Amoxicillin before or after. Amoxicillin (tablets, capsules, suspension) - instructions, application features. "Know-how" is a modern form of release. Know-how: modern forms of release of Amoxicillin

That is, regardless of the environment into which Amoxicillin enters (with or without food), the amount of the active substance absorbed in the gastrointestinal tract will not change.

When is the best time to take medicine after meals?

Do not drink Amoxicillin before meals for people with hypersensitivity to any component of the drug, as well as those patients who suffer from the following diseases of the gastrointestinal tract:

• gastritis with increased or, conversely, decreased acidity;
• ulcerative lesions of the stomach or intestines;
• manifestations of dysbacteriosis;
• enteritis or colitis;
• stool disorders (passage or constipation);

It is also not recommended to take the drug before eating for those who suffer from irritable bowel syndrome, and for children under 10 years of age. This is due to the fact that the gastrointestinal mucosa in these categories of patients is easily irritated and inflamed.

Why is Amoxicillin better taken after meals, not before?

Amoxicillin is an antibiotic that is most often used to treat ENT organs (tonsillitis, otitis media, sinusitis) and infections of the genitourinary system. Rarely, when a drug is prescribed as a monodrug, clavulanic acid is added to it for better effect. It protects the active substance of the drug from the destructive effects of the internal environment of the body, but at the same time stimulates the motility of the stomach and intestines, and therefore can cause side effects:

• pain in the abdomen;
• intestinal spasm;
• diarrhea;
• nausea and vomiting.

To prevent this from happening, it is better to take Amoxicillin after meals or during meals, even if there were no problems with the digestive organs before. This will reduce the risk of developing complications from taking the antibiotic.

How the drug is prescribed

The appointment of the drug should be carried out by a doctor. He will tell you when to take Amoxicillin, in what doses and for how long. The dosage will depend on who is being treated - an adult, a child, a pregnant girl. During pregnancy, it is allowed to drink the drug only under the supervision of the attending physician, since there is no data on the effect of the drug on the fetus, and there is a possibility that it can bring not only benefit, but also harm. Also during this period, it is necessary to take Amoxicillin after or during meals, so as not to once again irritate the gastrointestinal tract of the expectant mother.

The instructions for use indicate that eating food does not affect the effectiveness of treatment. Once inside the tablet does not interact with the environment of the stomach, and its bioavailability does not change.

Amoxicillin is allowed to be taken from infancy. Children under 10 years of age are prescribed the drug in the form of a suspension, at an older age tablets are used. In patients under 2 years of age, the dosage of the active substance should not exceed 20 mg per 1 kg of body weight, for patients who weigh 40 kg or more, the daily dose is 1.5 g.

Judging by the reviews of doctors and patients, if you take Amoxicillin following the rules specified in the instructions, the drug rarely causes side effects. Exceptions are dysbacteriosis, which accompanies the use of any antibiotic.

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Amoxicillin before or after food?

The drug Amoxicillin is an antibiotic, pharmacological properties similar to Ampicillin. Amoxicillin is indicated for use in pyelonephritis, cystitis, otitis, tonsillitis, meningitis, intestinal diseases, pharyngitis, laryngitis, bronchitis, pneumonia, tracheitis.

If you take this drug on an empty stomach, you may experience irritation of the gastric mucosa. Therefore, it is better to take it with meals or after meals with plenty of fluids.

Amoxicillin - instructions for use, analogues, reviews, price

The drug amoxicillin

Release form

1. Capsules 250 mg (16 pieces per pack).

2. Capsules of 500 mg (16 pieces per pack).

3. Granules in a vial (for suspension preparation).

Amoxicillin - instructions for use

Indications

• With respiratory tract infections (pharyngitis, sinusitis, tracheitis, laryngitis, bronchitis, pneumonia).
• With infections of the upper respiratory tract (tonsillitis, otitis media).
• With infections of the urinary tract and genital organs (cystitis, urethritis, pyelonephritis; endometritis, gonorrhea, etc.).
• With skin infections (impetigo, erysipelas).
• With a number of intestinal infections (dysentery, salmonellosis, typhoid fever and paratyphoid).
• With meningitis.
• With sepsis.
• With infections such as listeriosis, leptospirosis, borreliosis.

Contraindications

• Allergic diseases (hay fever, bronchial asthma, allergy to penicillins);
• liver failure;
• Infectious mononucleosis;
• dysbacteriosis;
• lymphocytic leukemia;
• breastfeeding.

Side effects

2. Negative effect on the digestive organs (dysbacteriosis; nausea, vomiting, taste disturbance; stomatitis, glossitis; diarrhea, etc.).

3. Influence on the nervous system (insomnia, agitation, anxiety, depression, headaches, dizziness, convulsions).

Treatment with amoxicillin

Amoxicillin in any form is taken orally. Eating does not affect the absorption of the drug from the gastrointestinal tract, so you can take it both before meals and after, at a time convenient for the patient.

The usual dosage of amoxicillin for adults and children over 12 years of age (weighing over 40 kg) is 500 mg 3 times a day. But in each case, the doctor determines the dose, and if necessary (in case of serious illnesses), it can be increased by 3 times a day, and even more. The maximum allowable daily dose for adults is 6 g.

Instructions for use of amoxicillin for children

Suspension of amoxicillin

Indications

• With acute otitis.
• With pharyngitis, tracheitis, bronchitis.
• For skin infections (impetigo).
• With mild forms of intestinal infections.
• Sometimes - for the treatment of gastric ulcer and 12 duodenal ulcer, as well as for the prevention of recurrence of this disease.

Contraindications

• Individual intolerance to the drug;
• allergic diathesis and other allergic diseases;
• intestinal dysbacteriosis;
• Infectious mononucleosis;
• lymphocytic leukemia;
• severe liver disease.

Caution must be exercised in the treatment of amoxicillin in children with increased bleeding and impaired renal function.

Dosage of amoxicillin for children

1. Children under 2 years old - 20 mg / kg body weight / day. This dose is divided into 3 doses.

2. Children 2-5 years old - 125 mg (i.e. 1/2 scoop of suspension) 3 times a day.

3. Children 5-10 years old - 250 mg (1 measuring spoon of suspension) 3 times a day.

Amoxicillin during pregnancy

Amoxicillin for angina

Amoxicillin and alcohol

Amoxicillin + clavulanic acid (Amoxiclav)

Indications for the use of Amoxiclav:

• Bacterial infections of the lower respiratory tract (pneumonia, bronchitis, lung abscess, pleural empyema).
• Infections of the ear, throat and nose (otitis media, tonsillitis, tonsillitis, sinusitis, frontal sinusitis).
• Infections of the urinary and genital organs (pyelonephritis, pyelitis, prostatitis, salpingitis, ovarian abscess, endometritis, postpartum sepsis, septic abortion, gonorrhea, chancre, etc.).
• Infections of the skin and soft tissues (abscess, phlegmon, erysipelas, infected wounds).
• Osteomyelitis.
• Postoperative infections and their prevention.

Amoxiclav release forms:

1. Tablets of 375 mg and 625 mg each (in mg the content of amoxicillin is indicated).

2. Powder for the preparation of a suspension with a drug concentration of 156 mg / 5 ml and 312 mg / 5 ml.

3. Powder for inhalation 600 mg per pack, and 1.2 g per pack.

Analogues

• Amoxicillin Solutab (manufacturer - Russia, Norton);
• Amoxicillin trihydrate (manufacturer - Russia);
• Amoxicillin-Ratiopharm (manufacturer - Germany);
• Amoxicillin-Teva (Israel);
• Amoxicillin Sandoz (Austria);
• Amoxillate (Germany);
• Apo-Amoxi (Canada);
• Amosin (Russia);
• Amoxisar (Russia);
• Bactox (France);
• Gonoform (Austria);
• Grunamox (Germany);
• Danemox (India);
• Ospamox (Austria);
• Thaisil (Bangladesh);
• Flemoxin solutab (Netherlands);
• Hikoncil (Slovenia);
• Ecoball (Russia);
• E-Mox (Egypt).

Flemoxin solutab (Netherlands) - these tablets of pleasant taste are well-deservedly popular. They can be taken in a way that is convenient for the patient: swallow, chew, dissolve in water, milk, juice, tea. The flavoring vanilla-apricot additive also has hypoallergenic properties (that is, it reduces the possibility of developing allergic reactions).

Do you know how to take Amoxicillin: before meals or after? Does it have compatibility with other drugs?

Amoxicillin belongs to the antibacterial drugs of the penicillin group and has a wide spectrum of action. The bactericidal effect extends to aerobic gram-positive and gram-negative bacteria.

The procedure for taking amoxicillin is determined individually for each patient based on his characteristics and the presence of diseases.

Amoxicillin

Amoxicillin, an antimicrobial agent of the penicillin group, mainly prescribed for respiratory, genitourinary infections and bacterial meningitis, is included in the 3rd line of anti-tuberculosis drugs. This means that the antibiotic is used to treat mycobacterial infection only when specific antibacterial agents of the 1st and 2nd lines are contraindicated for the patient for health reasons.

Taking Amoxicillin in combination with other drugs

More often, Amoxicillin is not used as a single drug, but in combination with clavulanic acid, which protects the antibiotic from adaptive bacterial enzymes aimed at destroying it. A protected combination due to high stability will be more powerful from a therapeutic point of view. It is part of the drug Amoxiclav.

Photo 1. Amoxiclav in the composition with clavulanic acid. Manufacturing company "LEK d.d., Slovenia"

Clavulanic acid is a gastrointestinal motility stimulant and may cause some side effects of the drug:

Amoxicillin, how to take: before meals or after?

It is not critical when you can take the medicine Amoxicillin, before meals or after meals. You can drink at any time, since the presence of gastric contents and a high concentration of hydrochloric acid do not reduce its bioavailability.

However, in people sensitive to the drug or suffering from gastrointestinal diseases, adverse reactions similar to those listed above occur. In order not to once again expose the mucous membrane to the local irritating effects of the antibiotic, you should drink the drug during or after a meal.

Food Compatibility

The widespread belief that penicillin antibiotics are incompatible with dairy products is erroneous with respect to Amoxicillin.

The antibiotic does not interact with the gastrointestinal contents.

It has long been proven that ethyl alcohol reduces the rate of absorption of antibiotics and activates liver enzymes, changing the rate of excretion of drugs.

The question of the interaction of alcohol and Amoxicillin remains open, although there are clinical studies that indicate the safety of the combination of these two substances.

Important! In some patients, Amoxicillin causes depression of liver function, against which alcohol intoxication occurs. It is impossible to guess who will fall into the number of these people, so it is better not to drink alcohol during treatment.

Useful video

Instructions for use Amoxicillin contains information about the indications (from what they are used) and contraindications, how to take and in what quantities, possible side effects. As well as other important data that you need to know about before using it.

Responsible treatment

Compliance with the rules for taking the drug is the key to maximum effectiveness of the antibiotic and a speedy recovery. Read the instructions for use in detail and do not expose the body to an additional load by avoiding the rules for taking the drug.

Amoxicillin for angina

Angina is a disease that occurs as a result of a viral infection or an overgrowth of bacteria in the body. If in the first case symptomatic treatment is prescribed, then with angina, which is of a bacterial nature, the attending physician always prescribes antibiotics.

Amoxicillin for angina: general information

Amoxicillin is one of the most popular antibiotics in the penicillin group. Doctors prescribe amoxicillin not only because it effectively copes with the bacteria that cause sore throats. The drug is popular because of the extremely rare side effects, with the exception of the destruction of the intestinal microflora, which is common to all antibiotics.

With angina, amoxicillin is used in a variety of dosage forms:

• In tablets 500 mg (chewable 200 and 400 mg); in capsules 250 and 500 mg;
• In powder for suspension in liquid (suspension) 125, 200, 250 or 400 mg in 5 ml.

How to take amoxicillin

Amoxicillin should be taken after meals. The action of the drug begins a minute after consumption and lasts about 7-8 hours. Eating does not affect the effectiveness of treatment, the drug does not break down in the stomach, but continues a long fight against harmful bacteria.

The method of application, as well as the dosage of amoxicillin, is determined by the attending physician. For children from 2 to 5 years old, the drug is prescribed 125 mg 3 times a day, children 5-10 years old should take 250 mg 3 times a day. For adults and children over 10 years old, whose body weight exceeds 40 kg, the drug is prescribed 500 mg 3 times a day. However, in severe cases of the disease, the dosage may be increased to 1 g 3 times a day.

For children under 2 years of age, the drug is prescribed in a daily dose of 20 mg per 1 kg of body weight in 3 divided doses. Children under 10 years of age should preferably take the drug in the form of a suspension, which is prepared by adding boiled water that has cooled to room temperature to the powder up to the 100 ml mark. The mixture must be shaken before use. The course of treatment averages 5-10 days.

Side effects

Amoxicillin, like any other drug, has side effects that are expressed as:

• diarrhea;
• vomit;
• stomach upset;
• pseudomembranous colitis;
• anaphylactic reactions;
• leukopenia;
• agranulocytosis.

drug overdose

An overdose of amoxicillin is expressed in diarrhea, nausea, vomiting, dehydration.

In such situations, you need to do a gastric lavage and take activated charcoal (1 tablet per 10 kg of weight). It will also be appropriate to take saline laxatives that help maintain the water and electrolyte balance in the body. During this period of time, the patient must be completely at rest.

Contraindications to the use of amoxicillin

• polyvalent hypersensitivity to the main components of the drug;
• allergic diagnosis;
• hay fever;
• bronchial asthma;
• lymphocytic leukemia;
• Infectious mononucleosis;
• liver failure;
• hidden diseases of the digestive system, in particular, colitis, which manifests itself during antibiotic treatment.

In addition to all of the above, the drug is contraindicated in women during breastfeeding, as penicillins penetrate into breast milk. Very carefully it is necessary to take amoxicillin for bleeding and people with kidney failure.

During the course of treatment, it is important to exclude alcohol.

Amoxicillin tablets for adults - detailed instructions

Treatment of infectious and inflammatory diseases is impossible without the use of antibiotics. Among modern antibacterial drugs, Amoxicillin is the most popular agent with a wide spectrum of action on various types of bacterial microflora.

Amoxicillin is a bactericidal antibiotic from the group of semi-synthetic penicillins with a wide spectrum of action.

What is the reason for such popularity of the drug, how to use the pills correctly and what you need to know about Amoxicillin before using it?

general description

Amoxicillin belongs to the semi-synthetic drugs of the penicillin group, it is a broad-spectrum antibiotic with the following composition:

• The main active substance is amoxicillin (trihydrate);
• Auxiliary components: talc, magnesium stearate, polyvidone, titanium dioxide, sodium carboxymethyl starch, hypromellose.

In terms of its therapeutic effect, amoxicillin is close to ampicillin, although compared to the latter it is more effective and reliable due to better absorption of the drug into the blood. This fact allows for acute bacterial and viral infections to prescribe for the fastest action not injections of benzopenicillin or ampicillin, but Amoxicillin tablets, which helps not only save money, but also greatly facilitates and simplifies the medication.

Note! Amoxicillin actively affects almost all harmful microorganisms, including streptococci, staphylococci, pathogens of salmonellosis, gonorrhea, meningitis.

The tablets are rapidly absorbed into the bloodstream, due to which the active ingredients begin to act within half an hour after ingestion and retain their effect for 8 hours.

What does Amoxicillin help with?

According to the results of studies, it has been proven that Amoxicillin is active against pathogens of respiratory tract infections. Because of this, the drug is usually prescribed in the treatment of pneumonia, colds, bronchitis.

Also, the antibiotic shows high efficiency in the treatment of otitis, pharyngitis, tonsillitis, inflammation of the sinuses, Helicobacter pylori infection.

Amoxicillin kills harmful bacteria such as streptococci, staphylococci, E. coli, etc.

What does Amoxicillin treat?

• Respiratory organs (tonsillitis, sinusitis, pneumonia, pharyngitis);
• Genitourinary organs (urethritis, pyelonephritis, gonorrhea, cystitis);
• ENT organs (tonsillitis, otitis media, bronchitis);
• Gastrointestinal tract (cholecystitis, peritonitis);
• Skin (sepsis, dermatoses, erysipelas).

As part of complex therapy, it is used in the treatment of uncomplicated forms of salmonellosis, leptospirosis, meningitis, endocarditis, Lyme disease, gastritis and peptic ulcer caused by Helicobacter pylori.

How to take amoxicillin tablets

The standard dose of Amoxicillin 250 mg is one tablet every 8 hours. If the condition is severe, then drink one tablet of Amoxicillin 500 mg after the same period of time.

The drug Amoxicillin 1000 mg is used extremely rarely - it is prescribed in special cases, but the tablet can be divided into several doses.

Amoxicillin is taken orally, before or after meals. Adults, children over 10 years old (weight over 40 kg) are prescribed 500 mg 3 times / day

The duration of the course of therapy is set individually for children and adults and can vary from 5 to 12 days.

Important! Amoxicillin tablets are taken regardless of food intake, because. food does not affect the absorption of the drug from the gastrointestinal tract. The exception is taking the drug for angina - Amoxicillin is drunk after meals to prolong the effect of the tablets directly on the tonsils.

Instructions for use has special instructions:

• In acute gonorrhea, the patient should take a single three grams of the drug. Moreover, after recovery, the dose should be taken again to avoid relapse.
• For infections of the biliary tract, gastrointestinal tract and liver, as well as for acute gynecological infections, Amoxicillin is prescribed three times a day, 1.5-2 grams each.
• In the treatment of leptospirosis for 6-12 days four times a day, the drug is taken at a dosage of 0.5-0.75 g.
• In case of violations of the normal functioning of the kidneys, it is recommended to maintain an interval of up to 12 hours between doses of the medicine.

Pregnant women should be aware that the antibiotic may adversely affect the development of the fetus. Therefore, when prescribing the drug to a future mother, the doctor must adequately assess the benefits of treatment with possible harm to the baby.

Side effects and contraindications

When taking Amoxicillin, side effects in the form of allergic reactions are possible: skin flushing, urticaria, angioedema, rhinitis, conjunctivitis, dermatitis, Stevens-Johnson syndrome

Other contraindications to the use of an antibiotic include lymphocytic leukemia, pronounced dysbacteriosis, severe damage to the kidneys and liver.

Note! When using an antibacterial agent, breastfeeding is prohibited, because. the medicine can cause side effects in the baby.

Most often, when taking an antibiotic, side effects were observed in the form of manifestations of allergic reactions: skin flushing, urticaria, angioedema, rhinitis, conjunctivitis, dermatitis, Stevens-Johnson syndrome, etc.

Other side effects are also possible:

• On the part of the hematopoietic organs (in rare cases) - thrombocytopenia, agranulocytosis;
• From the gastrointestinal tract: itching in the anus, dyspepsia, stool disorders, rarely - hemorrhagic and pseudomembranous colitis;
• From the urinary system - interstitial nephritis, vaginal candidiasis;
• From the nervous system - headache, agitation, confusion, convulsions, anxiety, dizziness.

With an overdose of the drug, diarrhea, nausea, vomiting, and a violation of the water-salt balance occur. Recommended gastric lavage, sorbent intake, in severe cases - hemodialysis.

additional information

What you need to know while taking Amoxicillin:

• It is not recommended to take an antibiotic for people under 18 years of age, as well as those with liver problems;
• After the disappearance of symptoms, the drug is continued for another 3-4 days;
• The antibiotic may reduce the effect of oral contraceptives;
• In the treatment of influenza and SARS, the drug does not have a therapeutic effect;
• Requires special monitoring of the state of the liver, kidneys, hematopoietic organs;
• When taking Amoxicillin, you should observe the correct drinking regimen (plentiful drinking) and control the frequency of urination.

If the disease is of a protracted nature and therefore long-term use of an antibiotic is implied, then antifungal drugs (for example, levorin or nystatin) should be taken at the same time.

With special care when using Amoxicillin, it is necessary to treat patients with a history of kidney and liver pathology, gastrointestinal diseases, bronchial asthma, allergic diathesis, hay fever.

Analogues

When a patient has contraindications to the drug, a side effect occurs during its use, or the antibiotic does not have the expected effect, the doctor may choose another antibacterial agent with a similar active composition.

Pharmacies sell analogues of Amoxicillin, which have a similar effect.

You can buy the drug at any pharmacy, and the price of the drug will depend on the manufacturer of the drug - for example, Amoxicillin price in tablets will vary within 50 rubles, Flemksin Solutab - from 240 rubles, Medoclav - from 290 rubles.

Feedback from doctors and patients

Doctors actively use Amoxicillin and its analogues in medical practice, noting the high efficacy of the drug, good tolerance by patients and excellent absorption of the antibiotic. Of the most common side effects, doctors note allergic reactions, dysbacteriosis and the appearance of thrush. Disorders of the gastrointestinal tract with the correct administration of the drug are extremely rare.

Patient reviews are mostly positive, noting the rapid action of the drug, ease of use, complete recovery at the end of the course, and relatively low cost. Negative reviews are usually associated with the fact that the antibiotic does not affect certain types of bacteria and therefore does not bring relief from diseases. Therefore, before using an antibacterial drug, it is desirable to conduct an analysis for sensitivity to the pathogen of the infectious-inflammatory process.

Amoxicillin: instructions for use

The drug Amoxicillin is a new generation antibiotic with a large spectrum of action, which belongs to the type of penicillin drugs.

This drug is designed to fight infectious diseases in the body. The task of the drug is to destroy pathogenic microorganisms. Amoxicillin release form: tablets, capsules, suspension for children, suspension for injection.

Sensitivity to the preparation of bacteria and viruses

In order to overcome a bacterial infection in the body, it is necessary that the microbes be sensitive to the drug and its effect. The following bacteria react to the drug Amoxicillin:

• streptococci;
• golden staphylococcus aureus;
• listeria;
• coli infection;
• bacterium enterococcus;
• bacteria that provoke peptic ulcer of the stomach and intestines;
• staphylococcal bacteria;
• proteus;
• Klebsiella microbes;
• shigella;
• gonococci;
• meningococcus;
• salmonella.

According to Amoxicillin indications for use, the drug does not affect viruses and fungal diseases in the human body.

Properties of the drug Amoxicillin

Amoxicillin has received great use in pediatrics and has the following properties:

• absolutely non-toxic - can be used by children from the moment of birth;
• bioavailability properties - the drug is absorbed in the intestine, which gives a good effect from taking tablets and suspensions, as well as from injections;
• acid resistance - does not respond to an increased acidic environment inside the stomach;
• wide distribution - a wide spectrum of action in the human body;
• does not have the ability to accumulate in the body - it is quickly excreted from the body by the kidneys.

What diseases is Amoxicillin used for?

Amoxicillin: what helps? Diseases in the body of a child and the body of an adult are caused by microorganisms: viruses, bacteria, fungi. Bacteria that cause infections are quite sensitive to the antibiotic Amoxicillin. Use this remedy for the following diseases:

• otitis of ENT organs;
• inflammation of the nasopharynx (sinusitis, sinusitis);
• infectious angina, pharyngitis, tonsillitis;
• ARI (bronchitis, tracheitis);
• infectious pneumonia;
• diseases pyelonephritis;
• bacterial cystitis;
• acute and latent form of urethritis;
• endometritis disease;
• diseases caused by Escherichia coli;
• salmonellosis;
• purulent meningitis;
• purulent sepsis;
• erysipelas of the skin;
• purulent diseases of the skin.

The therapeutic effect of the use of this drug shows a positive result - already from the second day of taking the medicine, there is a positive trend

The drug does not decompose in the gastric acidic environment, which is its distinguishing feature and maximum efficiency.

The use of Amoxicillin during childbearing and breastfeeding

Amoxicillin during pregnancy, the instruction of the pharmacological company does not recommend taking the medicine during the period of bearing a child and when breastfeeding a small child.

The remedy during pregnancy is prescribed in an extreme situation, if the benefit of taking the medication is much higher than the threat of adverse pathologies for the developing fetus.

If you take Amoxicillin during pregnancy, then the unborn child may experience inflammation of the large intestine.

Amoxicillin during pregnancy does not lead to fetal pathologies, but it should be taken only if other less dangerous drugs are not suitable.

Amoxicillin during pregnancy the second trimester can be used once, but only under the supervision of a doctor.

The drug contains amoxicillin, and during lactation, a woman in breast milk has enough amoxicillin for a baby. When taking an antibiotic by a woman in labor, the child may experience an overdose of the drug.

If there is an urgent need during lactation to take Amoxicillin while breastfeeding, then you need to switch to feeding with mixtures.

The use of Amoxicillin in the treatment of children

Amoxicillin for children up to the age of 10 years, give 20 mg per kilogram of the child's weight. If the weight of the child is more than 40 kg, in this case, Amoxicillin tablets are dosed, according to the instructions for an adult. For the youngest children from the age of 3 months, the medicine must be used in the form of Amoxicillin suspension - the suspension for children is easier to dose and the child can swallow it.

Amoxicillin suspension composition includes granules with amoxicillin and raspberry or strawberry flavor.

A child from 2 years to 5 years old - a dose of suspension per day 125 mg, which is divided into 3 doses.

A child from 5 years to 10 years old - a dose of suspension per day 250 mg, which is divided into 3 doses or Amoxicillin 250 capsules.

Most often, Amoxicillin is prescribed for children with:

• infectious angina;
• staphylococcus;
• streptococcus;
• intestinal poisoning of the body and infections;
• infectious inflammation of the bladder.

The use of a drug for an adult human body

How to take the antibiotic Amoxicillin for adults before meals or after meals?

The antibiotic Amoxicillin 500, Amoxicillin 1000, Amoxicillin is used orally, not tied to the time of eating, but to reduce its negative effect on the stomach, it is better to take it at the time of eating. It is desirable to drink antibiotics at the same time. In diseases caused by infections of a mild nature of the disease and the course of the disease of moderate severity Amoxicillin capsules 250 -3 - 4 times a day, one capsule.

Amoxicillin 500 mg - 1 capsule once a day.

The combined use of Amoxicillin and alcohol can aggravate the course of the disease and spread the infection further.

Amoxicillin is an indication for use in severe infectious diseases, it is necessary to increase the frequency of administration up to 4 times a day or take Amoxicillin tablets at a dose of 1000 mg 2 times a day.

With gonorrhea in the acute form of the disease, it is necessary together with medications:

• Cefixime - taken orally, one tablet of 400 mg. It is possible to use during the period of bearing a child.
• Ciprofloxacin - orally, once 500 mg, for gonorrhea at the initial stage of infection. It is not recommended to take this drug during pregnancy.
• Ofloxacin - orally, once 400 mg. If in the body, in addition to gonococcal infection, diseases caused by other infections are observed, treatment is carried out for days. When carrying a child, the drug is not taken.

With cystitis, a positive result in treatment is provided by Amoxicillin.

Amoxicillin for cystitis - adult dosage of the drug:

If, for some reason, the drug is missed, it is strictly forbidden to take a double dose of the drug. After the symptoms of the disease have passed, the drug must be taken until the end of the course of treatment.

Amoxicillin 15 is used in veterinary medicine. For the treatment of dogs and cats from infection, use Amoxicillin 15 strictly according to the instructions. For positive treatment of animals, injections with Amoxicillin 15 are necessary, it is necessary for the course prescribed by the veterinarian. An overdose of Amoxicillin 15 occurs from improper use of the drug or from exceeding the time of taking the medication.

Side effects of taking Amoxicillin

Amoxicillin instructions clearly indicate the side effects of the drug. After using the antibiotic Amoxicillin, a number of side effects occur:

• change in taste buds;
• constant nausea, after eating - vomiting;
• painful diarrhea, constipation;
• acute form of dysbacteriosis;
• overexcitation;
• anxiety state;
• insomnia;
• cramps in the legs and body;
• state of confused consciousness partial loss of memory;
• manic depressive state;
• sharp pain in the head;
• morning strong circling of the head;
• acute conjunctivitis;
• anaphylactic shock and possibly coma;
• candidomycosis of the vaginal mucosa;
• oral candidiasis;
• leukopenia;
• thrombocytopenia;
• thrombocytosis;
• bleeding.

Before you start taking this medication, be sure to consult with your doctor.

The reaction to the drug from allergies is manifested in angioedema, rash on the skin, anaphylactic shock, as well as conjunctivitis and rhinitis.

Dyspeptic indicators are disturbances in the state of appetite, severe nausea, belching, vomiting after ingestion or during meals.

Side effects are reversible and if you stop taking this drug, the side effects go away on their own.

Amoxicillin and alcohol are not compatible.

Contraindications to the use of this medication

Like any drug, Amoxicillin has a contraindication for various diseases of the body:

• intolerance to components;
• an allergic reaction to substances in the composition of the product;
• allergic intolerance to penicillins;
• insomnia;
• myocardial infarction and heart failure;
• epilepsy;
• nervous excitability;
• convulsions;
• chronic and acute liver diseases;
• cirrhosis of the liver;
• diseases of the kidneys and adrenal glands;
• lymphocytic leukemia and mononucleosis;
• alcoholism;
• bearing and feeding a child;

Overdose of Amoxicillin

With an overdose of the drug Amoxicillin, symptoms occur: nausea, vomiting, cutting pain in the abdomen and stomach cramps. Signs in the nervous system: inhibited actions, groundless drowsiness, depressive and irritable state are manifested. Noise and pain in the ears. Also, overdose symptoms may occur if you take Amoxicillin and alcohol.

On the part of the internal organs, acute renal and hepatic failure is observed, which can lead to long-term drug treatment.

If an overdose occurs, you should immediately flush the stomach with a large amount of liquid using potassium permanganate.

Reasonable use of Amoxicillin has a positive effect on the patient's well-being and contributes to a quick recovery.

Analogues of the drug Amoxicillin

Medication Amoxicillin analogues with a similar spectrum of effects on bacteria and produced by various pharmaceutical companies:

• antibiotic Augmentin;
• antibiotic Amoxicillin Solutab;
• Amoxicillin-Ratiopharm;
• Amoxicillin Sandoz;
• Amoxilate agent;
• medicine Amosin;
• means Danemox;
• drug Taysil;
• enhanced antibiotic Gonoform;
• drug Bactox;
• antibiotic Amoxicar;
• drug Apo-Amoxi;
• medicine Ecoclave;
• drug E-Mox;
• Means Amoxicillin trihydrate .;

These medicines contain the active substance amoxicillin in different doses.

Amoxicillin application

If you have amoxicillin tablets in front of you, the instructions for which are not attached or lost during the storage of the drug, then do not rush to print it and take it orally. First, we suggest that you read the instructions for use of the drug amoxicillin. This antibiotic has a huge number of contraindications and side effects. It is possible that it is you who are strictly forbidden to take it. Does amoxicillin have analogues? Yes, there are a huge number of antibiotics that can be taken with less risk to your health. But more on that later. In the meantime, you can read the opinions of doctors and patients. The drug amoxicillin reviews are mostly positive. But this is only if the dosage of amoxicillin is chosen correctly and taking into account the severity of the disease.

Suspension amoxicillin instructions

Instructions for use

In modern medical practice, amoxicillin 500 is most often used. This is a fairly stable substance that perfectly retains its medicinal properties in the acidic environment of gastric juice. In this regard, this drug is often used in the treatment of stomach ulcers.

The drug amoxicillin and the instructions for use speak directly about this, it refers to bactericidal agents. This means that its action is not aimed at suppressing the growth and reproduction of pathogenic bacteria. Amoxicillin destroys the cellular structure of harmful bacteria. Thus, causing their mass death.

On the one hand, this is very good. So the patient's body in a short time gets rid of the pathogen. But on the other hand, the mass death of bacteria causes an increase in intoxication. This should be taken into account when taking the drug amoxicillin: although this is not mentioned in the instructions for use. But you should know that, even before you start taking amoxicillin, you should start taking antihistamines and increase the patient's drinking regimen.

Amoxicillin for angina dosage

Amoxicillin is a broad-spectrum antibiotic

The antibiotic amoxicillin belongs to the broad-spectrum group. It gives excellent results in the treatment of diseases such as:

• diseases of the upper respiratory tract, including laryngitis, sinusitis and tracheitis;
• pneumonia, bronchitis;
• kidney and genital diseases of an infectious nature, including pyelonephritis, glomerulonephritis, cystitis, urethritis, gonorrhea, prostatitis;
• cholecystitis,
• gastritis, stomach ulcer;
• erysipelas of the skin;
• dysentery and salmonellosis;
• meningitis, myocarditis and endocarditis.

Amoxicillin is rapidly absorbed from the gastrointestinal tract. It is excreted from the body with urine and feces.

Tablets and suspension, price

If you are prescribed a suspension or amoxicillin tablets, the price will not upset you much. This is a fairly affordable drug. Usually, the cost of domestically produced amoxicillin 500 rarely exceeds fifty rubles for a course of treatment. The low price of amoxicillin does not mean a low degree of effectiveness of this antibiotic.

Capsules and tablets for children

The drug amoxicillin for children can be used from the moment of birth. Even for premature infants, amoxicillin is used to prevent complications of an infectious genesis. For the treatment of children, a suspension of amoxicillin is mainly used. Amoxicillin tablets for children begin to be given only from the age of five. Until the age of two years, the dosage of amoxicillin for children is calculated based on body weight. The usual dose is 20 mg per 1 kg of the baby's weight. It is allowed to increase the dosage to 60 mg of the drug amoxicillin per 1 kg of the child's weight.

Use of the drug during pregnancy

Taking amoxicillin during pregnancy should be done with caution and under constant medical supervision. This drug may cause occult bleeding. It does not have a pathogenic effect on the fetus.

Amoxicillin during breastfeeding in a certain dose passes into breast milk. This should be taken into account. In some cases, this can lead to the development of dysbacteriosis in an infant.

Amoxicillin and alcohol

The drug amoxicillin and alcohol are not compatible. This combination can cause a severe allergic reaction. In severe cases, coma and death of the patient may occur. The problem is that the combination of amoxicillin and alcohol completely paralyzes the liver and excretory system. When taking alcohol and amoxicillin at the same time, it is recommended to immediately call an ambulance. After the end of the course of treatment with amoxicillin, it is necessary to refrain from drinking alcohol for 7 to 10 days.

Indications and contraindications

The main indications for treatment with amoxicillin are inflammatory diseases of an infectious bacterial nature. The drug does not have a therapeutic effect in viral diseases. In SARS and influenza, amoxicillin can be used only if there are complications of a bacterial nature. Only a qualified doctor can install them.

Contraindications for taking amoxicillin: instructions for use:

• sensitivity to antibiotics of the penicillin group;
• bronchial asthma;
• ulcerative colitis;
• breastfeeding period;
• allergic skin reactions;
• diathesis in children;
• liver failure.

Like any other antibiotic, amoxicillin should be taken with caution in the elderly and debilitated people. The initial dose of the drug is best reduced in dose by two or three times. Be sure to take in combination with antihistamines.

Dosage

The dosage of amoxicillin for adults is usually the standard for many inflammatory diseases. This is 1 tablet of amoxicillin 500 or two tablets of amoxicillin 250 to be taken 3 times a day for ten days. Amoxicillin should be taken after meals. It should be washed down with alkaline mineral water or milk in sufficient quantities. In severe cases, the dosage may be doubled. Children from five to ten years of age are given amoxicillin 0.25 g 3 times a day.

For the treatment of acute gonorrhea, amoxicillin is taken once at a dose of 6 tablets of 0.5 g. In acute intestinal infections, amoxicillin 500 should be taken 3-4 tablets 3 times a day for five days.

Side effects of the antibiotic

The main side effects of amoxicillin are associated with:

• the development of allergic reactions;
• dysfunction of the gastrointestinal tract.

The first are manifested in the form of rashes on the skin, difficulty breathing, swelling of the face and limbs. The second group of side effects of amoxicillin is manifested in the form of diarrhea, abdominal pain, nausea, loss of appetite.

If you experience any side effects of amoxicillin, you should stop taking the drug and consult a doctor. With extreme caution, you should take amoxicillin for angina.

Amoxicillin - instructions for use, analogs, testimonials and release forms (capsules and tablets 250 mg and 500 mg, suspension) drugs for the treatment of bronchitis, pneumonia and other infections in adults, children and pregnancy

In this article, you can read the instructions for using the drug Amoxicillin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Amoxicillin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Amoxicillin in the presence of existing structural analogues. Use for the treatment of bronchitis, pneumonia, pyelonephritis and other infectious diseases of the pulmonary, genitourinary and other body systems of adults, children, as well as during pregnancy and lactation. Effects of co-administration of a drug and alcohol.

Amoxicillin is a broad-spectrum antibacterial bactericidal acid-resistant agent from the group of semi-synthetic penicillins. Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting protein of the cell wall) during division and growth, causes bacterial lysis.

Active against aerobic gram-positive and aerobic gram-negative bacteria. Microorganisms producing penicillinase are resistant to the action of amoxicillin.

Eating does not affect absorption, is not destroyed in the acidic environment of the stomach. It is found in high concentrations in plasma, sputum, bronchial secretions (poor distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bones , adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times. It is excreted by 50-70% by the kidneys unchanged by tubular secretion (80%) and glomerular filtration (20%), by the liver. A small amount is excreted in breast milk. Amoxicillin is removed by hemodialysis.

Bacterial infections caused by sensitive microflora:

• infections of the respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media; bronchitis, pneumonia);
• infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis);
• gastrointestinal infections (peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
• infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses); leptospirosis;
• listeriosis;
• Lyme disease (borreliosis);
• dysentery;
• salmonellosis;
• salmonellosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Tablets 250 mg and 500 mg.

Capsules 250 mg and 500 mg.

Granules for the preparation of a suspension for oral administration of 250 mg (children's form of the drug).

Forms in the form of injections (shots) do not exist.

Instructions for use and dosage

Inside, before or after a meal.

Adults and children over 10 years old (weighing more than 40 kg) are prescribed 500 mg 3 times a day; in severe infections - 0.75-1 g 3 times a day.

Children are prescribed in the form of a suspension: at the age of 5-10 years - 250 mg (5 ml of suspension) 3 times a day; 2-5 years - 125 mg (2.5 ml of suspension) 3 times a day; under 2 years - 20 mg / kg of body weight per day, divided into 3 doses.

In premature and newborns, the dose is reduced and / or the interval between doses is increased. Course of treatment days.

Suspension preparation: add water to the vial up to the risk and shake well. The prepared suspension is stable at room temperature for 14 days. Before each use, the suspension must be shaken. 5 ml of the prepared suspension (1 scoop) contains 250 mg of amoxicillin.

In acute uncomplicated gonorrhea, 3 g is prescribed once; in the treatment of women, repeated administration of the indicated dose is recommended.

In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, in gynecological infectious diseases for adults - 1.5-2 g 3 or 1-1.5 g 4 times a day.

With leptospirosis for adults - 0.5-0.75 g 4 times a day for 6-12 days.

With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions for adults 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours.

In children, the dose is reduced by 2 times.

• hives;
• skin hyperemia;
• erythema;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• Stevens-Johnson syndrome;
• anaphylactic shock;
• dysbacteriosis;
• vomiting, nausea;
• diarrhea;
• stomatitis, glossitis;
• excitation;
• anxiety;
• insomnia;
• confusion;
• behavior change;
• depression;
• headache, dizziness;
• leukopenia, neutropenia;
• anemia;
• tachycardia;
• superinfection (especially in patients with chronic diseases or reduced body resistance).

• allergic diathesis;
• bronchial asthma;
• hay fever;
• Infectious mononucleosis;
• lymphocytic leukemia;
• liver failure;
• a history of gastrointestinal disease (especially colitis associated with the use of antibiotics);
• lactation period;
• hypersensitivity (including to other penicillins, cephalosporins, carbapenems).

With caution - pregnancy, renal failure, history of bleeding.

Use during pregnancy and lactation

Use the drug with caution during pregnancy. Contraindicated during lactation.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When administered to patients with bacteremia, a bacteriolysis reaction (Jarish-Herxheimer reaction) may develop.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.

Treatment necessarily continues even after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used whenever possible.

The use of Amoxicillin and alcohol is unacceptable. Co-administration can lead to severe hepatic and renal disorders.

Pharmaceutically incompatible with aminoglycosides (cannot be mixed to avoid mutual inactivation).

Antacids, glucosamine, laxatives, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) - a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which paraaminobenzoic acid is formed, ethinyl estradiol - the risk of breakthrough bleeding.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, NSAIDs, drugs that block tubular secretion, reduce tubular secretion, increase concentration.

Allopurinol increases the risk of skin rashes.

Reduces clearance and increases the toxicity of methotrexate.

Enhances the absorption of digoxin.

Analogues of the drug Amoxicillin

Structural analogs of the active substance.

Table of contents [Show]

Antibiotics in the treatment of colds

Antibiotics are traditionally considered in our country as one of the best remedies for the treatment of colds. Therefore, many of our compatriots, as soon as the fire of the disease breaks out in the body, even before going to the doctor, prescribe this effective, in their opinion, remedy.

About how effective antibiotics are for treating a cold, how long a course of antibiotic treatment should last and whether they are harmless to the body, we will be briefly told by the experts of the portal - the official website of the drug Amoxicillin.

First, about the fundamentally important - the use of antibiotics in the treatment of influenza and SARS. Influenza and SARS are caused by viruses, while antibiotics are antibacterial drugs, not antiviral ones.

In particular, amoxicillin, which is considered one of the best bactericidal drugs, when it enters our body, kills all gram-negative and gram-positive microorganisms. It should be borne in mind that these may not only be the microbes that caused the disease, but also others that may be sensitive to them. Thus, any antibiotic should be taken with caution.

At the same time, the above does not mean at all that, taking an antibiotic prescribed by a doctor, the patient, having barely felt some improvement in his condition, should immediately stop treatment.

Take, for example, funicular tonsillitis. The result of her antibiotic treatment can be noticed quite quickly: in fact, after three days, the patient usually stops having a sore throat, and the swelling goes away. Meanwhile, not all microbes are destroyed by treatment in this case. The remaining microbes that are not killed will later acquire resistance to the drug and in the future it simply will not help. The average course of antibiotic treatment usually lasts about 10 days!

Editing - Leonid Chirkov
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Amoxicillin is an antibiotic made from penicillin and has a very broad spectrum of action. This antibiotic copes well with the fight against various cocci, E. coli and other bacteria.

However, readers should be cautioned that this antibiotic is not able to cope with every infection - there is a certain group of bacteria that ignore the action of this drug. Therefore, before using - consult your doctor.

Amoxicillin is present on the market in three forms:

Capsules. The content of the active substance is approximately 240 mg and 490 mg in each capsule. Produced in a regular cardboard box, the box contains up to 100 capsules. Coated tablets. The content of the active substance is approximately 240 mg and 490 mg in each tablet. Produced in a regular cardboard box, the box contains up to 100 capsules. Granular Amoxicillin. A suspension is prepared from the granules. From 4-6 ml of this powder, approximately 200-300 mg of Amoxicillin trihydrate is obtained. Produced in a dark glass bottle up to 100 ml. A dosing spoon is included with the vial.

Amoxicillin is excreted from the body by the kidneys. With the help of the enzyme penicillinase (also known as beta-lactamase), produced inside the body, the body breaks down amoxicillin. The peak concentration in the blood is approximately 1.5 hours after application. The drug is resistant to acid, so it is taken orally.

Amoxicillin is prescribed as an antibacterial. This drug copes well with cocci (both gram-positive and gram-negative), and is also effective against various other anaerobic and penicillin G-resistant bacteria. However, this medication should not be taken against strains that are capable of synthesizing beta-lactamase.

The drug should be taken only after being prescribed by your doctor. Your doctor may prescribe Amoxicillin for various respiratory tract infections. These include tonsillitis, pharyngitis, laryngitis, bronchitis, pneumonia, etc. Also, the drug can be prescribed for infections of the gastrointestinal tract and gallbladder (cholecystitis). Another appointment of the drug can be with an infectious disease of the urinary canals (gonorrhea, urethritis, pyelonephritis). Doctors may recommend the drug for sepsis. When combined with metronidazole, it can be prescribed for duodenal ulcers and gastritis.

Children over 11 years of age and adults are prescribed Amoxicillin three times a day (500 mg each). If the disease is severe - 1000 mg. It takes one to two weeks to take the drug.

Children under 11 years old - 250 mg per dose, three times a day.

Children under 6 years old - 125 mg per dose, three times a day.

Children under 2 years of age to receive this antibiotic are calculated - 18-20 mg per kg of weight. It is also recommended to take 3 times a day. Take approximately 4-11 days.

It is better for children to take Amoxicillin powder, previously dissolved in water.

As mentioned above, it is better for children to take an antibiotic in the form of a powder dissolved in water - a suspension. To prepare the suspension, you need to fill the powder bottle up to the mark line with boiled water at room temperature, and then shake well. The approximate shelf life of the mixture is 15 days. A measuring spoon contains approximately 4-6 ml of powder.

Amoxicillin should not be taken by people who are allergic, especially to penicillin. The medicine should not be taken in liver failure - this can aggravate the situation. If you have dysbacteriosis - you should also wait a little while using the drug, do not forget - antibiotics also have a detrimental effect on beneficial bacteria. Infectious mononucleosis, lymphocytic leukemia, pregnancy and lactation are also reasons for choosing a different drug.

In people with allergies, it can cause typical symptoms - rashes, rhinitis, sometimes anaphylaxis. Due to its properties, it can cause dysbacteriosis, vomiting, diarrhea and other problems associated with the gastrointestinal tract. Amoxicillin can cause headaches and mood swings, accompanied by excessive arousal, insomnia, and depression. There is a risk of antibiotic-resistant superinfection

We hope that this article was useful to you. Be healthy.

Pharmacological instruction

According to the official instructions for the use of amoxicillin, the drug is resistant to the effects of hydrochloric acid of gastric juice. As a result, almost complete absorption of the active substance of the antibacterial agent is achieved. Care must be taken when dosing in view of possible overdoses due to negligence.

When it enters the tissues of the human body, amoxicillin begins to actively produce transpeptidase, which disrupts the production of protein compounds in the cellular structures of bacteria. This makes it impossible for the reproduction and growth of the bacterial flora. There is a breakdown of bacterial cells with the release of a large amount of toxins into the blood. This can provoke a short-term deterioration in the condition of a sick person in the first 12 to 24 hours after the start of therapy.

In the course of clinical trials, a negative effect of the drug on the following forms of pathogenic microflora was revealed:

strains of staphylococci that do not produce penicillinase; streptococci of all types; salmonella; shigella; klebsiella; other forms of aerobic bacteria.

You can take the drug at any time, regardless of the use of food. They do not have any effect on the mechanism of penetration of the components of the drug into the bloodstream. After taking the suspension, tablets or capsules of amoxicillin, the maximum concentration of the active substance is reached after 2 hours. After 5 hours, amoxicillin is found in almost all physiological fluids and tissues of the human body. The most accessible concentrations are formed in the pleural cavity, pericardium, soft tissues, alveoli, mucous membranes of the lungs, bronchi and oral cavity. It easily penetrates into the abdominal cavity, female genital organs, urine and bile. This determines the possible indications for the use of amoxicillin. inaccessible environments for this antibiotic are the meninges and the spinal cord. Amoxicillin can penetrate into these tissues only at concentrations up to 20 percent. This amount is not enough to affect the pathogenic microflora that causes encephalitis,
meningitis and archnoiditis. In these forms of disease, the drug is not recommended for use except in extreme cases. From the body, the drug is excreted by the kidneys and liver in an almost unchanged form.

To reduce side effects and to prevent the development of emetic syndrome, it is advisable to give amoxicillin to children in the form of a suspension, which is prepared on the basis of special granules. Depending on the doctor's prescription, a certain amount of granules is taken for a single dose of the drug. But more often, one-stage preparation of a suspension for the entire course of treatment is recommended. To do this, water at room temperature is added to the bottle with granules to the specified level. After vigorous shaking, a homogeneous suspension is obtained, the shelf life of which is 12 days. You need to store in a cool dark place. Before use, it is re-stirred and measured using a special dispenser, which is included in the drug package.

Treatment for angina

It is possible to use amoxicillin for angina only after preliminary seeding of the material obtained during the collection of a swab from the pharynx. The active component of this drug is a stimulant for the rapid growth of diphtheria bacillus. This can be a fatal mistake that will lead to the death of the patient. Especially this indication applies to young children who are prone to diphtheria lesions of the tonsils and larynx.

With the exclusion of diphtheria and the identification of sensitive types of bacterial microflora, amoxicillin for angina is prescribed according to the standard scheme:

5 days - course of treatment; single dose - 500 mg in adults and 250 mg in children; 4 doses of the drug are required per day.

During breastfeeding, amoxicillin is strictly contraindicated. During pregnancy, the drug can be used only under constant supervision by the attending physician.

Other contraindications for the use of amoxicillin include renal and hepatic insufficiency.

Do not use this antibiotic for:

bronchial asthma; violations of the functions of hematopoiesis; leukemias and lymphoses; hypersensitivity of an individual nature to the penicillin series of drugs.

In the presence of contraindications, an analog of amoxicillin is prescribed. It can be ampioks, flemoxin, ampicillin at the doctor's choice.

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A cold is the result of bacteria and viruses entering the body. Most often it affects the disease in the autumn-spring period. If a person’s immunity is strong, then he is able to cope with the symptoms of a cold within 5 days. But sometimes the disease is protracted and then it is necessary to involve antibiotics in the treatment regimen, one of which remains Amoxicillin.

It can be used in the treatment of various forms of the common cold, and its main task is to stop the inflammatory process and eliminate the pathogenic microflora that caused the development of a cold.

When developing the drug, a component such as amoxicillin was involved. It is present in tablets, suspensions and granules. Even small children can use the drug in the form of a suspension in the treatment of colds.

On the shelves of pharmacy kiosks there is Amoxicillin in various formats: tablets, capsules and granules. The latter option is used to obtain a suspension for small children. There are also funds in ampoules. It is used for injections, which are used for severe colds in animals.

The drug in question belongs to the group of penicillins. It is based on the suppression of cell wall synthesis by various pathogenic microorganisms.

In the photo - amoxicillin for colds

It has bactericidal action against the following microorganism:

1. Gram-positive bacteria, which include staphylococci and its various groups.
2. Gram-negative microorganisms that lead to the development of gonorrhea and meningitis.
3. Gram-negative rods.
4. anaerobic bacteria.
5. Corynebacteria, Erysipeloid, Actinomycetes, Streptobacilli, Listeria, Spirochete

When using the drug during the treatment of a cold, the following side effects may occur:

1. Symptoms that indicate an allergy. The patient will visit swelling, erythema, small rash, painful sensations in the joints, rhinitis. It is extremely rare for anaphylactic shock to occur.
2. Clinical picture, which is a consequence of chemotherapy exposure. Against this background, a person can be struck by superinfection, which is the result of chronic pathologies.
3. Symptoms are the result of prolonged use of the drug at an increased dosage.. Thus, the patient experiences ataxia, depression, dizziness, fainting, convulsions. To prevent this from happening, you must strictly adhere to the indicated dosage by the doctor.
4. If you use Amoxicillin in tandem with Metronidazole, then such a clinical picture as vomiting, feeling of nausea, sudden weight loss, diarrhea, stomatitis, pain in the abdomen, colitis, hepatitis may occur.
5. In tandem Amoxicillin with Clavulanic acid, then this leads to the development of hepatitis, jaundice, dermatitis, toxic necrolysis.

The antibacterial drug Amoxicillin belongs to the group of semi-synthetic antibiotics of the penicillin series. The drug is characterized by a wide spectrum of influence in relation to aerobic gram-positive or gram-negative bacteria.

Amoxicillin can be used provided that the following pathological changes have been diagnosed:

• bronchitis;
• angina;
• pneumonia;
• otitis;
• intestinal infections;
• inflammatory kidney disease;
• inflammatory gynecological diseases;
• skin infections.

To get the long-awaited therapeutic effect when taking the drug, you need to know its dosage and dosage regimen. As a rule, this should be done by the attending physician. He establishes a treatment regimen taking into account the symptoms, diagnosis and age of the patient.

If it is necessary to treat a cold in an adult, then the dosage will be 4 tablets, which must be consumed in 3 doses. If a severe infection has occurred, then the dosage should be increased to 2 tablets 3 times a day. As for the duration of admission, it should be at least 5-12 days. Before taking the medication, you need to wait at least 8 hours.

What folk remedies for colds during pregnancy should be used, and how to choose the right remedy, is described in great detail in this article.

But how acetylsalicylic acid is used with paracetamol for colds, and how this remedy can help with the disease, is described here in the article.

What medicine for colds without fever should be used, and how to choose the right remedy, is indicated in this article:

You may also be interested to know which antibiotics for colds for children under one year old should be used.

Antibiotic use in the treatment of acute attacks of gonorrhea, which are not characterized by complications. Amoxicillin is taken in an amount of 3 g. Most often, this should be taken in combination with 1 g of probenecid. Women should drink a similar dose of medication to improve the effectiveness of treatment every other day.

If it is necessary to cure the pathology in children, then the doctor prescribes the dosage of the drug, taking into account the age of the crumbs and the severity of the disease. If the baby is very small, then he will have to give the drug in the form of a suspension. Up to 2 years, the dose is 20 mg/kg. The resulting number must be divided into 3 doses. In this case, the amount of medicine will depend on the weight of the child. If the child is 5-10 years old, then the dosage will be half a tablet 3 times a day. For children 2-5 years old, the recommended dosage is 125 mg 3 times a day.

It is necessary to treat a cold in children with Amoxicillin within 5-12 days. Between doses, observe an intermediate interval of 8 hours.

But how the child is treated at the first sign of a cold, and what medicines should be used in the first place, this article will help to understand.

It will also be interesting to learn about how to drink Paracetamol for a cold, and how effective this remedy is, described in this article.

You may also be interested to know if Kagocel helps with colds.

It will also be useful to learn about whether Cycloferon is worth using after a cold, and how effective this remedy is.

For those who want to learn more about the instructions for using Nimesil for colds, and how effective this remedy is, you should follow this link.

At the first detection of symptoms of a cold, you should not immediately resort to the use of antibiotics. This is due to the fact that the body can cope with the infection on its own. There are situations when a person from the first day of the lesion is given Ampicillin, and after five days he feels relief. At the same time, he believes that the positive dynamics is solely the merit of the antibiotic.

On the video application of amoxicillin:

But this is not always the case, because with an uncomplicated and mild course of a cold, all symptoms will pass within 5-6 days. If we talk about the effectiveness of Amoxicillin, then it treats a cold and helps get rid of unpleasant symptoms. This is due to the fact that the drug in question is used exclusively for the treatment of colds.

Amoxicillin is an antibacterial drug that today is one of the most effective in the treatment of colds. But as for the flu, in this case, the active components of the drug are powerless. The dosage and timing of therapy are determined solely by the doctor, who takes into account the course of the disease and the age of the patient.

What helps the antibiotic amoxicillin. We get acquainted with the recommendations of doctors for use.

Amoxicillin is a semi-synthetic penicillin with a wide spectrum of action.

The drug is indicated for the treatment of infections of bacterial origin, and has an effective effect. when eliminating the following diseases:

• Pneumonia and bronchitis;
• Sinusitis, pharyngitis, tonsillitis, acute otitis media;
• Pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis;
• Peritonitis, cholecystitis and cholangitis;
• Erysipelas, impetigo, infected dermatoses;
• Leptospirosis, listeriosis, Lyme disease;
• Dysentery, salmonellosis;
• Meningitis, endocarditis, sepsis;
• Gastritis, stomach ulcers.

In modern medicine, amoxicillin 500 mg is used.

This substance is resistant and able to maintain its medicinal properties when interacting with gastric juice.

Active the substance inhibits growth and prevents the reproduction of bacteria by destroying their cellular structure.

This leads to rapid death.

This allows the human body to get rid of pathogens in a short period.

It should be noted that during the period of rapid death of bacteria, increased intoxication of the body occurs, therefore, before you start taking amoxicillin, you need to use antihistamines and increase the amount of drinking.

You will learn about the treatment of narrowing of cerebral vessels by reading our article.

We get acquainted with the methods of treatment of polyps in the gallbladder. We discuss the advice of doctors. We get acquainted with useful recommendations.

Adults and children over ten years of age are prescribed one tablet of amoxicillin 500 three times a day, or two tablets of 250 mg.

For children aged five to ten years, the dosage of the drug is 250 mg in the morning, afternoon and evening.

Children under two years of age should calculate the dose individually. The proportion is 20 milligrams medicines per kilogram of the baby's weight.

A course of treatment the drug is ten days.

Tablets should be taken after meals, while alkaline mineral water or milk in sufficient quantities is used to wash them down.

If the patient is diagnosed with acute gonorrhea, then the treatment with amoxicillin is one-time. One dose is six tablets of 0.5 g. Acute intestinal infections involve taking the drug in the amount of four tablets three times a day. The course of treatment is five days.

Since it is difficult for a small child to swallow a tablet, amoxicillin suspension is used.

It is designed for children under five years of age. In this case, it is necessary to drink the drug with water in large quantities.

Amoxicillin can be used by newborns .

It is mandatory to give the child one of the antihistamines thirty minutes before taking the suspension. Which one is suitable for the baby will tell the specialist.

Treatment with amoxicillin during pregnancy should be carried out only if constant monitoring of the attending physician is possible.

This is due to the fact that the use of the drug can cause hidden bleeding. The medicine does not affect the development of the fetus.

You should be aware that during breastfeeding a small amount of antibiotic can pass into mother's milk. therefore, lactating women should take this factor into account, since in some cases the development of dysbacteriosis in infants was observed.

Amoxicillin is powerless if taken to treat a viral disease.

If a person has influenza or SARS, the use of the drug will be effective if there is a complication, the nature of which is bacterial in nature, which is established by a specialist.

Do not use amoxicillin in the following cases :

• If the patient is sensitive to an antibiotic of this group;
• With bronchial asthma;
• With ulcerative colitis;
• When a woman is breastfeeding;
• If a person has an allergic skin reaction;
• If the child has diathesis;
• With liver failure.

Elderly people, or those with a weakened state of health, should take the drug carefully. This applies to all types of antibiotics. At the beginning of treatment, the dosage should be halved. Be sure to use antihistamines.

You can find out what is the normal blood glucose level in men in our material here:.

The main side effects that the use of amoxicillin can cause are allergic reactions and disruption of the gastrointestinal tract.

The manifestation of an allergy is characterized by skin rashes, difficulty breathing, may be on the face and limbs. puffiness appears .

With disorders in the gastrointestinal tract, diarrhea, pain in the abdomen, bouts of nausea and lack of appetite may appear.

In the event of any side effect, the drug should no longer be taken, and consultation with a specialist is desirable. Cautious use of amoxicillin is recommended in the treatment of angina.

The combination of amoxicillin and alcoholic beverages can result in a severe allergic reaction. In some cases, this can lead to coma and even death.

This is due to the fact that when the drug is combined with alcohol, the liver is paralyzed. If alcohol has been taken, it is necessary to call a doctor.

After course of treatment with amoxicillin ends, you should refrain from drinking alcohol for a week.

Doctors' advice on the use of antibiotics

Amoxicillin for angina caused by staphylococci, streptococci, or other bacteria is an effective drug often used to treat acute tonsillitis. This drug belongs to semi-synthetic antibiotics with a powerful bactericidal effect. As a rule, the patient's condition after taking amoxicillin improves the very next day. However, it is strictly forbidden to interrupt the course of treatment prescribed by a specialist.

Amoxicillin for angina in adults is prescribed quite often, since its effectiveness in the fight against bacterial infection is high, and the risk of side effects is minimal. This drug works by disrupting the synthesis of the main protein in the bacterium, which is an integral part of the cell wall of the pathogenic microorganism. Thus, the protective shell of the bacterium is destroyed and the unicellular organism dies.

However, a penicillin antibiotic for angina - amoxicillin or any other drug of this series - sometimes does not cope with the infection. This is due to the fact that some bacteria are able to create a specific enzyme - beta-lactamase, which destroys the antibacterial agent. Therefore, the treatment of acute tonsillitis is very important to carry out under the strict supervision of a specialist who, according to the patient's well-being, will be able to determine whether this antibiotic is suitable for him or whether a stronger agent should be prescribed.

Treatment of angina with amoxicillin can be carried out by taking tablets (200 mg, 400 mg or 500 mg), capsules (500 mg, 250 mg) or suspension (400 mg, 250 mg, 200 mg or 125 mg in every 5 ml). Usually, adults and children under 10 years of age are prescribed tablets or capsules. And kids who still do not know how to swallow capsules and tablets take the drug in suspension.

The maximum amount of amoxicillin for angina (adult dosage) is 1500 mg. As a rule, the daily dose is divided into three equal parts of 500 mg each and taken strictly every 8 hours. However, each person has a different disease course, so the frequency of use and the dose are determined in each case individually and only by a competent specialist. Self-treatment is categorically unacceptable, since first you need to conduct a differentiated diagnosis of the disease, determine the type of angina and the features of its course. When ascertaining purulent tonsillitis, amoxicillin can be prescribed in an amount of 3 g daily (1 g for each dose).

For young patients, this antibiotic also effectively helps with various forms of acute tonsillitis. However, in this case, the treatment of the child, which is not carried out by a doctor, but at his own discretion or on the recommendation of a pharmacist, can have extremely serious consequences, even death. Therefore, it is important to remember that an antibiotic can only be prescribed by a pediatrician or family doctor. The daily dose of amoxicillin for angina for children aged 5 to 10 years is 750 mg and, as in the treatment of adults, it is divided into three parts of 250 mg.

Children 2-5 years of age are prescribed this drug 3 times a day, 125 mg (usually in the form of a suspension). The suspension is prepared by combining and then shaking boiled water at room temperature and dry matter. In this case, it is water that is added to the dry matter, and not vice versa.

Amoxicillin for angina in children under 2 years of age is prescribed in a dosage corresponding to the weight of the child #8212; 20 mg per 1 kg of weight.

The drug is taken after a meal and begins to act almost immediately: after 15-30 minutes, its concentration in the blood is quite high. After 8 hours, the effect of the drug weakens, therefore it is recommended to divide the daily dose into three equal parts, which should be taken at regular intervals. Excretion of the antibiotic is carried out through the kidneys. In the presence of any chronic diseases of the genitourinary system and liver, only the attending physician can determine how to drink amoxicillin in case of angina.

Acute tonsillitis- an insidious disease, with improper treatment, threatening with various complications. Children are especially affected by the consequences of this disease. Sometimes adults have problems with the heart, joints or kidneys after an illness. The use of amoxicillin for angina is considered the "gold standard" of conservative treatment of acute tonsillitis, because:

1. this drug is certified, it is considered a safe drug and can be used even in the treatment of children under 1 year old;
2. amoxicillin is well absorbed in the gastrointestinal tract (gastrointestinal tract);
3. both domestic and foreign analogues of the drug are not too expensive;
4. timely antibacterial therapy significantly reduces the risk of possible complications.

In addition, amoxicillin helps with sore throat, otitis media, sinusitis and other bacterial infections.

It is forbidden to take this antibiotic for infectious mononucleosis and hypersensitivity to the constituent components of the drug. During breastfeeding and pregnancy, the medicine is prescribed only when comparing the risk of developing undesirable consequences after taking an antibacterial agent and the complications of the disease that threaten the mother or baby. If necessary, it is possible to select an alternative treatment using folk remedies.

Treatment of angina with antibiotics (amoxicillin, penicillin, ceftriaxone, etc.) often causes allergic reactions, candidiasis, and dyspeptic disorders. Sometimes there are problems in the work of the nervous and cardiovascular systems. Therefore, if a patient, while taking the drug, begins to have a severe stomach ache, feels sick and vomits, then he definitely needs to consult a specialist. The doctor will either cancel the medicine or prescribe additional drugs that mitigate the side effects of the antibiotic.

Amoxicillin in tablets for angina is not used in the treatment of patients with allergic diathesis, bronchial asthma, hay fever, lymphocytic leukemia, colitis and liver failure. If there is a history of renal failure, the drug is recommended to be taken under the supervision of a specialist. For children prone to allergies, it makes sense to do an allergy test before taking the medicine.

The question of how to replace amoxicillin with angina often arises with individual intolerance to this drug. There are a number of broad spectrum antibiotics #8212; klacid, sumamed, lendacin, cephalexin, erythromycin, siflox, cefazolin, #8212; which can easily cope with acute tonsillitis. However, it must be borne in mind that the guarantee of successful treatment is a timely visit to the doctor to make an accurate diagnosis and prescribe adequate treatment.

If you have questions for the doctor, please ask them on the consultation page. To do this, click on the button:

Indications. Bacterial infections caused by susceptible pathogens: infections of the respiratory tract and ENT organs (bronchitis, pneumonia, tonsillitis, acute otitis media, pharyngitis, sinusitis), genitourinary system (urethritis, cystitis, pyelitis, pyelonephritis, endometritis, cervicitis), skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), abdominal and gastrointestinal infections (peritonitis, cholecystitis, cholangitis, typhoid fever, dysentery, salmonellosis, salmonella carriage); leptospirosis, listeriosis, meningitis, sepsis, Lyme disease (borreliosis), gonorrhea; eradication

Dosage and administration. Inside, in / m, in / in jet and drip. Before prescribing, the sensitivity of the isolated pathogen should be determined. The dosage regimen is determined individually depending on the severity of the infection. Adults and children over 10 years old (weighing more than 40 kg) - inside, 500 mg 3 times a day (up to 0.75-1 g 3 times a day for severe infections); the maximum daily dose is 6 g, children are prescribed in the form of a suspension, the dose depends on age, body weight and severity of infection. The daily dose for children is 30 mg / kg (up to 60 mg / kg), the frequency of administration is 2-3 times. With acute uncomplicated gonorrhea

Contraindications. Hypersensitivity (including to other penicillins), infectious mononucleosis.

Side effects and precautions. Allergic reactions: skin flushing, rhinitis, conjunctivitis, exfoliative dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, anaphylactic shock, maculopapular rash, itching, urticaria, Quincke's edema, reactions similar to serum sickness. From the digestive tract: nausea, vomiting, taste changes, diarrhea, pain in the anus, stomatitis, glossitis. From the nervous system and sensory organs: agitation, anxiety, insomnia, confusion, behavior change, headache, dizziness, convulsive reactions. From the side

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Having had ARVI and having sinusitis, I was forced to agree to start taking antibiotics. Usually I try to do without it, antibiotics are a last resort, I think. But not this time. The temperature is high, the nose is running, the eyes are watery, and there are terrible headaches when bending over, especially. The otolaryngologist prescribed to drink Amoxicillin. I bought this drug in a pharmacy Farmland 1000 mg. for 175 rubles with a 7% discount. (Here is a review about the Farmland pharmacy - flap.rf / ufa / Farmland-47 / Reviews / 7333676).

Amoxicillin like all antibiotics, it has many side effects: tachycardia, decreased blood pressure, nervousness, anxiety, sleep disturbance, diarrhea. These are all the delights I felt on myself. Especially from the gastrointestinal tract there were problems. Now you need to urgently buy Linex and fix these problems. It was not possible to buy right away, but she took Hilak forte, since this drug was at home.

Amoxicillin quite a powerful drug, especially since I purchased a dosage of 1000 mg. The tablet is large in length 2.3 cm, so it was hard for me to take such a large drug. I also smelled an antibiotic when I urinated, and pain in my kidneys.

From my own experience I can say that amoxicillin is a good, effective antibiotic. Based on it, other, more expensive antibiotics are made. They prescribed me amoxicillin for angina, it helped quite well. The angina was strong enough, it was very painful to swallow, the inflammatory process was in full swing.

Like all antibiotics, amoxicillin has contraindications, their list in the instructions is impressive. I had no side effects when taking amoxicillin, in parallel I drank Bifiform to avoid problems with the intestines.

In combination with other drugs, amoxicillin helped quickly, I drank this antibiotic for five days. The doctor prescribed to drink for seven days, but I did not continue. Because taking antibiotics for a long time will not lead to anything good.

If you have trouble swallowing, you may have problems taking this drug. The tablet has an impressive size. I drink pills easily, I can even not drink them with water, so I didn’t have any difficulties.

She took Amoxicillin last year. At that time, they wrote it to me for the first time, I had not even heard about it before. I was surprised by the price in the first place, 84 rubles per pack of 16 capsules, dosage 500 mg. One of the cheapest antibiotics I have ever been prescribed.

I will clarify right away that the sore throat was normal, not purulent, and was just beginning. I took capsules for 5 days, one capsule three times a day, after meals. Plus, she rinsed her throat, puffed with a spray and drank hexoral tabs - the doctor prescribed the treatment. Angina is gone.

Plus, that the stomach did not react to the reception in any way, both the doctor and I forgot about Linex.

Suitable for both children and adults. My children tolerate it normally, side effects and allergies have never been noticed after taking it.

Content

Infectious diseases, if not promptly treated, can be life threatening. Amoxicillin - instructions for the use of which stipulate the dose, course of treatment for an adult and a child, is an effective remedy for numerous bacterial pathologies, if there is no allergy to the components. It is released from pharmacies without a prescription. How to use an antibiotic correctly, are there any contraindications and side effects - more on this in the annotation of the medicine.

Antibiotic Amoxicillin

The drug is used as a means of antibiotic therapy. Amoxicillin is a broad-spectrum antibiotic, part of the semi-synthetic penicillin group. The drug is an analogue of ampicillin, but when taken orally it is characterized by better bioavailability. According to the instructions for use, the drug has an antibacterial effect against:

• aerobic Gram-positive bacteria– Staphylococcus spp., Streptococcus spp.;
• Gram-negative–Salmonella spp., Neisseria meningitidis, Klebsiella spp.,Shigella spp.,Escherichia coli.

Compound

According to the instructions, Amoxicillin has the main active ingredient - amoxicillin trihydrate, which is in a dosage corresponding to the release form. Auxiliary components give the tablets additional properties, a familiar look, and increase the shelf life. The composition, in addition to the trihydrate form, includes:

• calcium stearate;
• lactose monohydrate;
• magnesium stearate;
• polysorbate;
• talc;
• potato starch.

Release form

Instructions for use stipulate the forms of release of the medicinal product. They depend on the purpose, differ in dosage - the amount of active substance. Amoxicillin is available in the form:

• powder for intravenous injection - 500, 1000 mg;
• coated tablets - 0.5, 1 g;
• dry matter for suspension preparation - 125, 250, 400 mg - for children;
• soluble tablets for dilution - 0.125, 0.25, 0.375, 0.5, 0.75, 1 g;
• capsules - 250, 500 mg;
• finished suspension - 5 mg - 150, 250 mg;
• dry composition for intramuscular injection - a bottle of 500 mg.

Pharmacodynamics and pharmacokinetics

According to the instructions for use, Amoxicillin has a bactericidal, antibacterial effect. A broad-spectrum antibiotic inhibits transpeptidase, alters the synthesis of peptidoglycan during growth and division, and causes cell destruction. Amoxicillin while taking:

• quickly absorbed;
• has a half-life of 1.5 hours;
• penetrates into organs and tissues;
• excreted unchanged by the kidneys, partly with bile.

Indications for use

The instruction prescribes for which diseases to drink Amoxicillin. Semi-synthetic antibiotics should be used only as directed by a doctor, taking into account the dose and duration of the course. The drug acts bactericidal in the presence of:

• intestinal infections;
• gonorrhea;
• pneumonia;
• pyelonephritis;
• bronchitis;
• infectious diseases of the skin, soft tissues;
• leptospirosis;
• pharyngitis;
• salmonellosis;
• acute otitis media;
• gynecological bacterial infections;
• tick-borne borreliosis.

Treatment with Amoxicillin in combination with Metronidazole is prescribed to patients with exacerbation of chronic gastritis, duodenal ulcer, provoked by Helicobacter pylori bacteria. The use of the tool has proven its effectiveness in the case of:

• infections of the digestive system;
• chronic sinusitis;
• sepsis;
• listeriosis;
• meningitis;
• bacterial pathologies of the oral cavity;
• infections of the genitourinary system;
• animal bites;
• bacterial diseases of the stomach;
• infections of bone, connective tissues;
• endocarditis.

Contraindications

The appointment of antibiotics of the penicillin group to the patient, even with serious pathologies, must be carried out taking into account contraindications. Instructions for use stipulate that the joint use of the drug with clavulanic acid is unacceptable if there is a history of liver disease, jaundice. It is forbidden to use Amoxicillin when the diagnosis is:

• lymphocytic leukemia;
• Infectious mononucleosis;
• allergic diathesis;
• bronchial asthma.

A bactericidal antibiotic has contraindications for use in case of:

• hypersensitivity to the components of the drug, penicillins, cephalosporins;
• infectious diseases of the gastrointestinal tract, complicated by diarrhea;
• allergic reactions;
• hematopoietic disorders;
• insufficiency of renal function;
• hay fever;
• colitis;
• bleeding history;
• diseases of the nervous system;
• the use of estrogen-containing contraceptives - weakens their effect.

Method of application and dosage

• a single dose for adults, children over 12 years old - 250, 500 mg;
• in severe infections - up to 1 gram;
• interval between doses is 8 hours;
• course of treatment from 5 to 14 days;
• in patients with impaired renal function, the interval is set individually;
• the dosage and duration of treatment is determined by the doctor.

special instructions

Instructions for use stipulates special points when using Amoxicillin. When treating with a medicine, observing the dosage, you can drive a car - there is no negative effect on the body. Important points:

• monitoring of the state of the kidneys, liver, hematopoietic organs is required;
• it is necessary to continue treatment within three days after the disappearance of symptoms;
• if side effects occur, consult a doctor for the appointment of another remedy;
• if the microflora is not sensitive to the antibiotic Amoxicillin, superinfection may develop.

During pregnancy and lactation

The instruction prohibits the use of Amoxicillin during breastfeeding. The antibiotic, getting into milk, can harm the baby. If treatment is necessary, feeding should be suspended. The use of the drug during pregnancy has its own characteristics. Penicillins cross the placenta and accumulate there. The concentration of Amoxicillin in the amniotic fluid reaches 25-30 percent of the level in the blood plasma of a pregnant woman, which is a risk to the development of the fetus.

• use the drug only if indicated;
• the dose and regimen are set by the doctor, taking into account the condition of the woman;
• treatment with the drug is permissible only in the second and third trimester, when the placenta is formed;
• control by the doctor over the patient's condition is required;
• all contraindications for use must be taken into account.

Amoxicillin for children

High temperature, weakening of the body by infections - a reason for prescribing a drug to a child. Amoxicillin for colds is given to children in the form of a suspension (see photo below). The medicine is prepared before use. The set includes a measuring spoon containing 250 mg of the active substance. The instruction prescribes:

• add water to the bottle with granules;
• shake the mixture;
• children under two years of age give 20 mg of medication per kilogram of body weight per day;
• at the age of two to five - the dose is 125 mg;
• from 5 to 10 years - the number doubles;
• older than ten - suspension dose up to 500 mg;
• in severe cases - up to 1 gram.

Interaction with drugs

During the use of the antibacterial agent Amoxicillin, you should carefully consider the simultaneous use of other medicines. According to the instructions, interaction with drugs can give a variety of results. Effects seen:

• Amoxicillin enhances the absorption of Digoxin;
• increases the effect of indirect anticoagulants;
• reduces the prothrombin index;
• reduces the effect of estrogen-containing oral contraceptives;
• increases the toxicity of Methotrexate;
• reduces the synthesis of vitamin K.

Please note - Amoxicillin has a bactericidal effect on multiplying microorganisms, so you should not use it in conjunction with bacteriostatic antimicrobial drugs - sulfonamides, tetracyclines. With simultaneous use:

• Glucosamine, laxatives, slow down the absorption of Amoxicillin, and ascorbic acid increases;
• Rifampicin suppresses antibacterial properties;
• non-steroidal anti-inflammatory drugs increase the concentration of the antibiotic.
• Allopurinol increases the risk of skin rashes.

Interaction with alcohol

According to the instructions, Amoxicillin tablets, capsules or suspension should not be used in conjunction with alcohol. Simultaneous use causes antagonism - direct incompatibility, which is dangerous for the body, increases the risk of impaired renal function. The following points should be taken into account:

• the antibiotic in the blood can be up to a week;
• alcohol is excreted from the body in about two days;
• dangerous not only simultaneous use;
• it is necessary to take into account the period of withdrawal of the antibiotic and alcohol.

Amoxicillin side effects

With independent use, violation of the dosage, incorrect duration of the course, side effects may occur. The instruction stipulates the occurrence of the body's reaction to taking Amoxicillin. There are side effects:

• loss of appetite;
• violation of the intestinal microflora;
• allergy;
• insomnia;
• dizziness;
• hives;
• stomach ache;
• diarrhea;
• nausea;
• erythematous rash;
• vomit;
• liver dysfunction;
• anxiety;
• convulsions;
• conjunctivitis;
• disturbance of consciousness;
• pain in the joints.

Side effects may occur in case of an overdose of the drug. It is possible that:

• anaphylactic shock;
• hemolytic anemia;
• allergic vasculitis;
• hyperemia;
• candidiasis;
• fever;
• cholestatic jaundice;
• dysbacteriosis;
• rhinitis;
• stomatitis;
• difficult breathing;
• tachycardia;
• angioedema;
• depression;
• eosinophilia;
• peripheral neuropathies;
• hepatitis A;
• anorexia.

Analogues

When the drug Amoxicillin has contraindications for use, the doctor may choose another drug for the patient to fight infections. Replacement is required and when side effects appear, when treatment stops, new medications are prescribed. The instruction informs that there are analogues of Amoxicillin for the active substance:

• Ecoclave;
• Flemoxin Solutab;
• Taromentin;
• Rapiclav;
• Medoklav;
• Klamosar;
• Bactoclav;
• Augmentin;
• Arlet;
• Amovicomb;
• ranclave;
• Panklav;
• Liklav;
• Verclave.

Amoxicillin price

An antibacterial drug can be bought at the nearest pharmacy or ordered through an online store. In this case, the doctor must prescribe the medicine. How much does Amoxicillin cost? The price will depend on the form of release, dosage, transport costs. The average cost of the drug and analogues in rubles is:

	Release form	Dosage, mg	Amount
Amoxicillin	tablets
	suspension (bottle 100 ml)
Augmentin	tablets
Flemoxin Solutab
Medoklav

Amoxicillin inhibits the enzyme transpeptidase, thereby disrupting the synthesis of peptidoglycan (which is the supporting protein of the cell wall of the microorganism), during growth and division, and causing the lysis of microorganisms. Amoxicillin has a wide spectrum of antibacterial action, it is active against aerobic gram-positive microorganisms (Staphylococcus spp. (Except for those strains that produce penicillinase), Streptococcus spp., including Streptococcus pneumoniae, Streptococcus faecalis), aerobic gram-negative microorganisms (Neisseria meningitidis, Proteus mirabilis, Neisseria gonorrhoeae, Haemophilus influenzae, Escherichia coli, some strains of Salmonella, Klebsiella, Shigella, Helicobacter pylori). Amoxicillin is not active against indole-positive strains of Proteus (P.rettgeri, P.vulgaris), Enterobacter spp., Pseudomonas spp., Serratia spp., Morganella morganii, rickettsia, viruses, mycoplasmas are also resistant to it. When taking amoxicillin orally in the form of suspensions in doses of 125 mg / 5 ml and 250 mg / 5 ml, it is well and quickly (75–90%) absorbed, the maximum concentration is created after 1–2 hours (1.5–3.0 μg / ml and 3.5–5.0 μg/ml, respectively). When ingesting amoxicillin capsules at doses of 250 and 500 mg, the maximum concentration (3.5–5.0 μg / ml and 5.5–7.5 μg / ml, respectively) is also reached after 1–2 hours. Amoxicillin is stable in an acidic environment, and food intake does not affect the absorption of the drug. With parenteral use of amoxicillin, rapid absorption and distribution in tissues and body fluids occurs; the maximum concentration is reached 1 hour after administration and remains at the required level for 6-8 hours. Amoxicillin binds to plasma proteins by about 20%. Easily penetrates through histohematogenous barriers, except for the whole blood-brain barrier, and into most body fluids and tissues; accumulates in therapeutic concentrations in urine, peritoneal fluid, middle ear (its fluid), the contents of skin blisters, lung tissue, pleural effusion, in the intestines (its mucosa), female genital organs, bile and gallbladder (during normal liver function), tissues fetus. The half-life is 1-1.5 hours. In case of impaired renal function, the time increases to 4-12.6 hours, depending on creatinine clearance. In the liver, amoxicillin is partially metabolized to inactive metabolites. By glomerular filtration and tubular secretion, 50–70% of amoxicillin is excreted unchanged, 10–20% by the liver. Traces of amoxicillin are determined in the blood serum 8 hours after ingestion. Small amounts of amoxicillin are excreted in breast milk.

Indications

Bacterial infections caused by susceptible microorganisms: infections of the respiratory system and ENT organs (bronchitis, tonsillitis, pneumonia, acute otitis media, sinusitis, pharyngitis); infections of the genitourinary system (urethritis, pyelitis, cystitis, pyelonephritis, cervicitis, endometritis); soft tissue and skin infections (impetigo, erysipelas, secondarily infected dermatoses); infections of the digestive system (cholecystitis, cholangitis, dysentery, typhoid fever, salmonella carriage, salmonellosis, peritonitis); listeriosis; leptospirosis; sepsis; meningitis; gonorrhea; Lyme disease (borreliosis); eradication of Helicobacter pylori (with combination therapy); prevention of surgical infections and endocarditis.

Method of application of amoxicillin and dose

Amoxicillin is used orally (after eating, drinking water), intramuscularly, intravenously by drip and jet. Before prescribing, it is necessary to determine the sensitivity of the pathogen to amoxicillin. The dosage regimen is set individually depending on the severity of the disease. Adults and children over 10 years old (weighing more than 40 kg) - inside, 500 mg 3 times a day (up to 0.75-1 g 3 times a day for severe infections); the maximum daily dose is 6 g, children are prescribed in the form of a suspension, the dose depends on age, body weight and severity of infection. The daily dose for children is 30 mg / kg (up to 60 mg / kg), the frequency of administration is 2-3 times. In uncomplicated acute gonorrhea, a single dose of 3 g (repeated administration of the drug is recommended for women). Patients with Cl creatinine less than 10 ml / min dose should be reduced by 15-50%, with anuria the dose is not more than 2 g per day. The average course is 5-7 days (with streptococcal infections - at least 10 days). Intravenous drip and jet, intramuscularly. With a single dose that exceeds 2 g, the drug is administered intravenously by drip. The daily dose is divided into 2-3 injections. The duration of intravenous administration is 5-7 days, followed by a transition, if necessary, to intramuscular administration or oral administration of the drug. The duration of treatment depends on the form and severity of the disease and is 5-14 days or more. A single dose for adults is 1-2 g, administered every 8-12 hours (3-6 g / day). A single dose for adults with intramuscular injection should not exceed 1 g. The maximum daily dose for adults is 6 g. Newborns, premature babies and children under 1 year of age are prescribed a daily dose of 100 mg / kg, children of other age groups - 50 mg / kg. A single dose for children with intramuscular injection is not higher than 0.5 g. In severe infections, doses for adults and children can be increased by 1.5–2 times, in which case the drug is administered intravenously. The daily dose is divided into 2-3 injections with an interval of 8-12 hours. If the patient has renal insufficiency, the treatment regimen must be adjusted by reducing the dose or increasing the interval between injections (24-48 hours). With Cl creatinine 10-30 ml / min, the drug is administered in a daily dose of 1 g, then 0.5 g every 12 hours; with Cl creatinine less than 10 ml / min - 1 g, then 0.5 g every day. In patients in a state of anuria, the daily dose should not exceed 2 g. Patients who are on hemodialysis are prescribed an additional 2 g of the drug: 0.5 g during a hemodialysis session and 0.5 g after it ends.
If you miss the next dose of amoxicillin, you must take the drug as you remember, the next dose should be taken after the time set by the doctor.
Amoxicillin is used with caution in patients who are prone to allergies. It is not recommended to use amoxicillin together with metronidazole in patients under 18 years of age. Against the background of combined treatment with metronidazole, alcohol should not be consumed. Therapy with amoxicillin must be continued for another 2-3 days after the disappearance of the clinical manifestations of the disease, and with streptococcal infection - 10 days. During course therapy, it is necessary to monitor the state of the hematopoietic organs, kidneys and liver. Perhaps the development of superinfection due to the growth of microflora insensitive to the drug. In this case, it is necessary to cancel amoxicillin and prescribe another antibiotic. When treating patients with bacteremia, a bacteriolysis reaction (the Jarisch-Herxheimer reaction) may develop. In patients who are hypersensitive to penicillins, cross-allergic reactions with antibiotics of the cephalosporin subgroup may occur. In the treatment of mild diarrhea against the background of course therapy, it is necessary to avoid prescribing antidiarrheal drugs that reduce intestinal motility; you can use kaolin - or attapulgite-containing antidiarrheals. For severe diarrhea, see a doctor. With the combined use of estrogen-containing oral contraceptives and amoxicillin, it is necessary, if possible, to use additional methods of contraception.

Contraindications and restrictions for use

Hypersensitivity (also to other penicillins), infectious mononucleosis. Reception of amoxicillin should be limited in case of allergic diathesis, polyvalent hypersensitivity to xenobiotics, hay fever, lymphocytic leukemia, bronchial asthma, renal failure, history of gastrointestinal tract diseases (especially colitis, which is associated with taking antibiotics).

Use during pregnancy and lactation

It is not recommended to use amoxicillin during pregnancy, but it is possible in cases where the expected benefit of treatment outweighs the possible risk to the fetus. Use amoxicillin with caution while breastfeeding.

Side effects of amoxicillin

Circulatory and blood system: tachycardia, thrombocytopenic purpura, transient anemia, leukopenia, eosinophilia, agranulocytosis, neutropenia;
nervous system: headache, insomnia, dizziness, convulsions, behavior change, confusion, anxiety, agitation;
digestive system: pain in the anus, vomiting, nausea, change in taste, diarrhea, glossitis, stomatitis;
allergic reactions: exfoliative dermatitis, rhinitis, conjunctivitis, skin flushing, exudative erythema multiforme, anaphylactic shock, Stevens-Johnson syndrome, pruritus, Quincke's edema, urticaria, maculopapular rash, reactions similar to serum sickness;
others: joint pain, interstitial nephritis, difficulty breathing, moderate increase in blood transaminases, dysbacteriosis, oral and vaginal candidiasis, hemorrhagic or pseudomembranous colitis, superinfection.

Interaction of amoxicillin with other substances

Amoxicillin reduces the effect of oral estrogen-containing contraceptives, reduces the clearance of methotrexate and increases its toxicity. Bactericidal antibiotics (such as cycloserine, cephalosporins, vancomycin, aminoglycosides, rifampicin) and metronidazole - a synergistic interaction; bacteriostatic drugs (lincosamides, chloramphenicol, tetracyclines, macrolides, sulfonamides) - antagonistic action. Amoxicillin increases the effectiveness of indirect anticoagulants (by suppressing the intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index). Non-steroidal anti-inflammatory drugs, including indomethacin, acetylsalicylic acid, oxyphenbutazone, phenylbutazone, sulfinpyrazone, allopurinol, diuretics, probenecid, and other agents that inhibit tubular secretion, prolong elimination time, and increase blood levels of amoxicillin. When taken together with allopurinol, the possibility of developing a skin rash increases. Taking antacids reduces the absorption of amoxicillin.

Overdose

With an overdose of amoxicillin, diarrhea, nausea, vomiting, disturbances in the water and electrolyte balance (due to vomiting with diarrhea) occur; with prolonged use in high doses, thrombocytopenia and neurotoxic reactions appear (but these phenomena are reversible and disappear after stopping the drug). Gastric lavage, laxatives (salt) and activated charcoal, correction of water-electrolyte disorders, hemodialysis are necessary.

Dosage form:   capsules Ingredients:

Active substance: Amoxicillin 250 mg

(as amoxicillin trihydrate) 287 mg

Excipients:

calcium stearate 1.5 mg

potato starch up to 300.0 mg

Hard gelatin capsules: titanium dioxide (2%), water (14-15%), gelatin (up to 100%).

Description: No. 0 hard gelatin capsules with white body and cap. The contents of the capsules are white granular powder. Pharmacotherapeutic group:Antibiotic, semi-synthetic penicillin ATX:  

J.01.C.A.04 Amoxicillin

Pharmacodynamics:

Antibacterial, bactericidal, acid-resistantspectrum of action from the group of semi-synthetic penicillins. Inhibits transpeptidase, disrupts the synthesis of peptidoglycanwalls) during the period of division and growth, causes lysis of bacteria. Clinically significant Gram-negative amoxicillin-susceptible organisms include Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Campylobacter, Haemophilus influenzae, Leptospira, Chlamydia (in vitro), Neis seria gonorrhoeae, Neisseria meningitidis, Klebsiella spp.

Active against aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. including Streprococcus faecalis, Streprococcus pneumoniae.

Amoxicillin is also active against Helicobacter pylori.

Does not affect indole-positive strains of Proteus(P. vulgaris, R. Rettgeri); Serratia spp., Enterobacter spp., Morganella morganii, Pseudomonas spp.)."Rickettsia, mycoplasmas, viruses are resistant to its action. Microorganisms producing penicillinase are resistant to the action of amoxicillin. The action develops 15-30 minutes after administration and lasts 8 hours.

Pharmacokinetics:

Absorption - fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach. 1-2 hours after oral administration of a dose of 250 mg, a maximum plasma concentration of 3.5-5 μg / ml is reached. Communication with plasma proteins is 17%. Passes histohematic barriers, except for unchanged blood-brain; has a large volume of distribution - high concentrations are found in plasma, sputum, bronchial secretions (poor distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate, fluid exudate of the middle ear with inflammation, bone and fatty tissues, gallbladder (with normal liver function), fetal tissues. With increasing dose, the concentration in organs and tissues increases proportionally. The concentration in bile is 2-4 times higher than the concentration in blood plasma. ATamniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. Poorly penetrates the blood-brain barrier, with inflammation of the meninges (meningitis), the concentration of amoxicillin in the cerebrospinal fluid is about 20% of the level in the blood plasma.

Partially metabolized to form inactive metabolites. The half-life of amoxicillin is 1-1.5 hours. It is excreted by 50-70% by the kidneys unchanged by tubular excretion (80%) and glomerular filtration (20%), by the liver - 10-20%. A small amount is excreted in breast milk. In case of impaired renal function (creatinine clearance less than or equal to 15 ml / min), the half-life increases to 8.5 hours. It is removed during hemodialysis.

Indications:

Infectious and inflammatory diseases caused by microorganisms sensitive to Amoxicillin:

Infections of the upper respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media);

Infections of the lower respiratory tract (acute and chronic bronchitis, pneumonia);

Infections of the genitourinary system (acute and chronic pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea); gynecological infections (endometritis, cervicitis);

Infections of the gastrointestinal tract (enterocolitis, typhoid fever, salmonellosis, carriage of salmonella, shigellosis); peptic ulcer of the stomach and duodenum, chronic gastritis associated with Helicobacter pylori as part of combination therapy;

Infections of the biliary tract (cholangitis, cholecystitis); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses); leptospirosis; acute and latent listeriosis;

Lyme disease (borreliosis);

Infective endocarditis, such as enterococcal.

Contraindications:

Hypersensitivity to amoxicillin and other components of the drug (including other penicillins, cephalosporins, carbapenems), atopic dermatitis, bronchial asthma, hay fever, infectious mononucleosis, lymphocytic leukemia, liver failure, history of gastrointestinal tract diseases (especially colitis, associated with the use of antibiotics), lactation period.

Children's age up to 5 years and / or body weight less than 40 kg (for this dosage form).

Carefully:

Renal failure, history of bleeding, allergic reactions (including history).

Pregnancy and lactation:

During pregnancy, it is possible if the benefit to the mother outweighs the potential risk to the fetus (adequate and well-controlled studies in pregnant women have not been conducted).

If necessary, the appointment during lactation should stop breastfeeding.

Dosage and administration:

Inside, before or after a meal. Adults and children over 10 years old (weighing more than 40 kg) are prescribed 250 mg 3 times a day; in severe infections - 500 mg 3 times a day. For children under the age of 10 years, the drug is prescribed in the form of a suspension, since at this age the dosing of the drug in capsules is difficult. The interval between each dose of 8 hours must be strictly observed. The maximum daily dose should not exceed 6 g. The course of treatment is 5-12 days. Treatment is recommended to continue for 48-72 hours after normalization of body temperature or after the reliable destruction of the pathogen.

Infections of the upper respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media): 250 mg every 8 hours.

Lower respiratory infections (acute and chronic bronchitis, pneumonia): 500 mg every 8 hours.

Acute uncomplicated urinary tract infections: high dose therapy is recommended: 2 doses of 3 g with an interval of 10-12 hours.

In acute uncomplicated gonorrhea, men are prescribed 3 g once; in the treatment of women, it is recommended to take the indicated dose twice with an interval of 10-12 hours due to the possible multiple nature of the lesion and the ascending inflammatory process with the transition to the pelvic organs.

Gynecological infections without fever: 250 mg every 8 hours.

Gynecological infections accompanied by fever: 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Infections of the gastrointestinal tract (enterocolitis, typhoid fever, shigellosis): 1.5 - 2 g 3 times a day or 1-1.5 g 4 times a day.

Salmonella carrier: 1.5 - 2 g 3 times a day for 2-4 weeks.

Peptic ulcer of the stomach and duodenum, chronic gastritis associated with Helicobacter pylori as part of combination therapy: 1 g 2 times a day.

Biliary tract infections (cholangitis, cholecystitis): 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses): 250 mg every 8 hours.

Leptospirosis: 500 mg - 750 mg 4 times a day for 6-12 days.

Lyme disease (borreliosis): at stage I of the disease 500 mg 3 times a day. Infective endocarditis, for example, enterococcal: for the prevention of endocarditis in minor surgical interventions for adults - 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours.

Patients with severely impaired renal function should reduce the dose or increase the intervals between doses of amoxicillin.

With creatinine clearance below 10 ml / min and for patients on peritoneal dialysis, the maximum daily dose is 500 mg (250 mg 2 times a day); with a creatinine clearance of 10-30 ml / min, the maximum daily dose is 1000 mg (500 mg 2 times a day); with a creatinine clearance of more than 30 ml / min, it is not necessary to adjust the dosing regimen; with anuria - the maximum dose should not exceed 2 g / day.

For children aged 5-10 years, the dose is calculated per kilogram of the child's weight. In pediatric practice, in the form of capsules, it is applicable if the daily dose is at least 500 mg with a double dose (250 mg 2 times a day).

With a child weighing less than 20 kg, the daily dose is 25 mg / kg / day, divided into 3 doses; in severe cases of the disease - 50 mg / kg / day, divided into 3 doses.

With a child's body weight in the range of 20-40 kg, it is prescribed at a dose of 40-90 mg / kg / day in 3 doses at low doses and in 2 doses at high doses.

For children weighing over 40 kg, the drug is prescribed based on the dosage regimen for adults. Tonsillitis: 50 mg/kg/day in 3 divided doses.

Acute otitis media: in severe cases and relapses, as an alternative treatment regimen, 750 mg 2 times a day for 2 days can be used.

Prevention of endocarditis: 1.5 g 1 hour before surgery once. For surgical interventions performed under general anesthesia, -1.5 g 4 hours before surgery once. If necessary, re-admission after 6 hours.

Children with impaired renal function with creatinine clearance less than 10 ml / min, the interval between doses should be increased to 24 hours, which corresponds to taking 1/3 of the usual dose; with creatinine clearance in the range of 10-30 ml / min, the interval between doses is increased to 12 hours, which corresponds to taking 2/3 of the usual dose; with a creatinine clearance of more than 30 ml / min, correction of the dosing regimen is not required.

If a dose is missed, take the capsule as soon as possible, without waiting for the next dose, and then observe equal intervals between doses.

Side effects:

allergic reactions : urticaria, skin flushing, erythema, angioedema, rhinitis, conjunctivitis, fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme exudative, Stevens-Johnson syndrome, reactions similar to serum sickness, anaphylactic shock.

From the digestive system : dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, abnormal liver function, moderate increase in the activity of "liver" transaminases, pseudomembranous colitis, itching in the anus.

From the side of the nervous system : agitation or psychomotor agitation, anxiety, insomnia, ataxia, confusion; behavior change, depression, peripheral neuropathy, headache, dizziness, convulsions, aseptic meningitis.

From the urinary system : crystalluria and acute interstitial nephritis.

Laboratory indicators : leukopenia, neutropenia and agranulocytosis, thrombocytopenic purpura, anemia.

Others:shortness of breath, tachycardia, candidiasis of the oral and vaginal mucosa, superinfection (especially in patients with chronic diseases or reduced body resistance). Brown, yellow, or gray teeth, primarily in children.

Overdose:

Symptoms of overdose: nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea).

Measures to help with overdose: gastric lavage, activated charcoal, saline laxatives, drugs to maintain water and electrolyte balance; hemodialysis.

Interaction:

Antacids, laxatives, aminoglycosides, food - slow down and reduce absorption; enhances absorption. Bactericidal antibiotics (including aminoglycosides, cephalosporins,) - synergistic action; bacteriostatic drugs (macrolides, lincosamides, tetracyclines, sulfonamides) - antagonistic.

When treated with the drug in combination with metronidazole, nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, digestive disorders, in rare cases jaundice, interstitial nephritis, and hematopoiesis disorders are observed.

Amoxicillin increases the effectiveness of indirect anticoagulants (by suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, drugs, during the metabolism of which para-aminobenzoic acid is formed and, contributing to the risk of bleeding "breakthrough".

Diuretics, oxyphenbutazone, non-steroidal anti-inflammatory drugs, drugs that block tubular secretion - reducing tubular secretion, increase the concentration of amoxicillin in the blood.

The simultaneous use of amoxicillin and allopurinol increases the risk of developing a skin rash.

Amoxicillin reduces clearance and increases the toxicity of methotrexate. Enhances the absorption of digoxin.

Special instructions:

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

In the treatment of patients with bacteremia, the development of a bacteriolysis reaction (the Jarisch-Herxheimer reaction) is possible.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing products can be used. In case of severe diarrhea, it is necessary to consult a doctor.

Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used whenever possible.

In case of allergic reactions, the drug should be discontinued and the usual treatment with norepinephrine, antihistamines and glucocorticosteroids should be prescribed. With the appearance of a maculopapular rash, treatment can be continued only in case of life-threatening conditions under the strict supervision of a physician.

Adequate fluid intake and maintenance of adequate diuresis are essential during therapy. Patients with cholangitis or cholecystitis can be prescribed antibiotics only with a mild course of the disease and in the absence of cholestasis.

If severe diarrhea persists, pseudomembranous colitis caused by antibiotics should be suspected, which can pose a threat to the life of the patient (watery feces mixed with blood and mucus; dull widespread or colicky abdominal pain; fever, sometimes tenesmus). In such cases, you should immediately cancel and prescribe a specific treatment for the pathogen, for example, Editsin (). Drugs that reduce the peristalsis of the gastrointestinal tract are contraindicated.

Before starting treatment of gonorrhea in patients with suspected primary syphilitic lesions, a dark field study should be performed. All other patients with suspected concomitant syphilis should have follow-up serologic testing for at least 4 months.

Influence on the ability to drive transport. cf. and fur.:

When using Amoxicillin, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, tk. the drug may cause dizziness and other side effects that may affect these abilities.

Release form / dosage:

Capsules of 250 mg.

Package:

10 capsules in a blister pack made of PVC film and aluminum foil.

1 or 2 blister packs together with instructions for use are placed in a pack of cardboard. Storage conditions:

In a dry, dark place at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Best before date:

2 years. Do not use after the expiration date.

Conditions for dispensing from pharmacies: On prescription Registration number: LS-000409 Date of registration: 25.06.2010 / 27.09.2012 Expiration date: Perpetual Registration certificate holder: AVVA RUS, OJSC Russia Manufacturer:   Information update date:   19.08.2017 Illustrated Instructions