Triftazin dosage for a 7 year old child. The drug "Triftazin": instructions for use, price, analogues, reviews. Overdose, side effects and withdrawal of Triftazine. Indications for use

The drug goes on sale in two versions:

1. Tablet form of 5 or 10 mg, available in a blue wafer with a marble pattern. They have a biconvex appearance. Cardboard boxes contain 1 or 5 blisters of 10 tablets. 50 or 100 tablets are packaged in dark glass or plastic bottles.
2. Injection form for intramuscular administration in the form of a solution. 1 ml ampoules contain 2 mg of active substance. Available in boxes of 5 and 10 doses.

Storage

The drug should not be frozen or kept in the refrigerator. The optimal condition for storing it: in a dry, dark place, away from heating devices. A wall cabinet works well to prevent children from getting to the medicine. After 3 years, the medication is no longer suitable for use.

How the drug works

Triftazin belongs to the group of typical antipsychotics. Its structure is similar to chlorpromazine, but with a predominant antipsychotic effect. The mechanism of action is associated with changes in the activity of neurotransmitters in various parts of the brain. Trifluoperazine clogs postsynaptic D2 receptors that are tropic to dopamine, making the effect of the mediator impossible. Blockade of the nerve impulse is associated with increased inhibition of the central nervous system, mainly the mesolimbic and mesocortical zones. A pronounced antiemetic effect is noted, which is associated with blockade of the vagal nerve and an effect on the cerebellum.

In addition to dopamine, it rarely blocks alpha-adrenergic receptors, which causes relaxation of blood vessels and a decrease in blood pressure. Inhibition of acetylcholine receptors is weakly expressed. Sedation and anticonvulsant effects are worse than those of chlorpromazine. In low dosages it exhibits activating properties. By affecting the hypothalamus and pituitary gland, it causes a decrease in their hormones, with the exception of prolactin.

When is the drug prescribed?

The main patient population for treatment with triftazine are patients with schizophrenia and other mental disorders accompanied by delusions and hallucinations.

In small dosages, indications for use:

1. Relieving paranoia, obsessive thoughts and actions.
2. In palliative oncology as an addition to opioid therapy.
3. In the elderly for the treatment of involutional psychoses and neuroses.

Used for vomiting, but only caused by pathology of the central nervous system. This can happen with brain tumors, meningitis, or increased intracranial pressure.

Dosage regimens

Triftazin is prescribed after meals, the tablet can be divided. The drug is well absorbed from the gastrointestinal tract, with the maximum concentration in the blood determined after 1-2 hours. The dosage is selected depending on the diagnosis, age, and severity of symptoms. Treatment begins with small values ​​with a slow increase to therapeutic levels. When a stable therapeutic effect is achieved, after about 1-3 months they switch to taking maintenance doses.

For anxiety and restlessness, no more than 2 mg per day is prescribed.

For psychoses, diseases with delusional and hallucinatory manifestations, the optimal dose of treatment is 1-2 tablets (5 mg) 2-3 times a day. Titration begins with 0.5-1 tablets (5 mg) 2 times a day, the maximum intake is not higher than 40 mg daily. In cases of pronounced manifestations of the disease that require a quick effect, the medicine is prescribed in the form of intramuscular injections of 0.5-1 ml (rarely 2-3 ml) with an interval of 4-6 hours. Then they switch to oral therapy.

The duration of treatment depends on the degree of the disorder; usually, regression of symptoms occurs after 2-3 weeks. For elderly patients, the optimal dosage is selected more slowly, starting with 1/8-1/4 tablets. In children, treatment doses should be small: at the age of over 12 years, 5-6 mg per day in 2 divided doses, at the age of 6-12 years, no more than 4 mg in 2 divided doses. For vomiting of central origin, it is possible to prescribe triftazine up to 4 mg in 2 doses; intoxication with other drugs must be excluded.

When the drug is contraindicated

Given the blocking effect on dopamine receptors, the drug is not prescribed when the activity of the central nervous system is inhibited, which happens with traumatic brain injuries, disturbances of consciousness up to coma, and progressive systemic diseases. Strict contraindications also include:

1. Suppressed hematopoietic function.
2. Failure of the excretory organs (liver and kidneys).
3. Acute ulcers of the wall of the stomach or duodenum.
4. Decompensation of diseases of the cardiovascular system.
5. Angle-closure glaucoma.
6. Severe form of hypothyroidism.
7. Periods of gestation and breastfeeding.
8. Individual intolerance.
9. The child's age is less than 3 years.

The drug relieves hallucinatory and delusional excitement well, but an increase in agitation has been observed with catatonia, anxiety and mania. The medicine is prescribed with caution for exhaustion, epilepsy, Parkinson's disease, ulcerative lesions of the stomach and duodenum, urinary retention, long-term respiratory diseases, breast cancer, as well as in elderly patients. Alcohol-related psychoses and chronic dependence require careful monitoring due to possible liver dysfunction.

Adverse drug reactions

Side effects of administration are manifested by various reactions from all organs and systems. Feedback from patients about treatment with small doses indicates that the drug is well tolerated. The most common side effects are extrapyramidal disorders:

• dyskinesia and hyperkinesis;
• akinetic-rigid syndrome, tremor;
• akathisia, or obsessive movements;
• autonomic dysfunctions.

To prevent the occurrence of extrapyramidal disorders, treatment with triftazine is accompanied by the simultaneous administration of cyclodol. Since the drug inhibits the activity of certain brain structures, patients may complain of lethargy, reluctance to do anything or be interested in anything.

The following reactions may be observed in other body systems:

1. Gastrointestinal tract: constipation or diarrhea, nausea, vomiting, loss of appetite, bile stagnation.
2. Endocrine system: increased body weight, swelling of the mammary glands, decreased blood sugar, glucosuria, menstrual irregularities.
3. Cardiovascular system: arrhythmias, blood pressure instability, myocardial ischemia.
4. Genitourinary system: urinary retention, oliguria, decreased potency and libido, priapism.

In addition, cases of skin staining, discoloration of the lens, the development of myasthenia gravis, phenylketonuria, thermoregulation disorders, suppression of hematopoiesis up to agranulocytosis, and various visual impairments were noted. An overdose, a rapid increase in daily intake or abrupt withdrawal can provoke the development of neuroleptic malignant syndrome, which is characterized by the following symptoms:

1. Extrapyramidal disorders.
2. Hyperthermia and autonomic disorders: dry skin and mucous membranes, sweating, surges in blood pressure and arrhythmias.
3. Confusion.
4. Myasthenia.
5. Increased mental disorders: delirium, catatonia, hallucinations, anxiety and agitation.

You should not drink alcohol while taking it. The medicine is not recommended for drivers. Interaction and simultaneous use with any other drugs should be discussed with your doctor.

Triftazine poisoning

Toxic doses of antipsychotics in adults are quite large - from 500 mg, but there have been cases of overdose with much smaller doses. In children under 3 years of age, intoxication can develop after taking even a few tablets, so it is necessary to ensure storage in a place inaccessible to them. It is typical that up to 20 hours can pass from the moment of administration to the appearance of a pronounced neurological deficit.

Where to buy the drug and its analogues

The analogue usually contains the same amount of trifluoperazine. The following drugs have a similar composition:

• Trazin;
• Stelazine;
• Exazin;
• Trifluoperazine-Apo.

You can buy an antipsychotic at any pharmacy, but only if you have a prescription form. Only a doctor will be able to correctly assess the patient’s condition and the required dosage regimen. The price of the medicine is low; on average, for 50 tablets you will be asked from 26 to 40 rubles, 10 ampoules will cost from 65 to 80 rubles. Despite the low cost of the medication, you should not purchase it on the advice of friends. Self-medication is strictly prohibited.

Latin name: Triphtazinum
ATX code: N05A B06
Active substance: trifluoperazine
Manufacturer: Dalkhimpharm (RF)
Dispensing from the pharmacy: on prescription
Storage conditions: at t 15-25°C
Best before date: 2 years

The drug Triftazin is an antipsychotic medicine (neuroleptic). Designed for treatment and elimination of:

• Psychotic disorders (including schizophrenia)
• Neuroses with severe anxiety, panic
• Psychomotor agitation
• Nausea, vomiting.

Composition and dosage form

In one tablet:

• Active ingredient: 5 or 10 mg trifluoperazine (hydrochloride form)
• Additional ingredients: sucrose (or sugar), potato starch, aerosil, E 572, gelatin, E 504, indigo carmine, PVP, beeswax, E 171, talc.

Medicines in tablets, convex on both sides, enclosed in a blue or turquoise coating with a “marble” effect. The core of the pill is two-layer.

Pills are packaged in 10 pieces in blisters or in polymer jars of 50 or 100 pieces. A pack of thick cardboard contains 5 plates or 1 container, description and manual.

Medicinal properties

The drug is an antipsychotic drug. The therapeutic effect is provided by the properties of trifluoperazine, a phenothiazine derivative. Like all substances of this type, it has the ability to block specific GM receptors. The potency of trifluoperazine is many times greater than that of chlopromazine; it neutralizes the urge to vomit by suppressing or blocking dopamine receptors in the central nervous system in the cerebellum and vagal nerve in the gastrointestinal tract.

The substance is distinguished by binding activity to plasma proteins. It is excreted from the body primarily by the kidneys.

Mode of application

Triftazin, according to the instructions for use, should be taken after meals. The dosage is selected individually in accordance with the patient’s diagnosis and the condition of his body. Determining the most effective amount is achieved by gradually increasing the drug. After reaching the maximum effect, the CH of the drug is gradually reduced to a maintenance level.

• For adults with psychotic disorders: the course begins with taking 1-5 mg x 2 times a day, then over the course of several weeks the daily dose is increased to 15-20 mg, which is taken three times a day. The therapeutic effect appears after 2-3 weeks. The highest daily value that should not be exceeded is 40 mg.

During therapy, it is necessary to constantly monitor the functions of the cardiovascular system, liver, kidneys, and blood condition. To avoid adverse reactions, it is necessary to refrain from alcohol-containing liquids (drinks and medications) and exposure to high temperatures.

If a patient is scheduled for myelography, then Triftazin should be stopped two days before the procedure and not taken for a day after it.

Use during pregnancy and lactation

Preparations containing trifluoperazine are prohibited for use in pregnant and lactating women. The basis for the limitation is information obtained experimentally. According to research data, the substance provokes developmental defects in the prenatal period, and delays weight gain in born babies.

The active substance of the drug enters the child's body with milk and can contribute to the development of tardive dyskinesia in the newborn and increase drowsiness.

Contraindications and precautions

Average price: (50 tablets) – 33 rubles, (100 pcs.) – 68 rubles.

Triftazin tablets should not be used for:

• High individual sensitivity to contained substances
• Severe forms of cardiovascular diseases
• Severe central nervous system dysfunction, coma of any origin
• Progressive pathologies of the brain and spinal cord
• Severe liver dysfunction
• Pregnancy and breastfeeding
• Childhood.

Relative contraindications for which Triftazine should be prescribed with special precautions:

• Alcoholism (due to high risk of liver damage)
• Angina pectoris, heart valve damage (risk of severe arterial hypertension)
• Pathological disorders of blood composition
• Breast cancer (due to increased production of prolactin, disease progression is possible)
• Angle-closure glaucoma
• Hyperplasia
• BPH
• Poor liver and/or kidney function
• Exacerbation of peptic ulcer and duodenum
• Any disease that provokes thromboembolic complications
• Parkinson's disease
• Epilepsy
• Chronic diseases of the respiratory system with associated breathing complications
• Reye's syndrome (especially dangerous for children and adolescents)
• Severe exhaustion of the body
• Vomit
• Old age of the patient
• Hyperthermia.

Cross-drug interactions

The use of Triftazin when taken simultaneously with other drugs requires caution, since unilateral or mutual distortion of the therapeutic effects of drugs is possible.

• When combined with medications that depress the central nervous system (drugs for anesthesia, narcotic painkillers, barbiturates, drugs with ethyl alcohol), the effect is enhanced, which can contribute to the development of unwanted psychomotor reactions.
• Combination with TCAs, maprotiline, and MAOIs can enhance and prolong the period of sedation, increasing the risk of NMS.
• Combination with barbiturates and other anticonvulsants causes a decrease in the threshold for the occurrence of a convulsive state.
• When combined with drugs for the treatment of thyroid hyperfunction, the likelihood of agranulocytosis increases.
• Combined therapy with beta blockers potentiates the hypotensive effect, increasing the risk of developing permanent retinopathy, tardive dyskinesia and arrhythmia.
• Combination with diuretic drugs accelerates sodium excretion and, accordingly, the development of hyponatremia.
• The active substance Triftazin potentiates the effect of atropine and worsens the course of therapy with indirect anticoagulants.
• Combining lithium with drugs reduces their absorption in the gastrointestinal tract and accelerates excretion by the kidneys, intensifying extrapyramidal disorders.
• Combined use with adrenergic stimulants leads to a sharp decrease in blood pressure.
• The effect of Triftazin is reduced under the influence of levodopa, phenamines, drugs with aluminum and magnesium.

Side effects and overdose

Treatment with Triftazin may be accompanied by negative reactions from the body:

• CNS and PNS: headaches, sleep disturbances (daytime drowsiness and nighttime insomnia, dizziness, general weakness, extrapyramidal reactions, pseudoparkinsonism (mask-like face, intense salivation, tongue protruding - symptoms disappear on their own after drug withdrawal), tardive dyskinesia (possibly irreversible), NMS, manifestation of mental indifference, inhibited reaction to external stimuli, hyperkinesis, tremors of the limbs, autonomic disorders, dystonia, thermoregulation disorder, fatigue, confusion, muscle hypertonicity, convulsions.
• Visual organs: accommodation disorder, retinopathy, cataracts, decreased vision clarity, conjunctivitis.
• Gastrointestinal tract: dry mouth, hyperactivity of the salivary glands, lack of appetite, nausea, vomiting, impaired bowel movement (constipation or diarrhea), intestinal paresis, tongue prolapse.
• Liver: hepatoxicity, intrahepatic cholestasis, hepatitis.
• Endocrine system and metabolism: hyper- or hypoglycemia, MC disorder, gynecomastia, weight gain, chest pain, nipple discharge, hyperprolactinemia.
• CVS: tachycardia, orthostatic hypotension, cardiac arrhythmia, angina attacks, ventricular arrhythmia, cardiac arrest.
• Circulatory system: thrombocytopenia, anemia, leukopenia, eosinophilia.
• Genitourinary system: decreased libido, erectile dysfunction, priapism, difficulty urinating, decreased urine output by the kidneys.
• Locomotor system: myasthenia gravis.
• Skin: photosensitivity, redness of the dermis, pigmentation disorders, exfoliative dermatitis.
• Immune system: allergic reactions, skin rash, urticaria, Quincke's edema, anaphylaxis.
• Laboratory tests: false positive pregnancy test.
• Other symptoms: general weakness, swelling.

Specific reactions to phenothiazine derivatives (including trifluoperazine): low body temperature, nightmares or unusual dreams, depression, cervical edema, convulsions, prolonged action of drugs that depress the central nervous system, nasal congestion, intestinal atony, liver dysfunction, increased appetite, hyperpigmentation, asphyxia , death.

Accidental or deliberate use of overdoses of the drug contributes to the development of negative reactions:

• NMS (convulsions, difficulty breathing, arrhythmia, high temperature, labile blood pressure, severe sweating, spontaneous urination, severe muscle hypertonicity, severe pallor, confusion, etc.)
• Collapse
• Low body temperature
• Inflammation of the liver (toxic hepatitis).

Overdose is eliminated with symptomatic treatment. To eliminate neurological complications, reduce the dosage, prescribe Cyclodol, and, if necessary, antidepressants and stimulants.

Indicators of the patient’s condition (pressure, cardiovascular system, respiratory activity, body temperature, etc.) after an overdose should be monitored by doctors for at least 5 days.

Analogs

If it is impossible to use Triftazine therapy, the drug should be replaced with analogues (Vertinex, Moditen Depot).

Tatchempreparations (RF)

Price: tablet 4 mg (50 pcs.) – 330 rub., 10 mg (50 pcs.) – 372 rub.

Neuroleptic based on perphenazine. Indicated for the treatment of psychotic disorders, it helps especially well with hyperactivity and nervous excitement, neuroses with accompanying severe fear, and schizophrenia. It is also prescribed to eliminate nausea, vomiting and skin itching of various origins.

Available in tablets with different concentrations of perphenazine.

Pros:

• Helps
• Reduces the level of general anxiety.

Minuses:

• Adverse reactions.

Triftazin belongs to the group of neuroleptics and is antipsychotic drug.

This product contains an active component - trifluoperazine hydrochloride (5 mg per tablet; 2 mg per 1 ml solution for injection), as well as excipients depending on the form of release.

The presence of an active substance, which, by blocking certain brain receptors, has a sedative, hypothermic, antiemetic, hypotensive and cataleptic effect, determines the therapeutic properties of the drug.

Compared to other drugs of similar action, Triftazin is more active and is better tolerated by patients.

Over the years of practice using the drug, Triftazin has proven its effectiveness in the treatment of psychoses, nervous disorders, delirium, paranoia and hallucinations.

Pharmacokinetics

After entering the body, the active component of Triftazine is “bound” by blood proteins. Maximum concentration is achieved within 1-2 hours after administration. Metabolized in the liver, and then excreted from the body with bile and urine.

Please note that this drug can pass into breast milk.

Indications for use

Due to the effect of the active component Triftazin on the nervous system, this drug indicated for the treatment of:

• schizophrenia (sluggish, periodic; paranoid, accompanied by hallucinations, neurosis-like and other forms of this disease);
• mental disorders accompanied by delusions and hallucinations, paranoia and obsessive states;
• neuroses (including age-related and those caused by alcohol).

Also used as an antiemetic for central vomiting.

Contraindications for use of the medicine

Triftazin is contraindicated at:

• brain injuries;
• comatose state of the patient;
• depression of central nervous system functions;
• diseases of the brain (brain and spinal cord);
• acute peptic ulcer of the stomach and duodenum;
• some blood and heart diseases;
• dysfunction of the liver and kidneys;
• closed glaucoma;
• myxedema.

In addition, the drug not prescribed for children under 3 years of age, as well as patients who have hypersensitivity to the drug or individual intolerance to its components.

Instructions for use state that if you have the following diseases, Triftazin should be used carefully:

• respiratory dysfunction;
• some diseases of the heart and vascular system;
• peptic ulcer in remission;
• malignant formations in the mammary glands;
• epilepsy;
• Parkinson's disease;
• alcohol addiction.

Mechanism of action

Once in the body, trifluoperazine has a blocking effect on some brain receptors. Thus, the drug exhibits its antipsychotic properties and normalizes the condition of patients.

By blocking certain receptors in the cerebellum and the vagus nerve in the gastrointestinal tract, Triftazin stops vomiting.

Directions for use and dosage

According to the instructions for use, Triftazin is administered orally (in tablet form) or by intramuscular injection (in solution form).

The dosage is prescribed individually, depending on the patient’s condition, his age, the desired effect and other factors.

The duration of treatment is also determined in each specific case, but, as a rule, does not exceed 12 weeks. The use of Triftazin should not be stopped abruptly; the dosage should be gradually reduced.

Treatment with tablets

Depending on the task and the disease, the following dosages will be drug:

1. Anxiety syndrome. The usual dose is 1-2 mg per day, but sometimes it can be increased to 6 mg.
2. Psychotic disorders. At the beginning of treatment, the dose of the drug is 2.5-5 mg per day and is divided into 2 doses. Gradually the dosage is increased to 15-20 mg, in rare cases up to 40 mg. The duration of treatment is 2-3 weeks.
3. Vomit. As a rule, 1-4 mg of Triftazine per day is prescribed.

Treatment by intramuscular injection

This method is used when a quick effect is needed. As a rule, they begin to administer 1-2 mg of the drug at intervals of 6-12 hours, gradually increasing the dosage to 6-10 mg per day.

What are the dangers of overdose?

An overdose of Triftazine is accompanied by the following symptoms: drowsiness, stupor, confusion, convulsions, cardiac arrhythmia, hypothermia, in severe cases the patient may fall into a coma.

Help for overdose is provided according to the symptoms. As a rule, first you need to do a gastric lavage.

If there are signs of an overdose, you should urgently go to the hospital so that the doctor can determine the drugs necessary for treatment, because for different manifestations of an overdose, treatment is determined individually. If necessary, artificial ventilation and oxygen therapy can be performed.

Side effect

Triftazin can have negative effects on the body even when used correctly.

Side effects of the drug on various body systems:

1. Nervous system: dizziness, insomnia at the initial stage of treatment and increased drowsiness in the future, muscle spasms, impaired coordination of movements, convulsions, non-standard reaction to external stimuli.
2. The cardiovascular system: surges in blood pressure, heart rhythm disturbances, anemia, suppression of bleeding in the bone marrow.
3. Digestive system: nausea, vomiting, constipation at the initial stage of treatment, diarrhea, loss of appetite, hepatitis.
4. Genitourinary system: disruption of the urinary system, decreased libido.
5. Endocrine system: glucosuria, gynecomastia, weight gain, pain in the mammary glands.
6. Allergic reactions: skin rashes, swelling.

In addition, as a result of taking the drug, vision may deteriorate, and sometimes discoloration of the cornea occurs. The patient may also become more sensitive to high temperatures.

Special instructions for use and precautions

During pregnancy, Triftazin is contraindicated, because its active component trifluoperazine can adversely affect the development of the fetus.

During lactation also you should stop taking this drug, because its active substance can pass into breast milk.

Carefully Triftazin should be used by older people, since the development of irreversible processes that cause involuntary movements (dyskinesia) is likely.
During treatment with this drug, exposure to high temperatures should be avoided because patients may experience impaired thermoregulation.

It is necessary to regularly monitor blood pressure, pulse rate, and also monitor the normal functioning of the kidneys and liver.

Drinking alcohol is prohibited while using this drug!

During the period of treatment with Triftazin, you should refrain from driving a car, as well as from engaging in activities that require attentiveness and concentration, because the drug causes drowsiness, lethargy and confusion.

Dispensed only with a doctor's prescription.

Interaction with other drugs

Triftazin interacts with many drugs, and this does not always have a positive effect on the patient’s health. Therefore, before combining medications, you should consult with doctor:

• when used simultaneously with drugs that depress the functions of the central nervous system, disruption of the central nervous system and respiratory function is possible;
• combination with analgesics can lead to hyperthermia; with antidepressants – to the development of neuroleptic malignant syndrome;
• Avoid simultaneous use with epinephrine, as this combination can cause a sharp drop in blood pressure, and with prochlorperazine, as this can lead to prolonged loss of consciousness.

Storage conditions and periods

The drug must be stored in a dark place out of reach of children.

Shelf life – 3-4 years.

Release form and cost

Triftazin is available in two forms: a solution for intramuscular injection (clear or slightly yellowish) and yellow or blue-green film-coated tablets.

The price of Triftazin depends on the form release:

• tablets – 30-60 rubles;
• ampoules for injections - 35-65 rubles.

Reviews from doctors and patients

Reviews from doctors and patients about Triftazin are mostly positive, but before use, you must study the instructions for use - every little detail is important.

Patients, who used Triftazin, they note that the drug is effective in the treatment of hallucinations, however, it does not always effectively cope with delusional states.

Almost all patients felt drowsiness and lethargy during treatment with this drug; in some, the side effects affected visual acuity, speech functions, and memory function. In isolated cases, patients write about weight gain while taking Triftazin.

Compared with haloperidol drugs, there is more soft action and safety Triftazina.

Many patients write that in parallel with this drug, doctors prescribe correctors that make it easier to tolerate the side effects of Triftazin and improve their general condition during the treatment period.

Doctors note that Triftazin in some cases is more effective than similar drugs in coping with delusions, anxiety, and obsessive states. However, you should strictly follow the rules for using the drug, as there is a high risk of overdose.

If you are concerned about any effect of the medicine or lack of visible effect, you should contact a specialist who can adjust the treatment if necessary.

Advantages:

• effective for the treatment of neuroses;
• after taking there is an improvement in sleep;
• some patients note that the drug acts as an antidepressant;
• copes well with hallucinatory states;
• milder effect compared to haloperidol drugs.

Flaws Triftazina:

A significant number of contraindications and side effects;

High risk of overdose;

Most patients report drowsiness, lethargy, and reluctance to do anything during the treatment period;

The drug negatively affects the ability to concentrate;

Cases of deterioration of vision and memory in patients taking Triftazin are not uncommon.

The drug has found wide application in neurology and other interesting facts are in our article.

With age, blood circulation in the brain may be impaired, senile dementia occurs, at the first stage these are not obvious and are difficult to detect.

Drugs that can replace Triftazin

Analogues of Triftazin are quite numerous and have advantages and disadvantages over it.

Exazin

Pharmacological group – neuroleptics. Used when schizophrenia, psychosis, hallucinatory state, vomiting of central origin.

The active substance component is trifluoperazine, the concentration of which in the drug is similar to Triftazin.

Contraindications, precautions and application features are similar to Triftazin. It is possible to use the drug during pregnancy if the benefit to the mother outweighs the potential risk to the fetus.

Available in the form of tablets and solution for intramuscular injection.

Stelazine

Belongs to the pharmacological group of neuroleptics and has antipsychotic properties. Dosage form: tablets and solution for intramuscular injection.

Indications for use, treatment features and contraindications are similar to Triftazin.

Contains one active component – ​​trifluoperazine. Each tablet contains 1 mg or 5 mg of the active substance, and the solution contains 1 mg per 1 ml.

Trazyn

Antipsychotic drug has antipsychotic effect.

Indications for use: similar to Triftazin.

Trifluoperazine is the active component of the drug and determines its medicinal properties. The content of the active component in the tablets is higher than in Triftazin (5 and 10 mg per tablet).

Contraindications and features of use are similar to Triftazin. Treatment with this drug during pregnancy is possible if the benefit to the mother outweighs the potential risk to the child.

Release form: tablets; solution for intramuscular injection.

In this article you can read the instructions for use of the drug Triftazin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Triftazin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Triftazin in the presence of existing structural analogues. Use for the treatment of schizophrenia, psychosis in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Triftazin- antipsychotic drug (neuroleptic), piperazine derivative of phenothiazine. It is believed that the antipsychotic effect of phenothiazines is due to the blocking of postsynaptic mesolimbic dopaminergic receptors in the brain. The intensity of the antipsychotic effect is superior to chlorpromazine. It has a strong antiemetic effect, the central mechanism of which is associated with inhibition or blockade of dopamine D2 receptors in the chemoreceptor trigger zone of the cerebellum, and the peripheral mechanism with blockade of the vagus nerve in the gastrointestinal tract. Has alpha-adrenergic blocking activity. Has some activating effect. Anticholinergic activity and hypotensive effect are weakly expressed. Has a pronounced extrapyramidal effect. Unlike chlorpromazine, it does not have antihistamine, antispasmodic or anticonvulsant effects.

Compound

Trifluoperazine hydrochloride + excipients.

Pharmacokinetics

Clinical data on the pharmacokinetics of trifluoperazine are limited.

Phenothiazines are highly bound to plasma proteins. They are excreted mainly by the kidneys and partly with bile.

Indications

• psychotic disorders, incl. schizophrenia;
• psychomotor agitation;
• neuroses with a predominance of anxiety and fear;
• symptomatic treatment of nausea and vomiting.

Release forms

Film-coated tablets 5 mg and 10 mg.

Solution for intramuscular administration (injections in injection ampoules).

Instructions for use and dosage regimen

Individual. Orally for adults - 1-5 mg 2 times a day; if necessary, within 2-3 weeks the dose is increased to 15-20 mg per day, the frequency of use is 3 times a day. Children aged 6 years and older - 1 mg 2-3 times a day; if necessary, the dose can be increased to 5-6 mg per day.

Intramuscularly for adults - 1-2 mg every 4-6 hours. Children - 1 mg 1-2 times a day.

Maximum doses: adults when taken orally - 40 mg per day, intramuscularly - 10 mg per day.

Side effect

• drowsiness;
• dizziness;
• dry mouth;
• sleep disorders;
• fatigue;
• visual impairment;
• extrapyramidal disorders;
• tardive dyskinesia;
• anorexia;
• cholestatic jaundice;
• thrombocytopenia, anemia, agranulocytopenia, pancytopenia;
• tachycardia;
• moderate orthostatic hypotension;
• heart rhythm disturbances;
• changes on the ECG (prolongation of the QT interval, smoothing of the T wave);
• skin rash;
• hives;
• angioedema;
• galactorrhea;
• amenorrhea.

Contraindications

• comatose states;
• diseases accompanied by myelodepression;
• severe liver dysfunction;
• pregnancy, lactation;
• hypersensitivity to trifluoperazine.

Use during pregnancy and breastfeeding

Triftazin is contraindicated for use during pregnancy and lactation.

Experimental studies have shown that trifluoperazine (in doses significantly higher than clinical) can increase the incidence of malformations and reduce the body weight of newborn animals.

Phenothiazines pass into breast milk and may cause drowsiness and increase the risk of tardive dyskinesia in the baby.

Use in children

Use in children is possible according to the dosage regimen.

Use in elderly patients

Elderly patients require adjustment of the Triftazine dosage regimen.

special instructions

Should not be used for depression.

Use with extreme caution in patients with glaucoma, cardiovascular diseases, epilepsy, benign prostatic hyperplasia; with hypersensitivity to other phenothiazine drugs. Phenothiazines are used after comparing the risks and benefits of treatment in patients with pathological changes in the blood picture, liver dysfunction, alcohol intoxication, Reye's syndrome, as well as breast cancer, Parkinson's disease, gastric and duodenal ulcers, urinary retention, chronic organ diseases breathing (especially in children), epileptic seizures, vomiting.

The simultaneous use of phenothiazines with absorbent antidiarrheals should be avoided.

Elderly patients require adjustment of the trifluoperazine dosage regimen. During the treatment period, alcohol consumption should be avoided.

Impact on the ability to drive vehicles and operate machinery

It should be used with caution in patients whose activities require increased concentration and high speed of psychomotor reactions.

Drug interactions

With the simultaneous use of drugs that have a depressant effect on the central nervous system, ethanol (alcohol), and ethanol-containing drugs, the depressant effect on the central nervous system and respiratory function may be enhanced.

When used simultaneously with anticonvulsants, the threshold for convulsive readiness may be reduced; with drugs that cause extrapyramidal reactions, an increase in the frequency and severity of extrapyramidal disorders is possible.

When Triftazin is used simultaneously with tricyclic antidepressants, maprotiline, and MAO inhibitors, the risk of developing neuroleptic malignant syndrome (NMS) increases.

When used simultaneously with drugs that cause arterial hypotension, severe orthostatic hypotension is possible.

When used simultaneously with drugs for the treatment of hyperthyroidism, the risk of developing agranulocytosis increases.

When used simultaneously with anticholinergic drugs, their anticholinergic effects are enhanced, while the antipsychotic effect of the antipsychotic may decrease.

With the simultaneous use of antacids and antiparkinsonian drugs, the absorption of phenothiazines is impaired.

With simultaneous use, the effect of oral anticoagulants is weakened, and the effectiveness of amphetamines, levodopa, clonidine, guanethidine, epinephrine, and ephedrine may be reduced.

With the simultaneous use of Triftazin with lithium salts, neurotoxic effects and the development of extrapyramidal symptoms are possible.

When used simultaneously with methyldopa, a case of the development of paradoxical arterial hypertension has been described.

When used simultaneously with fluoxetine, the development of extrapyramidal symptoms and dystonia is possible.

Analogues of the drug Triftazin

Structural analogues of the active substance:

• Trazin;
• Trifluoperazine Apo;
• Triftazin Darnitsa;
• Triftazine hydrochloride;
• Triftazin solution in ampoules 0.2%;
• Eskazin.

Analogs by pharmacological group (neuroleptics):

• Abilify;
• Azaleptin;
• Alimemazine tartrate;
• Aminazine;
• Aripiprazole;
• Barnetyl;
• Betamax;
• Haloperidol;
• Hedonin;
• Droperidol;
• Zalasta;
• Zeldox;
• Zilaksera;
• ziprasidone;
• Zyprexa;
• Invega;
• Quentiax;
• Quetiapine;
• Kvetitex;
• Ketiap;
• Clozapine;
• Closasten;
• Clopixol;
• Lakvel;
• Leponex;
• Leptinorm;
• Limipranil;
• Majeptyl;
• Melleril;
• Mirenil;
• Moditen;
• Olanzapine;
• Piportil;
• Propazine;
• Prosulpin;
• Rileptide;
• Risperidone;
• Rispolept;
• Rispolux;
• Risset;
• Serdolect;
• Seroquel;
• Sonapax;
• Sulpiride;
• Teraligen;
• Tizercin;
• Thioridazine;
• Torendo;
• Truxal;
• Fluanxol;
• Chlorpromazine;
• Chlorprothixene;
• Eglonyl;
• Etaperazine.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Country of origin

Product group

Antipsychotic drug (neuroleptic),

Release forms

• 1 ml - ampoules (10) - cardboard packs. 1 ml - ampoules (5) - cardboard packs. 10 - contour cell packaging (5) - cardboard packs. 50 tablets per pack

Description of the dosage form

• Round, biconvex, film-coated tablets, blue or blue with a green tint. Marbling is allowed on the surface of the tablets. The cross section shows two layers. Solution for intramuscular administration 0.2% Film-coated tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• Trifluoperazine hydrochloride 5 mg

Triftazin indications for use

• Psychotic disorders, incl. schizophrenia. Psychomotor agitation. Neuroses with a predominance of anxiety and fear. Symptomatic treatment of nausea and vomiting.

Triftazine contraindications

• Comatose states; diseases accompanied by myelodepression; severe liver dysfunction; pregnancy, lactation; hypersensitivity to trifluoperazine.

Triftazine dosage

• 2 mg/ml 5 mg

Triftazine side effects

• From the central nervous system: drowsiness, dizziness, insomnia (at the beginning of treatment), dry mouth, with prolonged use of high doses - akathisia, dystonic extrapyramidal disorders (spasms of the muscles of the face, neck and back, tic-like movements or twitching, bending movements of the body, inability to move eyes, weakness in arms and legs), parkinsonism (difficulty speaking and swallowing, loss of balance control, mask-like face, shuffling gait, stiffness in arms and legs, tremors of hands and fingers), tardive dyskinesia (smacking and puckering of lips, puffy cheeks , rapid or worm-like movements of the tongue, uncontrolled chewing movements, uncontrolled movements of the arms and legs). Dyskinesias are relieved by subcutaneous injection of 2 ml of 20% sodium caffeine solution and 1 ml of 0.1% atropine solution), neuroleptic malignant syndrome (convulsions, difficulty or rapid breathing, rapid heartbeat or irregular pulse, hyperthermia, unstable blood pressure, sweating, loss of control urination, pronounced muscle rigidity, unusually pale skin, unusual fatigue and weakness), phenomena of mental indifference, delayed reaction to external irritations and other mental changes, in isolated cases - convulsions (antiparkinsonian drugs are used as correctors - tropacin, cyclodol, etc.) ; paradoxical reactions - hallucinations, psychomotor agitation. From the senses: blurred visual perception, accommodation paresis (at the beginning of treatment), with long-term use - retinopathy, clouding of the lens and cornea. From the digestive system: loss of appetite, anorexia, constipation (at the beginning of treatment), bulimia, nausea, vomiting, diarrhea, gastralgia, rarely - cholestatic jaundice, hepatitis, intestinal paresis. From the genitourinary system: urinary retention, decreased potency and libido, frigidity (at the beginning of treatment), ejaculation disorders, priapism, oliguria. From the endocrine system: hypo- or hyperglycemia, glucosuria, amenorrhea, hyperprolactinemia, dysmenorrhea, galactorrhea, swelling or pain in the mammary glands, gynecomastia, weight gain. From the cardiovascular system: tachycardia, increased frequency of angina attacks (against the background of increased physical activity), at the beginning of treatment - a decrease in blood pressure (including orthostatic hypotension), especially in elderly patients and people suffering from alcoholism; heart rhythm disturbances, changes in the electrocardiogram (prolongation of the QT interval, decrease or inversion of the T wave). Allergic reactions: skin rash, urticaria, angioedema, exfoliative dermatitis. Laboratory indicators: leukopenia, thrombocytopenia, anemia, agranulocytosis (on days 4-10 of treatment), pancytopenia, eosinophelia (less common than other phenothiazines), hemolytic anemia, false-positive tests for phenylketonuria, false-positive pregnancy tests. Other: photosensitivity, staining of the skin and conjunctiva, discoloration of the sclera and cornea, decreased tolerance to high temperatures (up to the development of heat stroke - hot dry skin, loss of the ability to sweat, muscle weakness, confusion), myasthenia gravis. Cases of sudden death (including those possibly caused by cardiac causes) have been reported when taking phenothiazine antipsychotics.

Drug interactions

Overdose

Storage conditions

• store in a dry place
• keep away from children
• store in a place protected from light

Synonyms

• Apo-Trifluoperazine, Trifluoperazine, Triftazin-Darnitsa, Escasin.