Nifedipine injections instructions for use. Long-acting nifedipine preparations in modern cardiology. Assumptions of the occurrence of the Raynaud phenomenon

Nifedipine is an antihypertensive and antianginal agent, a selective calcium channel blocker of the II class. Effectively reduces pressure, improves coronary blood supply, has a pronounced anti-ischemic effect.

Antagonist of calcium ions, inhibits their entry into cardiomyocytes and smooth muscle cells of the coronary and peripheral arteries through slow membrane channels. Expands the coronary and peripheral arterial vessels, reduces myocardial oxygen demand, lowers peripheral vascular resistance and blood pressure.

It is quickly absorbed in the digestive tract (when used as a solution or tablets with a regular release of the active substance). The maximum plasma concentration when taking conventional dosage forms is reached after 30-60 minutes.

Nifedipine does not affect the tone of the veins. It reduces spasm, dilates peripheral and coronary vessels (mainly arterial), lowers blood pressure and total peripheral vascular resistance, reduces myocardial tone, afterload and oxygen demand of the heart muscle, and prolongs diastolic relaxation of the left ventricle.

Under its influence, coronary blood flow increases, blood supply to ischemic areas of the myocardium improves, and the functioning of collaterals is activated. Almost no effect on the atrioventricular and sinoatrial nodes and has no antiarrhythmic effect. Increases blood flow in the kidneys, causes a moderate excretion of sodium in the urine.

The clinical effect occurs after 20 minutes and lasts from 4 to 6 hours. When using various retard forms, the maximum concentration of nifedipine in the blood plasma is observed several hours after oral administration, the duration of action is on average 10-12 hours, some dosage forms - up to 24 hours.

Indications for use

What helps Nifedipine? According to the instructions, the drug is prescribed in the following cases:

• Angina at rest and exertion (including variant) in coronary heart disease;
• Arterial hypertension (as a single drug or in combination with other antihypertensive drugs).

At what pressure is Nifedipine used? As we can see from the indications for use, with increased (hypertension). This drug reduces blood pressure, and with low blood pressure it is dangerous to take it.

Instructions for use Nifedipine, dosage

Tablets are taken orally after meals, they are not chewed and washed down with a sufficient amount of water. The dosage and mode of taking the drug are set by the doctor individually, depending on the therapeutic efficacy.

According to the instructions for use, the initial dose of Nifedipine is 10 mg once a day. If necessary and in the absence of a therapeutic effect, it is increased to 20 mg 1-2 times a day.

• The maximum daily dose should not exceed 40 mg.

To stop a hypertensive crisis, it is used sublingually at a dose of 10 mg as a solution for oral administration (or after chewing the tablet), if necessary, after 20–30 minutes, the administration is repeated, sometimes increasing the dose to 20–30 mg. Or the drug is administered intravenously at a dose of 5 mg for 4-8 hours, the maximum dose is 15-30 mg / day (for no more than 3 days).

For the elderly, as well as for patients with a concomitant decrease in the functional activity of the liver or kidneys, a dosage reduction is required.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Nifedipine:

• From the digestive system: diarrhea, heartburn, nausea, worsening of the liver; in some cases - gingival hyperplasia. With prolonged use of the drug in high doses, dyspeptic symptoms, the development of intrahepatic cholestasis or an increase in liver transaminase activity may occur.
• From the side of the cardiovascular system: a feeling of warmth, hyperemia of the skin, peripheral edema, arterial hypotension, tachycardia, asystole, ventricular tachycardia, increased angina attacks, bradycardia.
• From the peripheral nervous system and central nervous system: headaches. With long-term therapy at high dosages, muscle pain, paresthesia, sleep disturbances, tremors, and minor visual disturbances are possible.
• From the urinary system: increased daily diuresis, impaired renal function (with prolonged use in high dosages).
• On the part of the hematopoietic system: extremely rarely - thrombocytopenia, leukopenia.
• From the endocrine system: the development of gynecomastia.
• Allergic reactions: rash on the skin.

When administered intravenously, the drug causes a burning sensation at the injection site.

With intracoronary administration, within a minute after the start of the infusion, hypotension and an increase in heart rate may develop.

Contraindications

Nifedipine is contraindicated in the following cases:

• Hypersensitivity to nifedipine or auxiliary components of the drug.
• Acute myocardial infarction (death of a section of the heart muscle due to acute circulatory disorders in it) within 4 weeks.
• Cardiogenic shock is an acute and severe insufficiency of the pumping function of the heart, accompanied by vascular collapse.
• Arterial hypotension is a decrease in the level of systemic arterial pressure, in which systolic blood pressure is less than 90 mm Hg. Art.
• Sick sinus syndrome is a functional insufficiency of the atrial pacemaker.
• Severe heart failure in the stage of decompensation.
• Stenosis (narrowing) of the mitral or aortic valve of the heart.
• Idiopathic hypertrophic subaortic stenosis, in which the cause of the narrowing remains unclear.
• Expressed increased heart rate (tachycardia).
• Children's age up to 18 years.
• Pregnancy at any time, breastfeeding.

Nifedipine is used with caution in chronic heart failure, a pronounced decrease in the functional activity of the liver and kidneys, severe circulatory disorders in the brain, diabetes mellitus, especially at the stage of decompensation, malignant arterial hypertension.

Also, with extreme caution, the drug is used in people on hemodialysis (hardware blood purification) due to the high risk of developing severe arterial hypotension.

Before using, you should make sure that there are no contraindications.

Overdose

Manifested by arterial hypotension, bradycardia, heart failure, shock, metabolic acidosis and convulsions.

Nifedipine analogues, price in pharmacies

If necessary, you can replace Nifedipine with an analogue for the active substance - these are drugs:

1. Cordipin,
2. Corinfar Retard,
3. Nifecard,
4. Calcigard Retard HL.

ATX code:

• Adalat,
• calciguard retard,
• Kordafen,
• Cordylin,
• Corinfar.

When choosing analogues, it is important to understand that the instructions for use of Nifedipine, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Nifedipine tablets 10 mg 50 pcs. - from 27 to 39 rubles, according to 739 pharmacies.

Store at temperatures up to 25 ºC in a place protected from light and moisture, out of the reach of children.

Shelf life - 3 years. Conditions for dispensing from pharmacies - by prescription.

What do the reviews say?

According to doctors, Nifedipine is a cheap, affordable and effective treatment for high blood pressure (including hypertensive crisis) and ischemia. However, some doctors note that the drug reduces the upper (systolic) pressure and has little effect on the lower (diastolic).

The disadvantages include a large number of contraindications and a whole list of side effects that may occur during treatment. Especially often patients complain of heartburn, headache, flushing to the face and drowsiness.

Nifedipine is a drug that lowers systolic blood pressure. It is used for many types of disorders of arterial blood supply to organs. Effective in acute course, pathologies of coronary blood flow,.

So, today we will talk about the drug Nifedipine, its instructions for use, price, reviews and analogues.

Features of the drug

Nifedipine is a synthetic drug made to inhibit calcium channels. According to the chemical composition, Nifedipine is produced from the precursor of the pyridine group, dehydrogenated in positions 1 and 4. Powder in the form of yellow crystals, hardly soluble in water and alcohol.

The mass of the Nifedipine C 17 H 18 N 2 O 6 molecule is 346.3 g/mol.

The following video will tell you more about the features of the drug Nifedipine:

Compound

According to the chemical composition of 1 tablet, the main substance is distinguished - a derivative of 1,4 dihydropyridine and additional substances for better absorption of Nifedipine:

• milk sugar;
• magnesium stearic;
• food gelatin;
• cellulose in microcrystals;
• wheat starch;
• colloidal titanium and silicon dioxide, talc and other shell substances.

Dosage forms

The production of Nifedipine is carried out in several dosage forms:

• tablets Nifedipine with 10 and 20 mg of the active basic substance, most often familiar to consumers;
• solution for drip infusions, 1 ml of which contains 0.01 mg of Nifedipine;
• solution in 2 ml ampoules for direct cardiac administration.

Also, Israeli pharmacies offer Nifedipine gel (ointment, emulsion) as a cure for hemorrhoids.

In city pharmacies, the minimum price for a drug is 36 rubles, the highest cost is 47 rubles abroad. Online pharmacies offer to buy Nifedipine for 27 rubles.

The mechanism of action of Nifedipine is discussed below.

pharmachologic effect

• By blocking calcium channels, Nifedipine limits the supply of calcium ions to the striated tissue of the heart chambers and smooth muscle myocytes of the coronary and peripheral arteries. Increasing the dosage of Nifedipine blocks the release of calcium ions from cellular structures into the bloodstream. Temporarily reduces the number of active calcium channels, without controlling the temporary mechanism of blocking and subsequent reactivation.
• It has a desynchronized effect on the rhythm of excitations and contractions, blocking the actions of angiocal calmodulin and cardiac troponins. The pathological process of increased transport of calcium ions through the membrane potential, which occurs with an increase in systolic pressure, leads to the norm. The selective action to blockade of calcium channels is expressed in ignoring the closure of channels in venous myocytes.
• Increases the speed of blood circulation in the coronary arteries, restores blood circulation in heart foci affected by coronary disease. Restoration of blood circulation occurs due to the opening of additional branches of the coronary arteries without infringement of blood circulation in the rest of the vascular bed.
• Decreased resistance of arterial vessels occurs due to vasodilation. The consequence of this process is the prolongation of the diastole of the ventricle, a decrease in the oxygen demand of the myocytes of the heart and the general tone of the striated muscle of the heart.
• It does not produce a pronounced effect on the functioning of pacemakers of the first and second order, therefore, the rhythm of contraction of the heart departments remains unchanged. Increases urinary excretion by the kidneys. Vasodilation of vessels is blocked by compensation of the sympathoadrenal system, expressed in an increase in the frequency of heart contractions.

Pharmacodynamics

• With oral administration of Nifedipine, the clinical effect is achieved after 20 minutes, intravenous infusion allows you to achieve the therapeutic effect of the drug after 5-7 minutes.
• With direct injection into the heart, the clinical effect is observed within 3-5 seconds after the administration of Nifedipine. Do not exceed a dose of more than 40 mg per day.

With prolonged daily use of Nifedipine, the effect of “addiction” of tissues occurs after 60-90 days. The therapeutic effect of Nifedipine persists for up to 24 hours.

Pharmacokinetics

When using Nifedipine, there is a high ability to absorb it by intestinal villi into the bloodstream (more than 92%). When taken orally with food, bioavailability exceeds 60%. Nifedipine taken on an empty stomach accounts for 40% of the bioavailability.

After absorption into the venous bed, it is “checked” and processed through the portal vein of the liver. Available to brain cells, milk alveoli and embryonic cytostructures when passing through the blood-brain, blood-milk and hematoplacental barriers. Half-life and disintegration of the drug is observed in the liver. The end products of Nifedipine metabolism are excreted through the urinary system (four-fifths of the products) and through bile (one-fifth of the metabolites). The half-life is 4 to 17 hours.

Indications

• angiotrophoneurosis with peripheral blood flow disorders in the terminal arterioles;
• (as an independent agent or in combination with other antihypertensive drugs);
• spasm of the arteries of the eyeball and inner ear;
• persistent chronic angina pectoris.

The drug is contraindicated in children and adolescents. It is also important to know about the indications for the use of Nifedipine during pregnancy: it must be taken with caution, especially in the last 3 months of gestation. To reduce the increased tone of the uterus during the period of gestation, there are safer analogues of calcium antagonists.

About how to take Nifedipine, we will tell you further.

Instructions for use

• Nifedipine tablets are taken orally during a meal, preferably liquid. It is acceptable to swallow the tablets with water.
• If the doctor has not prescribed a large dosage, then it is forbidden to take more than 2 tablets per day of 20 mg.
• The maximum daily dose of Nifedipine should not exceed 80 mg (four tablets per day), if a dose of 40 mg is not very effective.

Systemic circulatory disorders of the brain and liver failure limit the use of Nifedipine. A lower dosage should be prescribed to the elderly and elderly patients, especially in combination with other angiotensive agents. The term of use of the drug should be within the competence of the attending physician .;

Side effects of Nifedipine

• In a number of patients using the drug Nifedipine, there were sharp drops in systolic pressure, lethargy, reddening of the skin of the face, pain and whirling in the head, swelling of the end sections of the limbs, a flush of heat.
• Long-term use of the drug led to an increase in the level of liver transaminases in the blood, nausea, and dyspeptic digestive disorders (constipation or diarrhea).
• The manifestation of skin allergic reactions, myalgia, exacerbations of arthritis is not excluded in individual patients. There is a decrease in the concentration of glucose in the blood, increased urination, gingival hyperplasia.
• When analyzing a blood smear, there is a decrease in the number of all blood cells, thrombocytopenic purpura.

special instructions

Stopping the drug should not be done abruptly. The treatment regimen involves a slow dose reduction over time. Reception of drinks containing ethyl alcohol is prohibited for the duration of treatment. Labor activity associated with increased attention and concentration should be limited for a while.

Antianginal and antihypertensive drugs are Nifedipine tablets. What helps this drug? The agent effectively reduces pressure, has a pronounced anti-ischemic effect, improves coronary blood supply. Capsules "Nifedipine" instructions for use suggest taking with high blood pressure, angina pectoris, Raynaud's disease and angiospastic disorders of cerebral circulation.

Release form and composition

1. long-acting tablets containing 20 mg "Nifedipin" a (Retard);
2. coated tablets containing 10 mg of the active substance;
3. solution for intracoronary administration (in 1 ml - 0.0001 g), which is sold in 2 ml syringes;
4. solution for infusion, 1 ml of which contains 0.0001 g of the active substance (in 50 ml vials);

Nifedipine gel is also produced, but its indications for use and composition are different. This form is intended for local treatment of manifestations of internal and external hemorrhoids (including pain, itching, anal fissures, hemorrhoids, bleeding). The composition includes: "Nifedipine" (0.2%), lidocaine (2%) and the Dead Sea biocomplex in the form of trace elements.

Pharmacological properties

The drug "Nifedipine", instructions for use indicates this, is a selective blocker of slow calcium channels, a derivative of 1,4-dihydropyridine. It has antianginal and antihypertensive action. Reduces the flow of extracellular calcium ions into cardiomyocytes and smooth muscle cells of the coronary and peripheral arteries.

Reduces spasm and dilates coronary and peripheral (mainly arterial) vessels, lowers blood pressure, total peripheral vascular resistance, reduces afterload and myocardial oxygen demand. Increases coronary blood flow.

Negative chrono-, dromo- and inotropic effects are overridden by reflex activation of the sympathoadrenal system in response to peripheral vasodilation. Enhances renal blood flow, causes moderate natriuresis. The onset of the clinical effect is 20 minutes, the duration of the clinical effect is 4-6 hours.

Tablets "Nifedipine": what does the medicine help with when prescribed

Apply according to the following indications:

• coronary heart disease, accompanied by an angina attack;
• spasm of the vessels of the inner ear and retina; hypertension and hypertensive crisis;
• angiospastic circulatory disorders of the brain;
• chronic heart failure.

Why is Nifedipine prescribed yet? In combination with bronchodilator drugs, tablets are prescribed for maintenance therapy in bronchial asthma. It is also used in Raynaud's disease.

The drug "Nifedipine": instructions for use and dosage

Dragee or tablets

The dosage regimen is set individually, depending on the severity of the disease and the patient's response to therapy. It is recommended to take the drug during or after a meal with a small amount of water. Initial dose: 1 tablet (tablet) (10 mg) 2-3 times a day.

If necessary, the dose of the drug can be increased to 2 tablets or dragees (20 mg) - 1-2 times a day. The maximum daily dose is 40 mg. In elderly patients or patients receiving combined (antanginal or antihypertensive) therapy, as well as in violation of liver function, in patients with severe cerebrovascular accident, the dose should be reduced.

Retard tablets

inside. Tablets should be swallowed whole, without chewing, during or after a meal, with a small amount of water. The recommended dose of the drug is 20 mg 2 times a day. With insufficient severity of the effect, it is possible to increase the dose of the drug to 40 mg 2 times a day.

The maximum daily dose is 80 mg. In case of impaired liver function, the daily dose should not exceed 40 mg. In elderly patients or patients receiving combined (antanginal or antihypertensive) therapy, smaller doses are usually prescribed. The duration of treatment is determined in each case individually.

injections

To remove a patient from a hypertensive crisis, Nifedipine is recommended to be administered at a dosage of 0.005 g for 4-8 hours, which corresponds to 6.3-12.5 ml of infusion solution per hour. The maximum dosage of Nifedipine according to the instructions is 30 mg per day.

Why is Nifedipine prescribed during pregnancy?

The instructions indicate that the medication is contraindicated during pregnancy and lactation. However, Nifedipine tablets are still used in pregnant women with heart disease. Very often, this medicine is prescribed to relieve uterine hypertonicity in order to reduce the threat of miscarriage. But they take it only after 16 weeks. In the first three months of pregnancy, they try not to use the medicine, because doctors are not sure of its safety for the baby at this stage.

Nifedipine is also prescribed for unstable blood pressure during pregnancy. Its regular use allows you to establish control over pressure in order to reduce the risk of exacerbation of cardiovascular diseases. This issue cannot be ignored, since cardiovascular diseases can cause either premature birth or the death of a future mother.

Absolute and relative contraindications

The use of the drug "Nifedipine" is strictly contraindicated if:

• Idiopathic hypertrophic subaortic stenosis.
• Lactation.
• Pregnancy.
• Severe aortic and mitral stenosis.
• Period 4 weeks after acute myocardial infarction.
• Arterial hypotension with systolic blood pressure below 90 mm Hg.
• Cardiogenic shock, collapse.
• Tachycardia.
• Sick sinus syndrome.
• Age up to 18 years.
• Hypersensitivity to dihydropyridine derivatives or the drug "Nifedipine", from which tablets can cause side effects.
• Decompensated heart failure.

The drug should be used with caution due to the risk of complications if the patient is diagnosed with:

• Severe disorders of cerebral circulation.
• Severe impairment of kidney and liver function.
• Malignant arterial hypertension.
• Chronic heart failure.
• Diabetes.

Caution requires medication by patients on hemodialysis.

Side effect

• headache;
• pronounced decrease in blood pressure;
• hives;
• pulmonary edema (difficulty breathing, coughing, stridor breathing);
• development or aggravation of the course of chronic heart failure;
• tachycardia;
• nervousness;
• anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis;
• asthenia;
• toxic epidermal necrolysis;
• nose bleed;
• fainting;
• chest pain (angina pectoris) up to the development of myocardial infarction;
• visual impairment (including transient loss of vision against the background of the maximum concentration of "Nifedipin" in the blood plasma);
• constipation;
• increased fatigue;
• nausea;
• chills;
• Pain in the eyes;
• galactorrhea;
• angioedema;
• tremor;
• photosensitivity;
• drowsiness;
• muscle cramps;
• symptoms of vasodilation (reddening of the skin of the face, a feeling of heat);
• arrhythmias;
• skin itching;
• dyspnea;
• gynecomastia (in elderly patients; completely disappearing after discontinuation of the drug);
• erectile dysfunction;
• myalgia;
• dryness of the oral mucosa;
• mood lability;
• peripheral edema (feet, ankles, legs);
• deterioration of kidney function (in patients with renal insufficiency);
• weight gain;
• diarrhea;
• increased appetite;
• pain in the stomach and intestines;
• dizziness;
• nasal congestion;
• swelling of the joints;
• cardiopalmus.

What are the analogues of the drug "Nifedipine"

Full analogues for the active substance:

1. Sponif 10.
2. Nifesan.
3. Sanfidipin.
4. Corinfar.
5. Nifehexal.
6. Vero Nifedipine.
7. Nifelat.
8. Nifebene.
9. Kordafen.
10. Nifedicap.
11. Nifadil.
12. Nifecard.
13. Fenigidin.
14. Nikardia.
15. Nifedicor.
16. Cordaflex.
17. Calciguard retard.
18. Cordipin.
19. Nifedex.
20. Cordaflex RD.
21. Adalat.
22. Osmo Adalat.

Holiday conditions and price

From pharmacies, the drug is dispensed by prescription. The average price of Nifedipine, 10 mg tablets (Moscow), is 26 rubles. In Minsk, pharmacies offer the drug for 3-6 bel. ruble. In Kyiv, the medicine costs 15 hryvnia, in Kazakhstan - 380 tenge.

Nifedipine is a calcium antagonist and is used to lower blood pressure. The drug is quite popular among doctors and patients, so it is often used to normalize pressure indicators. Instructions for the use of Nifedipine tablets will help patients understand the dosage of the drug and the method of application, however, the doctor should prescribe the drug.

The composition and form of release of the drug

The drug contains the active substance of the same name nifedipine. Each tablet of the drug contains 10 or 20 mg of active ingredient. In addition, the composition of the drug includes excipients, among which lactose, starch, gelatin, glycerin, polysorbate and others can be mentioned.

The drug is available in tablet form, as well as in the form of dragees of 0.1 mg and 0.2 mg. Nifedipine tablets are packed in a blister, each tablet has an individual package. There are 10 pieces in one blister, and 50 pieces in a carton. There is also a package of 30 pieces in a dosage of 0.1 mg. Nifedipine spirig tablets have a dosage of 40 mg of active ingredient, a carton contains 30 pieces.

Nifedipine in the form of dragees is available in a plastic jar, each of which also contains fifty tablets of the drug. A variety of forms of release allows patients to choose the most convenient remedy for themselves. The cost of the medicine is low - an average of about 50 rubles.

Important! Patients looking for Nifedipine in a pharmacy should not confuse the gel form with tablet preparations. Nifedipine gel is a combination drug with lidocaine, which is intended for the treatment of hemorrhoids. Nifedipine gel is not an antihypertensive drug.

Features of the medicinal product

The pharmacological group of Nifedipine is selective calcium antagonists. It is a derivative of dihydroperidines. The drug acts selectively and is fundamentally different from the work of calcium blockers. Initially, this group of drugs was intended for the treatment of angina pectoris, and in the process of application, doctors drew attention to the ability of drugs to lower blood pressure.

Selective agents, including Nifedipine, partially limit the access of calcium ions to cells. The drugs themselves are not calcium channel blockers, and Nifedipine cannot be attributed to calcium antagonists either. The main function of the drug is to slow down the opening of calcium channels, due to which a limited amount of this substance enters the cell.

This group of the drug makes it possible:

• reduce the load on the heart muscle;
• expand blood vessels;
• normalize the heart rhythm by influencing the conduction system;
• reduce the risk of blood clots.

Who is the drug indicated for?

Annotation to the drug Nifedipine contains indications for the appointment of this drug:

• patients with vasospastic angina;
• patients with chronic stable angina pectoris;
• with essential hypertension.

Contraindications to the appointment of the drug

The drug is contraindicated in pregnancy, breastfeeding, and do not use it for children.

In addition, the medicine should not be taken by patients with the following pathologies:

• in the presence of hypovolemia or circulatory shock (a sharp decrease in the volume of circulating blood);
• a history of myocardial infarction that occurred less than a month;
• the need to take Rifampicin;
• unstable angina;
• aortic stenosis.

Important! Obvious contraindications to the use of the drug are intolerance to the main active substance and other components that make up the medicinal substance. Also, the instructions for use warn doctors against prescribing the drug for decompensated heart failure, hypotension, those who are on hemodialysis.

When taking into account contraindications, doctors always analyze the compatibility of drugs and in some cases replace Nifedipine with other drugs. It is also worth considering that alcohol and Nifedipine are incompatible - doctors especially warn patients with hypertension.

How to take Nifedipine

It is recommended to take the drug to lower blood pressure before meals, washing down the tablets with a sufficient amount of water. The dosage of the drug is prescribed by the doctor depending on the pathology that the patient has. With vasospastic angina, you need to drink one tablet twice a day. With stable angina, two to three tablets per day are indicated. And essential hypertension requires taking two tablets per day. In case of urgent need, the dosage may be increased to 60 mg.

If the patient has a high risk of myocardial infarction, the prescription may need to be adjusted. If the patient has a hypertensive crisis, the first tablet is taken immediately upon the onset of symptoms, but is not swallowed, but chewed in the mouth so that the effect occurs as quickly as possible. If anxiety symptoms persist, the second tablet is taken no earlier than thirty minutes after the first.

Important! If the patient for some reason missed taking the drug, do not double the dose next time. This may lead to undesirable consequences.

Possible unwanted effects

Like any medicine, Nifedipine can cause side effects in the patient, which must be taken into account by the cardiologist.

Since Nifedipine is not a long-acting drug, but works for 6-8 hours, in patients suffering from coronary heart disease, the symptoms of the disease may worsen, and in some cases even myocardial infarction develops. Fortunately, such cases are rare.

Hematopoietic organs can give the following negative effects - leukopenia, anemia, thrombocytopenia. Agranulocytosis is rarely recorded. Some patients also experienced metabolic abnormalities. In particular, hyperglycemia was recorded.

The nervous system can give such negative complications as headache, fatigue, drowsiness, dizziness. Possible reactions such as anxiety, fear, manifestations of depression, tremor, insomnia, decreased sensitivity.

Negative changes in the organs of vision are also possible - a change in the perception of images, hemorrhages in the eyes, deterioration of vision. At the beginning of taking the drug, side effects also occur from the work of the heart - this is an increase in heart rate, severe hypotension, and occasionally angina pectoris occurs.

People with allergies may experience symptoms such as skin rashes, itching, urticaria, erythema, angioedema, photodermatitis. A weak urinary system can respond to taking the drug with a violation of the kidneys, frequent urination.

Overdose

If patients experience an overdose of the drug, severe symptoms of intoxication develop. Blood pressure drops sharply, there is pain in the chest, the heart rhythm goes astray. The patient appears pale, frightened, and may lose consciousness. An increase in blood sugar is possible. In especially severe cases, cardiogenic shock and pulmonary edema develop.

Important! In case of an overdose, it is urgent to remove the drug from the body and stabilize the work of the heart. At home, you can do a gastric lavage, but only doctors can professionally help - drugs are injected to stabilize cardiac activity, and plasmapheresis is performed. After stabilization of the condition, the doctor prescribes analogues of the drug - the original Adalat, Corinfar, Kordipin, Fenigidin.

Compound

pharmachologic effect

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Synonyms