviews written by patients. They are listed in the last part of the article.

Release form and composition

The drug is made in the form:

1. Tablets 40 mg, having a film shell of a red brick color. Tablets are round, biconvex with a break. 15 tablets are placed in a blister made of aluminum foil and PVC. The cardboard pack contains 2 or 6 blisters. That is, the package contains 30 or 90 tablets.
2. Solution for internal use brown-orange color with a specific odor. The packaging is a dark glass bottle with a plastic screw cap. A pipette dispenser with a capacity of 1 ml is applied.

The active ingredients of Tanakan tablets are:

• 40 mg ginkgo biloba leaf extract,
• 24% flavonoid glycosides,
• 6% terpene substances,
• bilobalides,
• ginkgolides A, C, B,
• proanthocyanides,
• organic acids.

As fillers in tablets are (in mg):

• 82.5 lactose,
• 50 monocrystalline cellulose,
• 37 maize starch,
• 28 colloidal anhydrous silica,
• 1.25 magnesium stearate,
• 1.5 polyethylene glycol 400,
• 1.5 polyethylene glycol 600,
• 6 methylhydroxyl propyl cellulose,
• 1.025 titanium dioxide,
• 0.65 red iron dioxide.

The solution contains the same active substances. Fillers are (in ml):

• 0.5 sodium saccharin,
• 0.75 soluble orange essence,
• 0.75 soluble lemon essence,
• 59 ethyl alcohol,
• 100 purified water.

Storage method

The medicine should be kept out of the reach of children. The recommended temperature is less than 25°C.

The shelf life is calculated in three years. After its expiration, the drug can not be used.

About useful properties

This medicine has the following positive qualities:

• improves the supply of glucose and oxygen to the brain,
• normalizes the tone of veins and arteries,
• activates microcirculation,
• thins the blood
• inhibits platelet activation
• improves metabolic processes,
• counteracts the formation of free radicals,
• fights edema in the brain and at the level of the periphery.

As a result, there is an improvement in cerebral circulation, an increase in the vascular tone of the whole organism, including the smallest vessels of the brain.

Bilobalides and ginkgolides have high bioavailability (80-90%). The maximum concentration is reached within an hour or two after ingestion. The main route of elimination is through the kidneys.

In what cases is the drug prescribed

Indications for the use of Tanakan include the following conditions:

• disorders of cerebral circulation of a diverse nature (excluding senile dementia and Alzheimer's disease);
• intermittent claudication in obliterating chronic arteriopathy of the legs;
• hearing impairment, tinnitus, dizziness and coordination disorders, mainly of vascular origin;
• visual impairment due to vascular problems, decreased visual acuity;
• syndrome and Raynaud's disease;
• after a stroke and traumatic brain injury (with a decrease in intellectual abilities and memory, sleep disorders);
• asthenia due to trauma or depression of a psychogenic nature.

Video

Video instruction for the use of the drug:

Contraindications

There is a list of contraindications for the use of Tanakan:

• high sensitivity to the composition or its elements,
• exacerbation of erosive gastritis,
• acute condition of peptic ulcer,
• impaired cerebral circulation in the acute stage,
• low degree of blood clotting,
• attack of myocardial infarction,
• the state of pregnancy and lactation (due to the lack of verified clinical data),
• age under 18 years old.

Due to the presence of lactose in tablets, the drug is not prescribed for:

• congenital galactosemia,
• malabsorption syndrome of galactose or glucose,
• lactose intolerance or lactose intolerance.

The presence of ethyl alcohol in a solution serves as an obstacle to its reception in the case of:

• alcoholism,
• liver disease,
• brain diseases,
• traumatic brain injury.

Despite the fact that the drug is contraindicated under 18 years of age, sometimes it is prescribed even to infants with cerebral circulation pathology, high intracranial pressure, or dysfunction of the autonomic system.

Application in these cases should be strictly according to individual indications and under the systematic supervision of a physician.

Side effects

After taking Tanakan, side effects may appear in the form of:

• allergies (rash, swelling, redness, itching);
• blood thinning and possible bleeding (with prolonged treatment);
• eczema,
• digestive disorders, diarrhea, nausea, abdominal pain;
• dizziness, headaches, tinnitus.

In the process of using the drug, it is better not to perform activities that require increased attention and quick psychomotor reactions. This is associated with possible dizziness.

Results of interaction with other drugs

Tanakan tablets are well compatible with almost any other drug. The exception is Aspirin or Warfarin, the combination with which increases the risk of bleeding.

When using the solution, you need to take into account the reaction to alcohol when combined with:

• disulfiram,
• Latamoxephom,
• Chloramphenicol,
• Trichopolum,
• glipizide,
• cefomandol,
• Ketoconazole
• Metronidazole, etc.

Method of application and dosage